' 
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Good
Based on 10 Reviews
8.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
Folate micelles for tumor diagnosis
Radiolabelled folate micellar carriers as proposed diagnostic aid for CNS tumors by nasal route.
High relevance to brain tumors
We explored the potential of folate as a diagnostic aid for brain tumors, specifically targeting gliomas—some of the most challenging brain cancers. A key part of our approach involved developing a micellar delivery system that could be given through the nose. This method is less invasive and may provide a more effective way to reach brain tumors.
In our research, we took advantage of the fact that folate receptors are overexpressed in brain tumors, making them an excellent target for diagnosis. We synthesized a folate-conjugated agent, labeled it with technetium (Tc), and encapsulated it within micelles for improved delivery.
Testing revealed that these micelles had a safe profile for nasal administration in rats. In mice, the micelles demonstrated significantly better uptake in the brain compared to a standard folate solution. Imaging studies using specialized techniques showed that these micelles could effectively accumulate in brain tissue.
The findings suggest that this innovative formulation could not only help detect brain tumors but might also be applicable to other cancers that express folate receptors, such as those in the cervical, breast, and lung areas. Overall, we believe our approach has the potential to enhance cancer diagnosis in a fast, accurate, and non-invasive manner.
In our research, we took advantage of the fact that folate receptors are overexpressed in brain tumors, making them an excellent target for diagnosis. We synthesized a folate-conjugated agent, labeled it with technetium (Tc), and encapsulated it within micelles for improved delivery.
Testing revealed that these micelles had a safe profile for nasal administration in rats. In mice, the micelles demonstrated significantly better uptake in the brain compared to a standard folate solution. Imaging studies using specialized techniques showed that these micelles could effectively accumulate in brain tissue.
The findings suggest that this innovative formulation could not only help detect brain tumors but might also be applicable to other cancers that express folate receptors, such as those in the cervical, breast, and lung areas. Overall, we believe our approach has the potential to enhance cancer diagnosis in a fast, accurate, and non-invasive manner.
Read More
9
Folate imaging for gliomas
High folate receptor expression in gliomas can be detected using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities.
High relevance for glioma detection
We explored how a folate analogue, [F]FOL, can be used for imaging brain tumors like gliomas. In our study, rats with gliomas were injected with the folate compound, which helps visualize areas with high levels of folate receptors (FRs) that are often found in tumors.
Through various imaging techniques, we were able to see that [F]FOL accrued significantly in glioma tissues. This suggests a direct relationship between the presence of FRs and the uptake of our imaging agent. Additionally, we examined human glioblastoma samples, confirming similar high FR expression.
Our findings not only highlight the potential of [F]FOL in enhancing the detection of gliomas but also pave the way for developing targeted therapies using folate. Overall, while our study showcases exciting possibilities for using folate in glioma imaging and treatment, specific effects of folate treatment alone weren't directly assessed.
Through various imaging techniques, we were able to see that [F]FOL accrued significantly in glioma tissues. This suggests a direct relationship between the presence of FRs and the uptake of our imaging agent. Additionally, we examined human glioblastoma samples, confirming similar high FR expression.
Our findings not only highlight the potential of [F]FOL in enhancing the detection of gliomas but also pave the way for developing targeted therapies using folate. Overall, while our study showcases exciting possibilities for using folate in glioma imaging and treatment, specific effects of folate treatment alone weren't directly assessed.
Read More
7
Folate enhances brain cancer therapy
Folic Acid-Conjugated Brush Polymers Show Enhanced Blood-Brain Barrier Crossing in Static and Dynamic Models Toward Brain Cancer Targeting Therapy.
Moderately relevant targeting method
We set out to investigate how folate could enhance the targeting of brain tumors using specially designed brush polymers. These polymers were modified to carry folic acid, which targets particular proteins on brain cell surfaces, effectively aiding in the delivery of treatments.
The researchers created these polymers by attaching folic acid to a brush polymer structure. This approach aimed to help the polymers cross the often challenging blood-brain barrier (BBB). We found that the folate-modified polymers significantly increased their uptake by brain endothelial cells, compared to non-modified versions.
To assess their effectiveness, we examined how well these polymers could cross models of the BBB and deliver therapy to glioblastoma cells after passing through. The results indicated that the more folate units incorporated into the polymers, the better they were at accumulating in glioma cells after crossing the BBB.
Overall, our findings suggest that these folate-modified brush polymers show great promise for improving the delivery of therapies aimed at treating brain cancers, making it a noteworthy advancement in the field.
The researchers created these polymers by attaching folic acid to a brush polymer structure. This approach aimed to help the polymers cross the often challenging blood-brain barrier (BBB). We found that the folate-modified polymers significantly increased their uptake by brain endothelial cells, compared to non-modified versions.
To assess their effectiveness, we examined how well these polymers could cross models of the BBB and deliver therapy to glioblastoma cells after passing through. The results indicated that the more folate units incorporated into the polymers, the better they were at accumulating in glioma cells after crossing the BBB.
Overall, our findings suggest that these folate-modified brush polymers show great promise for improving the delivery of therapies aimed at treating brain cancers, making it a noteworthy advancement in the field.
Read More
Most Useful Reviews
9.5
Essential for development
The folic acid dosage is very good. I began taking it in hopes of getting pregnant, and the results were swift, as I conceived in nearly two months. Before taking the pills, it did not work for over seven months. During pregnancy, folic acid is crucial for the development of the child, especially the brain and spinal cord. A deficiency can lead to severe consequences, including potential psychoses or mental retardation in the child.
Read More
9.5
Vital for fetal health
Folic acid, part of the B-vitamin group, is crucial for DNA synthesis and cellular function. In early pregnancy, the fetus's organs, including the brain, develop quickly. Any defects during this critical period may lead to severe disabilities or death. Folic acid effectively reduces the risk of neural tube defects, making it essential for every woman, especially those who may become pregnant.
Read More
9.5
Supports nervous system
I took folic acid (B9) for my pregnant girlfriend as prescribed by her gynaecologist to ensure the child's brain, heart, and genitourinary system develop normally. I highly recommend it for expectant mothers!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
- All Researches
9
Folic acid improves glioma treatment
Folic acid-decorated astrocytes-derived exosomes enhanced the effect of temozolomide against glioma.
Study shows targeted delivery potential
We conducted a study focused on improving the treatment of gliomas, a type of brain tumor, by using an innovative drug delivery system. This system utilized exosomes—tiny vesicles that can carry drugs—and modified them with folic acid to target tumor cells. By loading temozolomide, a common chemotherapy drug, into these folate-decorated exosomes, we aimed to enhance the drug's effectiveness and reduce its side effects.
Our findings showed that these modified exosomes, termed Astro-exo-FA, were more effectively taken up by U-87 glioma cells compared to non-modified exosomes. This means that the folic acid decoration was successful in improving the targeting of brain tumor cells. Furthermore, treatments using Astro-exo-FA significantly reduced the growth and spread of these cancerous cells and led to improved outcomes in mouse models, showing extended survival and minimized weight changes.
Overall, our research highlights the potential of using folic acid in drug delivery systems to specifically attack brain tumors while mitigating the adverse effects usually associated with chemotherapy. This approach opens up exciting new avenues for targeted treatments against gliomas.
Our findings showed that these modified exosomes, termed Astro-exo-FA, were more effectively taken up by U-87 glioma cells compared to non-modified exosomes. This means that the folic acid decoration was successful in improving the targeting of brain tumor cells. Furthermore, treatments using Astro-exo-FA significantly reduced the growth and spread of these cancerous cells and led to improved outcomes in mouse models, showing extended survival and minimized weight changes.
Overall, our research highlights the potential of using folic acid in drug delivery systems to specifically attack brain tumors while mitigating the adverse effects usually associated with chemotherapy. This approach opens up exciting new avenues for targeted treatments against gliomas.
Read More
9
Folate imaging for gliomas
High folate receptor expression in gliomas can be detected using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities.
High relevance for glioma detection
We explored how a folate analogue, [F]FOL, can be used for imaging brain tumors like gliomas. In our study, rats with gliomas were injected with the folate compound, which helps visualize areas with high levels of folate receptors (FRs) that are often found in tumors.
Through various imaging techniques, we were able to see that [F]FOL accrued significantly in glioma tissues. This suggests a direct relationship between the presence of FRs and the uptake of our imaging agent. Additionally, we examined human glioblastoma samples, confirming similar high FR expression.
Our findings not only highlight the potential of [F]FOL in enhancing the detection of gliomas but also pave the way for developing targeted therapies using folate. Overall, while our study showcases exciting possibilities for using folate in glioma imaging and treatment, specific effects of folate treatment alone weren't directly assessed.
Through various imaging techniques, we were able to see that [F]FOL accrued significantly in glioma tissues. This suggests a direct relationship between the presence of FRs and the uptake of our imaging agent. Additionally, we examined human glioblastoma samples, confirming similar high FR expression.
Our findings not only highlight the potential of [F]FOL in enhancing the detection of gliomas but also pave the way for developing targeted therapies using folate. Overall, while our study showcases exciting possibilities for using folate in glioma imaging and treatment, specific effects of folate treatment alone weren't directly assessed.
Read More
9
Folate-targeted nanoparticle effectiveness
Effect of folate-targeted Erlotinib loaded human serum albumin nanoparticles on tumor size and survival rate in a rat model of glioblastoma.
Relevant treatment approach evaluated
We set out to explore how folate-targeted Erlotinib-loaded human serum albumin nanoparticles might impact brain tumors, specifically glioblastomas. Our research used both laboratory cell lines and a live rat model to examine the effectiveness of this treatment. The nanoparticles we developed, measuring around 135 nanometers in size, were designed to improve the delivery of Erlotinib, a drug known for its potential against certain tumors.
In laboratory tests, we observed that these folate-targeted nanoparticles showed a significantly lower concentration needed to inhibit cell growth compared to the free Erlotinib. For example, within 72 hours of treatment, the nanoparticles had an IC value of about 52.18 micrograms per milliliter for U87MG cells, while free Erlotinib required nearly double that amount.
Further investigations revealed that these nanoparticles also enhanced the rate of apoptosis, or programmed cell death, which is crucial for effectively shrinking tumors. In the rat model, we noted a remarkable reduction in tumor size—from nearly 87 mm to just over 1 mm after consistent treatment with the nanoparticles. Additionally, we found that the survival rate of these rats extended beyond 100 days, outperforming the control group.
Overall, this study strongly suggests that folate-targeted Erlotinib nanoparticles can effectively reduce tumor size and improve survival in a glioblastoma model, highlighting the potential role of folate in targeted cancer therapy.
In laboratory tests, we observed that these folate-targeted nanoparticles showed a significantly lower concentration needed to inhibit cell growth compared to the free Erlotinib. For example, within 72 hours of treatment, the nanoparticles had an IC value of about 52.18 micrograms per milliliter for U87MG cells, while free Erlotinib required nearly double that amount.
Further investigations revealed that these nanoparticles also enhanced the rate of apoptosis, or programmed cell death, which is crucial for effectively shrinking tumors. In the rat model, we noted a remarkable reduction in tumor size—from nearly 87 mm to just over 1 mm after consistent treatment with the nanoparticles. Additionally, we found that the survival rate of these rats extended beyond 100 days, outperforming the control group.
Overall, this study strongly suggests that folate-targeted Erlotinib nanoparticles can effectively reduce tumor size and improve survival in a glioblastoma model, highlighting the potential role of folate in targeted cancer therapy.
Read More
8
Folate enhances drug delivery in glioma
Surface-Modified Biobased Polymeric Nanoparticles for Dual Delivery of Doxorubicin and Gefitinib in Glioma Cell Lines.
Folate's isolated effect unclear
We investigated the potential of using nanoparticles modified with folate to deliver two cancer-fighting drugs, doxorubicin and gefitinib, specifically targeting glioma, a challenging type of brain cancer. Our study focused on how these folate-conjugated nanoparticles could affect glioma cells, given that folate receptors are often overexpressed in these tumors.
The nanoparticles were designed to enhance drug delivery to the brain, and we assessed their size, charge, and release profiles at different pH levels. It was exciting to observe that both our standard and folate-modified nanoparticles inhibited glioma cell growth significantly, with lower concentrations of the drugs required when folate was present.
However, while the folate-modified nanoparticles showed promising results, it remains uncertain how much of that effect can be attributed solely to folate since both formulations performed well. Our analysis also revealed that the drugs were predominantly found in the brain, but we couldn't isolate the individual impact of folate itself.
Overall, the introduction of folate-conjugated nanoparticles for glioma therapy presents a potential avenue for treating this aggressive cancer. Further studies would be necessary to clarify the unique contributions of folate in enhancing treatment outcomes.
The nanoparticles were designed to enhance drug delivery to the brain, and we assessed their size, charge, and release profiles at different pH levels. It was exciting to observe that both our standard and folate-modified nanoparticles inhibited glioma cell growth significantly, with lower concentrations of the drugs required when folate was present.
However, while the folate-modified nanoparticles showed promising results, it remains uncertain how much of that effect can be attributed solely to folate since both formulations performed well. Our analysis also revealed that the drugs were predominantly found in the brain, but we couldn't isolate the individual impact of folate itself.
Overall, the introduction of folate-conjugated nanoparticles for glioma therapy presents a potential avenue for treating this aggressive cancer. Further studies would be necessary to clarify the unique contributions of folate in enhancing treatment outcomes.
Read More
8
Folate micelles for tumor diagnosis
Radiolabelled folate micellar carriers as proposed diagnostic aid for CNS tumors by nasal route.
High relevance to brain tumors
We explored the potential of folate as a diagnostic aid for brain tumors, specifically targeting gliomas—some of the most challenging brain cancers. A key part of our approach involved developing a micellar delivery system that could be given through the nose. This method is less invasive and may provide a more effective way to reach brain tumors.
In our research, we took advantage of the fact that folate receptors are overexpressed in brain tumors, making them an excellent target for diagnosis. We synthesized a folate-conjugated agent, labeled it with technetium (Tc), and encapsulated it within micelles for improved delivery.
Testing revealed that these micelles had a safe profile for nasal administration in rats. In mice, the micelles demonstrated significantly better uptake in the brain compared to a standard folate solution. Imaging studies using specialized techniques showed that these micelles could effectively accumulate in brain tissue.
The findings suggest that this innovative formulation could not only help detect brain tumors but might also be applicable to other cancers that express folate receptors, such as those in the cervical, breast, and lung areas. Overall, we believe our approach has the potential to enhance cancer diagnosis in a fast, accurate, and non-invasive manner.
In our research, we took advantage of the fact that folate receptors are overexpressed in brain tumors, making them an excellent target for diagnosis. We synthesized a folate-conjugated agent, labeled it with technetium (Tc), and encapsulated it within micelles for improved delivery.
Testing revealed that these micelles had a safe profile for nasal administration in rats. In mice, the micelles demonstrated significantly better uptake in the brain compared to a standard folate solution. Imaging studies using specialized techniques showed that these micelles could effectively accumulate in brain tissue.
The findings suggest that this innovative formulation could not only help detect brain tumors but might also be applicable to other cancers that express folate receptors, such as those in the cervical, breast, and lung areas. Overall, we believe our approach has the potential to enhance cancer diagnosis in a fast, accurate, and non-invasive manner.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Essential for development
The folic acid dosage is very good. I began taking it in hopes of getting pregnant, and the results were swift, as I conceived in nearly two months. Before taking the pills, it did not work for over seven months. During pregnancy, folic acid is crucial for the development of the child, especially the brain and spinal cord. A deficiency can lead to severe consequences, including potential psychoses or mental retardation in the child.
Read More
9.5
Vital for fetal health
Folic acid, part of the B-vitamin group, is crucial for DNA synthesis and cellular function. In early pregnancy, the fetus's organs, including the brain, develop quickly. Any defects during this critical period may lead to severe disabilities or death. Folic acid effectively reduces the risk of neural tube defects, making it essential for every woman, especially those who may become pregnant.
Read More
9.5
Supports nervous system
I took folic acid (B9) for my pregnant girlfriend as prescribed by her gynaecologist to ensure the child's brain, heart, and genitourinary system develop normally. I highly recommend it for expectant mothers!
9.5
Prevents brain cancer
Folic acid restores immunity and supports heart function; it’s vital for expectant mothers and aids in cancer prevention while enhancing brain health. It plays a significant role in egg maturation, normalising the menstrual cycle, and fetal development. I recommend consuming 400-800 mcg daily.
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8.8
Prevents tumour growth
Folic acid is known for its excellent price and quality. The small, easy-to-swallow tablets play a vital role in many bodily processes, including cell growth and DNA integrity. A deficiency can lead to tumours, so it helps prevent neoplasms. It is also necessary for proper immune system function, cardiovascular health, and amino acid synthesis. Additionally, it benefits our nervous system, mood, and productivity, especially during pregnancy.
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