' 
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
9
Causal link: Folic acid and ulcers
Causal association of folic acid supplementary therapy and gastric ulcer: a Mendelian randomisation study.
High relevance to folate research
Our investigation focused on the potential benefits of folic acid (FA) supplementary therapy in reducing the risk of gastric ulcers (GU). Using a method called Mendelian randomisation, we tapped into data from the UK Biobank, which provided a rich source of information for our analysis.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
Read More
9
Effects of folate on ulcerative colitis
Effects of folate-chicory acid liposome on macrophage polarization and TLR4/NF-κB signaling pathway in ulcerative colitis mouse.
Combined effects of folate and chicory
We delved into how folate treatment, specifically through folate-chicory acid liposomes, affects ulcerative colitis (UC). This study involved both laboratory models that mimic inflammation caused by LPS and a mouse model of UC induced by dextran sulfate sodium (DSS). Our goal was to see whether these specialized liposomes could help target macrophages and improve symptoms associated with UC.
Our findings revealed that the folate-chicory acid liposomes not only targeted macrophages effectively but also exhibited high encapsulation efficiency and a manageable particle size. In laboratory tests, we observed that they reduced inflammation in macrophages and controlled the expression of key inflammatory markers. When applied to UC mice, these liposomes showed promising results by alleviating clinical symptoms, increasing colon length, and reducing histopathological damage.
We noted that the treatment worked by inhibiting the polarization of macrophages towards the harmful M1 phenotype while downregulating the TLR4/NF-κB signaling pathway, which is often associated with inflammation. Overall, the folate-chicory acid liposome demonstrated significant therapeutic potential for managing ulcerative colitis.
Our findings revealed that the folate-chicory acid liposomes not only targeted macrophages effectively but also exhibited high encapsulation efficiency and a manageable particle size. In laboratory tests, we observed that they reduced inflammation in macrophages and controlled the expression of key inflammatory markers. When applied to UC mice, these liposomes showed promising results by alleviating clinical symptoms, increasing colon length, and reducing histopathological damage.
We noted that the treatment worked by inhibiting the polarization of macrophages towards the harmful M1 phenotype while downregulating the TLR4/NF-κB signaling pathway, which is often associated with inflammation. Overall, the folate-chicory acid liposome demonstrated significant therapeutic potential for managing ulcerative colitis.
Read More
9
Genetic insights into ulcer healing
Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations.
Vitamin B12 aids in ulcer healing
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Read More
Most Useful Reviews
8.3
Rapid healing effect
I took this to heal ulcers in my stomach, and the effect has been excellent. I've noticed that my hair and nails have also started to grow significantly faster.
Read More
8
Effective for ulcers
I purchased this product to address my mouth ulcer and rough skin. It comes highly recommended as it is small, easy to consume, and reasonably priced. During this fluctuating period, I hope to keep taking it for some time and maintain my current condition.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.5
- All Researches
9.5
Vitamin B12's Role in Oral Health
Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis.
Moderate relevance to hematological factors
We explored the connection between recurrent aphthous stomatitis (RAS), commonly known as oral ulcers, and various hematological parameters, particularly focusing on vitamin B12. Our systematic review and meta-analysis brought together multiple studies to identify how deficiencies in this vitamin and other blood-related factors might influence the formation and recurrence of these painful ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
From our analysis, we discovered that individuals suffering from RAS had significantly lower levels of vitamin B12 and hemoglobin compared to healthy individuals. Specifically, our findings showed that participants with vitamin B12 deficiency were nearly three times more likely to develop RAS than those without the deficiency. This suggests that vitamin B12 may play a crucial role in maintaining oral health and preventing the occurrence of these ulcers.
The study highlights that addressing vitamin B12 levels could be a beneficial strategy in managing RAS. By ensuring adequate levels of this essential vitamin, we might reduce the frequency and severity of ulcers that many deal with regularly. Overall, our research emphasizes the importance of monitoring and potentially supplementing vitamin B12 for those experiencing recurrent oral ulcers.
Read More
9
Causal link: Folic acid and ulcers
Causal association of folic acid supplementary therapy and gastric ulcer: a Mendelian randomisation study.
High relevance to folate research
Our investigation focused on the potential benefits of folic acid (FA) supplementary therapy in reducing the risk of gastric ulcers (GU). Using a method called Mendelian randomisation, we tapped into data from the UK Biobank, which provided a rich source of information for our analysis.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
The analysis involved identifying seven genetic markers associated with FA supplementation. Through robust testing that included several statistical methods, we found that those genetically predisposed to higher FA intake had a significantly lower risk of developing GU.
Specifically, we observed that the odds of having a gastric ulcer dropped by about 13% among participants who were genetically linked to higher levels of FA supplementation. This finding remained consistent across various statistical approaches, reinforcing our confidence in the results.
Furthermore, we confirmed that no single genetic marker skewed the overall results, suggesting a reliable association. Overall, this study provides compelling evidence that supplementing our diet with folic acid could play a protective role against gastric ulcers.
Read More
9
Effects of folate on ulcerative colitis
Effects of folate-chicory acid liposome on macrophage polarization and TLR4/NF-κB signaling pathway in ulcerative colitis mouse.
Combined effects of folate and chicory
We delved into how folate treatment, specifically through folate-chicory acid liposomes, affects ulcerative colitis (UC). This study involved both laboratory models that mimic inflammation caused by LPS and a mouse model of UC induced by dextran sulfate sodium (DSS). Our goal was to see whether these specialized liposomes could help target macrophages and improve symptoms associated with UC.
Our findings revealed that the folate-chicory acid liposomes not only targeted macrophages effectively but also exhibited high encapsulation efficiency and a manageable particle size. In laboratory tests, we observed that they reduced inflammation in macrophages and controlled the expression of key inflammatory markers. When applied to UC mice, these liposomes showed promising results by alleviating clinical symptoms, increasing colon length, and reducing histopathological damage.
We noted that the treatment worked by inhibiting the polarization of macrophages towards the harmful M1 phenotype while downregulating the TLR4/NF-κB signaling pathway, which is often associated with inflammation. Overall, the folate-chicory acid liposome demonstrated significant therapeutic potential for managing ulcerative colitis.
Our findings revealed that the folate-chicory acid liposomes not only targeted macrophages effectively but also exhibited high encapsulation efficiency and a manageable particle size. In laboratory tests, we observed that they reduced inflammation in macrophages and controlled the expression of key inflammatory markers. When applied to UC mice, these liposomes showed promising results by alleviating clinical symptoms, increasing colon length, and reducing histopathological damage.
We noted that the treatment worked by inhibiting the polarization of macrophages towards the harmful M1 phenotype while downregulating the TLR4/NF-κB signaling pathway, which is often associated with inflammation. Overall, the folate-chicory acid liposome demonstrated significant therapeutic potential for managing ulcerative colitis.
Read More
9
Genetic insights into ulcer healing
Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations.
Vitamin B12 aids in ulcer healing
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Read More
9
Vitamin B enhances ulcer recovery
Vitamin B is a limiting factor for induced cellular plasticity and tissue repair.
Vitamin B12 effects not isolated
We examined how vitamin B, particularly in the context of induced cellular plasticity, can impact ulcer healing. The research reveals that when the reprogramming factors OCT4, SOX2, KLF4, and MYC (known as OSKM) were expressed in mice, there was a notable depletion of vitamin B. This depletion was coupled with signs of methionine starvation, which can hinder proper metabolic functioning.
Our findings indicate that adding vitamin B can boost the efficiency of cellular reprogramming and enhance tissue repair processes. Specifically, vitamin B supplementation showed a considerable effect in accelerating recovery in models of ulcerative colitis. We also uncovered that vitamin B affects key epigenetic markers, which are essential for maintaining accurate gene expression during reprogramming and repair.
While the study highlights vitamin B's significant role in tissue healing, it doesn't specifically isolate vitamin B12 from other elements, making it difficult to pinpoint its individual contribution. Nonetheless, we can confidently say that boosting vitamin B levels could enhance the body's natural healing processes, particularly regarding ulcers.
Our findings indicate that adding vitamin B can boost the efficiency of cellular reprogramming and enhance tissue repair processes. Specifically, vitamin B supplementation showed a considerable effect in accelerating recovery in models of ulcerative colitis. We also uncovered that vitamin B affects key epigenetic markers, which are essential for maintaining accurate gene expression during reprogramming and repair.
While the study highlights vitamin B's significant role in tissue healing, it doesn't specifically isolate vitamin B12 from other elements, making it difficult to pinpoint its individual contribution. Nonetheless, we can confidently say that boosting vitamin B levels could enhance the body's natural healing processes, particularly regarding ulcers.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.3
Rapid healing effect
I took this to heal ulcers in my stomach, and the effect has been excellent. I've noticed that my hair and nails have also started to grow significantly faster.
8
Effective for ulcers
I purchased this product to address my mouth ulcer and rough skin. It comes highly recommended as it is small, easy to consume, and reasonably priced. During this fluctuating period, I hope to keep taking it for some time and maintain my current condition.
