Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 4 Researches
9
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 3 Softgels
Amount Per Serving
%DV
Garlic Oil Concentrate (Allium sativum) (Bulb) (Equivalent to 4,500 mg of Whole Clove Garlic)
9 mg
*
Top Medical Research Studies
9
Garlic polysaccharides aid ulcerative colitis
We examined how water-soluble garlic polysaccharides can impact ulcerative colitis, a chronic inflammatory condition affecting the colon. This study highlighted the importance of garlic’s role in improving gut health by influencing the intestinal barrier and the balance of gut bacteria.
Throughout our research, we observed that garlic polysaccharides not only strengthened the intestinal barrier but also played a significant role in modulating the metabolites produced by intestinal flora. By enhancing these aspects, garlic showed potential as a supportive treatment for individuals grappling with ulcerative colitis.
The results suggest that incorporating garlic polysaccharides into one's diet could be beneficial for gut health. However, it’s essential to approach garlic treatment as a complementary option rather than a standalone solution. We believe these findings contribute to a better understanding of dietary interventions for ulcerative colitis.
Throughout our research, we observed that garlic polysaccharides not only strengthened the intestinal barrier but also played a significant role in modulating the metabolites produced by intestinal flora. By enhancing these aspects, garlic showed potential as a supportive treatment for individuals grappling with ulcerative colitis.
The results suggest that incorporating garlic polysaccharides into one's diet could be beneficial for gut health. However, it’s essential to approach garlic treatment as a complementary option rather than a standalone solution. We believe these findings contribute to a better understanding of dietary interventions for ulcerative colitis.
Read More
9
We investigated how Diallyl trisulfide (DATS), a natural compound found in garlic, can help alleviate ulcerative colitis (UC). The study focused on how DATS affects inflammation in the intestines of mice suffering from colitis induced by dextran sodium sulfate (DSS).
Over a span of 10 days, we administered DATS to the mice and observed a significant reduction in both macrophage infiltration and detrimental changes in the colon's tissue. Importantly, DATS seemed to lower the levels of inflammatory markers like IL-1β and IL-18 and inhibited the activation of the NLRP3 inflammasome, which plays a role in the body’s inflammatory response.
Mechanistically, we noticed that DATS effectively reduced the production of reactive oxygen species (ROS) in macrophages. Interestingly, when we interfered with the ability of macrophages to produce ROS, the benefits of DATS on inflammation were diminished. This suggests that ROS are crucial for the actions of DATS.
Furthermore, our findings indicated that DATS suppressed the NF-κB signaling pathway by inhibiting the expression of Trx-1, a protein that influences NLRP3 inflammasome activation. This interplay is vital as it showcases the potential of garlic and DATS not just in managing, but possibly preventing UC by modulating inflammatory responses through a specific pathway.
The implications of these findings point to the promising role of garlic extracts as a natural approach in the treatment of ulcerative colitis, emphasizing the importance of continuing research in this area.
Over a span of 10 days, we administered DATS to the mice and observed a significant reduction in both macrophage infiltration and detrimental changes in the colon's tissue. Importantly, DATS seemed to lower the levels of inflammatory markers like IL-1β and IL-18 and inhibited the activation of the NLRP3 inflammasome, which plays a role in the body’s inflammatory response.
Mechanistically, we noticed that DATS effectively reduced the production of reactive oxygen species (ROS) in macrophages. Interestingly, when we interfered with the ability of macrophages to produce ROS, the benefits of DATS on inflammation were diminished. This suggests that ROS are crucial for the actions of DATS.
Furthermore, our findings indicated that DATS suppressed the NF-κB signaling pathway by inhibiting the expression of Trx-1, a protein that influences NLRP3 inflammasome activation. This interplay is vital as it showcases the potential of garlic and DATS not just in managing, but possibly preventing UC by modulating inflammatory responses through a specific pathway.
The implications of these findings point to the promising role of garlic extracts as a natural approach in the treatment of ulcerative colitis, emphasizing the importance of continuing research in this area.
Read More
9
We evaluated the effects of water-soluble garlic polysaccharide (WSGP) on ulcerative colitis (UC), a chronic condition that causes inflammation in the colon. Our study used a mouse model, where we assessed improvements in health by monitoring food intake, weight gain, and colon length alongside various measures of inflammation and tissue damage.
Notably, WSGP supplementation showed promise in improving the overall health of UC-affected mice. The results indicated that WSGP not only helped restore intestinal integrity but also reduced inflammation, which we observed by measuring specific signaling pathways.
The key findings highlighted that WSGP decreased the production of inflammation-related factors and positively influenced gut microbial metabolites. This indicates that garlic's benefits might extend beyond just physical healing; it may also support a healthier balance of gut bacteria, which plays a crucial role in our digestive health.
Overall, our research underscores the potential of garlic polysaccharides as a therapeutic option for managing ulcerative colitis, demonstrating significant improvements in both tissue health and digestive function.
Notably, WSGP supplementation showed promise in improving the overall health of UC-affected mice. The results indicated that WSGP not only helped restore intestinal integrity but also reduced inflammation, which we observed by measuring specific signaling pathways.
The key findings highlighted that WSGP decreased the production of inflammation-related factors and positively influenced gut microbial metabolites. This indicates that garlic's benefits might extend beyond just physical healing; it may also support a healthier balance of gut bacteria, which plays a crucial role in our digestive health.
Overall, our research underscores the potential of garlic polysaccharides as a therapeutic option for managing ulcerative colitis, demonstrating significant improvements in both tissue health and digestive function.
Read More
Most Useful Reviews
9
Helps prevent ulcers
Excellent! Garlic oil, 1500 mg, is highly beneficial for the body. It assists in suppressing pathogenic microorganisms in the digestive system, boosts immunity, normalises lipid metabolism, and reduces blood cholesterol levels. Additionally, it helps prevent atherosclerosis and cardiovascular issues, neutralises free radicals, slowing down natural ageing, and may prevent the onset and growth of cancer cells. Regularly using garlic is effective in eliminating parasites, healing the body and averting infections, particularly from Helicobacter bacteria, which cause ulcers.
Read More
6
Supports ulcer relief
This product is good; you can definitely taste the garlic. I've noticed improvements in my cardiovascular health, and the packaging is designed to prevent burning, making it suitable for those with ulcers. I am just starting to take it, so I look forward to experiencing more benefits, especially concerning my immunity.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 4 Researches
9
- All Researches
9
We evaluated how garlic oil, in combination with nanochitosan, influences the treatment of diabetic foot ulcers caused by harmful bacteria. Our study involved testing different types of nanochitosan, derived from crab, shrimp, and squilla, all coated with garlic oil to see if they could effectively combat bacterial infections.
The analysis revealed that the combination of garlic oil with nanochitosan showed promising antibacterial activity, particularly against resistant strains of bacteria. Through techniques like GC-MS and dynamic light scattering, we confirmed that garlic oil had significant components that contributed to this activity.
Findings indicated that the formulation using squilla nanochitosan and garlic oil, when paired with the antibiotic pipercillin, not only reduced the bacteria's virulence but also showed lower minimum inhibitory concentration values, suggesting it could enhance treatment outcomes.
This combined approach may offer a legitimate alternative for managing diabetic foot infections, particularly those that resist conventional treatments. Overall, garlic oil along with nanochitosan emerges as a potential powerhouse in our fight against these tough infections.
The analysis revealed that the combination of garlic oil with nanochitosan showed promising antibacterial activity, particularly against resistant strains of bacteria. Through techniques like GC-MS and dynamic light scattering, we confirmed that garlic oil had significant components that contributed to this activity.
Findings indicated that the formulation using squilla nanochitosan and garlic oil, when paired with the antibiotic pipercillin, not only reduced the bacteria's virulence but also showed lower minimum inhibitory concentration values, suggesting it could enhance treatment outcomes.
This combined approach may offer a legitimate alternative for managing diabetic foot infections, particularly those that resist conventional treatments. Overall, garlic oil along with nanochitosan emerges as a potential powerhouse in our fight against these tough infections.
Read More
9
Garlic polysaccharides aid ulcerative colitis
We examined how water-soluble garlic polysaccharides can impact ulcerative colitis, a chronic inflammatory condition affecting the colon. This study highlighted the importance of garlic’s role in improving gut health by influencing the intestinal barrier and the balance of gut bacteria.
Throughout our research, we observed that garlic polysaccharides not only strengthened the intestinal barrier but also played a significant role in modulating the metabolites produced by intestinal flora. By enhancing these aspects, garlic showed potential as a supportive treatment for individuals grappling with ulcerative colitis.
The results suggest that incorporating garlic polysaccharides into one's diet could be beneficial for gut health. However, it’s essential to approach garlic treatment as a complementary option rather than a standalone solution. We believe these findings contribute to a better understanding of dietary interventions for ulcerative colitis.
Throughout our research, we observed that garlic polysaccharides not only strengthened the intestinal barrier but also played a significant role in modulating the metabolites produced by intestinal flora. By enhancing these aspects, garlic showed potential as a supportive treatment for individuals grappling with ulcerative colitis.
The results suggest that incorporating garlic polysaccharides into one's diet could be beneficial for gut health. However, it’s essential to approach garlic treatment as a complementary option rather than a standalone solution. We believe these findings contribute to a better understanding of dietary interventions for ulcerative colitis.
Read More
9
We investigated how Diallyl trisulfide (DATS), a natural compound found in garlic, can help alleviate ulcerative colitis (UC). The study focused on how DATS affects inflammation in the intestines of mice suffering from colitis induced by dextran sodium sulfate (DSS).
Over a span of 10 days, we administered DATS to the mice and observed a significant reduction in both macrophage infiltration and detrimental changes in the colon's tissue. Importantly, DATS seemed to lower the levels of inflammatory markers like IL-1β and IL-18 and inhibited the activation of the NLRP3 inflammasome, which plays a role in the body’s inflammatory response.
Mechanistically, we noticed that DATS effectively reduced the production of reactive oxygen species (ROS) in macrophages. Interestingly, when we interfered with the ability of macrophages to produce ROS, the benefits of DATS on inflammation were diminished. This suggests that ROS are crucial for the actions of DATS.
Furthermore, our findings indicated that DATS suppressed the NF-κB signaling pathway by inhibiting the expression of Trx-1, a protein that influences NLRP3 inflammasome activation. This interplay is vital as it showcases the potential of garlic and DATS not just in managing, but possibly preventing UC by modulating inflammatory responses through a specific pathway.
The implications of these findings point to the promising role of garlic extracts as a natural approach in the treatment of ulcerative colitis, emphasizing the importance of continuing research in this area.
Over a span of 10 days, we administered DATS to the mice and observed a significant reduction in both macrophage infiltration and detrimental changes in the colon's tissue. Importantly, DATS seemed to lower the levels of inflammatory markers like IL-1β and IL-18 and inhibited the activation of the NLRP3 inflammasome, which plays a role in the body’s inflammatory response.
Mechanistically, we noticed that DATS effectively reduced the production of reactive oxygen species (ROS) in macrophages. Interestingly, when we interfered with the ability of macrophages to produce ROS, the benefits of DATS on inflammation were diminished. This suggests that ROS are crucial for the actions of DATS.
Furthermore, our findings indicated that DATS suppressed the NF-κB signaling pathway by inhibiting the expression of Trx-1, a protein that influences NLRP3 inflammasome activation. This interplay is vital as it showcases the potential of garlic and DATS not just in managing, but possibly preventing UC by modulating inflammatory responses through a specific pathway.
The implications of these findings point to the promising role of garlic extracts as a natural approach in the treatment of ulcerative colitis, emphasizing the importance of continuing research in this area.
Read More
9
We evaluated the effects of water-soluble garlic polysaccharide (WSGP) on ulcerative colitis (UC), a chronic condition that causes inflammation in the colon. Our study used a mouse model, where we assessed improvements in health by monitoring food intake, weight gain, and colon length alongside various measures of inflammation and tissue damage.
Notably, WSGP supplementation showed promise in improving the overall health of UC-affected mice. The results indicated that WSGP not only helped restore intestinal integrity but also reduced inflammation, which we observed by measuring specific signaling pathways.
The key findings highlighted that WSGP decreased the production of inflammation-related factors and positively influenced gut microbial metabolites. This indicates that garlic's benefits might extend beyond just physical healing; it may also support a healthier balance of gut bacteria, which plays a crucial role in our digestive health.
Overall, our research underscores the potential of garlic polysaccharides as a therapeutic option for managing ulcerative colitis, demonstrating significant improvements in both tissue health and digestive function.
Notably, WSGP supplementation showed promise in improving the overall health of UC-affected mice. The results indicated that WSGP not only helped restore intestinal integrity but also reduced inflammation, which we observed by measuring specific signaling pathways.
The key findings highlighted that WSGP decreased the production of inflammation-related factors and positively influenced gut microbial metabolites. This indicates that garlic's benefits might extend beyond just physical healing; it may also support a healthier balance of gut bacteria, which plays a crucial role in our digestive health.
Overall, our research underscores the potential of garlic polysaccharides as a therapeutic option for managing ulcerative colitis, demonstrating significant improvements in both tissue health and digestive function.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Helps prevent ulcers
Excellent! Garlic oil, 1500 mg, is highly beneficial for the body. It assists in suppressing pathogenic microorganisms in the digestive system, boosts immunity, normalises lipid metabolism, and reduces blood cholesterol levels. Additionally, it helps prevent atherosclerosis and cardiovascular issues, neutralises free radicals, slowing down natural ageing, and may prevent the onset and growth of cancer cells. Regularly using garlic is effective in eliminating parasites, healing the body and averting infections, particularly from Helicobacter bacteria, which cause ulcers.
Read More
6
Supports ulcer relief
This product is good; you can definitely taste the garlic. I've noticed improvements in my cardiovascular health, and the packaging is designed to prevent burning, making it suitable for those with ulcers. I am just starting to take it, so I look forward to experiencing more benefits, especially concerning my immunity.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Barakat KM, Gohar YM, Ghonam HE, Bashir GA. New nano-chemotherapeutic chitosans-garlic oil-antibiotics against diabetic foot virulent spp. Iran J Microbiol. 2024;16:666. doi:10.18502/ijm.v16i5.16802
- Shao X, Li J, Shao Q, Qu R, Ouyang X, et al. Author Correction: Water-soluble garlic polysaccharide (WSGP) improves ulcerative colitis by modulating the intestinal barrier and intestinal flora metabolites. Sci Rep. 2024;14:24498. doi:10.1038/s41598-024-75663-z
- He Y, Xiao L, Zhang J, Zhu Y, Guo Y, et al. Diallyl trisulfide alleviates dextran sulphate sodium-induced colitis in mice by inhibiting NLRP3 inflammasome activation via ROS/Trx-1 pathway. Basic Clin Pharmacol Toxicol. 2024;135:593. doi:10.1111/bcpt.14083
- Shao X, Li J, Shao Q, Qu R, Ouyang X, et al. Water-soluble garlic polysaccharide (WSGP) improves ulcerative volitis by modulating the intestinal barrier and intestinal flora metabolites. Sci Rep. 2024;14:21504. doi:10.1038/s41598-024-72797-y
