' 
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
The product is found useful for the following medical conditions
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.8
9.5
Eicosapentaenoic acid helps migraines
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.
Most Relevant Research
We conducted a thorough investigation into how eicosapentaenoic acid (EPA) can impact episodic migraines. In a carefully designed study, we gathered 70 participants who experienced these migraines and divided them into two groups. One group received a high dose of EPA, while the other was given a placebo. This approach ensured that we could see the true effects of EPA without bias.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
10
Migraine relief
Most Useful Review
What a quality omega! The effect is highly noticeable, particularly on my skin. My migraine has disappeared.
Reflux details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 13 Reviews
8.8
10
No reflux
Most Useful Review
Easy to take! I had given up on fish oil as every brand gave me reflux. My sister-in-law recommended these, and they're amazing! There’s no fishy taste, no reflux, and no burping. They are also surprisingly easy to swallow given their size.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.4
USERS' SCORE
Good
Based on 12 Reviews
8.7
8
DHA improves milk and reduces anxiety
DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring.
Most Relevant Research
We explored how supplementing obese mothers with docosahexaenoic acid (DHA) affects milk composition and the anxiety behavior of their offspring. In a study involving female Wistar rats, some were placed on a high-fat diet while others ate regular chow. We supplemented half of the mothers from one month before mating until they weaned their pups with DHA. The goal was to see if this supplementation could improve the quality of their milk and influence the anxiety levels of their babies.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
9.5
Anxiety diminished
Most Useful Review
It just works! I've tried every fish oil on the market but never found any benefits. After trying Sports Research fish oil, I noticed immediate relief from my knee pain and a remarkable improvement in my anxiety. My anxiety has lessened considerably since taking it, and I will never switch back to other brands.
Arteriosclerosis details
SCIENTIFIC SCORE
Questionable
Based on 28 Researches
6.9
USERS' SCORE
Good
Based on 7 Reviews
8.7
9
DHA stabilizes arterial plaques
Injectable liposomal docosahexaenoic acid alleviates atherosclerosis progression and enhances plaque stability.
Most Relevant Research
We embarked on a quest to understand how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact atherosclerosis, a condition where fatty deposits clog the arteries. Our focus was on a specially developed injectable formulation that delivers DHA directly to the site of arterial plaques.
Through our research, we discovered that this liposomal DHA formulation not only protects the compound but also enhances its effectiveness. When we administered it intravenously, DHA particles were specifically absorbed by macrophages—immune cells involved in the inflammation seen in atherosclerosis. This targeted delivery helps reduce inflammation and prevents the formation of foam cells, which are a hallmark of atherosclerotic plaques.
Furthermore, our analysis of the plaques revealed that the DHA treatment led to less macrophage infiltration and reduced lipid build-up, which improves overall plaque stability. In simpler terms, we observed that the treatment makes plaques less likely to rupture, which is critical in preventing serious cardiovascular problems. Additionally, sophisticated imaging techniques showed that DHA can help restore some of the healthy lipid profiles typical of earlier stages of plaque development.
In summary, using injectable DHA offers exciting potential for stabilizing arterial plaques and slowing down the progression of atherosclerosis. Given the importance of addressing this condition, our findings could pave the way for new therapeutic strategies to reduce the risk of heart-related issues.
Through our research, we discovered that this liposomal DHA formulation not only protects the compound but also enhances its effectiveness. When we administered it intravenously, DHA particles were specifically absorbed by macrophages—immune cells involved in the inflammation seen in atherosclerosis. This targeted delivery helps reduce inflammation and prevents the formation of foam cells, which are a hallmark of atherosclerotic plaques.
Furthermore, our analysis of the plaques revealed that the DHA treatment led to less macrophage infiltration and reduced lipid build-up, which improves overall plaque stability. In simpler terms, we observed that the treatment makes plaques less likely to rupture, which is critical in preventing serious cardiovascular problems. Additionally, sophisticated imaging techniques showed that DHA can help restore some of the healthy lipid profiles typical of earlier stages of plaque development.
In summary, using injectable DHA offers exciting potential for stabilizing arterial plaques and slowing down the progression of atherosclerosis. Given the importance of addressing this condition, our findings could pave the way for new therapeutic strategies to reduce the risk of heart-related issues.
9.5
Lowered triglyceride levels
Most Useful Review
I began taking Omega 3 due to its reputation for lowering blood triglycerides and decreasing the risk of arteriosclerosis and heart disease. After three and a half months, my triglycerides decreased from 96 to 67 mg/dl. My HDL dropped from 71 to 65 mg/dl, and my LDL went from 132 to 121 mg/dl. I don’t consume much fish, so I attribute these improvements to the supplement.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.6
USERS' SCORE
Good
Based on 32 Reviews
8.7
8
Eicosapentaenoic acid benefits MS
The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
9.5
Improved health
Most Useful Review
EXCELLENT QUALITY OMEGA! This was my first order from this manufacturer, and I’m impressed. I take omega regularly, especially since I don't consume fish often. After three months on it, I noticed significant improvements in my hair growth, nail strength, and overall cheerfulness. My skin is also hydrated and nourished. The quality-to-price ratio is excellent, making it a must-buy!
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.6
USERS' SCORE
Good
Based on 47 Reviews
8.7
9
Eicosapentaenoic acid influences clotting
Emergence of omega-3 fatty acids in biomedical research.
Most Relevant Research
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting processes. The interest in EPA grew substantially after the 1970s when researchers Dyerberg and Bang noted that Greenland Eskimos had lower rates of coronary disease linked to their diet rich in marine lipids.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
9.5
Skin condition improved
Most Useful Review
The ideal dosage for everyday vitamins comes in a plastic jar with protective mica on the lid. The sleek black design conveys quality. The capsules are large, dense, and rich golden colour, with no smell, which delighted me! They swallow easily with a glass of water, and I don’t feel them in my throat. No fishy burps or unpleasant aftertastes! I track my skin condition, especially dryness on my elbows and legs. Without omega, my skin stays dry, needing constant moisturising. With omega, my skin feels normal, soft, and delicate. I can't identify its effects on heart health or blood vessels, but I do maintain good blood pressure for my age.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 34 Reviews
8.7
9.5
Bone pain reduced
Most Useful Review
The best Omega 3 pills I've tried, with a dose of 1250 mg in just one pill per day as opposed to others requiring two. I always had bone pain problems, and I swear this has reduced it significantly. I would recommend buying it; this is my second time purchasing.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 12 Reviews
8.7
9.5
Eicosapentaenoic acid benefits CFS
Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes.
Most Relevant Research
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
9.5
Fatigue disappeared
Most Useful Review
Excellent value for money and quality! I have taken this omega for over a month and it's given me a remarkable boost in energy throughout the day! As a parent, sleepless nights leave me feeling broken, but since I started this omega, my fatigue has vanished! Additionally, it has improved my skin and nails significantly!
Constipation details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.7
10
Helps constipation
Most Useful Review
Hello Omega good helps with constipation, very satisfied. 😀
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Effective for cramps
Most Useful Review
Regarding the nails, the reception of this complex did not impact me. As for my hair, many beneficial products are used, but since nutrition is important from within, and my hair grows well without dryness, I attribute this to taking fish oil. Concerning leg cramps, I frequently experience them, particularly when I am cold. Recently, however, my legs have ceased cramping during sleep. Since I have not taken magnesium B6 since summer, fish oil has clearly made a difference. Thus, I will award it a point for relieving leg cramps.
Menopause details
SCIENTIFIC SCORE
Questionable
Based on 27 Researches
6.8
USERS' SCORE
Good
Based on 7 Reviews
8.7
9
DHA alleviates menopausal symptoms
Neurovegetative disorders of perimenopausal women treated with docosahexaenoic acid (DHA, 625 mg).
Most Relevant Research
We explored how docosahexaenoic acid (DHA), at a dosage of 625 mg, affects menopausal symptoms among perimenopausal women. Our study involved 42 participants who were assessed for various symptoms using the Kupperman Index, along with quality of life and sexual function measured through standardized scales.
After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.
Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.
Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.
Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.
Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
9.5
Cholesterol improvement
Most Useful Review
I have angina, and during menopause, LDL cholesterol tends to rise. After taking this fish oil daily, my LDL cholesterol dropped from 130 to 65 within a month. Alongside light exercise and avoiding dairy products, even my doctor was surprised. It was more effective than statins, so I intend to continue.
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.5
USERS' SCORE
Good
Based on 9 Reviews
8.7
9
DHA's role in osteoporosis treatment
Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice.
Most Relevant Research
We recently looked into how docosahexaenoic acid (DHA), through its enriched phosphatidylcholine form (DHA-PC), affects osteoporosis. Using a model that simulates the condition in women after ovariectomy, we compared the impact of DHA-PC with eicosapentaenoic acid (EPA) enriched phosphatidylcholine (EPA-PC). Our findings revealed that both DHA-PC and EPA-PC significantly improved the structural quality of trabecular bone, boosted the rate of new bone formation, and elevated bone mineral density, which are crucial factors in combating osteoporosis.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
9.5
Prevents osteoporosis
Most Useful Review
This Omega-3 fish oil, certified by IFOS, is extracted from wild Alaska pollock. Each capsule contains significant amounts of EPA and DHA. Its benefits include reducing cholesterol and triglycerides, managing blood pressure, preventing osteoporosis, and enhancing joint health. It’s recommended to take 1-2 capsules daily, and it’s a great value, currently on sale.
Stroke details
SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8.1
USERS' SCORE
Good
Based on 10 Reviews
8.7
9
Eicosapentaenoic Acid reduces stroke risk
Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies.
Most Relevant Research
We investigated the relationship between eicosapentaenoic acid (EPA) levels and stroke risk by pooling data from 29 international studies, involving over 183,000 participants. Our goal was to understand how circulating and tissue omega-3 fatty acid levels, specifically EPA, affect the occurrence of different types of stroke, including total, ischemic, and hemorrhagic strokes.
Our findings revealed that higher levels of EPA are linked to a lower risk of both total and ischemic strokes. For participants who had the highest levels of EPA, there was a 17% lower incidence of total strokes compared to those with the lowest levels, and an 18% reduction in ischemic strokes. This suggests that increasing EPA intake could be beneficial in reducing the risk of these stroke types.
However, it's important to note that EPA showed no significant relationship with hemorrhagic stroke risk. This indicates that while EPA may help prevent some stroke types, it does not appear to reduce the risk of bleeding strokes. These results were consistent across various demographics, regardless of whether participants had a history of atrial fibrillation or existing cardiovascular disease. Overall, our study presents strong evidence that EPA can be a valuable addition to dietary strategies aimed at reducing stroke risks.
Our findings revealed that higher levels of EPA are linked to a lower risk of both total and ischemic strokes. For participants who had the highest levels of EPA, there was a 17% lower incidence of total strokes compared to those with the lowest levels, and an 18% reduction in ischemic strokes. This suggests that increasing EPA intake could be beneficial in reducing the risk of these stroke types.
However, it's important to note that EPA showed no significant relationship with hemorrhagic stroke risk. This indicates that while EPA may help prevent some stroke types, it does not appear to reduce the risk of bleeding strokes. These results were consistent across various demographics, regardless of whether participants had a history of atrial fibrillation or existing cardiovascular disease. Overall, our study presents strong evidence that EPA can be a valuable addition to dietary strategies aimed at reducing stroke risks.
9.5
Improves brain function
Most Useful Review
Omega 3 from RS provides a high level of fatty acids per capsule, accelerating metabolism and lowering blood viscosity and blood pressure. It effectively reduces the risk of stroke and heart attacks and enhances brain function while boosting skin and hair conditions. I highly recommend it for its genuine results.
Ulcer details
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.5
USERS' SCORE
Good
Based on 3 Reviews
8.7
9
Eicosapentaenoic acid aids ulcer healing
Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-κB and TGF-β/ EGFR signaling pathways.
Most Relevant Research
We examined how Eicosapentaenoic acid (EPA) could protect against ulcerative colitis (UC), a chronic condition that inflames the large intestine. In our research, we used acetic acid to induce UC in rats, administering oral EPA for 28 days in doses of 300 and 1000 mg/kg before the acetic acid treatment.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
10
No more ulcers
Most Useful Review
Excellent! I've been taking this for three years now and haven't had any more mouth ulcers. The delivery is always prompt.
Alzheimer details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
DHA shows promise in Alzheimer's
Nose-to-brain delivery of DHA-loaded nanoemulsions: A promising approach against Alzheimer's disease.
Most Relevant Research
We investigated the potential benefits of docosahexaenoic acid (DHA) in fighting Alzheimer's disease (AD) through a novel intranasal administration method. By using a specially formulated nanoemulsion that protects DHA from oxidation, we aimed to enhance its delivery to the brain. In our study, we administered this DHA-rich nanoemulsion to J20 mice, a well-known transgenic model for AD.
The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.
Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.
The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.
Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.
9.5
Comprehensive health benefits
Most Useful Review
This Omega-3 fish oil soft gel is derived from high-quality deep-sea fish, ensuring purity and efficacy. It provides significant health benefits: it lowers cholesterol and triglyceride levels, promotes brain development, improves mood, and helps prevent Alzheimer’s. It effectively relieves joint inflammation and pain, making it a convenient and beneficial supplement with excellent quality and easy-to-take soft gel design.
Asthma details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Eicosapentaenoic acid improves asthma
Effects of low-dust forages on dust exposure, airway cytology, and plasma omega-3 concentrations in Thoroughbred racehorses: A randomized clinical trial.
Most Relevant Research
We compared how different types of forage affected asthma in Thoroughbred racehorses. Our focus was on assessing dust exposure, airway health, and the presence of eicosapentaenoic acid (EPA), an omega-3 fatty acid known for its anti-inflammatory properties. The horses were randomly assigned to three diets: dry hay, steamed hay, or haylage for a period of six weeks.
Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.
In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.
Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.
In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.
9.5
Significant improvement
Most Useful Review
I decided to order vitamins for my husband, who has asthma and has relied on a inhaler for years. At just 32, he struggled with fatigue and often missed work due to his condition. After researching online, we ordered these vitamins, hoping for a solution. To our surprise, after just 2-3 weeks of taking them, he felt significantly better and was shocked that he no longer needed his inhaler. We are truly grateful for this change and will continue using the vitamins.
Bronchitis details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
DHA reduces bronchitis in infants
Infants fed formula with added long chain polyunsaturated fatty acids have reduced incidence of respiratory illnesses and diarrhea during the first year of life.
Most Relevant Research
We explored the impact of docosahexaenoic acid (DHA) on bronchitis in infants through a multi-center study involving 325 participants. Infants were fed either formula enriched with DHA and arachidonic acid (ARA) or a control formula without these additions.
Our findings showed that infants consuming the formula with DHA/ARA had a notably lower incidence of bronchitis, alongside other respiratory illnesses, during their first year of life. Specifically, we observed a significant reduction in the odds of experiencing bronchitis—a 59% decrease compared to those not receiving these nutritional supplements.
Not only did DHA help in reducing the number of bronchitis cases, but it also played a role in reducing symptoms like cough and nasal congestion. The overall impression from the data indicates that incorporating DHA into infant formula could bolster the immune response and lessen common respiratory challenges faced by infants.
Deciding on a formula for our little ones can be daunting, but the evidence suggests that choosing a DHA-enhanced option might provide valuable health benefits.
Our findings showed that infants consuming the formula with DHA/ARA had a notably lower incidence of bronchitis, alongside other respiratory illnesses, during their first year of life. Specifically, we observed a significant reduction in the odds of experiencing bronchitis—a 59% decrease compared to those not receiving these nutritional supplements.
Not only did DHA help in reducing the number of bronchitis cases, but it also played a role in reducing symptoms like cough and nasal congestion. The overall impression from the data indicates that incorporating DHA into infant formula could bolster the immune response and lessen common respiratory challenges faced by infants.
Deciding on a formula for our little ones can be daunting, but the evidence suggests that choosing a DHA-enhanced option might provide valuable health benefits.
8.8
Prevents bronchitis
Most Useful Review
Fish oil effectively protects the respiratory tract from infections, making it useful for preventing bronchitis. Additionally, it enhances antibody activity and stimulates the production of anti-inflammatory substances, thus benefiting overall health.
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.4
USERS' SCORE
Good
Based on 32 Reviews
8.6
9
EPA's role in diabetic heart health
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Most Relevant Research
We explored the impact of eicosapentaenoic acid (EPA), a nutrient known for its heart benefits, on diabetic cardiomyopathy (DC), a condition leading to heart failure. Our study focused on diabetic mice and revealed that EPA plays a protective role against DC, particularly by reducing harmful M1-polarized macrophages in the heart.
In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.
We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.
Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.
In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.
We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.
Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.
8.8
Supports cardiovascular health
Most Useful Review
My choice! As a nutritionist, I am always studying, and this Omega is highly recommended by reputable functional medicine doctors. I suggest it to my clients and take it myself. It has a decent composition and provides excellent results in supporting cardiovascular health. A tip: to prevent omega-3 from oxidising in the body, take it alongside vitamin E. To check the quality of omega-3, cut the capsule and sniff or taste its contents; it should be fresh and pleasant without any rancid aftertaste. I’ve tested it and the quality is superb! Fresh fish oil inside! I highly recommend this manufacturer and hope my review helps you. Wishing you and your family good health.
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
8.8
Gradual pain relief
Most Useful Review
The rTG type of fish oil from this brand offers the highest absorption rate. The high concentration of EPA feels excellent after consumption. Following several tests, I've found that after taking it, my shoulder and neck pain symptoms are gradually alleviated. My spirits improve, and I feel much more relaxed. I look forward to my next health check to confirm these positive feelings.
Hypertension details
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.6
USERS' SCORE
Good
Based on 8 Reviews
8.6
9
Eicosapentaenoic acid benefits hypertension
5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway.
Most Relevant Research
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
9.5
Essential for hypertension
Most Useful Review
Excellent! Omega-3 becomes an essential supplement after a certain age, particularly for individuals with hypertension.
Influenza details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Docosahexaenoic acid's antiviral effects
Anti-inflammatory and anti-virus potential of poxytrins, especially protectin DX.
Most Relevant Research
We explored the potential of docosahexaenoic acid (DHA) and its derived compound, protectin DX (PDX), specifically in the context of influenza virus replication. The research highlights how poxytrins, which are dihydroxy derivatives formed from PUFA, may play a significant role in addressing inflammation and viral issues due to their unique structure.
Protectin DX is known for its ability to inhibit the activities of cyclooxygenase (COX), which are linked to inflammatory processes, as well as reducing the formation of harmful reactive oxygen species (ROS). Interestingly, we observed that PDX also has the potential to limit the replication of influenza viruses by interfering with their RNA metabolism.
While the study emphasizes this unique dual action, it should be noted that it primarily focuses on the effect of PDX alone, without comprehensive exploration of combined effects with other treatments. Regardless, the findings suggest a promising pathway for using DHA-derived compounds in viral mitigation, particularly relating to influenza.
Protectin DX is known for its ability to inhibit the activities of cyclooxygenase (COX), which are linked to inflammatory processes, as well as reducing the formation of harmful reactive oxygen species (ROS). Interestingly, we observed that PDX also has the potential to limit the replication of influenza viruses by interfering with their RNA metabolism.
While the study emphasizes this unique dual action, it should be noted that it primarily focuses on the effect of PDX alone, without comprehensive exploration of combined effects with other treatments. Regardless, the findings suggest a promising pathway for using DHA-derived compounds in viral mitigation, particularly relating to influenza.
9.5
Influenza support benefits
Most Useful Review
Fish oil offers significant benefits due to its Omega-3 fatty acids, EPA and DHA. These nutrients maintain heart health, support vision, combat inflammation and infection, and promote brain health. Notably, Omega-3s have been shown to inhibit influenza viruses while also helping to alleviate rheumatoid arthritis pain. The high-quality ingredients and lack of unusual taste make it an essential nutritional supplement for overall well-being and fitness.
Insomnia details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
4
Eicosapentaenoic acid shows limited benefits
Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial.
Most Relevant Research
We explored the effectiveness of eicosapentaenoic acid, a type of omega-3 fatty acid, on insomnia among junior hospital nurses in a well-structured trial. In this study, 80 nurses were randomly assigned to receive either 1200 mg of eicosapentaenoic acid along with 600 mg of docosahexaenoic acid daily or a placebo for 13 weeks.
Our main focus was to see how these supplements influenced insomnia and overall mental health. While we noted some improvements in various measures, including insomnia severity at the 13-week mark, the results didn't demonstrate a significant advantage when compared to the placebo group.
After analyzing data at multiple checkpoints—13, 26, and 52 weeks—we found that the effects of eicosapentaenoic acid on insomnia were not strong enough to conclude it as a beneficial treatment. Overall, while there were some positive indicators at certain times, the overall impact on insomnia was not substantial, leaving us to conclude that more research is needed to confirm any real benefits from omega-3 fatty acids for sleep disturbances.
Our main focus was to see how these supplements influenced insomnia and overall mental health. While we noted some improvements in various measures, including insomnia severity at the 13-week mark, the results didn't demonstrate a significant advantage when compared to the placebo group.
After analyzing data at multiple checkpoints—13, 26, and 52 weeks—we found that the effects of eicosapentaenoic acid on insomnia were not strong enough to conclude it as a beneficial treatment. Overall, while there were some positive indicators at certain times, the overall impact on insomnia was not substantial, leaving us to conclude that more research is needed to confirm any real benefits from omega-3 fatty acids for sleep disturbances.
8.8
Improved sleep quality
Most Useful Review
The pill is quite large, but it's normal to swallow and has no taste. After three months of taking Omega 3 due to high cholesterol, I’m pleased to say that my levels have started to drop. I noticed a significant improvement in my sleep after experiencing insomnia; I took two pills a day after meals with a large glass of water.
Kidney Stones details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Eicosapentaenoic acid reduces stone risk
Effect of n-3 fatty acid supplementation on urinary risk factors for calcium oxalate stone formation.
Most Relevant Research
We explored the effects of eicosapentaenoic acid, an omega-3 fatty acid, on urinary factors linked to the formation of calcium oxalate kidney stones. In our study, we had 15 healthy participants follow a standardized diet over several phases to assess how daily supplementation with eicosapentaenoic acid and docosahexaenoic acid influenced their urinary excretion of calcium and oxalate.
Initially, during a 5-day control phase, we collected daily urine samples and observed no changes in the urinary parameters. However, after 30 days of supplementation, we noted a significant decrease—23%—in the relative supersaturation of calcium oxalate, primarily due to reduced oxalate excretion. This suggests that the supplementation may lower the risk of stone formation by affecting how the body manages oxalate.
Our findings propose that long-term use of eicosapentaenoic acid could be beneficial for those prone to calcium oxalate stones. The beneficial effect appears to arise from changes at the cellular level, altering how oxalate is exchanged. In summary, eicosapentaenoic acid supplementation holds promise as a preventive measure against kidney stones for certain individuals.
Initially, during a 5-day control phase, we collected daily urine samples and observed no changes in the urinary parameters. However, after 30 days of supplementation, we noted a significant decrease—23%—in the relative supersaturation of calcium oxalate, primarily due to reduced oxalate excretion. This suggests that the supplementation may lower the risk of stone formation by affecting how the body manages oxalate.
Our findings propose that long-term use of eicosapentaenoic acid could be beneficial for those prone to calcium oxalate stones. The beneficial effect appears to arise from changes at the cellular level, altering how oxalate is exchanged. In summary, eicosapentaenoic acid supplementation holds promise as a preventive measure against kidney stones for certain individuals.
9.5
Inflammation reduction
Most Useful Review
Excellent! It has significantly reduced the inflammation in my kidney.
Prostate Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.1
USERS' SCORE
Good
Based on 1 Review
8.6
8
Eicosapentaenoic acid's anti-cancer effects
Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells.
Most Relevant Research
We investigated how eicosapentaenoic acid (EPA) influences prostate cancer cells, particularly focusing on its effects on PC3 prostate cancer cells. To understand this, we treated the cells with various concentrations of EPA and monitored their survival, migration, and invasion abilities over time.
Our findings revealed that EPA reduces the survival rate of PC3 cells in a dose-dependent manner, showing significant effectiveness at a concentration of 500 μmol/L within just three hours of treatment. Moreover, we observed that EPA inhibits key cellular pathways linked to cancer cell growth, particularly the phosphorylation of a protein known as Pyk2. Interestingly, even though EPA affected Pyk2, this action occurred independently of reactive oxygen species (ROS) production, while growth inhibition appeared to depend significantly on the induction of ROS.
Overall, our research highlighted how the combined inhibition of Pyk2 and ROS contribute to the anti-cancer properties of EPA. This suggests that EPA could be a valuable component in therapeutic strategies for combating prostate cancer.
Our findings revealed that EPA reduces the survival rate of PC3 cells in a dose-dependent manner, showing significant effectiveness at a concentration of 500 μmol/L within just three hours of treatment. Moreover, we observed that EPA inhibits key cellular pathways linked to cancer cell growth, particularly the phosphorylation of a protein known as Pyk2. Interestingly, even though EPA affected Pyk2, this action occurred independently of reactive oxygen species (ROS) production, while growth inhibition appeared to depend significantly on the induction of ROS.
Overall, our research highlighted how the combined inhibition of Pyk2 and ROS contribute to the anti-cancer properties of EPA. This suggests that EPA could be a valuable component in therapeutic strategies for combating prostate cancer.
9.5
Protects prostate health
Most Useful Review
I purchased this product to try and was very pleased with the results. It’s a great quality supplement that helps maintain health without leaving a fishy aftertaste. The capsule size is perfect for easy swallowing, making it essential for those wishing to support their cardiovascular system. It also aids male health by helping to protect the prostate.
Cataract details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Cholesterol improvement noted
Most Useful Review
EDIT: My cholesterol dropped significantly over the last year, which has made me very happy. I attributed this change to taking an omega supplement with astaxanthin consistently. This is the only notable change I have made, and my doctor was impressed with the results. I have taken Nordic Naturals for years, but now I find that this new product is equally effective and more cost-efficient.
Hot Flashes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Almost complete cessation
Most Useful Review
It stops hot flashes 98%! I take this for severe hot flashes, and it almost eliminates them. One a day keeps the hot flashes away.
Indigestion details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Happy with results
Most Useful Review
Works well and doesn’t have a fishy taste. Initially, I was reluctant to take fish oil due to prior unpleasant experiences with indigestion and the taste. I decided to choose this well-reviewed supplement and couldn’t be more pleased.
Rheumatoid Arthritis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Significant inflammation reduction
Most Useful Review
I love this product! I have suffered from severe rheumatoid arthritis for over 40 years. My pain levels are often horrific while on medication. My son suggested I try Sports Research brand fish oil. Within a month, I noticed a tremendous reduction in inflammation throughout my body. It is working alongside my other medications. I hope to avoid the awful compression socks and shoes that used to alleviate my swelling.
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.2
USERS' SCORE
Good
Based on 1 Review
8.5
8
We observed that acne is a common skin condition, particularly affecting individuals under 30. Our exploration into the role of diet revealed that nutrition significantly influences acne development. Among the various dietary components, omega-3 fatty acids stood out due to their potential anti-inflammatory properties.
The research indicates that foods rich in omega-3 can help reduce the production of inflammatory substances that may contribute to acne. Additionally, specific fatty acids, such as docosapentaenoic acid and γ-linolenic acid, have shown promise in improving acne lesions.
By integrating omega-3 into the diet, we might be able to mitigate some of the troublesome symptoms associated with acne. While the evidence is still unfolding, the link between omega-3 fatty acids and reduced acne severity offers a hopeful avenue worth considering for those battling breakouts.
The research indicates that foods rich in omega-3 can help reduce the production of inflammatory substances that may contribute to acne. Additionally, specific fatty acids, such as docosapentaenoic acid and γ-linolenic acid, have shown promise in improving acne lesions.
By integrating omega-3 into the diet, we might be able to mitigate some of the troublesome symptoms associated with acne. While the evidence is still unfolding, the link between omega-3 fatty acids and reduced acne severity offers a hopeful avenue worth considering for those battling breakouts.
8.8
Quality Omega-3 effect
Most Useful Review
The best Omega-3 option! Each capsule contains 1250 mg of fish oil. I've noticed a decrease in the number of acne and an overall improvement in skin quality. It's worth investing in quality Omega-3 for better absorption.
Bloating details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 19 Reviews
8.5
9.5
Weight loss achieved
Most Useful Review
I lost weight, but that isn’t my main reason for taking it. I've struggled with obesity for over 50 years and have faced constant bloating, pressure, and discomfort in my stomach area for the last five years. After extensive research on how to alleviate the bloating and pain, I came across Omega-3 fatty acids. Though I consume 2500mg daily mixed into a protein shake, in just three months, I've lost 18 pounds. I no longer have bloating or pressure in my stomach, and my blood pressure has improved significantly.
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
DHA liposomes show promise
Microfluidic-derived docosahexaenoic acid liposomes for glioblastoma therapy.
Most Relevant Research
We explored an innovative approach to treating glioblastoma, the most common malignant brain tumor, by utilizing docosahexaenoic acid (DHA) liposomes. These liposomes were created using a microfluidic system that allowed for fine-tuning various properties, which could enhance their effectiveness in targeting tumor cells.
Our findings revealed that these DHA liposomes, ranging in size from 80 nm to 130 nm, were successfully taken up by glioblastoma cells. This uptake was promising, as we saw a reduction in the viability of these cancerous cells. Interestingly, we also observed that DHA liposomes were significantly better at triggering cell death mechanisms compared to free DHA, specifically through pathways that involved caspase-3.
Overall, our study suggests that these microfluidic-derived DHA liposomes might offer new avenues for developing therapies using omega-3 fatty acids against brain tumors, potentially leading to more effective treatment options in the future.
Our findings revealed that these DHA liposomes, ranging in size from 80 nm to 130 nm, were successfully taken up by glioblastoma cells. This uptake was promising, as we saw a reduction in the viability of these cancerous cells. Interestingly, we also observed that DHA liposomes were significantly better at triggering cell death mechanisms compared to free DHA, specifically through pathways that involved caspase-3.
Overall, our study suggests that these microfluidic-derived DHA liposomes might offer new avenues for developing therapies using omega-3 fatty acids against brain tumors, potentially leading to more effective treatment options in the future.
8.8
Stimulates brain development
Most Useful Review
I find that omega-3s from cold water fish provide the best absorption. This supplement restores neurons, positively impacting brain function and development. While it can cause hyperactivity, the effects are generally very beneficial.
Bruise details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Improves circulation
Most Useful Review
I believe it genuinely assists with blood circulation. Even if I have a bruise, it heals well. There’s no unpleasant odour, and the pill size is just right. The quality is excellent, so I will continue to buy it.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.5
9
Impact of Omega-3 on Cancer
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.
Most Relevant Research
We explored the effects of eicosapentaenoic acid, a type of omega-3 fatty acid, on pancreatic cancer using a specially designed mouse model that closely mimics human disease. This model allowed us to examine how adding omega-3 to the diet could impact cancer progression.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
9.5
Essential for family
Most Useful Review
Due to my family's struggles with cancer, I need to take high doses of fish oil, particularly those rich in EPA. Just one fish oil a day is manageable, especially for the elderly, and it is in an easily absorbed Tg form. I highly recommend it.
Diabetes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.5
8
Dietary importance!
Most Useful Review
Omega-3 essential fatty acids are critical for the body, forming cell membranes and impacting the heart and brain's functionality. They normalise blood pressure and cholesterol levels and help in preventing diabetes. Unfortunately, our diets typically lack these fats, particularly those found in cold-water fish. Therefore, supplementing omega-3 is vital for good health.
Epilepsy details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
2
No benefit observed in epilepsy
Effects of essential fatty acid supplementation in dogs with idiopathic epilepsy: a clinical trial.
Most Relevant Research
We conducted a study to investigate whether essential fatty acid supplementation, specifically eicosapentaenoic acid (EPA), could help control idiopathic epilepsy in dogs. This involved a carefully designed approach where fifteen dogs received a daily dose of purified Omega-3 oil for 12 weeks, followed by a 12-week placebo period using olive oil.
Throughout the study, dog owners diligently recorded seizure frequency and severity, along with any side effects that may have arisen. Despite hopes that these essential fatty acids would provide some benefit, the results were quite clear: we found no significant reduction in seizure frequency or severity for those dogs receiving the Omega-3 supplement compared to the placebo group.
These findings suggest that while EPA is a popular supplement often touted for various health benefits, it does not appear to have a positive effect on managing idiopathic epilepsy in dogs. This research can help pet owners make informed decisions about treatment options for their furry companions struggling with seizures.
Throughout the study, dog owners diligently recorded seizure frequency and severity, along with any side effects that may have arisen. Despite hopes that these essential fatty acids would provide some benefit, the results were quite clear: we found no significant reduction in seizure frequency or severity for those dogs receiving the Omega-3 supplement compared to the placebo group.
These findings suggest that while EPA is a popular supplement often touted for various health benefits, it does not appear to have a positive effect on managing idiopathic epilepsy in dogs. This research can help pet owners make informed decisions about treatment options for their furry companions struggling with seizures.
8.8
Stabilise nerves
Most Useful Review
The child has epilepsy; assistance in stabilising the nerves is crucial, and the adults will presumably benefit as well!
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.7
USERS' SCORE
Good
Based on 10 Reviews
8.5
9
DHA-PS promotes liver recovery
DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis.
Most Relevant Research
We investigated the potential of DHA-enriched phosphatidylserine (DHA-PS) in addressing liver injuries caused by cyclophosphamide in mice. By administering cyclophosphamide over five days, we created a model to simulate this liver damage. Following this, we treated the mice with different doses of DHA-PS for a week to see if it could help heal their livers.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
8.3
Liver index declining
Most Useful Review
I initially took this to alleviate dry eye syndrome, recommended by my doctor. While that didn't improve much, I did notice my liver index decreased significantly after consuming one can (90 pills). My total cholesterol varied slightly. I plan to continue with the next can and monitor for any further changes over three months.
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 12 Reviews
8.5
7
Dysmenorrhea influences pregnancy nausea
Association of the Verbal Rating Scale-Measured Dysmenorrhea with Nausea and Vomiting in Pregnancy: A Retrospective Cohort Study.
Most Relevant Research
We conducted a retrospective cohort study to investigate the relationship between nausea and vomiting in pregnancy (NVP) and dysmenorrhea measured by a verbal rating scale. Our research included 443 pregnant women, divided into those experiencing NVP and a control group.
From our findings, we noticed a clear association between moderate to severe dysmenorrhea and a heightened risk of NVP, especially during the first trimester. This suggests that those with painful menstrual symptoms may face an increased likelihood of nausea and vomiting as part of their pregnancy experience.
Importantly, we also examined the impact of periconceptional supplementation with docosahexaenoic acid (DHA). Our results indicated that taking DHA could potentially lower the risk of NVP, offering a glimmer of hope for managing nausea during pregnancy. This suggests that combining DHA with standard prenatal care might be beneficial for those who struggle with these symptoms.
Overall, our study sheds light on the intricate connections between menstrual pain and pregnancy-related nausea, emphasizing the potential protective role of DHA in improving women's health during this time.
From our findings, we noticed a clear association between moderate to severe dysmenorrhea and a heightened risk of NVP, especially during the first trimester. This suggests that those with painful menstrual symptoms may face an increased likelihood of nausea and vomiting as part of their pregnancy experience.
Importantly, we also examined the impact of periconceptional supplementation with docosahexaenoic acid (DHA). Our results indicated that taking DHA could potentially lower the risk of NVP, offering a glimmer of hope for managing nausea during pregnancy. This suggests that combining DHA with standard prenatal care might be beneficial for those who struggle with these symptoms.
Overall, our study sheds light on the intricate connections between menstrual pain and pregnancy-related nausea, emphasizing the potential protective role of DHA in improving women's health during this time.
10
No nausea noted
Most Useful Review
Great, I don't experience any nausea and it's superb. I'm recommending it to those around me!
Pneumonia details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Very effective treatment
Most Useful Review
I take omega 3 after a viral pneumonia, along with vitamin D3, and I am satisfied with the results.
Psoriasis details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
USERS' SCORE
Good
Based on 6 Reviews
8.5
8
EPA benefits psoriatic skin health
Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells.
Most Relevant Research
We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
9.5
Improves skin health
Most Useful Review
Excellent! Omega 3 has many benefits: it helps treat psoriasis, improves brain activity, reduces weight, enhances eyesight, bolsters the immune system, and prevents cardiovascular diseases, among other advantages.
Tinnitus details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8
Condition improving
Most Useful Review
Sports Research Omega-3 Fish Oil is a triple strength supplement offered in 90 softgels. I have severe tinnitus, and I have been taking Source Naturals and Pycnogenol Supreme, 30 tablets. Currently, I observe that my condition appears to be improving gradually.
Neuropathy details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8
Quality of life improvement
Most Useful Review
I've used this product for pain relief related to diabetic neuropathy and other conditions. After three months, I struggled to notice improvements. However, when I ran out, my symptoms flared up, and upon returning, I noticed a significant enhancement in my quality of life.
Arthritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.3
USERS' SCORE
Good
Based on 25 Reviews
8.4
8
Eicosapentaenoic acid aids arthritis
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Most Relevant Research
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
8.8
Pain relief
Most Useful Review
Despite the high price, I find this omega-3 to be the best available in terms of quality and ingredients. It effectively alleviates my arthritis pain when combined with vitamin D and curcumin, and even enhances my focus, which I had been losing due to my condition.
Common Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 20 Reviews
8.4
8
DHA reduces infant cold symptoms
Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial.
Most Relevant Research
We conducted a double-blind randomized controlled trial to understand how prenatal supplementation of docosahexaenoic acid (DHA) might influence infant health, particularly concerning the common cold. Pregnant women were given either a daily dose of 400 mg of DHA or a placebo starting at 18 to 22 weeks of gestation until childbirth.
Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.
While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.
Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.
This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.
Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.
While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.
Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.
This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.
9.5
Strengthened immunity
Most Useful Review
Great Omega 3! I bought this Omega 3 specifically for my husband. The dosage is excellent in one capsule, lasting two months. He takes one capsule daily, alongside vitamin D3 with meals. He appreciates the ease of use and its effectiveness. Before taking Omega 3, he frequently caught a common cold and suffered from weakness. Since its regular intake began, he hasn't been ill all autumn nor now! He has noticed an increase in strength and energy! An excellent result! We will reorder.
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.4
USERS' SCORE
Good
Based on 6 Reviews
8.4
9
Omega-3 aids hypothyroid cognition
The effect of omega-3 on cognition in hypothyroid adult male rats.
Most Relevant Research
We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
9.5
Softened dry skin
Most Useful Review
I absolutely love this omega! After just a few days of taking it, the difference in my skin and nails is evident. My elbows, often very dry due to hypothyroidism, feel smoother and softer after using this omega. We take it as a family, and I appreciate that one capsule contains 1000 mg of essential fatty acids. The capsule is large but easy to swallow.
Multiple Sclerosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.4
8
Eicosapentaenoic acid reduces MS symptoms
Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis.
Most Relevant Research
We explored the therapeutic effects of eicosapentaenoic acid (EPA) in tackling multiple sclerosis through a study involving mice with experimental autoimmune encephalomyelitis (EAE). The mice were given diets enriched with or without EPA. Remarkably, the mice that received the EPA-infused diet displayed significantly lower clinical scores compared to those that did not.
Furthermore, we observed that the production of inflammatory markers like IFN-γ and IL-17 was notably reduced in the EPA-treated mice. This reduction is particularly important, as these markers are associated with the progression of multiple sclerosis. Additionally, there was an enhancement in the expression levels of peroxisome proliferator-activated receptors within the CD4T cells infiltrating the central nervous system.
These findings suggest that EPA could serve as a promising new approach to therapy for multiple sclerosis, showcasing its potential in reducing inflammation and improving clinical outcomes in those affected by this condition.
Furthermore, we observed that the production of inflammatory markers like IFN-γ and IL-17 was notably reduced in the EPA-treated mice. This reduction is particularly important, as these markers are associated with the progression of multiple sclerosis. Additionally, there was an enhancement in the expression levels of peroxisome proliferator-activated receptors within the CD4T cells infiltrating the central nervous system.
These findings suggest that EPA could serve as a promising new approach to therapy for multiple sclerosis, showcasing its potential in reducing inflammation and improving clinical outcomes in those affected by this condition.
7.8
Improved health benefits
Most Useful Review
Sports Research Triple Strength Omega-3 Fish Oil is an excellent choice for anyone aiming to enhance their overall health. The high concentration of EPA and DHA in a single capsule makes it incredibly convenient, eliminating the need for multiple doses. I’ve noticed improvements in my joint comfort and focus, and it’s beneficial for heart health too. The capsules are easy to swallow and leave no fishy aftertaste, which is a significant advantage. A premium-quality product that I would highly recommend to anyone serious about their daily Omega-3 intake!
Sleep Apnea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 21 Reviews
8.4
8
DHA levels linked to OSA severity
Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea.
Most Relevant Research
We investigated how the omega-3 fatty acid docosahexaenoic acid (DHA) impacts the severity of obstructive sleep apnea (OSA) in 350 patients undergoing sleep studies. Our study aimed to determine if there is a relationship between the levels of DHA in red blood cells (RBC) and the severity of sleep apnea, categorized as none/mild, moderate, or severe based on apnea hypopnea index (AHI) scores.
Our findings revealed that lower levels of DHA are linked to more severe cases of OSA. For each standard deviation increase in DHA, patients were about 50% less likely to be classified in the severe apnea category. Specifically, we noted decreased odds of falling into the severe OSA group when DHA levels were higher, suggesting that DHA may play an important role in the severity of this condition.
These insights imply that maintaining healthy DHA levels could potentially influence OSA severity and could aid in developing treatment strategies. We believe that future research should explore the potential benefits of DHA supplementation for those suffering from sleep apnea.
Our findings revealed that lower levels of DHA are linked to more severe cases of OSA. For each standard deviation increase in DHA, patients were about 50% less likely to be classified in the severe apnea category. Specifically, we noted decreased odds of falling into the severe OSA group when DHA levels were higher, suggesting that DHA may play an important role in the severity of this condition.
These insights imply that maintaining healthy DHA levels could potentially influence OSA severity and could aid in developing treatment strategies. We believe that future research should explore the potential benefits of DHA supplementation for those suffering from sleep apnea.
9.5
Improved sleep quality
Most Useful Review
I purchased this fish oil after thorough research. Since using it, my sleep has significantly improved. Previously, I found it difficult to fall asleep even when I felt tired. However, after just three days of taking this fish oil, I find myself falling asleep within ten minutes each night. I intend to continue using it.
Yeast Infection details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.4
9
Eicosapentaenoic acid combats yeast biofilms
Eicosapentaenoic acid as an antibiofilm agent disrupts mature biofilms of .
Most Relevant Research
We set out to explore how eicosapentaenoic acid (EPA), a type of healthy fat, can disrupt the mature biofilms formed by a significant human fungal pathogen. These biofilms are important since they enhance the pathogen's ability to cause infections. Our investigation focused on the effects of a 1 mM EPA treatment on these established biofilms.
Through various assays, we observed that EPA significantly reduced the viability of these preformed biofilms. The use of advanced microscopy techniques allowed us to see that EPA could block the transformation from yeast to a more invasive form and damaged the biofilm's structure.
We also found that EPA prompted changes at the genetic level. Specifically, it downregulated genes linked to the development of hyphae and biofilms. Additionally, EPA affected two key signaling pathways involved in biofilm formation. Notably, it reduced the production of a crucial messenger in one of these pathways.
Lastly, we noted that treatment with EPA downregulated genes related to ergosterol biosynthesis, suggesting it may lower the chances of developing resistance to existing antifungal treatments. Our findings emphasize the potential of EPA as a promising alternative or complementary option in treating yeast infections.
Through various assays, we observed that EPA significantly reduced the viability of these preformed biofilms. The use of advanced microscopy techniques allowed us to see that EPA could block the transformation from yeast to a more invasive form and damaged the biofilm's structure.
We also found that EPA prompted changes at the genetic level. Specifically, it downregulated genes linked to the development of hyphae and biofilms. Additionally, EPA affected two key signaling pathways involved in biofilm formation. Notably, it reduced the production of a crucial messenger in one of these pathways.
Lastly, we noted that treatment with EPA downregulated genes related to ergosterol biosynthesis, suggesting it may lower the chances of developing resistance to existing antifungal treatments. Our findings emphasize the potential of EPA as a promising alternative or complementary option in treating yeast infections.
7.5
Improved condition
Most Useful Review
The uncomfortable yeast infection in the private area has improved with the combination of fish oil and probiotics.
Heart Attack details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 50 Reviews
8.3
9
Eicosapentaenoic acid aids heart recovery
Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats.
Most Relevant Research
We investigated how eicosapentaenoic acid (EPA) may help improve heart health after a heart attack. In our study, we induced myocardial infarction (MI) in male rats by ligating their coronary artery. Some of these rats received daily treatment with EPA, while others did not, allowing us to compare the effects.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
9.5
Significant improvement
Most Useful Review
After three months of use, I noticed a significant improvement in my memory quality, mental presence, and heart health. The ingredients are gentle on my stomach and did not cause any digestion issues. The packaging is well done, maintaining the product's texture and taste.
Heartburn details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 16 Reviews
8.3
9.5
No heartburn experienced
Most Useful Review
Great product. I only need one pill instead of three, with no aftertaste, burping, or heartburn. These are fantastic!
Back Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.1
9
Eicosapentaenoic acid alleviates back pain
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Most Relevant Research
We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
9.5
Reduced inflammation
Most Useful Review
I have suffered from severe rheumatoid arthritis for over 40 years, with pain levels often between 6 and 10. My son suggested trying Sports Research brand omega-3 fish oil, which I commenced taking twice daily. Within a month, I noticed a considerable reduction in inflammation throughout my body, including my painfully swollen ankles. Thanks to this product, I hope to avoid returning to uncomfortable footwear meant to reduce swelling.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5
USERS' SCORE
Good
Based on 2 Reviews
8.1
5
Fatty acids affect IBS metabolism
Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome.
Most Relevant Research
Our study focused on understanding how eicosapentaenoic acid, alongside other fatty acids, influences irritable bowel syndrome (IBS). We designed an experiment where we treated both maternally separated and non-separated rats with Bifidobacterium breve and explored its effect on colonic sensitivity and fatty acid metabolism over a period of seven weeks.
Throughout our research, we observed significant changes in fatty acid profiles, especially in liver and serum tissues, after administering Bifidobacterium breve. Notably, in the maternally separated rats, the treatment appeared to enhance levels of palmitoleic acid, arachidonic acid, and docosahexaenoic acid in various tissues, which are fatty acids that others believe could be influential in managing symptoms related to IBS.
However, while eicosapentaenoic acid was present in the research context, it was largely studied in combination with other treatments. This made it challenging to evaluate its isolated effect on IBS directly. Thus, while we noted some positive metabolic changes with our treatment approach, the specific impact of eicosapentaenoic acid on IBS symptoms wasn’t definitively established.
Overall, our findings suggest that while Bifidobacterium breve and fatty acid supplementation may influence host fatty acid metabolism, further focused studies are necessary to clarify the role of eicosapentaenoic acid in managing irritable bowel syndrome.
Throughout our research, we observed significant changes in fatty acid profiles, especially in liver and serum tissues, after administering Bifidobacterium breve. Notably, in the maternally separated rats, the treatment appeared to enhance levels of palmitoleic acid, arachidonic acid, and docosahexaenoic acid in various tissues, which are fatty acids that others believe could be influential in managing symptoms related to IBS.
However, while eicosapentaenoic acid was present in the research context, it was largely studied in combination with other treatments. This made it challenging to evaluate its isolated effect on IBS directly. Thus, while we noted some positive metabolic changes with our treatment approach, the specific impact of eicosapentaenoic acid on IBS symptoms wasn’t definitively established.
Overall, our findings suggest that while Bifidobacterium breve and fatty acid supplementation may influence host fatty acid metabolism, further focused studies are necessary to clarify the role of eicosapentaenoic acid in managing irritable bowel syndrome.
9.5
Bowel movements improved
Most Useful Review
As soon as I started taking it, my bowel movements improved and the odour disappeared. It's gotten so much better that I cannot live without it now.
Dizziness details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8
9.5
Gut-friendly
Most Useful Review
This is the best! All other omega products make me feel nauseous and dizzy, but I can take this on an empty stomach without any issues. I have a sensitive stomach and gastritis, yet I'm fine with this.
Whooping Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 1 Review
7.9
2.3
Cough aggravation
Most Useful Review
It's not appropriate for me to cough every night after meals.
Diarrhea details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.8
8
5,6-DiHETE alleviates diarrhea
Efficient Attenuation of Dextran Sulfate Sodium-Induced Colitis by Oral Administration of 5,6-Dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic Acid in Mice.
Most Relevant Research
We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
10
No diarrhea noted
Most Useful Review
Very good, no taste and no diarrhoea after eating.
Hives details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.7
8.8
Reduced facial hives
Most Useful Review
Originally, I was consuming omega-3 from here, but it was out of stock, so I purchased 30 tablets. As it is an IFOS® 5-Star certified fish oil, I trust its quality and ingredients. I take it for chronic inflammation, and it appears to be effective as the number of hives on my face has decreased. It's unfortunate that the 90's are always out of stock.
Eczema details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.6
9
Eicosapentaenoic Acid reduces eczema
Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.
Most Relevant Research
We embarked on a study to find out how dietary eicosapentaenoic acid (EPA) could help children suffering from atopic dermatitis, a common form of eczema. In a randomized triple-blind clinical trial, 48 children with this condition were divided into two groups—one received 250 mg of EPA twice daily, while the other received a placebo for four weeks.
Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.
Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.
Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.
Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.
9.5
Eczema relief experienced
Most Useful Review
This product helps with eczema.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.2
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.6
9.5
Eicosapentaenoic acid reduces migraines
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.
Most Relevant Research
We conducted a 12-week study to explore how eicosapentaenoic acid (EPA) affects individuals suffering from episodic migraines. In our trial, 70 participants were randomly split into two groups—one received 2 grams of fish oil with 1.8 grams of pure EPA daily, while the other group got a placebo made of soybean oil.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
10
Energy boost
Most Useful Review
The best omega I've tried. Each capsule has a high concentration and is small, making it easy to swallow without any unpleasant taste. It's great for fitness enthusiasts, as it naturally boosts energy levels. Additionally, it has significantly helped with my headaches.
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.9
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.3
8
Omega-3s and skin allergies
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.
Most Relevant Research
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
7
Resolved allergies
Most Useful Review
I bought this on my doctor's recommendation. After taking it for three months, my body returned to normal and I had no allergies. I gave it three stars to keep the price down, but the brand is excellent!
