Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Medium or Average
Based on 3 Reviews
6.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
9.5
We aimed to explore how vitamin B12 supplementation affects individuals suffering from chronic diarrhea. In our quasi-experimental study conducted at Pakistan Ordinance Factory Hospital, we focused on new patients aged between 12 and 65 years who exhibited low serum vitamin B12 levels and normal folate levels.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
Read More
9.5
Chronic diarrhea connected to parasites
We explored a fascinating case involving two patients suffering from chronic diarrhea who also exhibited vitamin B12 deficiency. Despite undergoing numerous tests, their stool samples continually came back negative for parasites, leaving their doctors puzzled.
It wasn鈥檛 until one patient underwent a colonoscopy and the other a capsule endoscopy that the root of their issues was identified: adult forms of Diphyllobotrium spp., a parasitic infection. This highlights an essential point about the limitations of standard stool tests in diagnosing certain infections.
Following the diagnosis, both patients received targeted treatment, and we observed a remarkable turnaround in their symptoms. Their diarrhea completely resolved, reinforcing the idea that addressing underlying issues like parasitic infections can significantly impact overall health and the effective management of conditions associated with vitamin B12 deficiency.
It wasn鈥檛 until one patient underwent a colonoscopy and the other a capsule endoscopy that the root of their issues was identified: adult forms of Diphyllobotrium spp., a parasitic infection. This highlights an essential point about the limitations of standard stool tests in diagnosing certain infections.
Following the diagnosis, both patients received targeted treatment, and we observed a remarkable turnaround in their symptoms. Their diarrhea completely resolved, reinforcing the idea that addressing underlying issues like parasitic infections can significantly impact overall health and the effective management of conditions associated with vitamin B12 deficiency.
Read More
9
We explored the intriguing case of a young adult with type 1 diabetes who experienced severe diarrhea linked to autoimmune gastritis. Our findings showed that vitamin B12 treatment played a significant role in alleviating her gastrointestinal and neurological symptoms, providing a much-needed relief in her condition.
The patient, who initially presented with bowel issues that included nocturnal, non-bloody diarrhea along with lower quadrant pain and nausea, had a notably low total Immunoglobulin A (IgA) level. Despite further gastroenterological evaluations revealing little on the surface, histological analysis pointed towards autoimmune gastritis.
What stood out was the elevated fasting gastrin level along with parietal cell antibodies, which led to the diagnosis of autoimmune gastritis. Even before any vitamin B12 deficiency was noted, we found that beginning parenteral vitamin B12 therapy significantly improved her symptoms, particularly concerning her nervous system and digestive tract.
This case underscores the need for vigilance in recognizing red flags in patients with autoimmune conditions, highlighting that symptoms can manifest before traditional deficiency markers arise. Thus, vitamin B12 supplementation should be considered early, specifically in cases showing neurologic symptoms, even if vitamin levels appear normal.
The patient, who initially presented with bowel issues that included nocturnal, non-bloody diarrhea along with lower quadrant pain and nausea, had a notably low total Immunoglobulin A (IgA) level. Despite further gastroenterological evaluations revealing little on the surface, histological analysis pointed towards autoimmune gastritis.
What stood out was the elevated fasting gastrin level along with parietal cell antibodies, which led to the diagnosis of autoimmune gastritis. Even before any vitamin B12 deficiency was noted, we found that beginning parenteral vitamin B12 therapy significantly improved her symptoms, particularly concerning her nervous system and digestive tract.
This case underscores the need for vigilance in recognizing red flags in patients with autoimmune conditions, highlighting that symptoms can manifest before traditional deficiency markers arise. Thus, vitamin B12 supplementation should be considered early, specifically in cases showing neurologic symptoms, even if vitamin levels appear normal.
Read More
Most Useful Reviews
0
Persistent diarrhea
I'm single, but I purchased this for its reported benefits for unmarried individuals. Although the pills are quite small and easy to swallow, I experienced considerable diarrhoea after taking them. Initially, I thought it might be due to the lactobacillus I was also consuming, so I continued for a few more days. However, the diarrhoea persisted even without the lactobacillus, indicating that this supplement wasn't right for me.
Read More
0
Severe discomfort faced
1 people found this helpful
I experienced intense stomach cramps after taking this. It wasn't just needing to use the bathroom, but severe cramps that forced me to leave work. I've never tried it since. It may have been too much folic acid for me, but the reaction was quite painful.
Read More
2
Caused diarrhea
Unfortunately, these tiny balls caused me stomach aches and diarrhoea, possibly due to the dosage. I suggest trying a dose of 400 mcg. Ultimately, I stopped using them.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
- All Researches
9.5
We aimed to explore how vitamin B12 supplementation affects individuals suffering from chronic diarrhea. In our quasi-experimental study conducted at Pakistan Ordinance Factory Hospital, we focused on new patients aged between 12 and 65 years who exhibited low serum vitamin B12 levels and normal folate levels.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
Read More
9.5
Chronic diarrhea connected to parasites
We explored a fascinating case involving two patients suffering from chronic diarrhea who also exhibited vitamin B12 deficiency. Despite undergoing numerous tests, their stool samples continually came back negative for parasites, leaving their doctors puzzled.
It wasn鈥檛 until one patient underwent a colonoscopy and the other a capsule endoscopy that the root of their issues was identified: adult forms of Diphyllobotrium spp., a parasitic infection. This highlights an essential point about the limitations of standard stool tests in diagnosing certain infections.
Following the diagnosis, both patients received targeted treatment, and we observed a remarkable turnaround in their symptoms. Their diarrhea completely resolved, reinforcing the idea that addressing underlying issues like parasitic infections can significantly impact overall health and the effective management of conditions associated with vitamin B12 deficiency.
It wasn鈥檛 until one patient underwent a colonoscopy and the other a capsule endoscopy that the root of their issues was identified: adult forms of Diphyllobotrium spp., a parasitic infection. This highlights an essential point about the limitations of standard stool tests in diagnosing certain infections.
Following the diagnosis, both patients received targeted treatment, and we observed a remarkable turnaround in their symptoms. Their diarrhea completely resolved, reinforcing the idea that addressing underlying issues like parasitic infections can significantly impact overall health and the effective management of conditions associated with vitamin B12 deficiency.
Read More
9
We explored the intriguing case of a young adult with type 1 diabetes who experienced severe diarrhea linked to autoimmune gastritis. Our findings showed that vitamin B12 treatment played a significant role in alleviating her gastrointestinal and neurological symptoms, providing a much-needed relief in her condition.
The patient, who initially presented with bowel issues that included nocturnal, non-bloody diarrhea along with lower quadrant pain and nausea, had a notably low total Immunoglobulin A (IgA) level. Despite further gastroenterological evaluations revealing little on the surface, histological analysis pointed towards autoimmune gastritis.
What stood out was the elevated fasting gastrin level along with parietal cell antibodies, which led to the diagnosis of autoimmune gastritis. Even before any vitamin B12 deficiency was noted, we found that beginning parenteral vitamin B12 therapy significantly improved her symptoms, particularly concerning her nervous system and digestive tract.
This case underscores the need for vigilance in recognizing red flags in patients with autoimmune conditions, highlighting that symptoms can manifest before traditional deficiency markers arise. Thus, vitamin B12 supplementation should be considered early, specifically in cases showing neurologic symptoms, even if vitamin levels appear normal.
The patient, who initially presented with bowel issues that included nocturnal, non-bloody diarrhea along with lower quadrant pain and nausea, had a notably low total Immunoglobulin A (IgA) level. Despite further gastroenterological evaluations revealing little on the surface, histological analysis pointed towards autoimmune gastritis.
What stood out was the elevated fasting gastrin level along with parietal cell antibodies, which led to the diagnosis of autoimmune gastritis. Even before any vitamin B12 deficiency was noted, we found that beginning parenteral vitamin B12 therapy significantly improved her symptoms, particularly concerning her nervous system and digestive tract.
This case underscores the need for vigilance in recognizing red flags in patients with autoimmune conditions, highlighting that symptoms can manifest before traditional deficiency markers arise. Thus, vitamin B12 supplementation should be considered early, specifically in cases showing neurologic symptoms, even if vitamin levels appear normal.
Read More
4
We investigated how vitamin B12 treatment affects diarrhea in dogs suffering from chronic enteropathies (CE), particularly focusing on the differences between those with cobalamin deficiency and those with normal levels. Our study included 29 dogs with CE and cobalamin deficiency, 18 dogs with CE but normal cobalamin levels, and 10 healthy controls.
While we found significant differences in the gut microbiome among these groups, including shifts in certain bacterial populations, the treatment with vitamin B12 alone did not restore the microbiome to a healthier state. Even after providing cobalamin through oral or injectable means, none of the treatments showed improvement in the dogs' microbiome composition, suggesting that cobalamin might not be directly influencing the clinical severity of diarrhea.
Ultimately, the study indicates that while vitamin B12 is essential for many bodily functions, its supplementation is unlikely to be a standalone solution for managing diarrhea in dogs with chronic enteropathies. This points to the possibility that cobalamin deficiency is more of a marker of dysbiosis rather than a root cause of gastrointestinal issues.
While we found significant differences in the gut microbiome among these groups, including shifts in certain bacterial populations, the treatment with vitamin B12 alone did not restore the microbiome to a healthier state. Even after providing cobalamin through oral or injectable means, none of the treatments showed improvement in the dogs' microbiome composition, suggesting that cobalamin might not be directly influencing the clinical severity of diarrhea.
Ultimately, the study indicates that while vitamin B12 is essential for many bodily functions, its supplementation is unlikely to be a standalone solution for managing diarrhea in dogs with chronic enteropathies. This points to the possibility that cobalamin deficiency is more of a marker of dysbiosis rather than a root cause of gastrointestinal issues.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 3 Reviews
6.7
- All Reviews
- Positive Reviews
- Negative Reviews
0
Persistent diarrhea
I'm single, but I purchased this for its reported benefits for unmarried individuals. Although the pills are quite small and easy to swallow, I experienced considerable diarrhoea after taking them. Initially, I thought it might be due to the lactobacillus I was also consuming, so I continued for a few more days. However, the diarrhoea persisted even without the lactobacillus, indicating that this supplement wasn't right for me.
Read More
0
Severe discomfort faced
1 people found this helpful
I experienced intense stomach cramps after taking this. It wasn't just needing to use the bathroom, but severe cramps that forced me to leave work. I've never tried it since. It may have been too much folic acid for me, but the reaction was quite painful.
Read More
2
Caused diarrhea
Unfortunately, these tiny balls caused me stomach aches and diarrhoea, possibly due to the dosage. I suggest trying a dose of 400 mcg. Ultimately, I stopped using them.
Read More
Frequently Asked Questions
0
Persistent diarrhea
I'm single, but I purchased this for its reported benefits for unmarried individuals. Although the pills are quite small and easy to swallow, I experienced considerable diarrhoea after taking them. Initially, I thought it might be due to the lactobacillus I was also consuming, so I continued for a few more days. However, the diarrhoea persisted even without the lactobacillus, indicating that this supplement wasn't right for me.
2
Caused diarrhea
Unfortunately, these tiny balls caused me stomach aches and diarrhoea, possibly due to the dosage. I suggest trying a dose of 400 mcg. Ultimately, I stopped using them.
9.5
We aimed to explore how vitamin B12 supplementation affects individuals suffering from chronic diarrhea. In our quasi-experimental study conducted at Pakistan Ordinance Factory Hospital, we focused on new patients aged between 12 and 65 years who exhibited low serum vitamin B12 levels and normal folate levels.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
Our patients received parenteral vitamin B12 treatment, and we followed up with those whose diarrhea improved over six months. Remarkably, we found that all patients maintained adequate vitamin B12 levels throughout the follow-up period. Most importantly, the results showed that vitamin B12 replacement led to the resolution of diarrhea within just one week for many participants.
These findings suggest that addressing vitamin B12 deficiency can significantly help in managing chronic diarrhea. This is an important consideration for both patients and healthcare providers, as it highlights a potentially treatable cause of an often frustrating condition.
9
We explored the intriguing case of a young adult with type 1 diabetes who experienced severe diarrhea linked to autoimmune gastritis. Our findings showed that vitamin B12 treatment played a significant role in alleviating her gastrointestinal and neurological symptoms, providing a much-needed relief in her condition.
The patient, who initially presented with bowel issues that included nocturnal, non-bloody diarrhea along with lower quadrant pain and nausea, had a notably low total Immunoglobulin A (IgA) level. Despite further gastroenterological evaluations revealing little on the surface, histological analysis pointed towards autoimmune gastritis.
What stood out was the elevated fasting gastrin level along with parietal cell antibodies, which led to the diagnosis of autoimmune gastritis. Even before any vitamin B12 deficiency was noted, we found that beginning parenteral vitamin B12 therapy significantly improved her symptoms, particularly concerning her nervous system and digestive tract.
This case underscores the need for vigilance in recognizing red flags in patients with autoimmune conditions, highlighting that symptoms can manifest before traditional deficiency markers arise. Thus, vitamin B12 supplementation should be considered early, specifically in cases showing neurologic symptoms, even if vitamin levels appear normal.
The patient, who initially presented with bowel issues that included nocturnal, non-bloody diarrhea along with lower quadrant pain and nausea, had a notably low total Immunoglobulin A (IgA) level. Despite further gastroenterological evaluations revealing little on the surface, histological analysis pointed towards autoimmune gastritis.
What stood out was the elevated fasting gastrin level along with parietal cell antibodies, which led to the diagnosis of autoimmune gastritis. Even before any vitamin B12 deficiency was noted, we found that beginning parenteral vitamin B12 therapy significantly improved her symptoms, particularly concerning her nervous system and digestive tract.
This case underscores the need for vigilance in recognizing red flags in patients with autoimmune conditions, highlighting that symptoms can manifest before traditional deficiency markers arise. Thus, vitamin B12 supplementation should be considered early, specifically in cases showing neurologic symptoms, even if vitamin levels appear normal.
4
We investigated how vitamin B12 treatment affects diarrhea in dogs suffering from chronic enteropathies (CE), particularly focusing on the differences between those with cobalamin deficiency and those with normal levels. Our study included 29 dogs with CE and cobalamin deficiency, 18 dogs with CE but normal cobalamin levels, and 10 healthy controls.
While we found significant differences in the gut microbiome among these groups, including shifts in certain bacterial populations, the treatment with vitamin B12 alone did not restore the microbiome to a healthier state. Even after providing cobalamin through oral or injectable means, none of the treatments showed improvement in the dogs' microbiome composition, suggesting that cobalamin might not be directly influencing the clinical severity of diarrhea.
Ultimately, the study indicates that while vitamin B12 is essential for many bodily functions, its supplementation is unlikely to be a standalone solution for managing diarrhea in dogs with chronic enteropathies. This points to the possibility that cobalamin deficiency is more of a marker of dysbiosis rather than a root cause of gastrointestinal issues.
While we found significant differences in the gut microbiome among these groups, including shifts in certain bacterial populations, the treatment with vitamin B12 alone did not restore the microbiome to a healthier state. Even after providing cobalamin through oral or injectable means, none of the treatments showed improvement in the dogs' microbiome composition, suggesting that cobalamin might not be directly influencing the clinical severity of diarrhea.
Ultimately, the study indicates that while vitamin B12 is essential for many bodily functions, its supplementation is unlikely to be a standalone solution for managing diarrhea in dogs with chronic enteropathies. This points to the possibility that cobalamin deficiency is more of a marker of dysbiosis rather than a root cause of gastrointestinal issues.
References
- Adil N, Mehraj A, Khan J, Bhutta S, Jamil M, et al. CHRONIC DIARRHOEA: NOT A RARE PRESENTATION OF VITAMIN B 12 DEFICIENCY. J Ayub Med Coll Abbottabad. 2024;36:155. doi:10.55519/JAMC-01-13026
- Meyers TM, Reeves PT, Lombardo JL, Anisowicz SK, Larson NS, et al. Autoimmune gastritis as an unexpected cause of diarrhea in a young adult with type I diabetes: a case report. J Med Case Rep. 2023;17:342. doi:10.1186/s13256-023-04039-0
- Cedr贸n-Cheng HG. [Diphyllobotrium Spp. as a cause of chronic diarrhea diagnosed only by colonoscopy or capsule endoscopy]. Rev Gastroenterol Peru. 2023;43:57.
- Toresson L, Suchodolski JS, Spillmann T, Lopes BC, Shih J, et al. The Intestinal Microbiome in Dogs with Chronic Enteropathies and Cobalamin Deficiency or Normocobalaminemia-A Comparative Study. Animals (Basel). 2023;13. doi:10.3390/ani13081378
