' 
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
2
No benefit observed in epilepsy
Effects of essential fatty acid supplementation in dogs with idiopathic epilepsy: a clinical trial.
Direct examination of EPA effects.
We conducted a study to investigate whether essential fatty acid supplementation, specifically eicosapentaenoic acid (EPA), could help control idiopathic epilepsy in dogs. This involved a carefully designed approach where fifteen dogs received a daily dose of purified Omega-3 oil for 12 weeks, followed by a 12-week placebo period using olive oil.
Throughout the study, dog owners diligently recorded seizure frequency and severity, along with any side effects that may have arisen. Despite hopes that these essential fatty acids would provide some benefit, the results were quite clear: we found no significant reduction in seizure frequency or severity for those dogs receiving the Omega-3 supplement compared to the placebo group.
These findings suggest that while EPA is a popular supplement often touted for various health benefits, it does not appear to have a positive effect on managing idiopathic epilepsy in dogs. This research can help pet owners make informed decisions about treatment options for their furry companions struggling with seizures.
Throughout the study, dog owners diligently recorded seizure frequency and severity, along with any side effects that may have arisen. Despite hopes that these essential fatty acids would provide some benefit, the results were quite clear: we found no significant reduction in seizure frequency or severity for those dogs receiving the Omega-3 supplement compared to the placebo group.
These findings suggest that while EPA is a popular supplement often touted for various health benefits, it does not appear to have a positive effect on managing idiopathic epilepsy in dogs. This research can help pet owners make informed decisions about treatment options for their furry companions struggling with seizures.
Read More
9
Eicosapentaenoic acid improves cognition
A Compared Study of Eicosapentaenoic Acid and Docosahexaenoic Acid in Improving Seizure-Induced Cognitive Deficiency in a Pentylenetetrazol-Kindling Young Mice Model.
Directly impacts seizure cognition
We investigated the potential effects of eicosapentaenoic acid (EPA) on cognitive impairment triggered by seizures, particularly in a model involving young mice. Our focus was on understanding how EPA, when compared to docosahexaenoic acid (DHA), could play a role in mitigating cognitive deficiencies related to epilepsy.
For our study, we fed young mice either a DHA-rich or EPA-rich diet for 21 days while exposing them to pentylenetetrazol (PTZ) injections to induce seizures. Through this approach, we observed that both EPA and DHA provided some improvement against seizure-related cognitive decline; however, EPA stood out with more significant benefits, particularly in maintaining iron balance in the brain.
We also found that both fatty acids helped balance neurotransmitter levels and reduced indicators of ferroptosis—a form of cell death linked to epilepsy. Notably, EPA was more effective in this aspect due to its ability to enhance certain signaling pathways in the brain. This suggests that incorporating EPA might be advantageous for managing cognitive impairments associated with seizures in children.
For our study, we fed young mice either a DHA-rich or EPA-rich diet for 21 days while exposing them to pentylenetetrazol (PTZ) injections to induce seizures. Through this approach, we observed that both EPA and DHA provided some improvement against seizure-related cognitive decline; however, EPA stood out with more significant benefits, particularly in maintaining iron balance in the brain.
We also found that both fatty acids helped balance neurotransmitter levels and reduced indicators of ferroptosis—a form of cell death linked to epilepsy. Notably, EPA was more effective in this aspect due to its ability to enhance certain signaling pathways in the brain. This suggests that incorporating EPA might be advantageous for managing cognitive impairments associated with seizures in children.
Read More
9
Eicosapentaenoic acid aids epilepsy
DHA and EPA Prevent Seizure and Depression-Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode-of-Actions in a Pentylenetetrazole-Induced Kindling Model in Mice.
Directly addresses EPA’s effects
We explored the effects of eicosapentaenoic acid (EPA) on epilepsy, particularly how it influences seizures and depression-like behavior in mice subjected to pentylenetetrazol (PTZ) induced seizures. Our study showed that administering EPA significantly reduced both seizure activity and depressive symptoms, indicating its potential as an anticonvulsant agent.
In our tests, we found that EPA outperformed docosahexaenoic acid (DHA) in these areas. We looked deeper to understand why EPA was more effective, discovering that it helps shift microglial cells toward a protective M2 state while inhibiting the harmful M1 state. This shift is linked to lower iron levels in the brain, likely due to EPA’s stronger activation of a protective pathway known as Nrf2.
Additionally, we noticed both EPA and DHA can inhibit inflammation related to a specific cellular process called NLRP3 inflammasome activation, but they do this in different ways. This means that while both fatty acids have benefits, EPA may provide a stronger effect due to its unique mechanisms.
Overall, our findings suggest that both EPA and DHA can relieve seizure and depression-like behaviors, but EPA stands out in effectiveness and its underlying functions.
In our tests, we found that EPA outperformed docosahexaenoic acid (DHA) in these areas. We looked deeper to understand why EPA was more effective, discovering that it helps shift microglial cells toward a protective M2 state while inhibiting the harmful M1 state. This shift is linked to lower iron levels in the brain, likely due to EPA’s stronger activation of a protective pathway known as Nrf2.
Additionally, we noticed both EPA and DHA can inhibit inflammation related to a specific cellular process called NLRP3 inflammasome activation, but they do this in different ways. This means that while both fatty acids have benefits, EPA may provide a stronger effect due to its unique mechanisms.
Overall, our findings suggest that both EPA and DHA can relieve seizure and depression-like behaviors, but EPA stands out in effectiveness and its underlying functions.
Read More
Most Useful Reviews
8.8
Stabilise nerves
The child has epilepsy; assistance in stabilising the nerves is crucial, and the adults will presumably benefit as well!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
- All Researches
9
Eicosapentaenoic acid improves cognition
A Compared Study of Eicosapentaenoic Acid and Docosahexaenoic Acid in Improving Seizure-Induced Cognitive Deficiency in a Pentylenetetrazol-Kindling Young Mice Model.
Directly impacts seizure cognition
We investigated the potential effects of eicosapentaenoic acid (EPA) on cognitive impairment triggered by seizures, particularly in a model involving young mice. Our focus was on understanding how EPA, when compared to docosahexaenoic acid (DHA), could play a role in mitigating cognitive deficiencies related to epilepsy.
For our study, we fed young mice either a DHA-rich or EPA-rich diet for 21 days while exposing them to pentylenetetrazol (PTZ) injections to induce seizures. Through this approach, we observed that both EPA and DHA provided some improvement against seizure-related cognitive decline; however, EPA stood out with more significant benefits, particularly in maintaining iron balance in the brain.
We also found that both fatty acids helped balance neurotransmitter levels and reduced indicators of ferroptosis—a form of cell death linked to epilepsy. Notably, EPA was more effective in this aspect due to its ability to enhance certain signaling pathways in the brain. This suggests that incorporating EPA might be advantageous for managing cognitive impairments associated with seizures in children.
For our study, we fed young mice either a DHA-rich or EPA-rich diet for 21 days while exposing them to pentylenetetrazol (PTZ) injections to induce seizures. Through this approach, we observed that both EPA and DHA provided some improvement against seizure-related cognitive decline; however, EPA stood out with more significant benefits, particularly in maintaining iron balance in the brain.
We also found that both fatty acids helped balance neurotransmitter levels and reduced indicators of ferroptosis—a form of cell death linked to epilepsy. Notably, EPA was more effective in this aspect due to its ability to enhance certain signaling pathways in the brain. This suggests that incorporating EPA might be advantageous for managing cognitive impairments associated with seizures in children.
Read More
9
Eicosapentaenoic acid aids epilepsy
DHA and EPA Prevent Seizure and Depression-Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode-of-Actions in a Pentylenetetrazole-Induced Kindling Model in Mice.
Directly addresses EPA’s effects
We explored the effects of eicosapentaenoic acid (EPA) on epilepsy, particularly how it influences seizures and depression-like behavior in mice subjected to pentylenetetrazol (PTZ) induced seizures. Our study showed that administering EPA significantly reduced both seizure activity and depressive symptoms, indicating its potential as an anticonvulsant agent.
In our tests, we found that EPA outperformed docosahexaenoic acid (DHA) in these areas. We looked deeper to understand why EPA was more effective, discovering that it helps shift microglial cells toward a protective M2 state while inhibiting the harmful M1 state. This shift is linked to lower iron levels in the brain, likely due to EPA’s stronger activation of a protective pathway known as Nrf2.
Additionally, we noticed both EPA and DHA can inhibit inflammation related to a specific cellular process called NLRP3 inflammasome activation, but they do this in different ways. This means that while both fatty acids have benefits, EPA may provide a stronger effect due to its unique mechanisms.
Overall, our findings suggest that both EPA and DHA can relieve seizure and depression-like behaviors, but EPA stands out in effectiveness and its underlying functions.
In our tests, we found that EPA outperformed docosahexaenoic acid (DHA) in these areas. We looked deeper to understand why EPA was more effective, discovering that it helps shift microglial cells toward a protective M2 state while inhibiting the harmful M1 state. This shift is linked to lower iron levels in the brain, likely due to EPA’s stronger activation of a protective pathway known as Nrf2.
Additionally, we noticed both EPA and DHA can inhibit inflammation related to a specific cellular process called NLRP3 inflammasome activation, but they do this in different ways. This means that while both fatty acids have benefits, EPA may provide a stronger effect due to its unique mechanisms.
Overall, our findings suggest that both EPA and DHA can relieve seizure and depression-like behaviors, but EPA stands out in effectiveness and its underlying functions.
Read More
9
Omega-3 reduces epilepsy seizures
The effect of omega-3 fatty acid supplementation on seizure frequency in individuals with epilepsy: a systematic review and meta-analysis.
Relevant but lacks specificity
We systematically reviewed and analyzed several studies to understand how omega-3 fatty acids, particularly eicosapentaenoic acid, can influence seizure frequency in people living with epilepsy. By searching through major medical databases and including various trials conducted up to October 2020, we aimed to provide clear insights into this subject.
Our analysis focused on various aspects such as the intervention duration and dosage of omega-3 supplementation. The studies included revealed that treatment with omega-3 fatty acids, particularly dosages around 1500 mg or less per day, showed significant reductions in seizure frequency. Notably, those who participated in studies lasting more than 16 weeks also experienced more substantial improvements.
Interestingly, we found that adults benefitted more from omega-3 supplementation compared to children with epilepsy. This highlights the need for tailored treatments based on age groups. Overall, our findings suggest that incorporating omega-3 fatty acids could be a valuable strategy in managing epilepsy symptoms effectively.
Our analysis focused on various aspects such as the intervention duration and dosage of omega-3 supplementation. The studies included revealed that treatment with omega-3 fatty acids, particularly dosages around 1500 mg or less per day, showed significant reductions in seizure frequency. Notably, those who participated in studies lasting more than 16 weeks also experienced more substantial improvements.
Interestingly, we found that adults benefitted more from omega-3 supplementation compared to children with epilepsy. This highlights the need for tailored treatments based on age groups. Overall, our findings suggest that incorporating omega-3 fatty acids could be a valuable strategy in managing epilepsy symptoms effectively.
Read More
9
Fatty acid imbalance in epilepsy
Plasma fatty acid abnormality in Sudanese drug-resistant epileptic patients.
Insufficient focus on eicosapentaenoic acid
We investigated how plasma fatty acid levels affect individuals with drug-resistant epilepsy (DRE) in Sudan. The study included 83 patients and 31 healthy controls, allowing us to compare their blood fatty acid compositions.
Our findings revealed that patients with DRE had higher levels of certain saturated and monounsaturated fatty acids compared to the healthy group. However, they showed lower levels of both omega-6 and omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are known for their potential benefits in managing seizures.
Interestingly, we also assessed the activity levels of important enzymes that help modify fatty acids in the body. These enzyme activities were found to be abnormal in the DRE patients, suggesting a metabolic disturbance related to fatty acids.
While the study highlights a clear fatty acid imbalance in DRE patients, it does not isolate the effects of eicosapentaenoic acid alone on seizure frequency. Therefore, we can't definitively say how effective EPA is in treating epilepsy. However, our findings indicate that incorporating omega-3 fatty acids into treatment plans could be beneficial and warrant further investigation.
Our findings revealed that patients with DRE had higher levels of certain saturated and monounsaturated fatty acids compared to the healthy group. However, they showed lower levels of both omega-6 and omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are known for their potential benefits in managing seizures.
Interestingly, we also assessed the activity levels of important enzymes that help modify fatty acids in the body. These enzyme activities were found to be abnormal in the DRE patients, suggesting a metabolic disturbance related to fatty acids.
While the study highlights a clear fatty acid imbalance in DRE patients, it does not isolate the effects of eicosapentaenoic acid alone on seizure frequency. Therefore, we can't definitively say how effective EPA is in treating epilepsy. However, our findings indicate that incorporating omega-3 fatty acids into treatment plans could be beneficial and warrant further investigation.
Read More
9
DHA and EPA mitigate epileptic depression
DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism.
Study highlights EPA's effectiveness
We explored the effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on depression associated with epilepsy in young mice. Using a well-structured approach, we treated three-week-old mice with a diet rich in either DHA or EPA for 21 days, followed by a series of pentylenetetrazole (PTZ) injections to induce depressive symptoms.
Our findings revealed that EPA was particularly effective in alleviating these symptoms compared to DHA. Both fatty acids significantly reduced neuronal damage in the hippocampus and improved myelin integrity, indicating potential protective effects on brain health.
Delving deeper, we discovered that DHA and EPA reduced neuroinflammation by helping microglial cells switch to a protective M2 phenotype. Moreover, both compounds lowered oxidative stress levels and enhanced mitochondrial function, which plays a crucial role in energy production and overall cellular health.
These results suggest that incorporating DHA and EPA into the diet may serve as an effective strategy to combat depression in children dealing with epilepsy, with EPA emerging as the more beneficial option.
Our findings revealed that EPA was particularly effective in alleviating these symptoms compared to DHA. Both fatty acids significantly reduced neuronal damage in the hippocampus and improved myelin integrity, indicating potential protective effects on brain health.
Delving deeper, we discovered that DHA and EPA reduced neuroinflammation by helping microglial cells switch to a protective M2 phenotype. Moreover, both compounds lowered oxidative stress levels and enhanced mitochondrial function, which plays a crucial role in energy production and overall cellular health.
These results suggest that incorporating DHA and EPA into the diet may serve as an effective strategy to combat depression in children dealing with epilepsy, with EPA emerging as the more beneficial option.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Stabilise nerves
The child has epilepsy; assistance in stabilising the nerves is crucial, and the adults will presumably benefit as well!
