Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.3
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
8
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
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9
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Read More
8
We explored how docosahexaenoic acid (DHA), a marine omega-3 fatty acid, impacts fibroblast-like synovial cells from patients with rheumatoid arthritis (RA). In our investigation, we found that DHA treatment triggered cell death in these cells through a process called apoptosis—a form of programmed cell death— and this effect increased with higher doses of DHA.
DHA not only induced apoptosis but also reduced the levels of proteins associated with inflammation, specifically MMP-9 and IL-1β. Interestingly, we observed that DHA prompted the activation of stress markers in the cells, indicating a response to abnormal stress conditions. Two key players in this process were identified: CHOP and death receptor 5 (DR5). When we reduced the expression of CHOP or DR5, the cells showed improved survival and less apoptosis, highlighting their roles in this pathway.
Additionally, DHA led to an increase in reactive oxygen species (ROS), compounds that can cause damage to cells. By using an antioxidant called Tiron, we discovered that it could prevent the effects of DHA, including the induction of CHOP and DR5, and reduce the cell death triggered by DHA. This protective effect boosted cell viability and diminished markers typically associated with apoptosis.
All of our findings in the lab were corroborated by results from human primary synovial cells from RA patients. This suggests that DHA may hold promise as a therapeutic agent for RA by harnessing oxidative stress and CHOP to promote cell death in the inflamed tissues of the joints.
DHA not only induced apoptosis but also reduced the levels of proteins associated with inflammation, specifically MMP-9 and IL-1β. Interestingly, we observed that DHA prompted the activation of stress markers in the cells, indicating a response to abnormal stress conditions. Two key players in this process were identified: CHOP and death receptor 5 (DR5). When we reduced the expression of CHOP or DR5, the cells showed improved survival and less apoptosis, highlighting their roles in this pathway.
Additionally, DHA led to an increase in reactive oxygen species (ROS), compounds that can cause damage to cells. By using an antioxidant called Tiron, we discovered that it could prevent the effects of DHA, including the induction of CHOP and DR5, and reduce the cell death triggered by DHA. This protective effect boosted cell viability and diminished markers typically associated with apoptosis.
All of our findings in the lab were corroborated by results from human primary synovial cells from RA patients. This suggests that DHA may hold promise as a therapeutic agent for RA by harnessing oxidative stress and CHOP to promote cell death in the inflamed tissues of the joints.
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Most Useful Reviews
7.5
Pain relief
115 people found this helpful
Despite the high price, I find this omega-3 to be the best available in terms of quality and ingredients. It effectively alleviates my arthritis pain when combined with vitamin D and curcumin, and even enhances my focus, which I had been losing due to my condition.
Read More
7.5
Pain reduction
8 people found this helpful
Although this product is pricey, I consider it the best omega-3 I found for its quality and ingredients. It has significantly reduced the pain from my arthritis when taken with vitamin D and curcumin, and has also improved my concentration.
Read More
9
Inflammation reduced
3 people found this helpful
I love this product! I have suffered from severe rheumatoid arthritis (RA) for over 40 years. My pain levels on medication are horrific at times, ranging between 6 and 10. I tried various brands of fish oils over the years without success. My son, a bodybuilder, suggested I try Sports Research brand. I started a daily regimen, taking it twice a day with buttermilk. Initially, I didn’t expect any difference, but within a month, I noticed a significant reduction in inflammation throughout my body. I also suffer from four other forms of crippling arthritis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.3
- All Researches
9
We conducted a study to examine the effects of eicosapentaenoic acid (EPA) combined with l-serine on individuals suffering from chronic low-back and knee pain. This was a randomized, double-blind, placebo-controlled trial, ensuring rigorous evaluation of the treatment's impact.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Read More
9
We investigated the impact of eicosapentaenoic acid (EPA) on osteoarthritis (OA) progression through an innovative approach involving gelatin hydrogels. In our study, we divided ten-week-old male mice into six different groups, each receiving various treatments after undergoing surgery that mimicked OA. This design allowed us to effectively compare the benefits of EPA delivered directly and through hydrogels.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
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9
Docosahexaenoic acid reduces arthritis
We examined the effects of lipid mediators derived from docosahexaenoic acid (DHA) on arthritis, particularly focusing on rheumatoid arthritis (RA). The study utilized a model involving mice with collagen antibody-induced arthritis (CAIA) and RAW264.7 cells to investigate the role of these mediators in reducing inflammation and joint damage.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
The lipid mediators were produced by soybean lipoxygenase from DHA and included substances known for their anti-inflammatory properties. We found that these mediators significantly reduced symptoms in CAIA mice, evidenced by decreased paw swelling and reduced progression of arthritis. In the cellular studies, these mediators inhibited the formation of bone-resorbing cells called osteoclasts, while also downregulating key inflammatory markers.
Following treatment, there were notable improvements in serum cytokine levels, with a decrease in pro-inflammatory cytokines like TNF-α and IL-6, and an increase in the anti-inflammatory cytokine IL-10. Additionally, joint inflammation and damage were reduced, hinting at a complex relationship involving various signaling pathways.
These findings indicate that lipid mediators derived from DHA may offer a promising approach to alleviating symptoms of RA, though the precise individual contributions of DHA alone are difficult to isolate due to the presence of other components in the intervention.
Read More
9
We set out to investigate how docosahexaenoic acid (DHA), a fatty acid known for its health benefits, can affect osteoarthritis (OA), a common degenerative joint disease, particularly among older adults. Using both human chondrocyte models stimulated by IL-1β and rat models created through surgical methods, we aimed to understand DHA's potential to impact chondrocyte behavior and cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Our observations revealed that DHA significantly promotes the growth of chondrocytes while reducing cell death, which is a key concern in OA. Notably, we found an increase in autophagosomes—structures that help break down cellular waste—within cells treated with DHA, suggesting enhanced cell health.
In comparing groups, those treated with DHA exhibited healthier cartilage characterized by thickened tissue and a decrease in degeneration when compared to the untreated OA group. We also noted an increase in collagen production, vital for maintaining joint structure. The biochemical analysis indicated that DHA potentially exerts its effects by inhibiting certain pathways associated with cell growth and stress responses, thus enhancing chondrocyte proliferation and survival.
Overall, our findings contribute valuable insights into how DHA can be leveraged as a therapeutic approach for OA, emphasizing its role in protecting and restoring cartilage health.
Read More
9
We observed a fascinating case involving a 22-year-old woman with juvenile idiopathic arthritis who was put on a very low calorie ketogenic diet (VLCKD). This diet included high-biological-value protein preparations that featured docosahexaenoic acid (DHA), an omega-3 fatty acid known for its potential health benefits.
The woman saw improvements in her overall weight and health after four months on this diet, including a noticeable reduction in joint pain and headaches. Laboratory tests indicated that her inflammatory markers returned to normal levels, suggesting that the dietary changes—including DHA—might have played a positive role in her experience.
However, it’s essential to note that while DHA is included in the treatment regimen, the isolated effect of DHA on her arthritis symptoms is challenging to determine definitively. This case highlights the potential benefits of dietary interventions for inflammatory conditions but also points to the need for further research to isolate the effects of specific dietary components like DHA.
The woman saw improvements in her overall weight and health after four months on this diet, including a noticeable reduction in joint pain and headaches. Laboratory tests indicated that her inflammatory markers returned to normal levels, suggesting that the dietary changes—including DHA—might have played a positive role in her experience.
However, it’s essential to note that while DHA is included in the treatment regimen, the isolated effect of DHA on her arthritis symptoms is challenging to determine definitively. This case highlights the potential benefits of dietary interventions for inflammatory conditions but also points to the need for further research to isolate the effects of specific dietary components like DHA.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Pain relief
115 people found this helpful
Despite the high price, I find this omega-3 to be the best available in terms of quality and ingredients. It effectively alleviates my arthritis pain when combined with vitamin D and curcumin, and even enhances my focus, which I had been losing due to my condition.
Read More
7.5
Pain reduction
8 people found this helpful
Although this product is pricey, I consider it the best omega-3 I found for its quality and ingredients. It has significantly reduced the pain from my arthritis when taken with vitamin D and curcumin, and has also improved my concentration.
Read More
9
Inflammation reduced
3 people found this helpful
I love this product! I have suffered from severe rheumatoid arthritis (RA) for over 40 years. My pain levels on medication are horrific at times, ranging between 6 and 10. I tried various brands of fish oils over the years without success. My son, a bodybuilder, suggested I try Sports Research brand. I started a daily regimen, taking it twice a day with buttermilk. Initially, I didn’t expect any difference, but within a month, I noticed a significant reduction in inflammation throughout my body. I also suffer from four other forms of crippling arthritis.
Read More
9
Dosage efficiency
1 people found this helpful
This high-dose fish oil meets my needs efficiently, providing the required 2000 mg of DHA and EPA with just two capsules, and is recommended by my nutritionist for managing my rheumatoid arthritis. I’ve repurchased it many times.
Read More
9
Inflammation reduction
1 people found this helpful
This omega-3 is an excellent choice with a strong dosage, particularly for muscle mass increase and inflammation reduction related to arthritis. It's derived from cold-water wild pollock, ensuring high quality.
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Frequently Asked Questions
9
Pain relief noted
I have knee joint arthritis, and this product alleviates my pain effectively. When I stop using it, the pain returns.
9
Condition improved
Since purchasing this high-content product, my arthritis and inflammation have noticeably improved.
8
Quality and effects
The quality is high, with significant EPA and DHA content. The non-fishy taste is a bonus, and it’s been beneficial for my arthritis over three years of use. Ideal for those in fitness or with EPA deficiencies.
7.5
Pain relief
115 people found this helpful
Despite the high price, I find this omega-3 to be the best available in terms of quality and ingredients. It effectively alleviates my arthritis pain when combined with vitamin D and curcumin, and even enhances my focus, which I had been losing due to my condition.
7.5
Pain reduction
8 people found this helpful
Although this product is pricey, I consider it the best omega-3 I found for its quality and ingredients. It has significantly reduced the pain from my arthritis when taken with vitamin D and curcumin, and has also improved my concentration.
9
Dosage efficiency
1 people found this helpful
This high-dose fish oil meets my needs efficiently, providing the required 2000 mg of DHA and EPA with just two capsules, and is recommended by my nutritionist for managing my rheumatoid arthritis. I’ve repurchased it many times.
7.5
Less pain
1 people found this helpful
A highly effective product that has considerably aided my rheumatoid arthritis, reducing inflammation and pain.
4
Eicosapentaenoic acid shows limited benefits
We conducted a systematic review to understand how eicosapentaenoic acid, a type of n-3 fatty acid, might influence arthritis symptoms. Our search covered various studies comparing eicosapentaenoic acid supplementation to a placebo, specifically looking for effects on pain, joint tenderness, and swelling in people with rheumatoid arthritis.
The results we found were quite revealing. We observed only a small reduction in pain and tenderness, with a standardized mean difference (SMD) of -0.16 for pain and -0.20 for tender joint count. The swollen joint count showed a slight difference as well, with an SMD of -0.10. While there was some indication that eicosapentaenoic acid might help reduce the need for non-steroidal anti-inflammatory drugs (NSAIDs), this effect was negligible.
Importantly, we noted that the quality of evidence was generally very low to low, suggesting that the benefits of eicosapentaenoic acid for arthritis management are limited, and our findings sync with earlier reports indicating similar outcomes. Given these insights, it's clear that while eicosapentaenoic acid was studied for its potential benefits in improving arthritis symptoms, the effects may not be significant or clinically impactful.
The results we found were quite revealing. We observed only a small reduction in pain and tenderness, with a standardized mean difference (SMD) of -0.16 for pain and -0.20 for tender joint count. The swollen joint count showed a slight difference as well, with an SMD of -0.10. While there was some indication that eicosapentaenoic acid might help reduce the need for non-steroidal anti-inflammatory drugs (NSAIDs), this effect was negligible.
Importantly, we noted that the quality of evidence was generally very low to low, suggesting that the benefits of eicosapentaenoic acid for arthritis management are limited, and our findings sync with earlier reports indicating similar outcomes. Given these insights, it's clear that while eicosapentaenoic acid was studied for its potential benefits in improving arthritis symptoms, the effects may not be significant or clinically impactful.
We investigated how eicosapentaenoic acid (EPA), a type of Omega-3 fatty acid, impacts arthritis and related conditions. Numerous studies suggest that EPA carries significant anti-inflammatory properties, which can be particularly beneficial for individuals suffering from autoimmune diseases like arthritis.
The research highlighted that EPA not only helps in reducing inflammation but also has the ability to inhibit immune cells that contribute to the inflammatory response. This is particularly essential for those dealing with rheumatoid arthritis, where inflammation can lead to joint damage and pain.
Interestingly, participants who supplemented with EPA reported a noticeable reduction in disease activity, leading to improved symptoms and potentially better quality of life. While the studies indicate promising outcomes, they emphasize the need for ongoing research to further validate these findings and identify optimal dosages for effective treatment.
Overall, incorporating EPA into our diets might be a supportive strategy for managing arthritis, addressing both inflammation and immune dysregulation.
The research highlighted that EPA not only helps in reducing inflammation but also has the ability to inhibit immune cells that contribute to the inflammatory response. This is particularly essential for those dealing with rheumatoid arthritis, where inflammation can lead to joint damage and pain.
Interestingly, participants who supplemented with EPA reported a noticeable reduction in disease activity, leading to improved symptoms and potentially better quality of life. While the studies indicate promising outcomes, they emphasize the need for ongoing research to further validate these findings and identify optimal dosages for effective treatment.
Overall, incorporating EPA into our diets might be a supportive strategy for managing arthritis, addressing both inflammation and immune dysregulation.
We conducted a randomized, double-blind, placebo-controlled study to explore how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, impacts individuals with rheumatoid arthritis (RA). Over a 16-week period, participants were assigned to one of four groups: a placebo, a placebo plus aerobic exercise, eicosapentaenoic acid alone, or eicosapentaenoic acid combined with aerobic exercise.
The goal was to assess how these interventions might affect disease progression, cardiometabolic health, and quality of life for those living with RA. Participants engaged in structured exercise while consuming either a gelatin capsule or a supplement rich in EPA. We collected blood and synovial fluid for detailed analysis to measure changes in inflammation and gene expression.
Our findings will help clarify whether EPA supplementation, especially when paired with aerobic exercise, contributes to meaningful improvements in arthritis symptoms and overall well-being. The potential relationship between changes in specialized pro-resolving mediators and improvements in health outcomes is of particular interest, giving us a deeper understanding of inflammatory processes in RA.
The goal was to assess how these interventions might affect disease progression, cardiometabolic health, and quality of life for those living with RA. Participants engaged in structured exercise while consuming either a gelatin capsule or a supplement rich in EPA. We collected blood and synovial fluid for detailed analysis to measure changes in inflammation and gene expression.
Our findings will help clarify whether EPA supplementation, especially when paired with aerobic exercise, contributes to meaningful improvements in arthritis symptoms and overall well-being. The potential relationship between changes in specialized pro-resolving mediators and improvements in health outcomes is of particular interest, giving us a deeper understanding of inflammatory processes in RA.
We explored the effects of blue mussel lipid extract (BMLE), rich in eicosapentaenoic acid (EPA), on people with type 2 diabetes mellitus (T2DM). This study involved 133 Chinese participants who were divided into groups receiving either BMLE, fish oil, or corn oil.
Over 60 days, we found noteworthy improvements in several health markers for those taking BMLE. For instance, participants in the BMLE group saw significant reductions in fasting insulin levels and a decrease in inflammatory markers like tumor necrosis factor-α.
However, while our study demonstrated some benefits from BMLE, the specific role of EPA on arthritis remains unclear. No direct studies were conducted on arthritis, so while there's promise, we cannot solely attribute these findings to the effects of eicosapentaenoic acid. It's exciting to consider how these results might translate into broader health implications, but further research is needed to fully understand how BMLE could impact conditions like arthritis.
Over 60 days, we found noteworthy improvements in several health markers for those taking BMLE. For instance, participants in the BMLE group saw significant reductions in fasting insulin levels and a decrease in inflammatory markers like tumor necrosis factor-α.
However, while our study demonstrated some benefits from BMLE, the specific role of EPA on arthritis remains unclear. No direct studies were conducted on arthritis, so while there's promise, we cannot solely attribute these findings to the effects of eicosapentaenoic acid. It's exciting to consider how these results might translate into broader health implications, but further research is needed to fully understand how BMLE could impact conditions like arthritis.
References
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- Jannas-Vela S, Candia AA, Peñailillo L, Barrios-Troncoso P, Zapata-Urzúa J, et al. Role of specialized pro-resolving mediators on inflammation, cardiometabolic health, disease progression, and quality of life after omega-3 PUFA supplementation and aerobic exercise training in individuals with rheumatoid arthritis: a randomized 16-week, placebo-controlled interventional trial. F1000Res. 2023;12:942. doi:10.12688/f1000research.138392.1
- Deng C, Presle N, Pizard A, Guillaume C, Bianchi A, et al. Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte. Int J Mol Sci. 2024;25. doi:10.3390/ijms25031810
- Poggioli R, Hirani K, Jogani VG, Ricordi C. Modulation of inflammation and immunity by omega-3 fatty acids: a possible role for prevention and to halt disease progression in autoimmune, viral, and age-related disorders. Eur Rev Med Pharmacol Sci. 2023;27:7380. doi:10.26355/eurrev_202308_33310
- Wadell AT, Bärebring L, Hulander E, Gjertsson I, Landberg R, et al. Dietary biomarkers and food records indicate compliance to study diets in the ADIRA (Anti-inflammatory Diet In Rheumatoid Arthritis) trial. Front Nutr. 2023;10:1209787. doi:10.3389/fnut.2023.1209787
- Marchand NE, Choi MY, Oakes EG, Cook NR, Stevens E, et al. Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2023;190:102542. doi:10.1016/j.plefa.2023.102542
- Lindqvist HM, Winkvist A, Gjertsson I, Calder PC, Armando AM, et al. Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis. Molecules. 2023;28. doi:10.3390/molecules28020717
- Kuang X, Shao X, Li H, Jiang D, Gao T, et al. Lipid extract from blue mussel (Mytilus edulis) improves glycemic traits in Chinese type 2 diabetic mellitus patients: a double-blind randomized controlled trial. J Sci Food Agric. 2023;103:2970. doi:10.1002/jsfa.12346
- Gkiouras K, Grammatikopoulou MG, Myrogiannis I, Papamitsou T, Rigopoulou EI, et al. Efficacy of n-3 fatty acid supplementation on rheumatoid arthritis' disease activity indicators: a systematic review and meta-analysis of randomized placebo-controlled trials. Crit Rev Food Sci Nutr. 2024;64:16. doi:10.1080/10408398.2022.2104210
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD, Hall S, et al. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2022;116:672. doi:10.1093/ajcn/nqac125
- Eckert T, Jährling-Butkus M, Louton H, Burg-Roderfeld M, Zhang R, et al. Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms. Mar Drugs. 2021;19. doi:10.3390/md19100542
- Ceotto BH, Figueroba SR, Ferreira LEN, Amorim KS, Sánchez JB, et al. The effect of association of aspirin and omega 3 in rat temporomandibular joint with induced arthritis. Ann Anat. 2022;239:151812. doi:10.1016/j.aanat.2021.151812
- Fan Z, Ross RP, Stanton C, Hou B, Zhao J, et al. CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota. Front Immunol. 2021;12:680073. doi:10.3389/fimmu.2021.680073
- Sasahara I, Yamamoto A, Takeshita M, Suga Y, Suzuki K, et al. l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Nutr. 2020;150:2278. doi:10.1093/jn/nxaa156
- Brown Z, Metcalf R, Bednarz J, Spargo L, Lee A, et al. Modifiable Lifestyle Factors Associated With Response to Treatment in Early Rheumatoid Arthritis. ACR Open Rheumatol. 2020;2:371. doi:10.1002/acr2.11132
- Tsubosaka M, Kihara S, Hayashi S, Nagata J, Kuwahara T, et al. Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model. J Orthop Res. 2020;38:2157. doi:10.1002/jor.24688
- Gowler PRW, Arendt-Tranholm A, Turnbull J, Jha RR, Onion D, et al. Monocyte eukaryotic initiation factor 2 signaling differentiates 17-hydroxy-docosahexaenoic acid levels and pain. iScience. 2025;28:111862. doi:10.1016/j.isci.2025.111862
- Franks SJ, Gowler PRW, Dunster JL, Turnbull J, Gohir SA, et al. Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain. Math Biosci. 2024;374:109228. doi:10.1016/j.mbs.2024.109228
- Su Y, Han Y, Choi HS, Lee GY, Cho HW, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis. Biomed Pharmacother. 2024;171:116153. doi:10.1016/j.biopha.2024.116153
- Yu H, Gong Z, Wang G, Cao R, Yin H, et al. DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis. In Vitro Cell Dev Biol Anim. 2023;59:455. doi:10.1007/s11626-023-00781-3
- Léger T, Brun A, Lanchais K, Rigaudière JP, Briat A, et al. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sci. 2023;327:121826. doi:10.1016/j.lfs.2023.121826
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