' 
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.7
USERS' SCORE
Moderately Good
Based on 28 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Significant relevance to folate's effects
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Read More
8
Cerebral venous sinus thrombosis case
Recurrent syncope after hysteroscopy finally diagnosed as cerebral venous sinus thrombosis: a case report.
Important for post-surgery diagnosis
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Read More
8
Pediatric blood clot management insights
CENTRAL RETINAL VEIN OCCLUSION IN 12-YEAR-OLD GIRL WITH METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION: A CASE REPORT AND REVIEW OF THE LITERATURE.
Research indicates folate's role
We examined the case of a healthy 12-year-old girl who experienced a central retinal vein occlusion. This incident was particularly notable because she later developed retinal neovascularization at the age of 24. This timing marks the longest gap reported between such a pediatric event and subsequent complications.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Read More
Most Useful Reviews
9.5
Maintained red blood cells
I've taken this supplement for over eight years, and it helps maintain my hair and keeps my red blood cell count normal. Since starting, I've avoided anaemia, which is remarkable.
Read More
9.5
Improves blood count
I started taking folic acid alongside iron and vitamin B complex to enhance my blood count. Although I dislike the need to take it with food, my blood health has improved significantly, as I’ve battled anaemia. It not only boosts metabolism but has helped me maintain my muscle while losing fat. I feel more energetic and much better overall. Highly recommend for quality ingredients!
Read More
9.5
Healthy blood maintenance
Folic acid helps maintain healthy blood production and supports the formation of red and white blood cells.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.7
- All Researches
9
Supplementation improves health outcomes
The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania.
High relevance in Parkinson's management
We conducted a multi-center trial in Romania to explore how vitamin B12, folic acid, and vitamin D3 supplements could help lower homocysteine levels in Parkinson's disease patients on levodopa treatment.
Over six months, we observed that participants who took these supplements experienced a significant reduction in homocysteine levels and an improvement in their overall quality of life.
The findings suggest that nutritional support can play a vital role in managing Parkinson's disease, potentially reducing risks associated with elevated homocysteine, such as blood clots and other complications.
Over six months, we observed that participants who took these supplements experienced a significant reduction in homocysteine levels and an improvement in their overall quality of life.
The findings suggest that nutritional support can play a vital role in managing Parkinson's disease, potentially reducing risks associated with elevated homocysteine, such as blood clots and other complications.
Read More
9
Folate's role in thrombosis treatment
Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report.
Moderately relevant case findings
We observed a fascinating case involving a 14-year-old girl who experienced severe headaches and nausea, leading to the discovery of cerebral venous thrombosis (CVT) and significantly elevated plasma homocysteine levels. Through comprehensive genetic testing, we identified a rare genetic change called loss of heterozygosity (LOH) affecting the methylenetetrahydrofolate reductase (MTHFR) gene, which plays a crucial role in processing folate in the body.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
Read More
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Significant relevance to folate's effects
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Read More
9
Vitamin B12's role in clot management
A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report.
Moderate relevance to findings
We examined a fascinating case involving a 25-year-old male who experienced severe headaches and vertigo due to cerebral venous thrombosis (CVT). This unique situation arose after the patient had been abusing nitrous oxide, leading to a vitamin B12 deficiency.
After arriving at the hospital, he underwent a set of examinations which raised suspicions of a cerebrovascular accident. A CT scan and subsequent MRI confirmed the presence of clotting in the brain’s venous structures. His unusually high levels of homocysteine and low vitamin B12 pointed directly to a deficiency as a contributing factor to the blood clot.
Treatment for the patient included vitamin B12 supplementation alongside anticoagulants. Remarkably, within just a week, we saw significant improvement in his symptoms. This case underscores the potential importance of vitamin B12 in managing conditions associated with blood clotting, especially in individuals with deficiencies.
While vitamin B12 treatment was part of the regimen, it’s crucial to note that it was not administered in isolation but rather alongside other medications. This complicates our ability to draw definitive conclusions about its individual effectiveness in this specific scenario.
After arriving at the hospital, he underwent a set of examinations which raised suspicions of a cerebrovascular accident. A CT scan and subsequent MRI confirmed the presence of clotting in the brain’s venous structures. His unusually high levels of homocysteine and low vitamin B12 pointed directly to a deficiency as a contributing factor to the blood clot.
Treatment for the patient included vitamin B12 supplementation alongside anticoagulants. Remarkably, within just a week, we saw significant improvement in his symptoms. This case underscores the potential importance of vitamin B12 in managing conditions associated with blood clotting, especially in individuals with deficiencies.
While vitamin B12 treatment was part of the regimen, it’s crucial to note that it was not administered in isolation but rather alongside other medications. This complicates our ability to draw definitive conclusions about its individual effectiveness in this specific scenario.
Read More
9
Vitamin B12 and blood clot relationship
Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review.
Combination therapy complicates assessment
We explored a case involving cerebral venous thrombosis (CVT) coinciding with hyperhomocysteinemia and iron-deficiency anemia, a condition attributed to autoimmune gastritis. The patient, a 47-year-old woman, presented with various symptoms including impaired movement and consciousness. Imaging tests revealed significant brain swelling and clot formations in the venous sinuses.
During the assessment, we noted that the patient suffered from anemia and elevated levels of homocysteine, both contributing factors to the development of blood clots. Interestingly, she also tested positive for intrinsic factor antibodies, leading to the diagnosis of autoimmune gastritis, which further compounded her condition.
Treatment for the patient included anticoagulants, as well as the replacement of iron and vitamin B12. Although the treatment approach effectively alleviated her symptoms and allowed for recovery without neurological deficits, it was difficult to isolate the specific impact of vitamin B12 on blood clot resolution since it was administered alongside other therapies.
Ultimately, while the combination of treatments was beneficial, the study does not provide clear evidence that vitamin B12 alone significantly contributes to the prevention or treatment of blood clots.
During the assessment, we noted that the patient suffered from anemia and elevated levels of homocysteine, both contributing factors to the development of blood clots. Interestingly, she also tested positive for intrinsic factor antibodies, leading to the diagnosis of autoimmune gastritis, which further compounded her condition.
Treatment for the patient included anticoagulants, as well as the replacement of iron and vitamin B12. Although the treatment approach effectively alleviated her symptoms and allowed for recovery without neurological deficits, it was difficult to isolate the specific impact of vitamin B12 on blood clot resolution since it was administered alongside other therapies.
Ultimately, while the combination of treatments was beneficial, the study does not provide clear evidence that vitamin B12 alone significantly contributes to the prevention or treatment of blood clots.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 28 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Maintained red blood cells
I've taken this supplement for over eight years, and it helps maintain my hair and keeps my red blood cell count normal. Since starting, I've avoided anaemia, which is remarkable.
9.5
Improves blood count
I started taking folic acid alongside iron and vitamin B complex to enhance my blood count. Although I dislike the need to take it with food, my blood health has improved significantly, as I’ve battled anaemia. It not only boosts metabolism but has helped me maintain my muscle while losing fat. I feel more energetic and much better overall. Highly recommend for quality ingredients!
Read More
9.5
Healthy blood maintenance
Folic acid helps maintain healthy blood production and supports the formation of red and white blood cells.
8.8
Effective blood recovery
After significant surgery and blood loss, my platelet count was dangerously low, and nothing helped for six months. My doctor recommended a combination of folic acid and vitamin B12. Within a month, my blood analysis showed improvement, and by three months, my platelets were normal again. Consistency in taking them is vital. Highly recommend!
Read More
9.5
Homocysteine reduction
I purchased it to lower my blood homocysteine levels. After six months of use, my test results showed a threefold decrease, returning to normal levels! I will continue buying this supplement regularly!
