' 
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-6 (from pyridoxal-5'-phosphate [Coenzymated™])
335 mcg
20%
Melatonin
5 mg
†
Top Medical Research Studies
7
Pyridoxine shows potential in Alzheimer's
Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Study relates B6 to Alzheimer's
We explored the effects of pyridoxine, commonly known as vitamin B6, in a cell model of Alzheimer's disease (AD). This study aimed to understand how pyridoxine works and whether it can help combat the challenges associated with AD.
Using various techniques, including MTT assays, western blotting, and reactive oxygen species (ROS) assays, we observed how pyridoxine can offer protection against AD. The findings showed that vitamin B6 seems to lower ROS levels, which are often elevated in the context of Alzheimer’s. Additionally, it appeared to decrease the presence of cytoplasmic Nrf2 while increasing whole-cell HO-1 expression.
Overall, we suggest that the benefits of pyridoxine in Alzheimer's cases may stem from its ability to act as an antioxidant, particularly by stimulating the Nrf2/HO-1 pathway. This suggests that vitamin B6 could potentially be a useful ally in addressing the oxidative stress associated with Alzheimer’s disease.
Using various techniques, including MTT assays, western blotting, and reactive oxygen species (ROS) assays, we observed how pyridoxine can offer protection against AD. The findings showed that vitamin B6 seems to lower ROS levels, which are often elevated in the context of Alzheimer’s. Additionally, it appeared to decrease the presence of cytoplasmic Nrf2 while increasing whole-cell HO-1 expression.
Overall, we suggest that the benefits of pyridoxine in Alzheimer's cases may stem from its ability to act as an antioxidant, particularly by stimulating the Nrf2/HO-1 pathway. This suggests that vitamin B6 could potentially be a useful ally in addressing the oxidative stress associated with Alzheimer’s disease.
Read More
9
Vitamin B6 shows potential effects
Evaluation of hydrazone and -acylhydrazone derivatives of vitamin B6 and pyridine-4-carbaldehyde as potential drugs against Alzheimer's disease.
Combining compounds limits effectiveness
We explored the potential of certain derivatives of vitamin B6 in combating Alzheimer's disease. Our focus was on hydrazone and acylhydrazone compounds combined with pyridine-4-carbaldehyde. We aimed to see how these compounds could serve as multi-target agents, effectively addressing several key factors in Alzheimer's progression.
Our findings were promising. We discovered that these hydrazones could inhibit key enzymes associated with Alzheimer's, such as acetylcholinesterase and butyrylcholinesterase. Furthermore, they helped reduce the formation of harmful beta-amyloid plaques by targeting both beta-secretase activity and the aggregation of amyloid proteins.
Besides addressing these symptoms, we also noted their ability to balance biometals in the brain by chelating essential metals. Overall, our results demonstrated that these compounds not only exhibited strong inhibition against cholinesterases but were also effective in lowering beta-secretase activity, preventing amyloid aggregation, and showed antioxidant properties.
Additionally, most of these vitamin B6 derivatives appeared capable of crossing the blood-brain barrier, which is crucial for any potential Alzheimer's treatment. They also exhibited moderate stability in the liver and could be absorbed in the intestines, further suggesting their viability as a treatment.
While these results are encouraging, it's important to note that the effectiveness of vitamin B6 derivatives is assessed in combination with other compounds, which may complicate isolating their specific contributions.
Our findings were promising. We discovered that these hydrazones could inhibit key enzymes associated with Alzheimer's, such as acetylcholinesterase and butyrylcholinesterase. Furthermore, they helped reduce the formation of harmful beta-amyloid plaques by targeting both beta-secretase activity and the aggregation of amyloid proteins.
Besides addressing these symptoms, we also noted their ability to balance biometals in the brain by chelating essential metals. Overall, our results demonstrated that these compounds not only exhibited strong inhibition against cholinesterases but were also effective in lowering beta-secretase activity, preventing amyloid aggregation, and showed antioxidant properties.
Additionally, most of these vitamin B6 derivatives appeared capable of crossing the blood-brain barrier, which is crucial for any potential Alzheimer's treatment. They also exhibited moderate stability in the liver and could be absorbed in the intestines, further suggesting their viability as a treatment.
While these results are encouraging, it's important to note that the effectiveness of vitamin B6 derivatives is assessed in combination with other compounds, which may complicate isolating their specific contributions.
Read More
9
Vitamin B6 mitigates cognitive decline
Vitamin B6 p-JNK/Nrf-2/NF-κB Signaling Ameliorates Cadmium Chloride-Induced Oxidative Stress Mediated Memory Deficits in Mice Hippocampus.
Potential link to Alzheimer's explored
We delved into the potential of vitamin B6 to alleviate memory problems related to exposure to cadmium chloride, a harmful heavy metal known for its association with neurodegenerative diseases such as Alzheimer's. In our study, we used adult albino mice, dividing them into four groups: a control group that received saline, a group exposed to cadmium, a group treated with both cadmium and vitamin B6, and a group receiving only vitamin B6.
Our behavioral tests, including the Morris Water Maze and Y-Maze, helped us assess any changes in memory and learning through these different treatments. We observed that the mice exposed to cadmium experienced notable cognitive impairments, showcasing the neurotoxic effects of this heavy metal. However, treatment with vitamin B6 led to significant improvements in the cognitive performance of the mice previously affected by cadmium.
Beyond just behavior, we also examined various biological markers. We found that cadmium exposure triggered oxidative stress and neuroinflammation, resulting in disrupted synaptic proteins and activation of certain stress-related pathways. Remarkably, administering vitamin B6 appeared to counteract these negative effects, restoring both synaptic function and memory capabilities.
Overall, our findings suggest that vitamin B6 does hold promise as a safe and effective therapeutic supplement for addressing cognitive decline, particularly in cases linked with environmental toxins like cadmium. This underscores the importance of nutritional strategies in combating neurodegenerative diseases that affect public health.
Our behavioral tests, including the Morris Water Maze and Y-Maze, helped us assess any changes in memory and learning through these different treatments. We observed that the mice exposed to cadmium experienced notable cognitive impairments, showcasing the neurotoxic effects of this heavy metal. However, treatment with vitamin B6 led to significant improvements in the cognitive performance of the mice previously affected by cadmium.
Beyond just behavior, we also examined various biological markers. We found that cadmium exposure triggered oxidative stress and neuroinflammation, resulting in disrupted synaptic proteins and activation of certain stress-related pathways. Remarkably, administering vitamin B6 appeared to counteract these negative effects, restoring both synaptic function and memory capabilities.
Overall, our findings suggest that vitamin B6 does hold promise as a safe and effective therapeutic supplement for addressing cognitive decline, particularly in cases linked with environmental toxins like cadmium. This underscores the importance of nutritional strategies in combating neurodegenerative diseases that affect public health.
Read More
Most Useful Reviews
8.8
Cognitive protection
Melatonin is not only a sleep aid but has numerous health benefits. It is linked to preventing memory disorders, including Alzheimer's, as it has powerful antioxidant properties. I have used it for years with positive results and feel reassured about its protective effects on my body.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
9
Vitamin B6 shows potential effects
Evaluation of hydrazone and -acylhydrazone derivatives of vitamin B6 and pyridine-4-carbaldehyde as potential drugs against Alzheimer's disease.
Combining compounds limits effectiveness
We explored the potential of certain derivatives of vitamin B6 in combating Alzheimer's disease. Our focus was on hydrazone and acylhydrazone compounds combined with pyridine-4-carbaldehyde. We aimed to see how these compounds could serve as multi-target agents, effectively addressing several key factors in Alzheimer's progression.
Our findings were promising. We discovered that these hydrazones could inhibit key enzymes associated with Alzheimer's, such as acetylcholinesterase and butyrylcholinesterase. Furthermore, they helped reduce the formation of harmful beta-amyloid plaques by targeting both beta-secretase activity and the aggregation of amyloid proteins.
Besides addressing these symptoms, we also noted their ability to balance biometals in the brain by chelating essential metals. Overall, our results demonstrated that these compounds not only exhibited strong inhibition against cholinesterases but were also effective in lowering beta-secretase activity, preventing amyloid aggregation, and showed antioxidant properties.
Additionally, most of these vitamin B6 derivatives appeared capable of crossing the blood-brain barrier, which is crucial for any potential Alzheimer's treatment. They also exhibited moderate stability in the liver and could be absorbed in the intestines, further suggesting their viability as a treatment.
While these results are encouraging, it's important to note that the effectiveness of vitamin B6 derivatives is assessed in combination with other compounds, which may complicate isolating their specific contributions.
Our findings were promising. We discovered that these hydrazones could inhibit key enzymes associated with Alzheimer's, such as acetylcholinesterase and butyrylcholinesterase. Furthermore, they helped reduce the formation of harmful beta-amyloid plaques by targeting both beta-secretase activity and the aggregation of amyloid proteins.
Besides addressing these symptoms, we also noted their ability to balance biometals in the brain by chelating essential metals. Overall, our results demonstrated that these compounds not only exhibited strong inhibition against cholinesterases but were also effective in lowering beta-secretase activity, preventing amyloid aggregation, and showed antioxidant properties.
Additionally, most of these vitamin B6 derivatives appeared capable of crossing the blood-brain barrier, which is crucial for any potential Alzheimer's treatment. They also exhibited moderate stability in the liver and could be absorbed in the intestines, further suggesting their viability as a treatment.
While these results are encouraging, it's important to note that the effectiveness of vitamin B6 derivatives is assessed in combination with other compounds, which may complicate isolating their specific contributions.
Read More
9
Vitamin B6 mitigates cognitive decline
Vitamin B6 p-JNK/Nrf-2/NF-κB Signaling Ameliorates Cadmium Chloride-Induced Oxidative Stress Mediated Memory Deficits in Mice Hippocampus.
Potential link to Alzheimer's explored
We delved into the potential of vitamin B6 to alleviate memory problems related to exposure to cadmium chloride, a harmful heavy metal known for its association with neurodegenerative diseases such as Alzheimer's. In our study, we used adult albino mice, dividing them into four groups: a control group that received saline, a group exposed to cadmium, a group treated with both cadmium and vitamin B6, and a group receiving only vitamin B6.
Our behavioral tests, including the Morris Water Maze and Y-Maze, helped us assess any changes in memory and learning through these different treatments. We observed that the mice exposed to cadmium experienced notable cognitive impairments, showcasing the neurotoxic effects of this heavy metal. However, treatment with vitamin B6 led to significant improvements in the cognitive performance of the mice previously affected by cadmium.
Beyond just behavior, we also examined various biological markers. We found that cadmium exposure triggered oxidative stress and neuroinflammation, resulting in disrupted synaptic proteins and activation of certain stress-related pathways. Remarkably, administering vitamin B6 appeared to counteract these negative effects, restoring both synaptic function and memory capabilities.
Overall, our findings suggest that vitamin B6 does hold promise as a safe and effective therapeutic supplement for addressing cognitive decline, particularly in cases linked with environmental toxins like cadmium. This underscores the importance of nutritional strategies in combating neurodegenerative diseases that affect public health.
Our behavioral tests, including the Morris Water Maze and Y-Maze, helped us assess any changes in memory and learning through these different treatments. We observed that the mice exposed to cadmium experienced notable cognitive impairments, showcasing the neurotoxic effects of this heavy metal. However, treatment with vitamin B6 led to significant improvements in the cognitive performance of the mice previously affected by cadmium.
Beyond just behavior, we also examined various biological markers. We found that cadmium exposure triggered oxidative stress and neuroinflammation, resulting in disrupted synaptic proteins and activation of certain stress-related pathways. Remarkably, administering vitamin B6 appeared to counteract these negative effects, restoring both synaptic function and memory capabilities.
Overall, our findings suggest that vitamin B6 does hold promise as a safe and effective therapeutic supplement for addressing cognitive decline, particularly in cases linked with environmental toxins like cadmium. This underscores the importance of nutritional strategies in combating neurodegenerative diseases that affect public health.
Read More
9
Exploring vitamin B6 in Alzheimer's
Changes in Biothiol Levels Are Closely Associated with Alzheimer's Disease.
Moderate relevance to treatment effects
We aimed to understand how vitamin B6 affects key thiol levels associated with Alzheimer's disease (AD). The study focused on the levels of homocysteine (Hcy), cysteine (Cys), and glutathione (GSH) in both the brain tissues of APP/PS1 mice and the serum of AD patients.
Our findings revealed an intriguing relationship between these thiols. In both the mouse and patient samples, Hcy was significantly elevated, while levels of Cys and GSH were notably decreased. This pattern aligns with common indicators of Alzheimer's disease.
The highlight of our results came when we introduced vitamin B6 into the mix. Supplementing with vitamin B6 helped bring Hcy levels back to normal and restored Cys and GSH levels in the brain of APP/PS1 mice and the Aβ1-42-treated PC12 cells.
While the results are promising, they suggest that vitamin B6 could have a role in managing thiol levels related to AD. It's essential to conduct further research to establish the potential of vitamin B6 as a therapeutic option in Alzheimer's treatment.
Our findings revealed an intriguing relationship between these thiols. In both the mouse and patient samples, Hcy was significantly elevated, while levels of Cys and GSH were notably decreased. This pattern aligns with common indicators of Alzheimer's disease.
The highlight of our results came when we introduced vitamin B6 into the mix. Supplementing with vitamin B6 helped bring Hcy levels back to normal and restored Cys and GSH levels in the brain of APP/PS1 mice and the Aβ1-42-treated PC12 cells.
While the results are promising, they suggest that vitamin B6 could have a role in managing thiol levels related to AD. It's essential to conduct further research to establish the potential of vitamin B6 as a therapeutic option in Alzheimer's treatment.
Read More
8
Vitamin B6 may reduce AD risk
Associations among dietary 1-carbon metabolism nutrients, genetic risk, and Alzheimer disease: a prospective cohort study.
Important but not conclusive
We analyzed the association between dietary nutrients, including vitamin B6, and the risk of Alzheimer’s disease (AD) using data from a large cohort of 192,214 participants. This study aimed to determine if high dietary intake of 1-carbon metabolism (OCM) nutrients, such as vitamin B6, could lower the chances of developing AD, particularly in individuals with a genetic predisposition to the disease.
Through a median follow-up of over 13 years, we identified 959 cases of AD, which included both early-onset and late-onset cases. Our findings revealed that people with higher intake of OCM nutrients had a lower risk of developing AD compared to those with lower nutrient intake. Specifically for vitamin B6, those who had higher intakes demonstrated a reduced risk, with a hazard ratio indicating a 29% reduction in risk for early-onset AD.
Importantly, we discovered that individuals with a high genetic risk for AD particularly benefited from increased dietary intake of these nutrients. This suggests that vitamin B6, among other OCM nutrients, may play a protective role in reducing the risk of Alzheimer’s, especially for those at greater genetic risk. Overall, our study suggests that incorporating vitamin B6 into the diet could be a promising strategy for mitigating the risk of this debilitating disease.
Through a median follow-up of over 13 years, we identified 959 cases of AD, which included both early-onset and late-onset cases. Our findings revealed that people with higher intake of OCM nutrients had a lower risk of developing AD compared to those with lower nutrient intake. Specifically for vitamin B6, those who had higher intakes demonstrated a reduced risk, with a hazard ratio indicating a 29% reduction in risk for early-onset AD.
Importantly, we discovered that individuals with a high genetic risk for AD particularly benefited from increased dietary intake of these nutrients. This suggests that vitamin B6, among other OCM nutrients, may play a protective role in reducing the risk of Alzheimer’s, especially for those at greater genetic risk. Overall, our study suggests that incorporating vitamin B6 into the diet could be a promising strategy for mitigating the risk of this debilitating disease.
Read More
7
Vitamin B6 enhances donepezil efficacy
Synergistic Effect of Donepezil and Neurotropic B Vitamins on Dysregulated Antioxidant, Inflammation and Neurotransmitter Status in Aluminium Chloride-Induced Neurotoxicity in Rats.
Combination therapy explored for Alzheimer’s
We conducted a study to investigate the potential benefits of vitamin B6 when used alongside donepezil in addressing neurotoxicity caused by aluminum chloride (AlCl) in rats. This research is particularly relevant because it explores treatment options for Alzheimer's disease, which affects millions worldwide.
In our study, we observed that Alzheimer-like symptoms were provoked in the rats through AlCl administration. The subjects receiving a combination of donepezil and vitamin B6 showed improvements in several biochemical markers compared to those treated with just AlCl alone. Notably, we found that the combination therapy effectively reduced markers of oxidative stress and inflammation, which are critical factors in Alzheimer’s progression.
While vitamin B6 alone’s effects were difficult to isolate, our findings suggested that it could enhance donepezil's neuroprotective properties. Overall, the combination therapy outperformed donepezil used by itself, particularly indicating that donepezil and vitamin B1 together provided the most significant benefit among the combinations we studied. However, we urge caution as the specific effects of vitamin B6 alone were not directly assessed, and further research would be essential to understand its standalone impact properly.
In our study, we observed that Alzheimer-like symptoms were provoked in the rats through AlCl administration. The subjects receiving a combination of donepezil and vitamin B6 showed improvements in several biochemical markers compared to those treated with just AlCl alone. Notably, we found that the combination therapy effectively reduced markers of oxidative stress and inflammation, which are critical factors in Alzheimer’s progression.
While vitamin B6 alone’s effects were difficult to isolate, our findings suggested that it could enhance donepezil's neuroprotective properties. Overall, the combination therapy outperformed donepezil used by itself, particularly indicating that donepezil and vitamin B1 together provided the most significant benefit among the combinations we studied. However, we urge caution as the specific effects of vitamin B6 alone were not directly assessed, and further research would be essential to understand its standalone impact properly.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Cognitive protection
Melatonin is not only a sleep aid but has numerous health benefits. It is linked to preventing memory disorders, including Alzheimer's, as it has powerful antioxidant properties. I have used it for years with positive results and feel reassured about its protective effects on my body.
Read More
