We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
Most Useful Reviews
10
Eliminates allergies
Since I started taking zinc, I have seen a tremendous improvement. I used to suffer from colds, phlegm, sneezing, and allergies, but zinc has helped me overcome all of that. I haven't caught a cold since, and even with dust exposure, I no longer have allergies. I highly recommend it!
Read More
9
Cold allergy relief
ZINC is a MAGICAL TRACE ELEMENT for women's beauty, men's health, and strong immunity. One tablet a day suffices to avoid cold allergies and to rejuvenate my hair. This supplement also strengthens the immune system and effectively deals with infections, making it indispensable in winter.
Read More
6
Supports allergy relief
6 people found this helpful
Zinc is an essential mineral that supports insulin and growth hormone production and plays a vital role in managing hay fever and allergy symptoms, enhancing rough skin, and detoxifying heavy metals. The recommended daily intake for this 30 mg supplement is 2 to 3 tablets, but taking it on an empty stomach may cause nausea, so I suggest starting with 1 tablet after a meal.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
Read More
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
8
Zinc supplementation may reduce allergies
Zinc Deficiency and Zinc Supplementation in Allergic Diseases.
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
Since I started taking zinc, I have seen a tremendous improvement. I used to suffer from colds, phlegm, sneezing, and allergies, but zinc has helped me overcome all of that. I haven't caught a cold since, and even with dust exposure, I no longer have allergies. I highly recommend it!
Read More
9
Cold allergy relief
ZINC is a MAGICAL TRACE ELEMENT for women's beauty, men's health, and strong immunity. One tablet a day suffices to avoid cold allergies and to rejuvenate my hair. This supplement also strengthens the immune system and effectively deals with infections, making it indispensable in winter.
Read More
6
Supports allergy relief
6 people found this helpful
Zinc is an essential mineral that supports insulin and growth hormone production and plays a vital role in managing hay fever and allergy symptoms, enhancing rough skin, and detoxifying heavy metals. The recommended daily intake for this 30 mg supplement is 2 to 3 tablets, but taking it on an empty stomach may cause nausea, so I suggest starting with 1 tablet after a meal.
Read More
Frequently Asked Questions
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been studied for its potential effects on the immune system, and some research suggests that it may play a role in managing allergic responses. While zinc is essential for maintaining overall immune function, a direct link between zinc supplementation and reduction in allergy symptoms has not been firmly established. Some studies indicate that zinc may help modulate inflammation and could potentially benefit those with allergic rhinitis or other allergic conditions, but results can vary widely among individuals.
If you're considering zinc as a supplement for allergies, it’s vital to consult with a healthcare professional first. They can provide personalized advice based on your health status and any medications you might be taking. Additionally, focusing on a balanced diet rich in zinc-containing foods like nuts, seeds, legumes, and whole grains can offer support to your overall health and immune function, which may indirectly influence how your body handles allergens.
Based on user reviews, the timeline for seeing results from taking zinc supplements for allergies can vary. Some users report immediate improvements in their allergy symptoms after starting the supplement. One reviewer mentions, "Since I started taking zinc, I have seen a tremendous improvement" and credits zinc with overcoming cold and allergy issues almost instantly (Read Review). Meanwhile, another user emphasizes the mineral's effectiveness as part of a long-term health routine, noting that it has become indispensable for managing cold and allergy symptoms particularly during winter months (Read Review).
However, the ideal duration before experiencing noticeable relief can depend on individual health factors and dosage. One user highlights the role of zinc in managing hay fever and suggests an optimal dosage of 2 to 3 tablets daily, though cautioning that taking it on an empty stomach might lead to discomfort (Read Review). Overall, while some see rapid results, for others, consistent use over time may be necessary to fully benefit from the supplement.
The research indicates promising support for zinc and quail egg supplements in managing allergies, particularly allergic rhinitis. One study highlighted that a combination of quail egg supplements with zinc significantly improved various symptoms associated with allergic rhinitis, such as nasal congestion and sneezing, and reduced the reliance on standard medication ([1]). Additionally, another investigation revealed that intranasal zinc treatment could alleviate allergy symptoms in individuals with Japanese cedar pollinosis, indicating its potential effectiveness ([2]).
Furthermore, several studies underscore the essential role of adequate zinc levels in modulating immune responses tied to allergic conditions, including asthma and atopic dermatitis. These findings suggest that zinc supplementation could be beneficial for individuals suffering from allergies, potentially reducing symptoms and improving overall immune function ([6], [7]). However, while these results are encouraging, it’s important to note that further research is necessary to fully understand the extent of zinc's impact on allergy management.
Users have reported a range of improvements in their allergy symptoms and overall health after incorporating zinc supplements into their routines. One reviewer noted a significant turnaround in their health, stating, "Since I started taking zinc, I have seen a tremendous improvement," highlighting a complete cessation of colds and allergy issues even with exposure to dust (Read Review). Another user referred to zinc as a "MAGICAL TRACE ELEMENT" for enhancing beauty and health, asserting that just one tablet a day was adequate to avoid cold allergies, which reflects a strong belief in its effectiveness in enhancing overall immune function during the winter months (Read Review).
While many users have experienced quick improvements, others emphasize the importance of dosage and timing. One user suggests an intake of 2 to 3 tablets daily for best results in managing hay fever and harmful symptoms, but also cautions against taking zinc on an empty stomach to avoid potential nausea (Read Review). These anecdotal experiences point to a generally positive sentiment regarding the effectiveness of zinc for alleviating allergy-related symptoms, though individual results can indeed vary.
Users have reported mixed experiences regarding the combination of zinc supplements with other allergy remedies. Some find that supplementing with zinc not only provides significant relief from allergy symptoms but also enhances the effectiveness of other measures they might be taking. One user noted a complete turnaround in their allergy issues, stating, "Since I started taking zinc, I have seen a tremendous improvement," and emphasized that they haven't caught a cold since they began taking the supplement (Read Review). This suggests that for some, zinc may work well in conjunction with other treatments or lifestyle changes to boost overall immunity and reduce allergy impacts.
However, it's crucial to consider proper dosage and timing, as highlighted by another user who cautioned against taking zinc on an empty stomach to avoid nausea (Read Review). This advisory indicates that users combining zinc with other supplements should be mindful of their intake protocols to experience optimal benefits. Additionally, another reviewer suggested a dosage of 2 to 3 tablets daily for better management of hay fever and other allergy symptoms, emphasizing the importance of a balanced approach to supplementation when addressing allergies (Read Review).
Users report varying experiences regarding the optimal dose of Zinc for treating allergies. Some suggest that even just one tablet of Zinc per day can effectively alleviate symptoms associated with allergies and colds, providing substantial relief from issues like sneezing and congestion (review id='52c7029f-7b97-4f00-973d-1b2851f5b2bc', review id='bd985e28-9a55-48e6-9c27-5bac76a1bf28'). Others, however, recommend a higher intake, noting that the daily recommended dose for a 30 mg supplement typically falls between 2 to 3 tablets. They caution that taking Zinc on an empty stomach may lead to nausea, advising users instead to start with one tablet after meals to avoid such side effects Read Review.
10
Eliminates allergies
Since I started taking zinc, I have seen a tremendous improvement. I used to suffer from colds, phlegm, sneezing, and allergies, but zinc has helped me overcome all of that. I haven't caught a cold since, and even with dust exposure, I no longer have allergies. I highly recommend it!
9
Cold allergy relief
ZINC is a MAGICAL TRACE ELEMENT for women's beauty, men's health, and strong immunity. One tablet a day suffices to avoid cold allergies and to rejuvenate my hair. This supplement also strengthens the immune system and effectively deals with infections, making it indispensable in winter.
6
Supports allergy relief
6 people found this helpful
Zinc is an essential mineral that supports insulin and growth hormone production and plays a vital role in managing hay fever and allergy symptoms, enhancing rough skin, and detoxifying heavy metals. The recommended daily intake for this 30 mg supplement is 2 to 3 tablets, but taking it on an empty stomach may cause nausea, so I suggest starting with 1 tablet after a meal.
9
Zinc and QES alleviate allergies
Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
8
Zinc supplementation may reduce allergies
Zinc Deficiency and Zinc Supplementation in Allergic Diseases.
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
8
Zinc gluconate helps atopic dermatitis
Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation.
We investigated how zinc affects atopic dermatitis (AD), a chronic skin condition linked to immune responses. Our analysis revealed that individuals with AD had significantly lower levels of zinc in their bloodstream compared to those without the condition. This connection led us to examine how zinc could potentially ease the symptoms associated with AD.
Through our research, we noticed that AD skin showed increased levels of a specific protein called CXCL10. This protein is known to be involved in inflammatory responses, and we found that its levels were inversely related to zinc levels in the serum. When we treated keratinocytes, the cells that make up the skin, with zinc gluconate, we observed a reduction in CXCL10 release, suggesting it may help manage inflammation associated with AD.
Moreover, in a mouse model mimicking AD, zinc gluconate therapy significantly reduced the severity of skin lesions and serum IgE levels—an indicator of allergic responses. The therapy also decreased skin thickness and CXCL10 production, showcasing its promise as a treatment option for managing atopic dermatitis.
Overall, our findings illustrate that zinc gluconate can be beneficial in reducing inflammation and symptoms in individuals with AD by modulating the immune response through specific cellular mechanisms.
References
Antonelli M, Mazzoleni E, Donelli D. Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies. Nutrients. 2025;17. 10.3390/nu17040712
Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. 10.1016/j.jacig.2025.100408
Otsuka T, Sato K, Kamiya T, Tanaka H, Hara H. Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells. Eur J Pharmacol. 2025;994:177391. 10.1016/j.ejphar.2025.177391
Wang S, Ilves M, Mäenpää K, Zhao L, El-Nezami H, et al. ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice. ACS Nano. 2024;18:29479. 10.1021/acsnano.4c04270
Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. 10.1159/000540376
Maywald M, Rink L. Zinc Deficiency and Zinc Supplementation in Allergic Diseases. Biomolecules. 2024;14. 10.3390/biom14070863
Wei Y, Zhu X, Lin S, Yang W, Wang T, et al. Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation. Biomed Pharmacother. 2024;177:117129. 10.1016/j.biopha.2024.117129