SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
9
Folic acid's potential in treatment
Efficient one-pot green synthesis of carboxymethyl cellulose/folic acid embedded ultrafine CeO nanocomposite and its superior multi-drug resistant antibacterial activity and anticancer activity.
Moderate relevance, practical limitations
We explored the potential of a unique nanocomposite made from cerium oxide nanoparticles, folic acid, and carboxymethyl cellulose to combat breast cancer and drug-resistant bacterial infections. Using a green synthesis approach with Moringa oleifera, this study highlights how bimolecular combinations, especially those involving folate, might improve therapeutic effectiveness.
Our findings revealed that the folate-infused nanocomposite demonstrated significant antibacterial properties, particularly against Methicillin-resistant Staphylococcus aureus (MRSA), achieving a remarkable 95.6% effectiveness. This high level of activity is largely attributed to the production of reactive oxygen species (ROS) that inflict damage on bacterial cells. Furthermore, we noted promising anticancer effects against breast cancer cells, with the nanocomposite showing a lower inhibitory concentration than the cerium oxide alone.
It’s important to recognize that while folate is a key component, the full effect comes from its synergy with other compounds within this nanocomposite structure. Our research indicates that this innovative approach may offer new pathways for treatment in both bacterial resistance and cancer therapies, marking an exciting development in the field of nanomedicine.
Our findings revealed that the folate-infused nanocomposite demonstrated significant antibacterial properties, particularly against Methicillin-resistant Staphylococcus aureus (MRSA), achieving a remarkable 95.6% effectiveness. This high level of activity is largely attributed to the production of reactive oxygen species (ROS) that inflict damage on bacterial cells. Furthermore, we noted promising anticancer effects against breast cancer cells, with the nanocomposite showing a lower inhibitory concentration than the cerium oxide alone.
It’s important to recognize that while folate is a key component, the full effect comes from its synergy with other compounds within this nanocomposite structure. Our research indicates that this innovative approach may offer new pathways for treatment in both bacterial resistance and cancer therapies, marking an exciting development in the field of nanomedicine.
Read More
8
Folate-targeted nanoparticles show promise
Bioinspired caffeic acid-laden milk protein-based nanoparticles targeting folate receptors for breast cancer treatment.
Strong focus on folate relevance
We investigated the effectiveness of folic acid-functionalized nanoparticles designed to deliver caffeic acid to target breast cancer cells. The nanoparticles were made using a simple coacervation method followed by a process called lyophilization. Our exploration focused on understanding how these nanoparticles might enhance treatment for breast cancer while minimizing side effects typically seen with conventional therapies.
Through a series of tests, we characterized the nanoparticles regarding size, surface charge, and their ability to release the drug. We observed that the conjugated nanoparticles had an average size of about 157 nm and showed promising cytotoxicity against cancer cells. Specifically, they significantly reduced the levels of certain biochemical markers associated with cancer while increasing beneficial enzyme levels in test subjects.
Additionally, our histopathological examinations indicated an improvement in tissue health in treated rats. While the study demonstrates the potential of these nanoparticles, the impact of the folate specifically within this nanoparticle system requires further investigation to confirm its unique role in targeting cancer cells effectively. Overall, we believe this approach holds great promise for developing more efficient breast cancer treatments with reduced side effects.
Through a series of tests, we characterized the nanoparticles regarding size, surface charge, and their ability to release the drug. We observed that the conjugated nanoparticles had an average size of about 157 nm and showed promising cytotoxicity against cancer cells. Specifically, they significantly reduced the levels of certain biochemical markers associated with cancer while increasing beneficial enzyme levels in test subjects.
Additionally, our histopathological examinations indicated an improvement in tissue health in treated rats. While the study demonstrates the potential of these nanoparticles, the impact of the folate specifically within this nanoparticle system requires further investigation to confirm its unique role in targeting cancer cells effectively. Overall, we believe this approach holds great promise for developing more efficient breast cancer treatments with reduced side effects.
Read More
8
Folate-targeted rapamycin delivery research
Rapamycin-loaded nanostructured lipid carrier modified with folic acid intended for breast cancer therapy.
Study highlights folate targeting
We examined an innovative approach to breast cancer treatment by utilizing folate to enhance the delivery of rapamycin, a known protein inhibitor. The research centered on developing a smart delivery system called a nanostructured lipid carrier, specifically designed to target breast cancer cells more effectively.
By modifying this carrier with folic acid, we aimed to latch onto folate receptors that are often overexpressed in cancer cells. Our findings showed that this strategy significantly increased the uptake of rapamycin in cancer cells compared to normal cells. We found that this folate-modified formulation, referred to as FA-NLC-RAP, not only reduced cancer cell viability but also had a similar efficacy to the rapamycin solution itself.
Additionally, the formulation demonstrated a prolonged release profile and proved safe in a model organism, Caenorhabditis elegans, with no toxic effects observed. These findings suggest a promising future for the use of folate-targeted therapy in treating breast cancer, making this an exciting avenue for further research and development.
By modifying this carrier with folic acid, we aimed to latch onto folate receptors that are often overexpressed in cancer cells. Our findings showed that this strategy significantly increased the uptake of rapamycin in cancer cells compared to normal cells. We found that this folate-modified formulation, referred to as FA-NLC-RAP, not only reduced cancer cell viability but also had a similar efficacy to the rapamycin solution itself.
Additionally, the formulation demonstrated a prolonged release profile and proved safe in a model organism, Caenorhabditis elegans, with no toxic effects observed. These findings suggest a promising future for the use of folate-targeted therapy in treating breast cancer, making this an exciting avenue for further research and development.
Read More
Most Useful Reviews
8.8
Cancer protection
It's important to consume folic acid not just before and during pregnancy, as it may protect against various cancers, including breast cancer.
Read More
8.8
Healthy blood cells
Folic acid (vitamin B9) is crucial for the formation of healthy blood cells and assists in reducing the risk of cancer through its involvement in numerous basic bodily functions.
Read More
8
Supports cancer prevention
Folic acid is a crucial vitamin for pregnant women, essential for maintaining heart health, aiding in cancer prevention, and promoting brain health. The dosage is excellent, and the large volume means one jar lasts quite a while.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
- All Researches
9.5
Folate enhances targeted cancer therapy
Thiophene engineering of near-infrared D-π-A nano-photosensitizers for enhanced multiple phototheranostics and inhibition of tumor metastasis.
Folate's impact not isolated
We explored the role of folate in enhancing breast cancer treatments involving a specialized type of light-sensitive compound known as photosensitizers (PSs). The study focused on a unique class of PSs that were modified to improve their effectiveness in both photodynamic therapy (PDT) and photothermal therapy (PTT), which are non-invasive techniques used to target and destroy cancer cells.
By incorporating folate into the design of these PSs, we aimed to boost their ability to specifically target tumor cells. The research showed that the engineered nanoparticles, when infused with folate, exhibited remarkable success in eradicating tumors and suppressing their spread using near-infrared light. This approach demonstrated that folate effectively enhances the targeting abilities of the treatment, making it especially promising for challenging cancers like triple-negative breast cancer.
Overall, while the presence of folate in the nanoparticle formulation helped improve targeting efficiency, the study did not isolate the effects of folate alone from the entire system. This means we can appreciate its role in the broader context of cancer therapy strategies but can't determine its standalone impact just yet.
By incorporating folate into the design of these PSs, we aimed to boost their ability to specifically target tumor cells. The research showed that the engineered nanoparticles, when infused with folate, exhibited remarkable success in eradicating tumors and suppressing their spread using near-infrared light. This approach demonstrated that folate effectively enhances the targeting abilities of the treatment, making it especially promising for challenging cancers like triple-negative breast cancer.
Overall, while the presence of folate in the nanoparticle formulation helped improve targeting efficiency, the study did not isolate the effects of folate alone from the entire system. This means we can appreciate its role in the broader context of cancer therapy strategies but can't determine its standalone impact just yet.
Read More
9
Folate-targeted delivery for cancer therapy
Cell membrane-inspired chitosan nanoparticles for prolonged circulation and tumor-targeted drug delivery.
Study highlights targeted drug delivery
We explored how folate-targeted drug delivery systems might enhance chemotherapy effectiveness in breast cancer treatment. By creating a new type of nanocarrier that mimics cell membranes, we combined folate with nanoparticles to increase their ability to reach cancer cells.
The study designed biomimetic chitosan nanoparticles that not only circulate longer in the bloodstream but also specifically target breast cancer cells. We engineered these nanoparticles with a folate ligand, which is known to bind to specific receptors on cancer cells, thus increasing the chances of drug uptake.
Our findings showed that these targeted nanoparticles were taken up by rat breast cancer cells significantly more than those without folate. The blood circulation results were promising, as the nanoparticles lasted much longer in circulation compared to typical treatments. This extended circulation time could pave the way for more effective drug delivery in clinical settings.
Overall, we observed that incorporating folate might enhance the delivery of cancer therapies, reducing the challenges posed by conventional chemotherapy. This innovative strategy could lead to better outcomes for breast cancer patients and represents a noteworthy advancement in treatment options.
The study designed biomimetic chitosan nanoparticles that not only circulate longer in the bloodstream but also specifically target breast cancer cells. We engineered these nanoparticles with a folate ligand, which is known to bind to specific receptors on cancer cells, thus increasing the chances of drug uptake.
Our findings showed that these targeted nanoparticles were taken up by rat breast cancer cells significantly more than those without folate. The blood circulation results were promising, as the nanoparticles lasted much longer in circulation compared to typical treatments. This extended circulation time could pave the way for more effective drug delivery in clinical settings.
Overall, we observed that incorporating folate might enhance the delivery of cancer therapies, reducing the challenges posed by conventional chemotherapy. This innovative strategy could lead to better outcomes for breast cancer patients and represents a noteworthy advancement in treatment options.
Read More
9
Effects of CA-FA on breast cancer
Evaluating the anticancer effects of carnosic acid against breast cancer: An In Vitro investigation.
Moderate relevance; limited folate insights
We sought to evaluate how combining carnosic acid (CA) with folic acid (FA) could influence breast cancer treatments. This study specifically focused on the effects of these compounds on several breast cancer cell lines, including MCF-7, MDA-MB-231, and MCA10.
Using the MTT assay, we measured the viability of these cell lines and found that CA alone significantly decreased their survival rates, particularly in MCF-7 and MDA-MB-231 cells. However, it was the combination of CA and FA that really stood out, displaying even greater effectiveness, especially against the MDA-MB-231 cells.
Our apoptosis analysis revealed that when treated with CA and CA-FA, both MCF-7 and MDA-MB-231 cells showed increased signs of cell death. Additionally, we observed higher levels of active caspase-3/7, which play a crucial role in the programmed cell death process. Notably, the combined treatment markedly increased levels of reactive oxygen species (ROS), indicating heightened oxidative stress that contributes to cancer cell death.
While our findings suggest that pairing CA with FA enhances its anticancer properties, the effects of FA alone were not fully explored in this study. This means there's more to learn about how folate specifically influences breast cancer treatment outcomes.
Overall, these results highlight the potential of CA-FA as a promising avenue in the management of aggressive breast cancer forms, but they also indicate that further research is needed to clarify its practical applications in clinical settings.
Using the MTT assay, we measured the viability of these cell lines and found that CA alone significantly decreased their survival rates, particularly in MCF-7 and MDA-MB-231 cells. However, it was the combination of CA and FA that really stood out, displaying even greater effectiveness, especially against the MDA-MB-231 cells.
Our apoptosis analysis revealed that when treated with CA and CA-FA, both MCF-7 and MDA-MB-231 cells showed increased signs of cell death. Additionally, we observed higher levels of active caspase-3/7, which play a crucial role in the programmed cell death process. Notably, the combined treatment markedly increased levels of reactive oxygen species (ROS), indicating heightened oxidative stress that contributes to cancer cell death.
While our findings suggest that pairing CA with FA enhances its anticancer properties, the effects of FA alone were not fully explored in this study. This means there's more to learn about how folate specifically influences breast cancer treatment outcomes.
Overall, these results highlight the potential of CA-FA as a promising avenue in the management of aggressive breast cancer forms, but they also indicate that further research is needed to clarify its practical applications in clinical settings.
Read More
9
Folate-enhanced treatment shows promise
Investigating the effect of rAzurin loaded mesoporous silica nanoparticles enwrapped with chitosan-folic acid on breast tumor regression in BALB/ mice.
Combination therapy complicates folate effects.
We explored the role of mesoporous silica nanoparticles combined with chitosan and folic acid in delivering recombinant Azurin to breast cancer cells. The goal was to see how this innovative approach could induce cell death and boost immune responses against both cancerous and normal cells using BALB/c mice as a model.
The results revealed that our specific formulation, rAzu-MSNs-CS-FA, offered a pH-responsive release of Azurin, leading to a slower, more controlled delivery compared to other treatments. This slower release allowed for greater inhibition of MCF7 breast cancer cells, triggering apoptosis, which is basically the programmed death of these unhealthy cells. We also noticed it caused DNA degradation, an important aspect of combating cancer.
Further, the treatment increased the absorption of Azurin and significantly enhanced immune markers like TNF-α, INF-γ, and IL-4 while reducing levels of IL-6. We also found changes in the expression of certain genes involved in immune response, which may enhance the treatment's effectiveness.
In our animal studies, we witnessed notable tumor regression and reduced tumor volume over a 21-day period. Overall, the study highlights that combining folic acid with mesoporous silica nanoparticles could be a promising strategy for breast cancer therapy, showcasing its potential to enhance cancer treatment effectiveness without significant side effects.
The results revealed that our specific formulation, rAzu-MSNs-CS-FA, offered a pH-responsive release of Azurin, leading to a slower, more controlled delivery compared to other treatments. This slower release allowed for greater inhibition of MCF7 breast cancer cells, triggering apoptosis, which is basically the programmed death of these unhealthy cells. We also noticed it caused DNA degradation, an important aspect of combating cancer.
Further, the treatment increased the absorption of Azurin and significantly enhanced immune markers like TNF-α, INF-γ, and IL-4 while reducing levels of IL-6. We also found changes in the expression of certain genes involved in immune response, which may enhance the treatment's effectiveness.
In our animal studies, we witnessed notable tumor regression and reduced tumor volume over a 21-day period. Overall, the study highlights that combining folic acid with mesoporous silica nanoparticles could be a promising strategy for breast cancer therapy, showcasing its potential to enhance cancer treatment effectiveness without significant side effects.
Read More
9
Folic acid's potential in treatment
Efficient one-pot green synthesis of carboxymethyl cellulose/folic acid embedded ultrafine CeO nanocomposite and its superior multi-drug resistant antibacterial activity and anticancer activity.
Moderate relevance, practical limitations
We explored the potential of a unique nanocomposite made from cerium oxide nanoparticles, folic acid, and carboxymethyl cellulose to combat breast cancer and drug-resistant bacterial infections. Using a green synthesis approach with Moringa oleifera, this study highlights how bimolecular combinations, especially those involving folate, might improve therapeutic effectiveness.
Our findings revealed that the folate-infused nanocomposite demonstrated significant antibacterial properties, particularly against Methicillin-resistant Staphylococcus aureus (MRSA), achieving a remarkable 95.6% effectiveness. This high level of activity is largely attributed to the production of reactive oxygen species (ROS) that inflict damage on bacterial cells. Furthermore, we noted promising anticancer effects against breast cancer cells, with the nanocomposite showing a lower inhibitory concentration than the cerium oxide alone.
It’s important to recognize that while folate is a key component, the full effect comes from its synergy with other compounds within this nanocomposite structure. Our research indicates that this innovative approach may offer new pathways for treatment in both bacterial resistance and cancer therapies, marking an exciting development in the field of nanomedicine.
Our findings revealed that the folate-infused nanocomposite demonstrated significant antibacterial properties, particularly against Methicillin-resistant Staphylococcus aureus (MRSA), achieving a remarkable 95.6% effectiveness. This high level of activity is largely attributed to the production of reactive oxygen species (ROS) that inflict damage on bacterial cells. Furthermore, we noted promising anticancer effects against breast cancer cells, with the nanocomposite showing a lower inhibitory concentration than the cerium oxide alone.
It’s important to recognize that while folate is a key component, the full effect comes from its synergy with other compounds within this nanocomposite structure. Our research indicates that this innovative approach may offer new pathways for treatment in both bacterial resistance and cancer therapies, marking an exciting development in the field of nanomedicine.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Cancer protection
It's important to consume folic acid not just before and during pregnancy, as it may protect against various cancers, including breast cancer.
8.8
Healthy blood cells
Folic acid (vitamin B9) is crucial for the formation of healthy blood cells and assists in reducing the risk of cancer through its involvement in numerous basic bodily functions.
8
Supports cancer prevention
Folic acid is a crucial vitamin for pregnant women, essential for maintaining heart health, aiding in cancer prevention, and promoting brain health. The dosage is excellent, and the large volume means one jar lasts quite a while.
Frequently Asked Questions
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