Last update
3/15/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%**
Vitamin E (as Natural d-alpha Tocopherol)
300 mg
2000%
Total tocopherols
600 mg
†
Gamma-Tocopherol
200 mg
†
Mixed Palm Tocotrienol Complex (Tocomin®)
10 mg
†
Top Medical Research Studies
9
We investigated the impact of vitamin E on treating frequent and severe nocturnal leg cramps. Patients received 100 I.U. of d, alpha-tocopheryl acetate three times daily before meals.
Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.
Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.
Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.
Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.
Read More
7
Vitamin E effective for leg cramps
We explored the effects of vitamin E on leg cramps through a controlled double-blind study involving 40 dialysis patients.
After a two-month placebo washout, participants were split into two groups receiving either quinine or vitamin E.
Both treatments significantly reduced the number of leg cramps. With average monthly cramps dropping to around 3.3 for vitamin E and 3.6 for quinine, the findings indicate both options were effective.
However, since quinine has potential side effects, vitamin E is recommended as the first-line treatment for leg cramps in this population.
After a two-month placebo washout, participants were split into two groups receiving either quinine or vitamin E.
Both treatments significantly reduced the number of leg cramps. With average monthly cramps dropping to around 3.3 for vitamin E and 3.6 for quinine, the findings indicate both options were effective.
However, since quinine has potential side effects, vitamin E is recommended as the first-line treatment for leg cramps in this population.
Read More
7
Vitamin E shows limited effectiveness
We examined the effectiveness of various treatments for leg cramps, focusing particularly on vitamin E. While quinine has long been a go-to option, its use has significantly decreased due to safety concerns and mixed results in studies. Our review highlighted that although vitamin E might show potential benefits for leg cramps in patients on dialysis, the evidence is not robust across all populations. Therefore, we should consider other medications, like verapamil or gabapentin, before reverting to quinine.
Read More
Most Useful Reviews
9
Stops cramps
6 people found this helpful
The best vitamin E; these have ceased my leg cramps. I take two a day.
Read More
6
Reduced leg dullness
5 people found this helpful
I switched from another brand due to stock issues, and this supplement has significantly reduced the dullness in my legs. It's a very high-quality product, though the capsules tend to stick together, so it's best to shake the container before use.
Read More
7.5
Reduced leg pain
My mother suffers from leg pain, and these tablets have proven effective in alleviating her discomfort due to her sugar issues, also reducing muscle pain significantly.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
9
We investigated the impact of vitamin E on treating frequent and severe nocturnal leg cramps. Patients received 100 I.U. of d, alpha-tocopheryl acetate three times daily before meals.
Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.
Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.
Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.
Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.
Read More
7
Vitamin E shows limited effectiveness
We examined the effectiveness of various treatments for leg cramps, focusing particularly on vitamin E. While quinine has long been a go-to option, its use has significantly decreased due to safety concerns and mixed results in studies. Our review highlighted that although vitamin E might show potential benefits for leg cramps in patients on dialysis, the evidence is not robust across all populations. Therefore, we should consider other medications, like verapamil or gabapentin, before reverting to quinine.
Read More
7
Vitamin E effective for leg cramps
We explored the effects of vitamin E on leg cramps through a controlled double-blind study involving 40 dialysis patients.
After a two-month placebo washout, participants were split into two groups receiving either quinine or vitamin E.
Both treatments significantly reduced the number of leg cramps. With average monthly cramps dropping to around 3.3 for vitamin E and 3.6 for quinine, the findings indicate both options were effective.
However, since quinine has potential side effects, vitamin E is recommended as the first-line treatment for leg cramps in this population.
After a two-month placebo washout, participants were split into two groups receiving either quinine or vitamin E.
Both treatments significantly reduced the number of leg cramps. With average monthly cramps dropping to around 3.3 for vitamin E and 3.6 for quinine, the findings indicate both options were effective.
However, since quinine has potential side effects, vitamin E is recommended as the first-line treatment for leg cramps in this population.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Stops cramps
6 people found this helpful
The best vitamin E; these have ceased my leg cramps. I take two a day.
Read More
6
Reduced leg dullness
5 people found this helpful
I switched from another brand due to stock issues, and this supplement has significantly reduced the dullness in my legs. It's a very high-quality product, though the capsules tend to stick together, so it's best to shake the container before use.
Read More
7.5
Reduced leg pain
My mother suffers from leg pain, and these tablets have proven effective in alleviating her discomfort due to her sugar issues, also reducing muscle pain significantly.
Read More
2
Caused leg cramps
I can't say I noticed a good improvement with this vitamin compared to the usual one. While taking two tablets as recommended, I experienced leg cramps. However, when I reduced it to one tablet, all side effects disappeared.
Read More
Frequently Asked Questions
6
Reduced leg dullness
5 people found this helpful
I switched from another brand due to stock issues, and this supplement has significantly reduced the dullness in my legs. It's a very high-quality product, though the capsules tend to stick together, so it's best to shake the container before use.
2
Caused leg cramps
I can't say I noticed a good improvement with this vitamin compared to the usual one. While taking two tablets as recommended, I experienced leg cramps. However, when I reduced it to one tablet, all side effects disappeared.
7.5
Reduced leg pain
My mother suffers from leg pain, and these tablets have proven effective in alleviating her discomfort due to her sugar issues, also reducing muscle pain significantly.
7
Vitamin E shows limited effectiveness
We examined the effectiveness of various treatments for leg cramps, focusing particularly on vitamin E. While quinine has long been a go-to option, its use has significantly decreased due to safety concerns and mixed results in studies. Our review highlighted that although vitamin E might show potential benefits for leg cramps in patients on dialysis, the evidence is not robust across all populations. Therefore, we should consider other medications, like verapamil or gabapentin, before reverting to quinine.
7
Vitamin E effective for leg cramps
We explored the effects of vitamin E on leg cramps through a controlled double-blind study involving 40 dialysis patients.
After a two-month placebo washout, participants were split into two groups receiving either quinine or vitamin E.
Both treatments significantly reduced the number of leg cramps. With average monthly cramps dropping to around 3.3 for vitamin E and 3.6 for quinine, the findings indicate both options were effective.
However, since quinine has potential side effects, vitamin E is recommended as the first-line treatment for leg cramps in this population.
After a two-month placebo washout, participants were split into two groups receiving either quinine or vitamin E.
Both treatments significantly reduced the number of leg cramps. With average monthly cramps dropping to around 3.3 for vitamin E and 3.6 for quinine, the findings indicate both options were effective.
However, since quinine has potential side effects, vitamin E is recommended as the first-line treatment for leg cramps in this population.
9
We investigated the impact of vitamin E on treating frequent and severe nocturnal leg cramps. Patients received 100 I.U. of d, alpha-tocopheryl acetate three times daily before meals.
Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.
Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.
Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.
Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.
References
- Guay DR. Are there alternatives to the use of quinine to treat nocturnal leg cramps?. Consult Pharm. 2008;23:141. PubMed
- Roca AO, Jarjoura D, Blend D, Cugino A, Rutecki GW, et al. Dialysis leg cramps. Efficacy of quinine versus vitamin E. ASAIO J. 1992;38:M481. PubMed
- Ayres S, Mihan R. Leg cramps (systremma0 and "restless legs" syndrome. Response to vitamin E (tocopherol). Calif Med. 1969;111:87. PubMed
Data last updated:
