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SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.3
USERS' SCORE
Good
Based on 25 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
8
Eicosapentaenoic acid aids arthritis
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Directly improves arthritis symptoms
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
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9
DHA benefits osteoarthritis treatment
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis.
High relevance to OA research
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Read More
8
DHA induces apoptosis in RA cells
DHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients.
High therapeutic relevance for RA
We explored how docosahexaenoic acid (DHA), a marine omega-3 fatty acid, impacts fibroblast-like synovial cells from patients with rheumatoid arthritis (RA). In our investigation, we found that DHA treatment triggered cell death in these cells through a process called apoptosis—a form of programmed cell death— and this effect increased with higher doses of DHA.
DHA not only induced apoptosis but also reduced the levels of proteins associated with inflammation, specifically MMP-9 and IL-1β. Interestingly, we observed that DHA prompted the activation of stress markers in the cells, indicating a response to abnormal stress conditions. Two key players in this process were identified: CHOP and death receptor 5 (DR5). When we reduced the expression of CHOP or DR5, the cells showed improved survival and less apoptosis, highlighting their roles in this pathway.
Additionally, DHA led to an increase in reactive oxygen species (ROS), compounds that can cause damage to cells. By using an antioxidant called Tiron, we discovered that it could prevent the effects of DHA, including the induction of CHOP and DR5, and reduce the cell death triggered by DHA. This protective effect boosted cell viability and diminished markers typically associated with apoptosis.
All of our findings in the lab were corroborated by results from human primary synovial cells from RA patients. This suggests that DHA may hold promise as a therapeutic agent for RA by harnessing oxidative stress and CHOP to promote cell death in the inflamed tissues of the joints.
DHA not only induced apoptosis but also reduced the levels of proteins associated with inflammation, specifically MMP-9 and IL-1β. Interestingly, we observed that DHA prompted the activation of stress markers in the cells, indicating a response to abnormal stress conditions. Two key players in this process were identified: CHOP and death receptor 5 (DR5). When we reduced the expression of CHOP or DR5, the cells showed improved survival and less apoptosis, highlighting their roles in this pathway.
Additionally, DHA led to an increase in reactive oxygen species (ROS), compounds that can cause damage to cells. By using an antioxidant called Tiron, we discovered that it could prevent the effects of DHA, including the induction of CHOP and DR5, and reduce the cell death triggered by DHA. This protective effect boosted cell viability and diminished markers typically associated with apoptosis.
All of our findings in the lab were corroborated by results from human primary synovial cells from RA patients. This suggests that DHA may hold promise as a therapeutic agent for RA by harnessing oxidative stress and CHOP to promote cell death in the inflamed tissues of the joints.
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Most Useful Reviews
8.8
Pain relief
Despite the high price, I find this omega-3 to be the best available in terms of quality and ingredients. It effectively alleviates my arthritis pain when combined with vitamin D and curcumin, and even enhances my focus, which I had been losing due to my condition.
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8.8
Pain reduction
Although this product is pricey, I consider it the best omega-3 I found for its quality and ingredients. It has significantly reduced the pain from my arthritis when taken with vitamin D and curcumin, and has also improved my concentration.
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9.5
Inflammation reduced
I love this product! I have suffered from severe rheumatoid arthritis (RA) for over 40 years. My pain levels on medication are horrific at times, ranging between 6 and 10. I tried various brands of fish oils over the years without success. My son, a bodybuilder, suggested I try Sports Research brand. I started a daily regimen, taking it twice a day with buttermilk. Initially, I didn’t expect any difference, but within a month, I noticed a significant reduction in inflammation throughout my body. I also suffer from four other forms of crippling arthritis.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.3
9
l-Serine and EPA effective for pain
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Study relevant for arthritis pain
We conducted a study to examine the effects of eicosapentaenoic acid (EPA) combined with l-serine on individuals suffering from chronic low-back and knee pain. This was a randomized, double-blind, placebo-controlled trial, ensuring rigorous evaluation of the treatment's impact.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Read More
9
Eicosapentaenoic acid aids arthritis
Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model.
Relevant but partly complex findings
We investigated the impact of eicosapentaenoic acid (EPA) on osteoarthritis (OA) progression through an innovative approach involving gelatin hydrogels. In our study, we divided ten-week-old male mice into six different groups, each receiving various treatments after undergoing surgery that mimicked OA. This design allowed us to effectively compare the benefits of EPA delivered directly and through hydrogels.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Read More
9
Docosahexaenoic acid reduces arthritis
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis.
Moderate relevance of findings
We examined the effects of lipid mediators derived from docosahexaenoic acid (DHA) on arthritis, particularly focusing on rheumatoid arthritis (RA). The study utilized a model involving mice with collagen antibody-induced arthritis (CAIA) and RAW264.7 cells to investigate the role of these mediators in reducing inflammation and joint damage.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
Read More
9
DHA benefits osteoarthritis treatment
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis.
High relevance to OA research
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Read More
9
DHA's ambiguous role in arthritis
Very low calorie ketogenic diet and common rheumatic disorders: A case report.
Mixed effects noted on symptoms
We observed a fascinating case involving a 22-year-old woman with juvenile idiopathic arthritis who was put on a very low calorie ketogenic diet (VLCKD). This diet included high-biological-value protein preparations that featured docosahexaenoic acid (DHA), an omega-3 fatty acid known for its potential health benefits.
The woman saw improvements in her overall weight and health after four months on this diet, including a noticeable reduction in joint pain and headaches. Laboratory tests indicated that her inflammatory markers returned to normal levels, suggesting that the dietary changes—including DHA—might have played a positive role in her experience.
However, it’s essential to note that while DHA is included in the treatment regimen, the isolated effect of DHA on her arthritis symptoms is challenging to determine definitively. This case highlights the potential benefits of dietary interventions for inflammatory conditions but also points to the need for further research to isolate the effects of specific dietary components like DHA.
The woman saw improvements in her overall weight and health after four months on this diet, including a noticeable reduction in joint pain and headaches. Laboratory tests indicated that her inflammatory markers returned to normal levels, suggesting that the dietary changes—including DHA—might have played a positive role in her experience.
However, it’s essential to note that while DHA is included in the treatment regimen, the isolated effect of DHA on her arthritis symptoms is challenging to determine definitively. This case highlights the potential benefits of dietary interventions for inflammatory conditions but also points to the need for further research to isolate the effects of specific dietary components like DHA.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.4
9.5
Dosage efficiency
This high-dose fish oil meets my needs efficiently, providing the required 2000 mg of DHA and EPA with just two capsules, and is recommended by my nutritionist for managing my rheumatoid arthritis. I’ve repurchased it many times.
9.5
Inflammation reduction
This omega-3 is an excellent choice with a strong dosage, particularly for muscle mass increase and inflammation reduction related to arthritis. It's derived from cold-water wild pollock, ensuring high quality.
9.5
Severe pain relief
This omega-3 is pricey yet unmatched in quality and effectiveness for reducing arthritis pain. It has also aided my focus. The supply lasts three months, making it convenient despite the cost.
9.5
Pain relief noted
I have knee joint arthritis, and this product alleviates my pain effectively. When I stop using it, the pain returns.
9.5
Immune support noted
Omega-3s boost the immune system with anti-inflammatory properties. They alleviate arthritis pain, enhance joint mobility, and aid biochemical processes throughout the body.
