Medical Researches
Moderately Effective
Based on 3 Researches
Vitamin K2 reduces anxiety symptomsVitamin K2 (Menaquinone-7) Reverses Age-Related Structural and Cognitive Deterioration in Naturally Aging Rats.
Direct focus on anxiety impact
We explored the potential of Vitamin K2 as a treatment for anxiety in aging rats. In this study, aged rats received a daily dose of Vitamin K2 for 17 months, while a control group received a vehicle. The results were promising; the rats treated with Vitamin K2 showed a notable reduction in social anxiety and depressive-like behavior.
Additionally, our observations reflected improvements in the rats' memory performance and overall emotional well-being. The administration of Vitamin K2 appeared to positively affect the brain by restoring oxidative balance and reducing inflammation-related markers linked to anxiety.
As we examined the brain's structure, particularly areas like the hippocampus and cerebral cortex, we noted enhancements that supported our behavioral findings. Overall, this research suggests that Vitamin K2 could be a valuable intervention for managing anxiety as we age.
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We explored how vitamin K2, specifically menaquinone-4 (MK-4), impacts anxiety in a rat model of cerebral ischemia. In our study, rats were subjected to a transient global cerebral ischemia, simulating conditions that often lead to anxiety and cognitive deficits. Post-injury, we observed that administering MK-4 significantly improved anxiety-like behaviors in these animals.
The effectiveness of MK-4 was measured through various neurological and behavioral assessments conducted 24 hours and seven days after ischemia. Notably, we noted improvements in short-term memory and spatial learning, which are often affected by such brain injuries. The administration of MK-4 also helped reduce brain swelling, cell death, and inflammation markers, indicating a protective role against damage caused by ischemia.
While we recognize that this study centers on a complex issue involving brain injury, the implications for anxiety treatment are clear. By demonstrating MK-4's neuroprotective effects, we provide exciting evidence that it could be a candidate for further research in addressing anxiety related to brain health.
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Vitamin K2 reduces anxiety in ratsVitamin K2 Improves Anxiety and Depression but not Cognition in Rats with Metabolic Syndrome: a Role of Blood Glucose?
Mildly high relevance to anxiety
We explored how vitamin K2 influences anxiety in rats suffering from metabolic syndrome, a condition known to affect energy use, leading to increased risks of anxiety and depression. To do this, we organized male Wistar rats into four groups: one group received a healthy diet while another was fed a high-fat, high-fructose diet. Additionally, we had groups receiving vitamin K2 treatment alongside their respective diets.
After ten weeks of the study, we assessed the rats' behavior through various tests designed to measure anxiety and depression, while also looking at their blood glucose levels. It was interesting to find that vitamin K2 effectively reduced feelings of anxiety in the rats with metabolic syndrome. This suggests that vitamin K2 not only has potential benefits for emotional well-being but may also be linked to better blood sugar control.
However, we also observed that vitamin K2 did not help improve memory function in these rats, as seen in our object recognition tests. This indicates that while vitamin K2 has promising effects on anxiety, it doesn't appear to influence cognitive abilities. Overall, our findings point to the possibility that the reduction in anxiety might at least partially be related to its impact on blood glucose levels, while the effects on depression seem to operate independently of glucose.
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