Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.5
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.9
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%

Top Medical Research Studies

9
Folic acid improves rheumatoid arthritis treatment
We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.
9
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.

Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.

This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.

During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.

The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.

Most Useful Reviews

9
Essential for pregnancies
257 people found this helpful
I absolutely adore this folate! I only need to take one small yellow tablet daily with food, which is far more convenient than the three doses required by other brands. It's essential for women who are pregnant or planning to be. It significantly contributes to the developing baby's neural tubes. I also share this with my pregnant friend, and let's just say 250 tablets will last us quite a while during our planning! Please support my review with a thumbs up!
9
Less stress felt
52 people found this helpful
I have been taking folate for three months now, having my sister recommend it initially. The results have been considerable; I have become much calmer, and my mood swings have significantly reduced. This supplement has transformed my experience while tutoring, where I previously struggled with my emotions. My endocrinologist recommended folic acid, and initially, I was sceptical about its efficiency, but I now see the benefits. I’m really glad this review could help!
7.5
Mental state improved
19 people found this helpful
I've been using this supplement for a month, and I've noticed a quick improvement in my mental and emotional state. Mood swings have greatly diminished, and my overall wellbeing has enhanced. The small, orange tablet is easy to swallow and has a pleasant aroma. I find this supplement especially beneficial for women in the autumn-winter season. I've definitely decided to order more!

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.5
  • All Researches
9.5
Vitamin B12 supplementation benefits autoimmune patients
We explored the impact of vitamin B12 on patients with autoimmune disorders, particularly those experiencing symptoms often attributed to their underlying conditions. The study presented three cases of individuals with neuropathic pain, depression, fatigue, and muscle weakness, who had their symptoms initially misattributed to rheumatic diseases.

Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.

Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
9
Folic acid improves rheumatoid arthritis treatment
We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.
9
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.

Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.

This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
9
Study on vitamin B12 in GBS
We explored a unique case involving a 54-year-old man who experienced symptoms that indicated both Guillain-Barré syndrome (GBS) and complications from autoimmune gastritis (AIG). Notably, he displayed progressive numbness and weakness along with gastrointestinal symptoms, which are often linked to vitamin B12 deficiency.

As part of his treatment, we utilized intravenous immunoglobulin alongside methylcobalamin, a form of vitamin B12. What was particularly interesting is that while the immunoglobulin treatment is typically aimed at addressing GBS, vitamin B12 was also administered to combat the neurological effects stemming from the deficiency due to AIG.

Our findings revealed that following these treatments, the patient showed significant clinical improvement before discharge. However, it's crucial to note that while vitamin B12 is commonly understood to aid neurological functions, the specific impact of its isolated use in this case remains unclear without additional studies focusing solely on its effectiveness in autoimmune disorders like GBS.

Overall, the integration of vitamin B12 treatment, particularly in the context of GBS and AIG, opens up discussions about managing similar cases in the future, although further research is necessary to firmly establish its benefits.
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.

During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.

The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.

User Reviews

USERS' SCORE
Moderately Good
Based on 20 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Essential for pregnancies
257 people found this helpful
I absolutely adore this folate! I only need to take one small yellow tablet daily with food, which is far more convenient than the three doses required by other brands. It's essential for women who are pregnant or planning to be. It significantly contributes to the developing baby's neural tubes. I also share this with my pregnant friend, and let's just say 250 tablets will last us quite a while during our planning! Please support my review with a thumbs up!
9
Less stress felt
52 people found this helpful
I have been taking folate for three months now, having my sister recommend it initially. The results have been considerable; I have become much calmer, and my mood swings have significantly reduced. This supplement has transformed my experience while tutoring, where I previously struggled with my emotions. My endocrinologist recommended folic acid, and initially, I was sceptical about its efficiency, but I now see the benefits. I’m really glad this review could help!
7.5
Mental state improved
19 people found this helpful
I've been using this supplement for a month, and I've noticed a quick improvement in my mental and emotional state. Mood swings have greatly diminished, and my overall wellbeing has enhanced. The small, orange tablet is easy to swallow and has a pleasant aroma. I find this supplement especially beneficial for women in the autumn-winter season. I've definitely decided to order more!
9
Heart health improved
7 people found this helpful
Folic acid is a B vitamin crucial for maintaining the nervous and cardiovascular systems. I took it for my father's heart condition as directed by his cardiologist. After a month of taking one tablet daily, his health significantly improved. We were pleasantly surprised by the results, and I have reordered.
9
Healthy child born
7 people found this helpful
I ordered folic acid as a part of my prenatal preparation. After becoming pregnant, I continued taking it throughout the pregnancy at a dosage of 800 mg, which suffices for both the mother's and child's needs. I took one tablet daily, and the 250-tablet count lasted a long while! My child was born healthy and on time. I highly recommend purchasing this.

Frequently Asked Questions

9
Less stress felt
52 people found this helpful
I have been taking folate for three months now, having my sister recommend it initially. The results have been considerable; I have become much calmer, and my mood swings have significantly reduced. This supplement has transformed my experience while tutoring, where I previously struggled with my emotions. My endocrinologist recommended folic acid, and initially, I was sceptical about its efficiency, but I now see the benefits. I’m really glad this review could help!
7.5
Mental state improved
19 people found this helpful
I've been using this supplement for a month, and I've noticed a quick improvement in my mental and emotional state. Mood swings have greatly diminished, and my overall wellbeing has enhanced. The small, orange tablet is easy to swallow and has a pleasant aroma. I find this supplement especially beneficial for women in the autumn-winter season. I've definitely decided to order more!
9
Regulated menstrual cycle
5 people found this helpful
I have always struggled with irregular periods, having tried various medications that did not suit me. However, after intuitively ordering folic acid with B12, my ovulation returned to a regular cycle within the first month. Now, a year later, it has stabilised to 28 days. I continue taking this folic acid, as it plays a vital role during pregnancy, especially in the first trimester. If you're planning for pregnancy like I am, start taking it early, after consulting your doctor!
2
Ineffective for mum
7 people found this helpful
Unfortunately, this product was not effective for my mother, who has a significant deficiency of vitamin B12 and folic acid. After three months of usage, her test results remained unchanged. The form of vitamins in these pills is quite common, with similar products available in pharmacies. It may be fine for prevention, but I recommend looking for vitamins in more active forms. If you find this review helpful, please click "yes."
9
Heart health improved
7 people found this helpful
Folic acid is a B vitamin crucial for maintaining the nervous and cardiovascular systems. I took it for my father's heart condition as directed by his cardiologist. After a month of taking one tablet daily, his health significantly improved. We were pleasantly surprised by the results, and I have reordered.
9
Cycle recovery amazing
6 people found this helpful
I ordered folic acid to restore my hormonal balance, which had been malfunctioning lately. At 40, I thought menopause was imminent, with no menstruation for months. To my astonishment, after taking two tablets daily with biotin and collagen, my cycle returned to its usual 21-22 days. Folic acid effectively normalises menstruation and supports the reproductive system due to vitamin B9's improvement of hormonal balance. I highly recommend it to other women facing similar challenges.
9
Healthy child born
7 people found this helpful
I ordered folic acid as a part of my prenatal preparation. After becoming pregnant, I continued taking it throughout the pregnancy at a dosage of 800 mg, which suffices for both the mother's and child's needs. I took one tablet daily, and the 250-tablet count lasted a long while! My child was born healthy and on time. I highly recommend purchasing this.
6
Improved haemoglobin
262 people found this helpful
Enough! I’ve been taking one tablet daily for a month and I’ve observed that my haemoglobin levels have returned to normal, despite previously suffering from anaemia. I initially purchased it in our local pharmacy, but that product didn't work. I'm using this folic acid alongside vitamin B12, which is vital for women planning for pregnancy. If you're not looking to conceive, this dosage may be too high; in that case, I’d recommend a smaller dose. If you find my review helpful, please click YES. I adore iHerb and frequently order for myself, my family, and friends, many of whom have tried and loved it. I hope my comments help others as well. Wishing you good health and pleasant shopping!
9
Folic acid improves rheumatoid arthritis treatment
We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.
We explored a promising new approach to treating inflammatory arthritis, focusing on a modified form of methotrexate (MTX) that uses folic acid to target inflamed joints. The study found that this prodrug could release the medication in a controlled way while reducing side effects common with traditional treatments.

In tests involving mouse models and human joint fluid samples, we observed that the prodrug not only accumulated in areas of inflammation but also matched the effectiveness of standard weekly MTX with much less dosage. While this treatment is still in the early stages, it shows exciting potential for improving care in those suffering from arthritis.
We examined a long-term study focusing on elderly patients with rheumatoid arthritis (RA) using methotrexate (MTX).

While higher MTX doses increased the risk of needing to stop treatment due to adverse effects, adding folic acid seemed to lower that risk significantly.

In fact, around 51.7% of patients had to discontinue MTX within 15 years, but those on folic acid had a much better outcome.

This suggests that doctors should consider lower MTX doses combined with folic acid for better results in elderly RA management.
9
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.

Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.

This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
We explored the intriguing relationship between vitamin B12 and autoimmune disorders through a case study involving a 64-year-old male with multiple autoimmune conditions. Our investigation revealed that this patient, who had a history of type 1 diabetes, was diagnosed with chronic autoimmune gastritis.

Upon further examination, we found he suffered from a deficiency in vitamin B12, which is often associated with autoimmune gastritis due to impaired absorption. Following this diagnosis, he commenced monthly vitamin B12 supplementation, which is a common treatment for individuals with similar conditions.

While vitamin B12 treatment addresses the deficiency, it's essential to acknowledge that its effects on autoimmune disorders as a standalone treatment remain unclear. This case illustrates the importance of monitoring vitamin levels in patients with autoimmune diseases but does not provide evidence suggesting significant benefits of B12 treatment on the autoimmune disorders themselves.

Ultimately, this emphasizes the need for continuous vigilance in identifying and addressing nutritional deficiencies, particularly in patients suffering from autoimmune conditions, even when specific symptoms may not be present.

References

  1. Han R, Zhou D, Ji N, Yin Z, Wang J, et al. Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway. J Nanobiotechnology. 2025;23:41. doi:10.1186/s12951-025-03096-5
  2. Nosrati Z, Chen YA, Bergamo M, Rodríguez-Rodríguez C, Chan J, et al. Prodrug Nanomedicine for Synovium Targeted Therapy of Inflammatory Arthritis: Insights from Animal Model and Human Synovial Joint Fluid. Adv Healthc Mater. 2024;13:e2401936. doi:10.1002/adhm.202401936
  3. Avalos-Salgado FA, Gonzalez-Lopez L, Gonzalez-Vazquez S, Ponce-Guarneros JM, Santiago-Garcia AP, et al. Risk Factors Associated with Adverse Events Leading to Methotrexate Withdrawal in Elderly Rheumatoid Arthritis Patients: A Retrospective Cohort Study. J Clin Med. 2024;13. doi:10.3390/jcm13071863
  4. Liu K, Li X, Li D. Connective tissue disease as a challenge in heart failure: Three case reports. Medicine (Baltimore). 2024;103:e36885. doi:10.1097/MD.0000000000036885
  5. Li Z, Han S, Cui G, Xue B, Li J, et al. Oral liposomes encapsulating ginsenoside compound K for rheumatoid arthritis therapy. Int J Pharm. 2023;643:123247. doi:10.1016/j.ijpharm.2023.123247
  6. Nasra S, Bhatia D, Kumar A. Targeted Macrophage Re-Programming: Synergistic Therapy With Methotrexate and RELA siRNA Folate-Liposome in RAW264.7 Cells and Arthritic Rats. Adv Healthc Mater. 2024;13:e2400679. doi:10.1002/adhm.202400679
  7. Pesqueda-Cendejas K, Parra-Rojas I, Campos-López B, Mora-García PE, Ruiz-Ballesteros AI, et al. Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study. Lupus. 2024;33:918. doi:10.1177/09612033241257158
  8. Patel AV, Morgan SL, Green R, Danila MI, Merriman TR, et al. Vitamin B12 status and hyperhomocysteinemia in patients with Rheumatoid arthritis treated with methotrexate and folic acid. Am J Med Sci. 2024;368:33. doi:10.1016/j.amjms.2024.03.020
  9. Wells L, O'Hara N, Frye RE, Hullavard N, Smith E. Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population. J Pers Med. 2024;14. doi:10.3390/jpm14020166
  10. Ma XY, Hao Y, Xie YH, Cao Q, Sun DF, et al. Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China. J Gastroenterol Hepatol. 2025. doi:10.1111/jgh.16912
  11. Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
  12. Subtil J, Carvalho R, Rebelo AF, Subtil P. Autoimmune Polyglandular Syndrome Type 3: A Case Report. Cureus. 2024;16:e76152. doi:10.7759/cureus.76152
  13. Mansour M, Shamasnah A, Alsaadi D, Abu Saif S, Krama A. Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto's thyroiditis and pernicious anemia: a case report. J Med Case Rep. 2024;18:643. doi:10.1186/s13256-024-05002-3
  14. Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9
  15. Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
  16. Xiang H, Cai M. Coexistence of Guillain-Barré Syndrome and Subacute Combined Degeneration of the Spinal Cord Due to Autoimmune Gastritis: A Case Report and Literature Review. Cureus. 2024;16:e63084. doi:10.7759/cureus.63084
  17. Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, et al. Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Sci Transl Med. 2024;16:eadl3758. doi:10.1126/scitranslmed.adl3758
  18. Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. doi:10.7759/cureus.58601
  19. Fernandez I, Touzot F. Looking for ALPS: The value of a combined assessment of biochemical markers. Pediatr Allergy Immunol. 2024;35:e14135. doi:10.1111/pai.14135
  20. Yamada H, Toko M, Nakamori M, Ueno H, Aoki S, et al. Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging. J Neurovirol. 2024;30:197. doi:10.1007/s13365-024-01203-0
  21. Yang CW, Hsu HY, Lee YZ, Lee SJ. Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice. Biochem Biophys Res Commun. 2024;704:149668. doi:10.1016/j.bbrc.2024.149668
  22. Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. doi:10.1007/s00296-024-05539-y
image