Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Read More
8
Folate impacts heart health progression
We focused on whether folate and vitamin B12 levels influence the progression of carotid intima-media thickness (cIMT), an early sign of atherosclerosis. Our research covered over 4,200 participants in São Paulo over eight years.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
Read More
8
We explored the role of the MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension using folic acid along with enalapril treatment. Over 540 patients were divided into groups based on folic acid treatment and monitored for a year.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
Read More
Most Useful Reviews
7.5
Supports healthy cell development
1 people found this helpful
NOW Foods Folic Acid is a quality product ideal for health maintenance. It is beneficial for all ages, particularly women planning to conceive. The large package of 250 tablets allows for long-term use. The high bioavailability of folic acid is essential for maintaining healthy homocysteine levels and cell development. Regular use visibly improves the nervous system and cardiovascular health. The neutral taste makes it easy to take.
Read More
7.5
Mind and body
3 people found this helpful
Stay focused with B12 and folic acid. These tablets help maintain a healthy body and mind, strengthening both the nervous and cardiovascular systems.
Read More
7.5
Boosts cardiovascular health
1 people found this helpful
High quality and quantity—folic acid significantly contributes to enhancing the health of both the cardiovascular and nervous systems.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
- All Researches
We investigated the link between maternal folic acid supplementation and the risk of congenital heart disease (CHD) in children, considering genetic factors too. In a hospital-based case-control study with 595 children diagnosed with CHD and 605 healthy children, we found that mothers who took folic acid reduced the risk of CHD in their children.
The data indicated a noteworthy interaction between maternal supplementation and certain genetic variants in the children, particularly one MTRR gene polymorphism. However, it's important to note that further research with larger samples is necessary to strengthen these findings.
The data indicated a noteworthy interaction between maternal supplementation and certain genetic variants in the children, particularly one MTRR gene polymorphism. However, it's important to note that further research with larger samples is necessary to strengthen these findings.
Read More
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Read More
8
Folate impacts heart health progression
We focused on whether folate and vitamin B12 levels influence the progression of carotid intima-media thickness (cIMT), an early sign of atherosclerosis. Our research covered over 4,200 participants in São Paulo over eight years.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
Read More
8
We explored the role of the MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension using folic acid along with enalapril treatment. Over 540 patients were divided into groups based on folic acid treatment and monitored for a year.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
Read More
8
We explored the relationship between folic acid levels and the outcomes of ischemic stroke in a study involving over 3,500 patients. Our findings indicated that higher folate levels were linked to a 29% reduced risk of death and serious disability after three months.
Conversely, high homocysteine levels correlated with a 52% increased risk of these adverse outcomes. Additionally, we found that part of folate's protective effect was mediated through homocysteine levels. This suggests that folic acid may play a crucial role in improving ischemic stroke prognosis.
Conversely, high homocysteine levels correlated with a 52% increased risk of these adverse outcomes. Additionally, we found that part of folate's protective effect was mediated through homocysteine levels. This suggests that folic acid may play a crucial role in improving ischemic stroke prognosis.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Supports healthy cell development
1 people found this helpful
NOW Foods Folic Acid is a quality product ideal for health maintenance. It is beneficial for all ages, particularly women planning to conceive. The large package of 250 tablets allows for long-term use. The high bioavailability of folic acid is essential for maintaining healthy homocysteine levels and cell development. Regular use visibly improves the nervous system and cardiovascular health. The neutral taste makes it easy to take.
Read More
7.5
Mind and body
3 people found this helpful
Stay focused with B12 and folic acid. These tablets help maintain a healthy body and mind, strengthening both the nervous and cardiovascular systems.
Read More
7.5
Boosts cardiovascular health
1 people found this helpful
High quality and quantity—folic acid significantly contributes to enhancing the health of both the cardiovascular and nervous systems.
Read More
9
Important for health
Folic acid is highly underestimated, yet it plays a crucial role in the functioning of the cardiovascular and nervous systems. I take several courses of it each year.
Read More
7.5
Energy boost
I took this during my first pregnancy. The ingredients include 800 mcg of folic acid and Vitamin B-12, all derived from plants, making it suitable for vegetarians. The size and packaging are perfect, and the quality and taste are good, providing energy. It supports homocysteine metabolism and contributes to the health of the cardiovascular and nervous systems.
Read More
Frequently Asked Questions
7.5
Supports healthy cell development
1 people found this helpful
NOW Foods Folic Acid is a quality product ideal for health maintenance. It is beneficial for all ages, particularly women planning to conceive. The large package of 250 tablets allows for long-term use. The high bioavailability of folic acid is essential for maintaining healthy homocysteine levels and cell development. Regular use visibly improves the nervous system and cardiovascular health. The neutral taste makes it easy to take.
7.5
Boosts cardiovascular health
1 people found this helpful
High quality and quantity—folic acid significantly contributes to enhancing the health of both the cardiovascular and nervous systems.
7.5
Energy boost
I took this during my first pregnancy. The ingredients include 800 mcg of folic acid and Vitamin B-12, all derived from plants, making it suitable for vegetarians. The size and packaging are perfect, and the quality and taste are good, providing energy. It supports homocysteine metabolism and contributes to the health of the cardiovascular and nervous systems.
7.5
Mind and body
3 people found this helpful
Stay focused with B12 and folic acid. These tablets help maintain a healthy body and mind, strengthening both the nervous and cardiovascular systems.
9
Important for health
Folic acid is highly underestimated, yet it plays a crucial role in the functioning of the cardiovascular and nervous systems. I take several courses of it each year.
7.5
Increased fertility protection
175 people found this helpful
I encourage my readers to appreciate the significance of folic acid. One small tablet tackles numerous vital issues, including enhancing sperm motility in men and reducing risks associated with the fetus's health during pregnancy. A deficiency can lead to severe complications such as pregnancy issues and potential developmental disorders in the fetus. Fortunately, it's difficult to overdose on this water-soluble vitamin because excess is generally excreted safely. Individuals with severe liver or kidney conditions should monitor intake. Bookmark my page for more insights on beneficial products!
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
8
We explored the role of the MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension using folic acid along with enalapril treatment. Over 540 patients were divided into groups based on folic acid treatment and monitored for a year.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
We observed that those receiving folic acid had a lower recurrence of cardiovascular events compared to others. Additionally, the lipid levels showed improvement in the folic acid group. Therefore, folic acid may enhance overall treatment outcomes and patient compliance in managing blood pressure.
8
Folate impacts heart health progression
We focused on whether folate and vitamin B12 levels influence the progression of carotid intima-media thickness (cIMT), an early sign of atherosclerosis. Our research covered over 4,200 participants in São Paulo over eight years.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
While vitamin B12 showed no significant connection, participants with the highest folate levels experienced a slower increase in cIMT compared to those with the lowest levels. This highlights folate’s potential positive impact on cardiovascular health, particularly in populations with adequate serum folate.
4
Folate intake and mortality association
We explored how dietary folate intake relates to mortality in American adults suffering from non-alcoholic fatty liver disease (NAFLD).
Using comprehensive data from NHANES (2003-2018), we found that greater folate intake is linked to a reduced risk of all-cause mortality.
However, there was no significant connection between higher folate levels and lower cardiovascular disease mortality.
This suggests that while folate may help improve the overall health of NAFLD patients, its effects on cardiovascular outcomes are less clear and need further study.
Using comprehensive data from NHANES (2003-2018), we found that greater folate intake is linked to a reduced risk of all-cause mortality.
However, there was no significant connection between higher folate levels and lower cardiovascular disease mortality.
This suggests that while folate may help improve the overall health of NAFLD patients, its effects on cardiovascular outcomes are less clear and need further study.
References
- Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. doi:10.3390/nu17010159
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. doi:10.1186/s41043-024-00699-w
- Chen X, Bishai D. Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue. BMC Public Health. 2024;24:3540. doi:10.1186/s12889-024-21005-7
- Palchetti CZ, Gonçalves NG, Suemoto CK, Santos IS, Lotufo PA, et al. Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification. Clin Nutr ESPEN. 2025;65:144. doi:10.1016/j.clnesp.2024.11.034
- Dong J, Li Z, Wang C, Zhang R, Li Y, et al. Dietary folate intake and all-cause mortality and cardiovascular mortality in American adults with non-alcoholic fatty liver disease: Data from NHANES 2003 to 2018. PLoS One. 2024;19:e0314148. doi:10.1371/journal.pone.0314148
- Kaushik A, Bhattacharjee D, Chaudhary V, Dahal S, Devi NK, et al. Hypertension and global DNA methylation: a population-based study in rural, Punjab, India. Sci Rep. 2024;14:25826. doi:10.1038/s41598-024-77437-z
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. doi:10.14715/cmb/2024.70.9.20
- Shi M, Zheng J, Liu Y, Mao X, Wu X, et al. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke. J Am Heart Assoc. 2024;13:e036527. doi:10.1161/JAHA.124.036527
- Liang X, Huang D, Bi Y, He Y, Mao T, et al. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study. J Hum Hypertens. 2024;38:844. doi:10.1038/s41371-024-00955-w
- Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. Int J Angiol. 2024;33:262. doi:10.1055/s-0044-1788280
- Siddiqi SM, Liu L, Du Y, Song Y, Chen P, et al. Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension. J Nutr. 2024. doi:10.1016/j.tjnut.2024.09.003
