Last update
6/17/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
7
We reviewed numerous studies to understand the skin reactions stemming from Methotrexate (MTX). Our analysis included data from over 8,000 papers, ultimately focusing on 31 relevant studies involving 38 patients.
Common skin issues included severe conditions like toxic epidermal necrolysis and erythema multiforme. While we found that immediate withdrawal of MTX and treatments, including folic acid supplementation, were beneficial, it's clear that healthcare providers must recognize these possible reactions to prevent severe consequences.
Common skin issues included severe conditions like toxic epidermal necrolysis and erythema multiforme. While we found that immediate withdrawal of MTX and treatments, including folic acid supplementation, were beneficial, it's clear that healthcare providers must recognize these possible reactions to prevent severe consequences.
Read More
Most Useful Reviews
8
No rash issues
4 people found this helpful
A good supplement for individuals with problematic skin, such as psoriasis. It is suitable for daily use and does not trigger allergic reactions that cause a rash on the skin.
Read More
9
Forgotten problem
It helps me combat persistent skin rashes; I take it in courses, and I can confidently say that I have forgotten this issue.
Read More
7
Improved skin
I noticed that while taking folic acid, my hair's structure has improved, becoming shinier, and there are fewer rashes on my face.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
- All Researches
7
We reviewed numerous studies to understand the skin reactions stemming from Methotrexate (MTX). Our analysis included data from over 8,000 papers, ultimately focusing on 31 relevant studies involving 38 patients.
Common skin issues included severe conditions like toxic epidermal necrolysis and erythema multiforme. While we found that immediate withdrawal of MTX and treatments, including folic acid supplementation, were beneficial, it's clear that healthcare providers must recognize these possible reactions to prevent severe consequences.
Common skin issues included severe conditions like toxic epidermal necrolysis and erythema multiforme. While we found that immediate withdrawal of MTX and treatments, including folic acid supplementation, were beneficial, it's clear that healthcare providers must recognize these possible reactions to prevent severe consequences.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8
No rash issues
4 people found this helpful
A good supplement for individuals with problematic skin, such as psoriasis. It is suitable for daily use and does not trigger allergic reactions that cause a rash on the skin.
Read More
9
Forgotten problem
It helps me combat persistent skin rashes; I take it in courses, and I can confidently say that I have forgotten this issue.
Read More
7
Improved skin
I noticed that while taking folic acid, my hair's structure has improved, becoming shinier, and there are fewer rashes on my face.
Read More
Frequently Asked Questions
9
Forgotten problem
It helps me combat persistent skin rashes; I take it in courses, and I can confidently say that I have forgotten this issue.
7
Improved skin
I noticed that while taking folic acid, my hair's structure has improved, becoming shinier, and there are fewer rashes on my face.
8
No rash issues
4 people found this helpful
A good supplement for individuals with problematic skin, such as psoriasis. It is suitable for daily use and does not trigger allergic reactions that cause a rash on the skin.
References
- Zuber M, Chhabra M, Venkataraman R, Kumar S, Rashid M. Methotrexate related cutaneous adverse drug reactions: a systematic literature review. J Basic Clin Physiol Pharmacol. 2022;33:549. 10.1515/jbcpp-2021-0165
