5/23/2025
Last update
5/23/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
USERS' SCORE
Good
Based on 1 Review
8.6
Top Medical Research Studies
9
We investigated the potential effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on inflammation caused by monosodium urate (MSU) in gout. The research included both laboratory and animal studies to understand how DHA might protect against the inflammatory responses triggered by MSU.
Our findings showed that DHA effectively reduces the production of inflammatory substances such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in immune cells. This suggests that DHA can help calm the body’s inflammatory response.
Additionally, DHA seemed to lower oxidative stress, which is often heightened in inflammatory conditions like gout. It encouraged the movement of a key antioxidant regulator, Nrf2, into the cell nucleus, promoting the creation of enzymes that help in managing oxidative stress.
Moreover, when administered to mice, DHA-rich microalgal oil led to lower levels of inflammatory markers and reduced the influx of neutrophils, a type of white blood cell that contributes to inflammation.
Ultimately, our results suggest that using DHA or DHA-rich oil might be a beneficial approach for preventing MSU-induced inflammation and potentially easing symptoms of acute gout, primarily through the reduction of oxidative stress.
Our findings showed that DHA effectively reduces the production of inflammatory substances such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in immune cells. This suggests that DHA can help calm the body’s inflammatory response.
Additionally, DHA seemed to lower oxidative stress, which is often heightened in inflammatory conditions like gout. It encouraged the movement of a key antioxidant regulator, Nrf2, into the cell nucleus, promoting the creation of enzymes that help in managing oxidative stress.
Moreover, when administered to mice, DHA-rich microalgal oil led to lower levels of inflammatory markers and reduced the influx of neutrophils, a type of white blood cell that contributes to inflammation.
Ultimately, our results suggest that using DHA or DHA-rich oil might be a beneficial approach for preventing MSU-induced inflammation and potentially easing symptoms of acute gout, primarily through the reduction of oxidative stress.
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4
We conducted a pilot study to understand how omega-3 fish oil supplements might influence serum urate levels and body weight in people dealing with gout. Over six months, forty participants with elevated serum urate levels were randomly assigned to take either 6.2 grams of omega-3 fish oil daily or no fish oil at all.
Our findings showed that there was no significant difference in serum urate changes between those taking fish oil and those who were not. In terms of weight and body mass index (BMI), both groups remained stable, with no major changes reported. However, we did observe a significant correlation: higher levels of omega-3 were linked to fewer gout flares.
Interestingly, some participants in the omega-3 group reported gastrointestinal side effects that were related to the fish oil supplementation. While our study did not demonstrate a clear benefit in lowering urate or weight, the association between omega-3 levels and reduced gout flares suggests promising potential for future research in this area.
Our findings showed that there was no significant difference in serum urate changes between those taking fish oil and those who were not. In terms of weight and body mass index (BMI), both groups remained stable, with no major changes reported. However, we did observe a significant correlation: higher levels of omega-3 were linked to fewer gout flares.
Interestingly, some participants in the omega-3 group reported gastrointestinal side effects that were related to the fish oil supplementation. While our study did not demonstrate a clear benefit in lowering urate or weight, the association between omega-3 levels and reduced gout flares suggests promising potential for future research in this area.
Read More
8
We explored the effects of omega-3 carboxylic acids on inflammation, particularly focusing on gout, which is caused by the buildup of urate crystals in the joints. The study utilized human immune cells and rat models to examine how omega-3 fatty acids might reduce inflammatory reactions triggered by different types of crystals, including those from gout.
Our findings revealed that the omega-3 fatty acid known as docosahexaenoic acid effectively suppressed the production of interleukin-1β (IL-1β), a key player in the inflammatory process, in both lab settings and live models. In the tests with rats, treatment with omega-3s led to significant reductions in cell migration, the volume of inflammation, and levels of IL-1β and prostaglandin E.
Interestingly, we noted that omega-3 became comparable to indomethacin, a common anti-inflammatory drug, in reducing pain and swelling after crystal-induced inflammation in the joints. This suggests that omega-3 fatty acids might serve as a beneficial alternative or complement to traditional treatments for gout, providing not just immediate relief but also potential long-term benefits for regulating inflammation.
Our findings revealed that the omega-3 fatty acid known as docosahexaenoic acid effectively suppressed the production of interleukin-1β (IL-1β), a key player in the inflammatory process, in both lab settings and live models. In the tests with rats, treatment with omega-3s led to significant reductions in cell migration, the volume of inflammation, and levels of IL-1β and prostaglandin E.
Interestingly, we noted that omega-3 became comparable to indomethacin, a common anti-inflammatory drug, in reducing pain and swelling after crystal-induced inflammation in the joints. This suggests that omega-3 fatty acids might serve as a beneficial alternative or complement to traditional treatments for gout, providing not just immediate relief but also potential long-term benefits for regulating inflammation.
Read More
Most Useful Reviews
10
Symptoms relief
7 people found this helpful
Great product. My husband cannot use fish-based Omega 3 supplements due to gout. We discovered this vegan brand on Amazon, and since using it, all of his symptoms went away. Highly recommended for anyone diagnosed with gout.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
- All Researches
9
We investigated the potential effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on inflammation caused by monosodium urate (MSU) in gout. The research included both laboratory and animal studies to understand how DHA might protect against the inflammatory responses triggered by MSU.
Our findings showed that DHA effectively reduces the production of inflammatory substances such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in immune cells. This suggests that DHA can help calm the body’s inflammatory response.
Additionally, DHA seemed to lower oxidative stress, which is often heightened in inflammatory conditions like gout. It encouraged the movement of a key antioxidant regulator, Nrf2, into the cell nucleus, promoting the creation of enzymes that help in managing oxidative stress.
Moreover, when administered to mice, DHA-rich microalgal oil led to lower levels of inflammatory markers and reduced the influx of neutrophils, a type of white blood cell that contributes to inflammation.
Ultimately, our results suggest that using DHA or DHA-rich oil might be a beneficial approach for preventing MSU-induced inflammation and potentially easing symptoms of acute gout, primarily through the reduction of oxidative stress.
Our findings showed that DHA effectively reduces the production of inflammatory substances such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in immune cells. This suggests that DHA can help calm the body’s inflammatory response.
Additionally, DHA seemed to lower oxidative stress, which is often heightened in inflammatory conditions like gout. It encouraged the movement of a key antioxidant regulator, Nrf2, into the cell nucleus, promoting the creation of enzymes that help in managing oxidative stress.
Moreover, when administered to mice, DHA-rich microalgal oil led to lower levels of inflammatory markers and reduced the influx of neutrophils, a type of white blood cell that contributes to inflammation.
Ultimately, our results suggest that using DHA or DHA-rich oil might be a beneficial approach for preventing MSU-induced inflammation and potentially easing symptoms of acute gout, primarily through the reduction of oxidative stress.
Read More
8
We explored the effects of omega-3 carboxylic acids on inflammation, particularly focusing on gout, which is caused by the buildup of urate crystals in the joints. The study utilized human immune cells and rat models to examine how omega-3 fatty acids might reduce inflammatory reactions triggered by different types of crystals, including those from gout.
Our findings revealed that the omega-3 fatty acid known as docosahexaenoic acid effectively suppressed the production of interleukin-1β (IL-1β), a key player in the inflammatory process, in both lab settings and live models. In the tests with rats, treatment with omega-3s led to significant reductions in cell migration, the volume of inflammation, and levels of IL-1β and prostaglandin E.
Interestingly, we noted that omega-3 became comparable to indomethacin, a common anti-inflammatory drug, in reducing pain and swelling after crystal-induced inflammation in the joints. This suggests that omega-3 fatty acids might serve as a beneficial alternative or complement to traditional treatments for gout, providing not just immediate relief but also potential long-term benefits for regulating inflammation.
Our findings revealed that the omega-3 fatty acid known as docosahexaenoic acid effectively suppressed the production of interleukin-1β (IL-1β), a key player in the inflammatory process, in both lab settings and live models. In the tests with rats, treatment with omega-3s led to significant reductions in cell migration, the volume of inflammation, and levels of IL-1β and prostaglandin E.
Interestingly, we noted that omega-3 became comparable to indomethacin, a common anti-inflammatory drug, in reducing pain and swelling after crystal-induced inflammation in the joints. This suggests that omega-3 fatty acids might serve as a beneficial alternative or complement to traditional treatments for gout, providing not just immediate relief but also potential long-term benefits for regulating inflammation.
Read More
8
We investigated the connection between gut microbiota, docosahexaenoic acid (DHA), and urate metabolism to see how they interact and affect conditions like gout. The study utilized extensive data from a large number of participants, pulling information from various databases focusing on microbiota taxa, gout prevalence, and urate levels.
Our findings highlight that the gut microbiota plays a significant role in hosting urate metabolism; specifically, we observed that certain microbiota taxa had a common causal effect on both gout and urate levels. Notably, two specific bacterial groups showed protective effects on urate levels, linked to the increased presence of DHA.
This indicates that changes in our gut bacteria could not only improve urate metabolism but might also signal changes in gout risk. However, while DHA appears to be involved in this process, the link is complex and warrants further exploration to better understand its influence on gout treatment and prevention.
Our findings highlight that the gut microbiota plays a significant role in hosting urate metabolism; specifically, we observed that certain microbiota taxa had a common causal effect on both gout and urate levels. Notably, two specific bacterial groups showed protective effects on urate levels, linked to the increased presence of DHA.
This indicates that changes in our gut bacteria could not only improve urate metabolism but might also signal changes in gout risk. However, while DHA appears to be involved in this process, the link is complex and warrants further exploration to better understand its influence on gout treatment and prevention.
Read More
8
We set out to explore how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, affects the body’s ability to manage urate levels, which is crucial for individuals dealing with gout. Gout is often a result of high serum urate, and the kidney plays a significant role in regulating this through a specialized transporter called URAT1.
Our investigation was focused on the inhibitory effects of various fatty acids on URAT1, using a lab setup with cells that express this transporter. Among the 25 fatty acids we examined, EPA stood out with its notable ability to inhibit URAT1. Specifically, we found that EPA had a half maximal inhibitory concentration value of 6.0 μM, indicating its potent effect compared to other fatty acids.
While these findings are promising, with indicators that EPA could assist in reducing urate re-absorption, further clinical studies are necessary to truly understand its potential as a treatment for gout. We didn’t directly assess clinical outcomes related to gout in patients, so more research will clarify whether EPA can really be employed as a uricosuric agent, helping those suffering from this condition.
Our investigation was focused on the inhibitory effects of various fatty acids on URAT1, using a lab setup with cells that express this transporter. Among the 25 fatty acids we examined, EPA stood out with its notable ability to inhibit URAT1. Specifically, we found that EPA had a half maximal inhibitory concentration value of 6.0 μM, indicating its potent effect compared to other fatty acids.
While these findings are promising, with indicators that EPA could assist in reducing urate re-absorption, further clinical studies are necessary to truly understand its potential as a treatment for gout. We didn’t directly assess clinical outcomes related to gout in patients, so more research will clarify whether EPA can really be employed as a uricosuric agent, helping those suffering from this condition.
Read More
7
We examined the link between omega-3 polyunsaturated fatty acids (n-3 PUFA) and the risk of recurrent gout flares in a study conducted over nearly a decade. Using data from the Boston University Online Gout Study, we gathered responses from participants about their diet and supplement intake during flare-ups and flare-free periods.
Our findings revealed that 22% of participants reported consuming some form of n-3 PUFA, with the majority being dietary sources like fatty fish. Notably, we found that eating two or more servings of n-3 PUFA-rich fish seemingly reduced the risk of gout flares, while relying solely on supplements did not demonstrate a significant benefit.
This indicates that while dietary sources of omega-3 may play a role in managing gout, over-the-counter supplements taken independently did not show the same protective effect. Further investigation is needed to understand the right sources and dosages of n-3 PUFA for effectively preventing gout flares.
Our findings revealed that 22% of participants reported consuming some form of n-3 PUFA, with the majority being dietary sources like fatty fish. Notably, we found that eating two or more servings of n-3 PUFA-rich fish seemingly reduced the risk of gout flares, while relying solely on supplements did not demonstrate a significant benefit.
This indicates that while dietary sources of omega-3 may play a role in managing gout, over-the-counter supplements taken independently did not show the same protective effect. Further investigation is needed to understand the right sources and dosages of n-3 PUFA for effectively preventing gout flares.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Symptoms relief
7 people found this helpful
Great product. My husband cannot use fish-based Omega 3 supplements due to gout. We discovered this vegan brand on Amazon, and since using it, all of his symptoms went away. Highly recommended for anyone diagnosed with gout.
Read More
Frequently Asked Questions
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References
- Abhishek A, Fuller A, Nakafero G, Zhang W, Dumbleton J, et al. Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment. Rheumatol Adv Pract. 2022;6:rkac086. 10.1093/rap/rkac086
- Stamp LK, Grainger R, Frampton C, Drake J, Hill CL. Effect of omega-three supplementation on serum urate and gout flares in people with gout; a pilot randomized trial. BMC Rheumatol. 2022;6:31. 10.1186/s41927-022-00263-1
- Zhang Y, Liu L, Sun D, He Y, Jiang Y, et al. DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress. Food Funct. 2019;10:4010. 10.1039/c9fo00573k
- Zhang M, Zhang Y, Terkeltaub R, Chen C, Neogi T. Effect of Dietary and Supplemental Omega-3 Polyunsaturated Fatty Acids on Risk of Recurrent Gout Flares. Arthritis Rheumatol. 2019;71:1580. 10.1002/art.40896
- Iverson C, Bacong A, Liu S, Baumgartner S, Lundström T, et al. Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation. Sci Rep. 2018;8:1217. 10.1038/s41598-018-19252-x
- Hou T, Dai H, Wang Q, Hou Y, Zhang X, et al. Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization. Front Immunol. 2023;14:1148591. 10.3389/fimmu.2023.1148591
- Saito H, Toyoda Y, Takada T, Hirata H, Ota-Kontani A, et al. Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber. Nutrients. 2020;12. 10.3390/nu12061601
