5/29/2025
Last update
5/29/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
This cross-sectional study analyzed data from nearly 10,000 adults to investigate the link between dietary folate intake and severe headaches. We found that individuals with higher folate intake were less likely to report severe headaches. For example, those in the highest intake category showed a notable decrease in headache prevalence. Interestingly, this connection seemed especially relevant for women aged 20-50, suggesting they could benefit from increasing their folate consumption. Overall, while the findings indicate a potential protective effect of folic acid, they highlight the importance of a balanced diet for headache management.
Read More
8
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
Read More
Most Useful Reviews
9
Noticed improvements
The capsule quality is commendable and while I felt persistent headaches and fatigue beforehand, now that I've been taking this for 10 days, I have more energy and no headaches. It’s an excellent supplement for everyone, especially athletes.
Read More
0
Side effects noted
3 people found this helpful
Although I adore this brand, I experienced side effects after 2-3 weeks, including drowsiness, headaches, and a tightness at the back of my neck. It may be my unique response to folate. I recommend caution and tuning into your body!
Read More
7.5
Headache relief
2 people found this helpful
Despite its small size, this tablet has a significant effect: I have headaches if I miss a dose. It truly works wonders, and I plan to continue taking it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
- All Researches
9
We investigated a unique case involving a 14-year-old girl suffering from headaches and diagnosed with cerebral venous thrombosis linked to a rare mutation at the MTHFR locus.
After identifying elevated homocysteine levels and significant intracranial pressure, her treatment combined anticoagulation and vitamin supplements. Remarkably, one month later, her headaches resolved, and imaging showed notable improvement in her condition.
This case suggests that rare genetic mutations and corresponding treatments could play a key role in managing headache and thrombotic conditions.
After identifying elevated homocysteine levels and significant intracranial pressure, her treatment combined anticoagulation and vitamin supplements. Remarkably, one month later, her headaches resolved, and imaging showed notable improvement in her condition.
This case suggests that rare genetic mutations and corresponding treatments could play a key role in managing headache and thrombotic conditions.
Read More
9
We explored how B vitamins, including folic acid, might alleviate migraine headaches in women with episodic migraine. Conducting a well-structured double-blind, placebo-controlled trial, we assessed 120 participants over 12 weeks.
Results showed significant improvements in headache frequency and migraine-related disability among those taking the B vitamins, compared to the placebo group. Folic acid, along with other B vitamins, appeared beneficial in reducing the need for abortive medication. However, more extensive studies are necessary to solidify these findings.
Results showed significant improvements in headache frequency and migraine-related disability among those taking the B vitamins, compared to the placebo group. Folic acid, along with other B vitamins, appeared beneficial in reducing the need for abortive medication. However, more extensive studies are necessary to solidify these findings.
Read More
9
We examined the connection between genetic differences in folate metabolism and migraine experiences in children aged 7 to 18. The study involved 54 children with migraine symptoms and a control group of 115 others without neurological issues.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Read More
8
We explored the relationship between dietary vitamin B and folate intake and the risk of migraines in US adults. Analyzing data from over 7,000 participants aged 20 and older from the National Health and Nutrition Examination Survey, we found that higher intake of these nutrients was linked to a lower risk of severe headaches or migraines.
Interestingly, those who consumed significant amounts of both vitamin B and folate experienced even greater benefits in preventing migraines. While further research is needed, these findings suggest that increasing our intake of vitamin B and folate might help in managing migraines.
Interestingly, those who consumed significant amounts of both vitamin B and folate experienced even greater benefits in preventing migraines. While further research is needed, these findings suggest that increasing our intake of vitamin B and folate might help in managing migraines.
Read More
8
This cross-sectional study analyzed data from nearly 10,000 adults to investigate the link between dietary folate intake and severe headaches. We found that individuals with higher folate intake were less likely to report severe headaches. For example, those in the highest intake category showed a notable decrease in headache prevalence. Interestingly, this connection seemed especially relevant for women aged 20-50, suggesting they could benefit from increasing their folate consumption. Overall, while the findings indicate a potential protective effect of folic acid, they highlight the importance of a balanced diet for headache management.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Noticed improvements
The capsule quality is commendable and while I felt persistent headaches and fatigue beforehand, now that I've been taking this for 10 days, I have more energy and no headaches. It’s an excellent supplement for everyone, especially athletes.
Read More
0
Side effects noted
3 people found this helpful
Although I adore this brand, I experienced side effects after 2-3 weeks, including drowsiness, headaches, and a tightness at the back of my neck. It may be my unique response to folate. I recommend caution and tuning into your body!
Read More
7.5
Headache relief
2 people found this helpful
Despite its small size, this tablet has a significant effect: I have headaches if I miss a dose. It truly works wonders, and I plan to continue taking it.
Read More
7.5
Improved condition
My ischemic headache condition has improved greatly.
Read More
7.5
Purchased again
I bought this specifically for headaches and will certainly repurchase once I finish the current supply.
Read More
Frequently Asked Questions
9
Noticed improvements
The capsule quality is commendable and while I felt persistent headaches and fatigue beforehand, now that I've been taking this for 10 days, I have more energy and no headaches. It’s an excellent supplement for everyone, especially athletes.
0
Side effects noted
3 people found this helpful
Although I adore this brand, I experienced side effects after 2-3 weeks, including drowsiness, headaches, and a tightness at the back of my neck. It may be my unique response to folate. I recommend caution and tuning into your body!
7.5
Improved condition
My ischemic headache condition has improved greatly.
7.5
Headache relief
2 people found this helpful
Despite its small size, this tablet has a significant effect: I have headaches if I miss a dose. It truly works wonders, and I plan to continue taking it.
8
This cross-sectional study analyzed data from nearly 10,000 adults to investigate the link between dietary folate intake and severe headaches. We found that individuals with higher folate intake were less likely to report severe headaches. For example, those in the highest intake category showed a notable decrease in headache prevalence. Interestingly, this connection seemed especially relevant for women aged 20-50, suggesting they could benefit from increasing their folate consumption. Overall, while the findings indicate a potential protective effect of folic acid, they highlight the importance of a balanced diet for headache management.
8
We explored the relationship between dietary vitamin B and folate intake and the risk of migraines in US adults. Analyzing data from over 7,000 participants aged 20 and older from the National Health and Nutrition Examination Survey, we found that higher intake of these nutrients was linked to a lower risk of severe headaches or migraines.
Interestingly, those who consumed significant amounts of both vitamin B and folate experienced even greater benefits in preventing migraines. While further research is needed, these findings suggest that increasing our intake of vitamin B and folate might help in managing migraines.
Interestingly, those who consumed significant amounts of both vitamin B and folate experienced even greater benefits in preventing migraines. While further research is needed, these findings suggest that increasing our intake of vitamin B and folate might help in managing migraines.
7
We delved into the link between serum folate levels and the occurrence of severe headaches or migraines in a large population. Using data from the National Health and Nutrition Examination Survey, we found that higher serum folate levels were associated with a lower likelihood of experiencing migraines.
The results suggested that this relationship was particularly strong among women, those aged 20 to 50, and non-Hispanic White individuals. However, while promising, further research is essential to confirm and broaden these findings.
The results suggested that this relationship was particularly strong among women, those aged 20 to 50, and non-Hispanic White individuals. However, while promising, further research is essential to confirm and broaden these findings.
9
We explored how B vitamins, including folic acid, might alleviate migraine headaches in women with episodic migraine. Conducting a well-structured double-blind, placebo-controlled trial, we assessed 120 participants over 12 weeks.
Results showed significant improvements in headache frequency and migraine-related disability among those taking the B vitamins, compared to the placebo group. Folic acid, along with other B vitamins, appeared beneficial in reducing the need for abortive medication. However, more extensive studies are necessary to solidify these findings.
Results showed significant improvements in headache frequency and migraine-related disability among those taking the B vitamins, compared to the placebo group. Folic acid, along with other B vitamins, appeared beneficial in reducing the need for abortive medication. However, more extensive studies are necessary to solidify these findings.
4
We explored the role of B6, folate, and B12 in managing migraines, particularly for those with aura. Our systematic search uncovered twelve articles on the subject.
While the use of these vitamins didn't show promise in treating acute attacks, they did demonstrate significant benefits for adults with migraine with aura when used as preventive measures. Folate alone, however, did not outperform placebo.
Despite the mixed findings, these vitamins were generally well-tolerated, with mild gastrointestinal issues being the most common side effects. Further research is needed to confirm these results.
While the use of these vitamins didn't show promise in treating acute attacks, they did demonstrate significant benefits for adults with migraine with aura when used as preventive measures. Folate alone, however, did not outperform placebo.
Despite the mixed findings, these vitamins were generally well-tolerated, with mild gastrointestinal issues being the most common side effects. Further research is needed to confirm these results.
References
- Luwen H, Ping C, Qing-Rong O, Lei X, Linlin L, et al. Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study. Medicine (Baltimore). 2024;103:e40458. 10.1097/MD.0000000000040458
- Tian S, Yu X, Wu L, Zheng H, Zhong X, et al. Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004. Nutr Res. 2024;121:51. 10.1016/j.nutres.2023.11.008
- Tian S, Wu L, Zheng H, Zhong X, Liu M, et al. Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey. Br J Nutr. 2024;131:438. 10.1017/S000711452300137X
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. 10.1186/s12883-023-03200-y
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. 10.18502/cjn.v21i2.10494
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. 10.17116/jnevro202512501147
- Zhao D, Long X, Wang J. Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey. Front Nutr. 2024;11:1456502. 10.3389/fnut.2024.1456502
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. 10.3892/mi.2022.45
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. 10.1007/s13760-020-01491-3
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. 10.1080/01616412.2025.2462735
