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SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.8
USERS' SCORE
Good
Based on 3 Reviews
8.6
Top Medical Research Studies
9
Vitamin B12 effectively treats anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Highlights vitamin B12's significance
We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
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9
Vitamin B12's role in anemia
Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency.
Direct relevance to treatment
We explored the intriguing link between vitamin B12 deficiency and anemia, particularly through a rare condition known as pseudo-thrombotic microangiopathy. This condition mimics other thrombotic microangiopathies and could lead to unnecessary treatments such as plasmapheresis.
Our findings suggest that this situation should be taken seriously in patients showing signs of microangiopathic hemolytic anemia. It's essential to promptly administer vitamin B12 supplements in these cases, as it can effectively address the root cause of the anemia.
While the lab results may initially appear similar to conditions like thrombotic thrombocytopenic purpura, we noted important differences, particularly in the reticulocyte production index, which can help differentiate between these conditions. Overall, it emphasizes the importance of recognizing how vitamin B12 treatment can alleviate symptoms related to its deficiency.
Our findings suggest that this situation should be taken seriously in patients showing signs of microangiopathic hemolytic anemia. It's essential to promptly administer vitamin B12 supplements in these cases, as it can effectively address the root cause of the anemia.
While the lab results may initially appear similar to conditions like thrombotic thrombocytopenic purpura, we noted important differences, particularly in the reticulocyte production index, which can help differentiate between these conditions. Overall, it emphasizes the importance of recognizing how vitamin B12 treatment can alleviate symptoms related to its deficiency.
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7
Parenteral B12 may be better
Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review.
Directly relates to anemia treatment
We sought to understand how effective vitamin B12 is in treating anemia in children. Our focus was on comparing two different methods of supplementation: parenteral (injections) and oral (pills). While previous studies in adults suggested both methods might have similar benefits, we found limited data for children, prompting our thorough investigation.
Our literature search pulled from multiple reputable databases for randomized controlled trials that specifically looked at vitamin B12 treatments in children with deficiency anemia. Of the thousands of studies reviewed, only one qualified for our analysis. In this study, children received an initial injection of vitamin B12 before being assigned to either the parenteral or oral treatment group.
We observed notable differences in the outcomes after three months. The children who received the parenteral treatment showed significantly higher vitamin B12 levels and better improvements in hemoglobin, indicating that this method may be more effective. However, we should note that the quality of the study was deemed high risk for bias, and there was no safety data reported, making it challenging to draw strong conclusions.
Overall, while the findings hint at a greater effectiveness of parenteral supplementation, the lack of robust evidence calls for caution in interpreting these results. Further high-quality research is necessary before definitive recommendations can be made.
Our literature search pulled from multiple reputable databases for randomized controlled trials that specifically looked at vitamin B12 treatments in children with deficiency anemia. Of the thousands of studies reviewed, only one qualified for our analysis. In this study, children received an initial injection of vitamin B12 before being assigned to either the parenteral or oral treatment group.
We observed notable differences in the outcomes after three months. The children who received the parenteral treatment showed significantly higher vitamin B12 levels and better improvements in hemoglobin, indicating that this method may be more effective. However, we should note that the quality of the study was deemed high risk for bias, and there was no safety data reported, making it challenging to draw strong conclusions.
Overall, while the findings hint at a greater effectiveness of parenteral supplementation, the lack of robust evidence calls for caution in interpreting these results. Further high-quality research is necessary before definitive recommendations can be made.
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Most Useful Reviews
9.5
Reduced exhaustion
Very impressed! I have low iron deficiency anemia that necessitates iron infusions every three months, alongside B12 deficiency requiring weekly injections. Recently unemployed with no medical insurance, I felt exhausted. I decided to try these and am thrilled with my choice; they help me function better and alleviate my extreme fatigue.
Read More
8.8
Convenient and effective
Easy to use and works. I was prescribed B12 for anemia and struggled with the messy under-the-tongue liquid. Then I discovered these tablets. I now use one daily as I walk to appointments. They dissolve quickly with a light cherry flavour, and I'm pleased to see my anemia numbers steadily improving. If texture is an issue, I highly recommend these B12 tablets.
Read More
8.8
Improved health
This one is my favourite! I also use the 1,000 mcg formula, but this one is best for my needs. My kitty has kidney disease, which comes with anaemia. This product helps keep her HCT closer to where it should be. I cut these little pills into smaller pieces and can mix them into her food, and she never notices.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.8
9.5
Vitamin B12 aids anemia recovery
Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review.
Moderate relevance of vitamin B12
We investigated how vitamin B12 treatment plays a role in addressing anemia in a young adolescent with complex health issues, including severe anemia, joint problems, and neurological symptoms. This individual presented with a deficiency in vitamin B12, alongside other autoimmune conditions, leading to a diagnosis of subacute combined degeneration of the spinal cord.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
Read More
9
Pernicious anemia linked to B12
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Focus on vitamin B12 efficacy
We explored the intriguing case of a 51-year-old man in Western Uganda who experienced lower limb weakness linked to pernicious anemia, a condition caused by vitamin B12 deficiency. His journey illustrates the importance of recognizing the signs of this often-overlooked autoimmune disease.
Initially presenting with macrocytic anemia, our patient had a history of similar symptoms seven years prior, which were treated for vitamin B12 deficiency. This time, additional tests confirmed that pernicious anemia was at play, allowing for targeted treatment.
After starting parenteral methylcobalamin therapy, he showed significant improvement in his symptoms. This case underscores that vitamin B12 is crucial not just for red blood cell production but also for neurological health, emphasizing the need for increased awareness and diagnosis of vitamin B12 deficiencies in resource-limited settings.
Initially presenting with macrocytic anemia, our patient had a history of similar symptoms seven years prior, which were treated for vitamin B12 deficiency. This time, additional tests confirmed that pernicious anemia was at play, allowing for targeted treatment.
After starting parenteral methylcobalamin therapy, he showed significant improvement in his symptoms. This case underscores that vitamin B12 is crucial not just for red blood cell production but also for neurological health, emphasizing the need for increased awareness and diagnosis of vitamin B12 deficiencies in resource-limited settings.
Read More
9
Vitamin B12's role in anemia
A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements.
Importance of B12 in treatment
We explored how vitamin B12 affects anemia, specifically through its role in correcting deficiencies. The research analyzes oral B12 intake and its absorption, particularly in individuals showing signs of deficiency.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
Read More
9
Pernicious anemia's vitamin B12 impact
[A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12].
Indicates complex vitamin B12 effects
We explored a notable case involving an 86-year-old man who experienced symptoms linked to anemia, such as tingling in his hands and later developed a condition known as pancytopenia. Initially diagnosed with myelodysplastic syndrome after a bone marrow analysis, his case took a turn when further tests revealed unusually high levels of serum vitamin B12 despite other concerning indicators.
As we delved deeper into his condition, we discovered that he had elevated homocysteine levels and tested positive for an anti-intrinsic factor antibody. These elements played a crucial role, as they pointed toward pernicious anemia, which can complicate the interpretation of vitamin B12 levels. Remarkably, he also exhibited T-weighted hyperintense lesions on his spinal cord MRI, indicating subacute combined degeneration—a severe condition caused by vitamin B12 deficiency.
Treatment with mecobalamin, a form of vitamin B12 administered through intramuscular injections, ultimately proved beneficial. It improved his pancytopenia and resolved the MRI lesions, highlighting the effectiveness of vitamin B12 in managing anemia, especially in the context of pernicious anemia. However, this case also serves as a reminder that simply measuring vitamin B12 levels may not provide a complete picture; additional tests like serum homocysteine and anti-intrinsic factor antibodies are critical in these scenarios.
Overall, it’s essential to consider the broader implications of vitamin B12 treatment in anemia assessment, particularly when dealing with complex conditions like pernicious anemia.
As we delved deeper into his condition, we discovered that he had elevated homocysteine levels and tested positive for an anti-intrinsic factor antibody. These elements played a crucial role, as they pointed toward pernicious anemia, which can complicate the interpretation of vitamin B12 levels. Remarkably, he also exhibited T-weighted hyperintense lesions on his spinal cord MRI, indicating subacute combined degeneration—a severe condition caused by vitamin B12 deficiency.
Treatment with mecobalamin, a form of vitamin B12 administered through intramuscular injections, ultimately proved beneficial. It improved his pancytopenia and resolved the MRI lesions, highlighting the effectiveness of vitamin B12 in managing anemia, especially in the context of pernicious anemia. However, this case also serves as a reminder that simply measuring vitamin B12 levels may not provide a complete picture; additional tests like serum homocysteine and anti-intrinsic factor antibodies are critical in these scenarios.
Overall, it’s essential to consider the broader implications of vitamin B12 treatment in anemia assessment, particularly when dealing with complex conditions like pernicious anemia.
Read More
9
Vitamin B12 improves anemia effectiveness
Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report.
High relevance due to treatment significance
We explored the impact of vitamin B12 treatment on anemia through the case of a 41-year-old man diagnosed with autoimmune polyglandular syndrome type 3 (APS-3). This syndrome included conditions like Hashimoto's thyroiditis and pernicious anemia due to autoimmune gastritis. The patient was admitted to the hospital due to severe fatigue and macrocytic anemia, which prompted a detailed evaluation.
Upon diagnosis, we observed that the patient's pernicious anemia was directly linked to his autoimmune issues. The treatment plan involved administering parenteral vitamin B12, which successfully improved his anemia symptoms. Interestingly, this case highlights how anemia can be overlooked in patients with autoimmune conditions, yet it's crucial for our understanding of APS-3.
While anemia isn't typically seen as a key feature of autoimmune syndromes, we found that in this instance, addressing the anemia with vitamin B12 was vital. The case illustrates the significance of thorough evaluations and the role of vitamin B12 as a potential lifeline for patients suffering from pernicious anemia linked to autoimmune gastritis.
Upon diagnosis, we observed that the patient's pernicious anemia was directly linked to his autoimmune issues. The treatment plan involved administering parenteral vitamin B12, which successfully improved his anemia symptoms. Interestingly, this case highlights how anemia can be overlooked in patients with autoimmune conditions, yet it's crucial for our understanding of APS-3.
While anemia isn't typically seen as a key feature of autoimmune syndromes, we found that in this instance, addressing the anemia with vitamin B12 was vital. The case illustrates the significance of thorough evaluations and the role of vitamin B12 as a potential lifeline for patients suffering from pernicious anemia linked to autoimmune gastritis.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Reduced exhaustion
Very impressed! I have low iron deficiency anemia that necessitates iron infusions every three months, alongside B12 deficiency requiring weekly injections. Recently unemployed with no medical insurance, I felt exhausted. I decided to try these and am thrilled with my choice; they help me function better and alleviate my extreme fatigue.
Read More
8.8
Convenient and effective
Easy to use and works. I was prescribed B12 for anemia and struggled with the messy under-the-tongue liquid. Then I discovered these tablets. I now use one daily as I walk to appointments. They dissolve quickly with a light cherry flavour, and I'm pleased to see my anemia numbers steadily improving. If texture is an issue, I highly recommend these B12 tablets.
Read More
8.8
Improved health
This one is my favourite! I also use the 1,000 mcg formula, but this one is best for my needs. My kitty has kidney disease, which comes with anaemia. This product helps keep her HCT closer to where it should be. I cut these little pills into smaller pieces and can mix them into her food, and she never notices.
Read More
