We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
Most Useful Reviews
9
Skin condition improvement
87 people found this helpful
I bought these pills for my atopic dermatitis. After struggling with various treatments, I tried zinc picolinate, as it’s better absorbed. Amazingly, the itching has now gone, and my skin is no longer dry. My husband even remarked on how delicate my skin looks!
Read More
10
Acne treatment success
41 people found this helpful
I purchased Now Zinc Picolinate to assist my son with allergies. I was astonished when his acne cleared up completely within three weeks of taking zinc. We’ve not seen a return of the acne since then!
Read More
9
Life-saving supplement
5 people found this helpful
I started taking zinc a month before I contracted COVID-19, while already suffering from allergies. The doctor said that the zinc I was taking possibly saved my life during this time.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
Read More
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
8
Zinc supplementation may reduce allergies
Zinc Deficiency and Zinc Supplementation in Allergic Diseases.
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
I bought these pills for my atopic dermatitis. After struggling with various treatments, I tried zinc picolinate, as it’s better absorbed. Amazingly, the itching has now gone, and my skin is no longer dry. My husband even remarked on how delicate my skin looks!
Read More
10
Acne treatment success
41 people found this helpful
I purchased Now Zinc Picolinate to assist my son with allergies. I was astonished when his acne cleared up completely within three weeks of taking zinc. We’ve not seen a return of the acne since then!
Read More
9
Life-saving supplement
5 people found this helpful
I started taking zinc a month before I contracted COVID-19, while already suffering from allergies. The doctor said that the zinc I was taking possibly saved my life during this time.
Read More
0
Cold prevention
4 people found this helpful
While it worked well to keep colds at bay, it did not prevent herpes. I didn't experience any gastrointestinal issues or allergies from this drug.
Read More
9
Effective for colds
2 people found this helpful
I take zinc at the first sign of colds or allergies. It helps my body combat infections effectively, and I've been very pleased with the results.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been studied for its potential effects on the immune system, and some research suggests that it may play a role in managing allergic responses. While zinc is essential for maintaining overall immune function, a direct link between zinc supplementation and reduction in allergy symptoms has not been firmly established. Some studies indicate that zinc may help modulate inflammation and could potentially benefit those with allergic rhinitis or other allergic conditions, but results can vary widely among individuals.
If you're considering zinc as a supplement for allergies, it’s vital to consult with a healthcare professional first. They can provide personalized advice based on your health status and any medications you might be taking. Additionally, focusing on a balanced diet rich in zinc-containing foods like nuts, seeds, legumes, and whole grains can offer support to your overall health and immune function, which may indirectly influence how your body handles allergens.
Based on user reviews, many individuals report seeing noticeable results from taking zinc for allergies within just a week to three weeks. For instance, one user noted a significant reduction in rash within a week of commencing the supplement Read Review, while another observed a complete clearing of acne associated with allergies after three weeks Read Review. Additionally, users have mentioned overall improvements in multiple allergy symptoms, such as sneezing, itching, and runny noses, often coupled with other health benefits during the initial month of use Read Review, Read Review.
However, experiences can vary, and some users noted less immediate effects, citing ongoing benefits with prolonged usage over several months Read Review. Overall, consistent intake seems beneficial for many, with shorter-term alleviation of allergy symptoms reported by several users aligning well with the two to three-week timeline. It’s crucial to remember that individual responses may vary, and results could depend on factors such as personal health conditions and the specific type and severity of allergies.
The scientific research suggests that zinc, particularly in the form of quail egg supplements, can provide relief for individuals suffering from allergies, notably allergic rhinitis. A systematic review indicated that combining quail egg-based supplements with zinc significantly improved key metrics such as nasal airflow and mucociliary transport, while also alleviating symptoms like nasal congestion and sneezing. This combination not only enhances symptom management but also appears to reduce reliance on conventional allergy medications [1]. Additionally, other studies have shown that intranasal zinc treatment may alleviate allergy symptoms by decreasing specific mucin-secreting cells in response to pollen exposure, suggesting that zinc can play an essential role in managing seasonal allergies [2].
Moreover, the exploration of zinc's effects on immune responses reinforces its potential therapeutic role in allergy management. Research indicates that zinc treatment can prevent cellular reactions that contribute to allergic responses, highlighting its immunomodulatory properties [3]. Furthermore, findings from various studies suggest a correlation between adequate zinc levels and a reduced risk of developing allergic conditions, such as allergic asthma and atopic dermatitis [5], indicating that maintaining sufficient zinc intake could be beneficial for those vulnerable to allergies. In summary, the existing body of research points towards zinc's promise in alleviating allergy symptoms, warranting further investigation into its applications in allergy management.
Based on user reviews, many individuals have reported significant improvements in various allergy-related symptoms after taking zinc supplements. For example, one user noted a complete resolution of acne associated with allergies within three weeks of starting zinc Read Review. Another user mentioned the relief of itching and dryness associated with atopic dermatitis, with visible changes in their skin remarked upon by others Read Review. Consistent reports indicate reductions in sneezing, itching, and runny nose, making the product particularly praised for seasonal allergies Read Review, Read Review.
While many users experienced quick improvements, with some mentioning benefits in as little as a week Read Review, results can vary. Some individuals didn’t notice immediate effects and suggested that longer-term use may be necessary to see the full benefits, particularly for chronic conditions like psoriasis and hay fever Read Review. Overall, while most feedback is positive, individual responses may differ based on health status and the specifics of their allergy conditions.
Based on user reviews, many individuals have reported positive experiences when combining zinc supplements with other treatments for managing allergies. Users mention significant improvements in allergy symptoms, such as decreased sneezing, itching, and runny nose, when taking zinc picolinate. One reviewer noted that they found it effective in reducing their hay fever symptoms and, with extended use, experienced enhanced immunity, which contributed to better overall health and fewer illness occurrences Read Review. Another user highlighted that since stabilizing their zinc levels, they have better managed their allergies Read Review.
Other users have also reported that zinc appears to work synergistically with other health practices for allergy management. For instance, individuals noted that zinc reduced their allergy symptoms when taken alongside other treatments, such as hydrating the skin for conditions like atopic dermatitis Read Review. However, reactions can vary; some individuals felt unwell or experienced allergy-like symptoms while taking the supplement, indicating that careful monitoring is necessary when combining it with other health products Read Review. Given the reported variability in experiences, it's advisable for users to approach supplementation thoughtfully, particularly when integrating with existing treatments.
Users report varying experiences regarding the appropriate dose of zinc for treating allergies. While some individuals find relief with regular use, such as experiencing a noticeable reduction in symptoms like sneezing and a runny nose after starting zinc picolinate, others express concern about higher dosages. For instance, one review mentioned a daily dosage of 50 mg led to acne breakouts, raising doubts about its suitability for that user Read Review. Conversely, many users report positive outcomes with lower dosages, achieving significant improvements in allergy symptoms after consistent use, suggesting that attention to dosage may be crucial.
Additionally, several reviewers indicated that a balanced dosage of zinc aids not only in alleviating allergy symptoms but also in enhancing overall immune function. One user noted a considerable improvement in their health and immunity over two years of use, emphasizing the efficacy of zinc in combatting seasonal allergies Read Review. However, a general recommendation is to find a suitable dose tailored to individual needs, as the right amount may differ significantly from person to person.
7.5
Rash improvement
2 people found this helpful
I took zinc to combat my spring allergies. To my surprise, the rash noticeably reduced within a week, without needing additional treatments. My husband also takes zinc, as men often face its deficiency.
10
Acne treatment success
41 people found this helpful
I purchased Now Zinc Picolinate to assist my son with allergies. I was astonished when his acne cleared up completely within three weeks of taking zinc. We’ve not seen a return of the acne since then!
9
Reduced allergy symptoms
1 people found this helpful
This zinc is fantastic for my seasonal allergies. My symptoms have lessened; I sneeze less, my eyes don't itch, and I no longer have a runny nose. Additionally, my immune system has strengthened over two years of use, and I rarely get ill now.
9
Reduced allergy symptoms
2 people found this helpful
Since taking zinc, I've noticed a significant reduction in my hay fever symptoms. I sneeze less, and there’s no itching or runny nose, along with other health benefits it provides.
7.5
Skin improvement
After three months of taking this supplement, my hair is breaking less. It's excellent for my allergies and psoriasis, although the dosage is quite high.
9
Skin condition improvement
87 people found this helpful
I bought these pills for my atopic dermatitis. After struggling with various treatments, I tried zinc picolinate, as it’s better absorbed. Amazingly, the itching has now gone, and my skin is no longer dry. My husband even remarked on how delicate my skin looks!
7.5
Stable zinc levels
As someone with atopic dermatitis and allergies, I frequently check my zinc levels. Since I began taking this supplement, my levels have stabilised, which has been essential for managing my allergies.
0
Caused nasal issues
Below average; it made me feel sick, and my nose kept running, similar to experiencing allergies. I'm really upset about this.
0
Acne instead of relief
I took the Zinc supplement for my hair problems, but it did not help at all. Instead, I developed a lot of acne on my face, shoulders, and back. I wonder if I have an allergy or if the daily dosage of 50 mg is unsuitable for me.
9
Zinc and QES alleviate allergies
Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
7
Zinc's mixed effects on allergies
Micronutrients and Allergic Diseases: A Mendelian Randomization Study.
We examined the relationship between zinc levels and common allergic diseases like allergic asthma, atopic dermatitis, and allergic rhinitis. By leveraging Mendelian randomization analysis, we looked into how varying concentrations of zinc could influence the risk of these allergies.
Our findings suggest that higher zinc levels in the bloodstream may help lower the chances of developing allergic asthma and atopic dermatitis. However, we also observed that an increase in vitamin C could potentially raise the risk of atopic dermatitis, indicating a complex interaction among nutrients.
Additionally, it seems that zinc, alongside phosphorus, could play a role in reducing the risk of allergic rhinitis. While these results are promising, it's important to note that they don't fully isolate zinc’s effects from other micronutrients, which means more focused research could clarify its role in managing allergies.
References
Antonelli M, Mazzoleni E, Donelli D. Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies. Nutrients. 2025;17. doi:10.3390/nu17040712
Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408
Otsuka T, Sato K, Kamiya T, Tanaka H, Hara H. Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells. Eur J Pharmacol. 2025;994:177391. doi:10.1016/j.ejphar.2025.177391
Wang S, Ilves M, Mäenpää K, Zhao L, El-Nezami H, et al. ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice. ACS Nano. 2024;18:29479. doi:10.1021/acsnano.4c04270
Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. doi:10.1159/000540376
Maywald M, Rink L. Zinc Deficiency and Zinc Supplementation in Allergic Diseases. Biomolecules. 2024;14. doi:10.3390/biom14070863
Wei Y, Zhu X, Lin S, Yang W, Wang T, et al. Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation. Biomed Pharmacother. 2024;177:117129. doi:10.1016/j.biopha.2024.117129