Last update
5/2/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 11 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
We examined a patient who experienced severe anemia following COVID-19, presenting with both cold agglutinin and cryoglobulin. Testing showed positivity for C3d but no significant signs of hemolytic anemia or thrombosis.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
Read More
8
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
Read More
7
In our exploration of neuropathic pain relief, we found that Vitamin B12 has a notable impact on cold sensitivity in rats with nerve injuries. The study involved male Wistar rats that underwent infraorbital nerve constriction, simulating a model of trigeminal neuropathic pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
Read More
Most Useful Reviews
9
Life-changing vitamin
84 people found this helpful
I am so pleased to have found this vitamin. It has been a life-altering experience for my family and me. My mood has improved, my energy levels have increased, and my immunity against colds is far better. I highly recommend it!
Read More
9
Helps with cold
Drinking during pregnancy, I found that my teeth were affected by the cold, yet this product provided significant relief. Subsequently, I struggled to handle cold drinks.
Read More
7.5
Quick recovery
This is a great supplement. I've only been taking it for a short time but have noticed my immune system strengthening. I caught a viral illness, possibly the most popular virus of 2020, but I got over it quickly with just a slight stuffy nose and weakness lasting two days. I previously had colds that lingered much longer.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
We examined a patient who experienced severe anemia following COVID-19, presenting with both cold agglutinin and cryoglobulin. Testing showed positivity for C3d but no significant signs of hemolytic anemia or thrombosis.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
Remarkably, the anemia improved with just folic acid supplementation, which also reduced the cold agglutination levels and normalized the direct antiglobulin test. Although cryoglobulinemia persisted, the patient remained symptom-free.
This suggests that thorough assessment is crucial before considering treatments for cold-related blood disorders following COVID-19.
Read More
8
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
Read More
7
In our exploration of neuropathic pain relief, we found that Vitamin B12 has a notable impact on cold sensitivity in rats with nerve injuries. The study involved male Wistar rats that underwent infraorbital nerve constriction, simulating a model of trigeminal neuropathic pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Life-changing vitamin
84 people found this helpful
I am so pleased to have found this vitamin. It has been a life-altering experience for my family and me. My mood has improved, my energy levels have increased, and my immunity against colds is far better. I highly recommend it!
Read More
9
Helps with cold
Drinking during pregnancy, I found that my teeth were affected by the cold, yet this product provided significant relief. Subsequently, I struggled to handle cold drinks.
Read More
7.5
Quick recovery
This is a great supplement. I've only been taking it for a short time but have noticed my immune system strengthening. I caught a viral illness, possibly the most popular virus of 2020, but I got over it quickly with just a slight stuffy nose and weakness lasting two days. I previously had colds that lingered much longer.
Read More
7.5
Strong immune system
I've recently started this supplement and have already noted a strengthening of my immune system. I caught a virus but recovered almost unnoticed, with just a slight stuffy nose and weakness lasting two days. This is a marked improvement from my usual colds.
Read More
7.5
Fast recovery
I've only been taking this supplement for a short time but have already noticed my immune system strengthening. I caught a viral illness and recovered quickly with just mild symptoms over two days, unlike my previous experiences with colds that lasted longer.
Read More
Frequently Asked Questions
8
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
7
In our exploration of neuropathic pain relief, we found that Vitamin B12 has a notable impact on cold sensitivity in rats with nerve injuries. The study involved male Wistar rats that underwent infraorbital nerve constriction, simulating a model of trigeminal neuropathic pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
We treated these rats with B vitamins, particularly focusing on Vitamin B12, to assess its effectiveness in alleviating cold hyperalgesia, which is an increased sensitivity to cold. The results showed that Vitamin B12, when given at a lower dose alongside carbamazepine, helped reduce cold pain sensitivity at certain time points.
However, the combination treatment limited our ability to fully understand the isolated effect of Vitamin B12. Still, it suggests that including B12 in pain management may offer additional benefits for those suffering from this type of nerve pain.
References
- Kaneko M, Masuda Y, Ishikawa K, Shikata H. Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection. Cureus. 2024;16:e75257. 10.7759/cureus.75257
- Tamaddonfard E, Samadi F, Egdami K. The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats. Vet Res Forum. 2013;4:19. PubMed
- Kopruszinski CM, Reis RC, Chichorro JG. B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats. Life Sci. 2012;91:1187. 10.1016/j.lfs.2012.08.025
