Garlic compounds reduce allergy symptomsN-benzyl-N-methyldecan-1-amine, derived from garlic, and its derivative alleviate 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice.
Garlic's role in allergy treatment
We explored the use of two compounds derived from garlic, N-benzyl-N-methyldecan-1-amine (BMDA) and its derivative, in addressing atopic dermatitis (AD) symptoms in mice. The study focused on whether these garlic-based treatments could alleviate skin lesions induced by a known irritant, 2,4-dinitrochlorobenzene (DNCB).
Our findings showed that topical application of BMDA and its derivative significantly reduced swelling, redness, and scratching associated with AD-like conditions. We noticed a remarkable decrease in skin inflammation and a reduction in the number of mast cells, which play a key role in allergic responses. Notably, the treatments also lowered IgE levels, a marker often related to allergic reactions, suggesting that these compounds could affect the underlying allergic response.
Furthermore, by analyzing skin samples, we found that the garlic-derived compounds decreased the levels of several inflammatory cytokines that typically drive allergic reactions. This extended to major inflammation-related signaling molecules, indicating that the treatment helped calm the overactive immune response often seen in allergic conditions like AD.
Overall, our research suggests that BMDA and DMMA have potential as novel treatments for managing inflammatory responses associated with allergies, particularly atopic dermatitis. This is exciting because it opens the door to new, plant-based approaches for allergy treatment while emphasizing the health benefits of garlic and its derivatives.
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