Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.6
Supplement Facts
Serving Size: 1 MicroLingual® Tablet
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
Read More
7
Vitamin D effects on asthma explored
We explored the role of vitamin D, specifically calcitriol, in managing allergic eosinophilic asthma and how it interacts with a key molecule, CD46, in T cells. Our research involved stimulating CD4 T cells from patients and healthy donors with specific antibodies and measuring the production of two important immune signals: IFN-γ and IL-10.
Our findings suggest that lower levels of CD46 on activated CD4 T cells are linked to a more favorable Th1 cell response to calcitriol. This means that individuals with certain profiles might benefit more from vitamin D supplementation, potentially reducing inflammation associated with their asthma.
However, we need further validation of these results in clinical settings. If proven effective, this stratification could pave the way for personalized treatments for people with allergic conditions and possibly other diseases influenced by immune responses.
Our findings suggest that lower levels of CD46 on activated CD4 T cells are linked to a more favorable Th1 cell response to calcitriol. This means that individuals with certain profiles might benefit more from vitamin D supplementation, potentially reducing inflammation associated with their asthma.
However, we need further validation of these results in clinical settings. If proven effective, this stratification could pave the way for personalized treatments for people with allergic conditions and possibly other diseases influenced by immune responses.
Read More
7
Vitamin D's role in allergies explored
We set out to examine the relationship between vitamin D levels and atopic dermatitis (AD), a common chronic inflammatory condition in children that involves skin sensitivity and allergies. In our study, we evaluated blood samples from 51 children with AD and compared their vitamin D levels and other immune markers to those of 20 healthy kids.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Read More
Most Useful Reviews
9
No reactions
An excellent quality product with perfectly selected ingredients; I experienced no allergies or negative reactions. The large package lasts a long time, and the medium-sized capsules have a pleasant taste. This vitamin is ideal for those in sunny deficiency areas and has excellent absorption. Remember to check your dosage!
Read More
9
Pleasant taste
This simple composition vitamin D has a pleasant taste and did not cause allergies. It provides the daily requirement of vitamin D.
Read More
9
Child-friendly
This vitamin D is simple in composition and has a pleasant taste. My child experienced no allergies, and unlike Aquadetrim, he enjoys taking it and I can see tangible results!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
- All Researches
9
We explored the effects of vitamin D in combination with fluticasone propionate on allergy-related symptoms in children with bronchial asthma. In this study, we grouped participants into two treatment plans: one group received only fluticasone, while the other group received both fluticasone and vitamin D. By comparing their progress, we noted various health improvements related to asthma control.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
Read More
9
Vitamin D metabolites aid pulmonary health
We explored the impact of vitamin D metabolites on respiratory health, particularly in the context of hypersensitivity pneumonitis (HP). Our study focused on C57BL/6J mice that were placed on a diet severely lacking in vitamin D to induce deficiency. These mice were then exposed to an antigen linked to HP while inhaling either 25(OH)-vitamin D3 or 1,25(OH)2-vitamin D3.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
Read More
8
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
Read More
8
We conducted an extensive review of multiple studies to understand how vitamin D might influence atopic dermatitis (AD), a skin condition that impacts many people, particularly children. Our focus was on randomized controlled trials that compared vitamin D supplementation with a placebo group.
After analyzing data from eleven studies involving a total of 686 participants, we found compelling evidence that vitamin D supplementation can significantly reduce the severity of AD. Participants who received vitamin D showed a marked improvement compared to those who did not, with a notable decrease in their disease severity scores.
It's important to highlight that while our findings are promising, we also recognize the need for larger and longer-term studies to confirm these results. By understanding the role of vitamin D, we can better explore potential treatments for managing allergy-related conditions like atopic dermatitis.
After analyzing data from eleven studies involving a total of 686 participants, we found compelling evidence that vitamin D supplementation can significantly reduce the severity of AD. Participants who received vitamin D showed a marked improvement compared to those who did not, with a notable decrease in their disease severity scores.
It's important to highlight that while our findings are promising, we also recognize the need for larger and longer-term studies to confirm these results. By understanding the role of vitamin D, we can better explore potential treatments for managing allergy-related conditions like atopic dermatitis.
Read More
7
Vitamin D's role in allergies explored
We set out to examine the relationship between vitamin D levels and atopic dermatitis (AD), a common chronic inflammatory condition in children that involves skin sensitivity and allergies. In our study, we evaluated blood samples from 51 children with AD and compared their vitamin D levels and other immune markers to those of 20 healthy kids.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
No reactions
An excellent quality product with perfectly selected ingredients; I experienced no allergies or negative reactions. The large package lasts a long time, and the medium-sized capsules have a pleasant taste. This vitamin is ideal for those in sunny deficiency areas and has excellent absorption. Remember to check your dosage!
Read More
9
Pleasant taste
This simple composition vitamin D has a pleasant taste and did not cause allergies. It provides the daily requirement of vitamin D.
Read More
9
Child-friendly
This vitamin D is simple in composition and has a pleasant taste. My child experienced no allergies, and unlike Aquadetrim, he enjoys taking it and I can see tangible results!
Read More
9
Perfect for winter
This vitamin D has a simple composition and a pleasant taste, causing no allergies in my child. With such a long winter with minimal sun, we decided to take a course of vitamin D3.
Read More
9
Instant dissolving
The tablets dissolve instantly under the tongue and have a tolerable taste. I felt the typical effects of vitamins: increased strength and a positive mood. I cannot comment on skin reactions at a solarium, but the benefits include small size, harmless composition, and no allergies.
Read More
Frequently Asked Questions
9
Comprehensive improvement
Prescribed by my hematologist, I replaced my usual tablets with these microlingual vitamin D3 tablets, which dissolve easily under the tongue. I've had a noticeable overall improvement in my condition and strength. This vitamin works well for me with no allergies and is free from harmful substances.
6
Effective treatment
Small yet effective, this drug is convenient to carry and easy to take. I’ve experienced no allergies despite being prone to them. After just a week, I noticed an improvement in my nails. Although I take other vitamins, the positive change is linked to this drug.
9
Child-friendly
This vitamin D is simple in composition and has a pleasant taste. My child experienced no allergies, and unlike Aquadetrim, he enjoys taking it and I can see tangible results!
9
Instant dissolving
The tablets dissolve instantly under the tongue and have a tolerable taste. I felt the typical effects of vitamins: increased strength and a positive mood. I cannot comment on skin reactions at a solarium, but the benefits include small size, harmless composition, and no allergies.
9
Child's preference
My child willingly accepts this small, quickly dissolving tablet with a pleasant taste and it does not cause allergies. We haven’t checked the lab effects yet.
9
Highly absorbed
I’ve tried various vitamin D products, but this one stands out. It's well absorbed, tolerated well, and does not cause allergies.
5
We examined the role of vitamin D supplementation in managing allergic rhinitis through a systematic review and meta-analysis. By reviewing randomized controlled trials focused on patients with allergic rhinitis, we aimed to determine the effectiveness of vitamin D in alleviating symptoms.
Our findings indicate that vitamin D may help reduce allergic rhinitis symptoms compared to placebos; however, the improvement was not statistically significant. We also discovered considerable variation among the studies we analyzed, pointing toward the complexities of measuring vitamin D's effects.
Interestingly, factors like the proportion of female participants and the use of corticosteroids impacted how patients responded to vitamin D. Specifically, vitamin D supplementation that was not paired with corticosteroids showed a more substantial impact on relieving symptoms.
While vitamin D appears to offer some benefits for allergic rhinitis, the overall effect may depend on individual circumstances, including gender and medication use. Thus, it's essential to consider these aspects when evaluating treatment options for allergies.
Our findings indicate that vitamin D may help reduce allergic rhinitis symptoms compared to placebos; however, the improvement was not statistically significant. We also discovered considerable variation among the studies we analyzed, pointing toward the complexities of measuring vitamin D's effects.
Interestingly, factors like the proportion of female participants and the use of corticosteroids impacted how patients responded to vitamin D. Specifically, vitamin D supplementation that was not paired with corticosteroids showed a more substantial impact on relieving symptoms.
While vitamin D appears to offer some benefits for allergic rhinitis, the overall effect may depend on individual circumstances, including gender and medication use. Thus, it's essential to consider these aspects when evaluating treatment options for allergies.
7
Vitamin D's role in allergies explored
We set out to examine the relationship between vitamin D levels and atopic dermatitis (AD), a common chronic inflammatory condition in children that involves skin sensitivity and allergies. In our study, we evaluated blood samples from 51 children with AD and compared their vitamin D levels and other immune markers to those of 20 healthy kids.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
9
We explored the effects of vitamin D in combination with fluticasone propionate on allergy-related symptoms in children with bronchial asthma. In this study, we grouped participants into two treatment plans: one group received only fluticasone, while the other group received both fluticasone and vitamin D. By comparing their progress, we noted various health improvements related to asthma control.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
8
We conducted an extensive review of multiple studies to understand how vitamin D might influence atopic dermatitis (AD), a skin condition that impacts many people, particularly children. Our focus was on randomized controlled trials that compared vitamin D supplementation with a placebo group.
After analyzing data from eleven studies involving a total of 686 participants, we found compelling evidence that vitamin D supplementation can significantly reduce the severity of AD. Participants who received vitamin D showed a marked improvement compared to those who did not, with a notable decrease in their disease severity scores.
It's important to highlight that while our findings are promising, we also recognize the need for larger and longer-term studies to confirm these results. By understanding the role of vitamin D, we can better explore potential treatments for managing allergy-related conditions like atopic dermatitis.
After analyzing data from eleven studies involving a total of 686 participants, we found compelling evidence that vitamin D supplementation can significantly reduce the severity of AD. Participants who received vitamin D showed a marked improvement compared to those who did not, with a notable decrease in their disease severity scores.
It's important to highlight that while our findings are promising, we also recognize the need for larger and longer-term studies to confirm these results. By understanding the role of vitamin D, we can better explore potential treatments for managing allergy-related conditions like atopic dermatitis.
References
- Kawada K, Sato C, Ishida T, Nagao Y, Yamamoto T, et al. Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis. Medicina (Kaunas). 2025;61. 10.3390/medicina61020355
- Molatefi R, Fouladi N, Asghariazar V, Samemaleki S, Golizadeh M, et al. The evaluation of the serum levels of vitamin D and interleukin-33 in children with atopic dermatitis and its association with diseases severity. Arch Dermatol Res. 2025;317:182. 10.1007/s00403-024-03709-3
- Akbulut O, Köksal BT, Aydın B, Oznacar T, Haberal A, et al. Does vitamin D deficiency predispose to allergic proctocolitis?. Nutrition. 2025;131:112659. 10.1016/j.nut.2024.112659
- Nielsen AY, Høj S, Thomsen SF, Meteran H. Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis. Nutrients. 2024;16. 10.3390/nu16234128
- Wu D, Wang J, Wei Y, Zhang X, Hou Z. Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy. Physiol Res. 2024;73:841.
- Lemieszek MK, Chojnacki M, Paśnik I, Gawryś W, Wilczyńska A, et al. Beneficial Impact of Inhaled 25(OH)-Vitamin D3 and 1,25(OH)2-Vitamin D3 on Pulmonary Response in the Murine Model of Hypersensitivity Pneumonitis. Int J Mol Sci. 2024;25. 10.3390/ijms251910289
- Stichova J, Slanina P, Chovancova Z, Baros J, Litzman M, et al. Low CD46 expression on activated CD4 T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donors. Front Allergy. 2024;5:1462579. 10.3389/falgy.2024.1462579
