' 
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
USERS' SCORE
Good
Based on 103 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
7
Folic acid shows limited protective effects
In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).
Combined treatment yields positive results.
We explored the effects of folic acid on hair loss in zebrafish larvae after exposure to different concentrations of ethanol. This study revealed how gestational ethanol exposure can harm the development of sensory hair cells. We found that even small amounts of ethanol lead to a significant decrease in hair cell count.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
Read More
7
Folate's role in hair growth unclear
L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes.
Limited specific effect on hair loss
We investigated the effects of folate within a well-structured study that examined its role in hair loss treatments. Although part of a marketed oral combination for diffuse hair loss, folate's specific impact was challenging to isolate because it was evaluated alongside other compounds.
Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.
Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.
Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
Read More
Most Useful Reviews
9.5
Mood improved
After two months on these supplements, my hair loss stopped within the first month. My overall health improved, especially my mood and sleep quality. I also noticed an enhancement in my skin condition, although that may relate more to my skincare routine.
Read More
9.5
Overcame hair loss
Folic acid with Biotin helped me during a crisis of hair loss. An integrated approach, perhaps including Merz vitamins, contributed to my success. Many believe only pregnant women need folic acid, but everyone, including men, does. Factors like smoking and poor diet can lead to a common deficiency. Symptoms may include irritability and hair loss. After two weeks, my psycho-emotional state improved, my skin became more even, dryness reduced, and notably, hair loss decreased considerably. My hair did become greasier at the roots, and the scalp was less dry throughout the supplementation period.
Read More
9.5
Recommended by doctor
My doctor suggested this before pregnancy for fetal health, and I noticed it significantly helped my hair loss. I highly recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
- All Researches
7
Folate's role in hair growth unclear
L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes.
Limited specific effect on hair loss
We investigated the effects of folate within a well-structured study that examined its role in hair loss treatments. Although part of a marketed oral combination for diffuse hair loss, folate's specific impact was challenging to isolate because it was evaluated alongside other compounds.
Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.
Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.
Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
Read More
7
Folic acid shows limited protective effects
In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).
Combined treatment yields positive results.
We explored the effects of folic acid on hair loss in zebrafish larvae after exposure to different concentrations of ethanol. This study revealed how gestational ethanol exposure can harm the development of sensory hair cells. We found that even small amounts of ethanol lead to a significant decrease in hair cell count.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.
Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
Read More
User Reviews
USERS' SCORE
Good
Based on 103 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Mood improved
After two months on these supplements, my hair loss stopped within the first month. My overall health improved, especially my mood and sleep quality. I also noticed an enhancement in my skin condition, although that may relate more to my skincare routine.
9.5
Overcame hair loss
Folic acid with Biotin helped me during a crisis of hair loss. An integrated approach, perhaps including Merz vitamins, contributed to my success. Many believe only pregnant women need folic acid, but everyone, including men, does. Factors like smoking and poor diet can lead to a common deficiency. Symptoms may include irritability and hair loss. After two weeks, my psycho-emotional state improved, my skin became more even, dryness reduced, and notably, hair loss decreased considerably. My hair did become greasier at the roots, and the scalp was less dry throughout the supplementation period.
Read More
9.5
Recommended by doctor
My doctor suggested this before pregnancy for fetal health, and I noticed it significantly helped my hair loss. I highly recommend it.
9.5
Reduced hair loss
This product is great for pregnant women in the early months. I personally observed that it improves my skin and hair significantly while wonderfully reducing hair loss.
9.5
Stopped hair loss
Pairing Now Foods Biotin with this supplement virtually stopped my hair loss. The package includes 250 tablets, taken once daily after breakfast. My overall health improved significantly. Within two weeks, I experienced smoother skin and less hair loss; my scalp became oilier, and it’s less dry now.
Read More
