Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.8
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folic Acid
400 mcg
100%
Vitamin B-12 (as Cyanocobalamin)
5 mg (5,000 mcg)
83,333%
Top Medical Research Studies
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
Read More
8
We evaluated whether B vitamins, particularly B1, B6, B12, and B9, could help reduce migraine headaches in women. This rigorous double-blind, placebo-controlled study involved 120 participants who took these vitamins or a placebo for 12 weeks.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
Read More
7
Cerebral venous thrombosis and treatment
We explored the case of a 25-year-old man who came to the hospital with severe headaches and dizziness. Following a diagnosis of cerebral venous thrombosis, linked to his vitamin B12 deficiency from nitrous oxide use, he received treatment that included vitamin B12 supplements.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
Read More
Most Useful Reviews
10
Headache relief
9 people found this helpful
While taking the vitamin, I noticed that constant drowsiness subsided, and I felt a strong desire for vigorous activity. The feeling of constant fatigue vanished, and my headaches disappeared completely.
Read More
10
Energy boost
This supplement has a good composition with fast delivery and high-quality packaging. The capsules are a bit large but easy to swallow and taste like citrus. After taking it alongside vitamin D3+K2 and magnesium, I noticed significant benefits. Frequent headaches and fatigue have stopped, and my energy levels are much higher. I would recommend it, especially for those into fitness or on a diet.
Read More
9
Cluster headache treatment
Excellent for cluster headaches! Following my doctor’s advice, I found that this treatment nearly eliminated my headache. I am grateful for the significant reduction in symptoms.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
- All Researches
9
We investigated a unique case where a 14-year-old girl experienced prolonged headaches and nausea due to cerebral venous thrombosis linked to a rare genetic mutation. Elevated homocysteine levels were discovered during examinations, leading to anticoagulation therapy.
Notably, after receiving additional vitamins like B12, the patient reported no headaches within a month, alongside a significant decrease in intracranial pressure and thrombosis size. Although the treatment context is specialized, this case emphasizes the importance of understanding genetic factors in headache disorders.
Notably, after receiving additional vitamins like B12, the patient reported no headaches within a month, alongside a significant decrease in intracranial pressure and thrombosis size. Although the treatment context is specialized, this case emphasizes the importance of understanding genetic factors in headache disorders.
Read More
8
We evaluated whether B vitamins, particularly B1, B6, B12, and B9, could help reduce migraine headaches in women. This rigorous double-blind, placebo-controlled study involved 120 participants who took these vitamins or a placebo for 12 weeks.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
Read More
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
Read More
7
Cerebral venous thrombosis and treatment
We explored the case of a 25-year-old man who came to the hospital with severe headaches and dizziness. Following a diagnosis of cerebral venous thrombosis, linked to his vitamin B12 deficiency from nitrous oxide use, he received treatment that included vitamin B12 supplements.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
Read More
7
We investigated the prevalence and impact of vitamin B12 deficiency in a diverse group of patients at a tertiary care hospital. With a focus on individuals aged 50 to 65, particularly strict vegetarians, we found that many suffered from significant symptoms, including headache.
Among the 220 cases studied, 95% reported head heaviness or headaches as a psychiatric manifestation, showcasing the importance of recognizing vitamin B12 deficiency. Early detection and treatment can reverse most related disorders, highlighting the need for greater awareness in clinical settings.
Among the 220 cases studied, 95% reported head heaviness or headaches as a psychiatric manifestation, showcasing the importance of recognizing vitamin B12 deficiency. Early detection and treatment can reverse most related disorders, highlighting the need for greater awareness in clinical settings.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Headache relief
9 people found this helpful
While taking the vitamin, I noticed that constant drowsiness subsided, and I felt a strong desire for vigorous activity. The feeling of constant fatigue vanished, and my headaches disappeared completely.
Read More
10
Energy boost
This supplement has a good composition with fast delivery and high-quality packaging. The capsules are a bit large but easy to swallow and taste like citrus. After taking it alongside vitamin D3+K2 and magnesium, I noticed significant benefits. Frequent headaches and fatigue have stopped, and my energy levels are much higher. I would recommend it, especially for those into fitness or on a diet.
Read More
9
Cluster headache treatment
Excellent for cluster headaches! Following my doctor’s advice, I found that this treatment nearly eliminated my headache. I am grateful for the significant reduction in symptoms.
Read More
9
Sleepiness reduction
After starting with vitamin B12, I experienced a notable increase in my vitamin B levels. The constant sleepiness vanished within a week, and I felt active again. The feeling of tiredness also went away, and remarkably, my headaches disappeared too.
Read More
Frequently Asked Questions
9
Sleepiness reduction
After starting with vitamin B12, I experienced a notable increase in my vitamin B levels. The constant sleepiness vanished within a week, and I felt active again. The feeling of tiredness also went away, and remarkably, my headaches disappeared too.
10
Headache relief
9 people found this helpful
While taking the vitamin, I noticed that constant drowsiness subsided, and I felt a strong desire for vigorous activity. The feeling of constant fatigue vanished, and my headaches disappeared completely.
10
Energy boost
This supplement has a good composition with fast delivery and high-quality packaging. The capsules are a bit large but easy to swallow and taste like citrus. After taking it alongside vitamin D3+K2 and magnesium, I noticed significant benefits. Frequent headaches and fatigue have stopped, and my energy levels are much higher. I would recommend it, especially for those into fitness or on a diet.
9
Cluster headache treatment
Excellent for cluster headaches! Following my doctor’s advice, I found that this treatment nearly eliminated my headache. I am grateful for the significant reduction in symptoms.
8
We evaluated whether B vitamins, particularly B1, B6, B12, and B9, could help reduce migraine headaches in women. This rigorous double-blind, placebo-controlled study involved 120 participants who took these vitamins or a placebo for 12 weeks.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
The results showed notable improvements for those taking the B vitamins, including fewer headache attacks and reduced need for medication. However, while these findings are promising, further research with larger groups and longer follow-ups is necessary to verify the effects.
7
We examined the role of vitamins B6, folate, and B12 in managing migraine headaches. Our systematic review uncovered twelve studies focused on their effects. While B6 showed promise in preventing migraines with aura when paired with folate or B12, these vitamins did not significantly alleviate acute migraine attacks. Additionally, the evidence for treating migraines without aura remains limited, particularly in children. Overall, vitamin supplementation appears to offer some benefit in prevention, but more thorough research is needed to solidify these findings.
7
Cerebral venous thrombosis and treatment
We explored the case of a 25-year-old man who came to the hospital with severe headaches and dizziness. Following a diagnosis of cerebral venous thrombosis, linked to his vitamin B12 deficiency from nitrous oxide use, he received treatment that included vitamin B12 supplements.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
After a week of therapy, both his headaches and vision issues notably improved, allowing for discharge. This case suggests vitamin B12 could be a helpful part of treating headaches associated with specific deficiencies.
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
References
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. doi:10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. doi:10.3892/mi.2022.45
- Singh J, Dinkar A, Gupta P, Atam V. Vitamin B12 deficiency in northern India tertiary care: Prevalence, risk factors and clinical characteristics. J Family Med Prim Care. 2022;11:2381. doi:10.4103/jfmpc.jfmpc_650_21
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. doi:10.18502/cjn.v21i2.10494
- Arıcan P, Bozkurt O, Cavusoglu D, Gencpınar P, Haspolat S, et al. Various Neurological Symptoms with Vitamin B12 Deficiency and Posttreatment Evaluation. J Pediatr Neurosci. 2020;15:365. doi:10.4103/jpn.JPN_130_19
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. doi:10.1111/head.13618
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. doi:10.1080/01616412.2025.2462735
