We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Read More
8
Zinc shows effectiveness against H. pylori
Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori.
We explored the effectiveness of zinc chloride (ZnCl) in treating Helicobacter pylori (H. pylori) infections, particularly concerning various gastritis conditions. Our study involved testing 116 clinical isolates of H. pylori to see how they responded to ZnCl, bismuth subsalicylate (BSS), and clarithromycin (CLR).
Using a method called agar gel dilution, we found that 95% of the H. pylori strains tested were susceptible to ZnCl at a concentration of 40 μg/ml. This is a promising figure, especially when compared to 98% susceptibility for BSS and 79% for CLR. Interestingly, H. pylori isolates from patients with nonulcer dyspepsia and peptic ulcers showed similar levels of susceptibility to ZnCl.
It's important to note that while ZnCl demonstrated a significant antimicrobial effect against H. pylori, making it a potential candidate for treatment, the study also indicated that its effectiveness was comparable to CLR, but slightly less than BSS. This suggests that while ZnCl may be beneficial in treating H. pylori infections, it should not be viewed as a standalone solution, particularly in gastritis management.
Ultimately, our findings indicate that zinc chloride holds promise in tackling H. pylori, potentially contributing to improved treatment strategies for those suffering from gastritis and related disorders.
Read More
9.5
Zinc Carnosine Enhances Eradication
Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study.
We conducted a study to explore the effectiveness of a modified bismuth quadruple therapy that included zinc carnosine in treating gastritis, compared to the standard triple therapy. Our participant group consisted of 92 patients who showed symptoms of dyspepsia and tested positive on a urea breath test for the infection.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
Read More
Most Useful Reviews
9
Affordable gastritis option
Zinc is essential for restoring the gastrointestinal tract and serves as a co-enzyme. I purchased a convenient course, taking one capsule after dinner. With 120 capsules, it lasts us about a month and a half at an affordable price. Picolinate is the best form for gastritis and ulcers. Pay attention to dosages; this one offers 50mg.
Read More
9
Gentle on stomach
I frequently buy dietary supplements from Now Foods. This zinc form does not irritate my stomach, which is a relief as I have gastritis.
Read More
7.5
Health through zinc
1 people found this helpful
Zinc picolinate is used for gastritis, especially during stressful times, as chronic diseases worsen. It is suitable for those with reduced stomach acidity. I wish health to everyone in Ukraine during these difficult times.
We conducted a study to explore the effectiveness of a modified bismuth quadruple therapy that included zinc carnosine in treating gastritis, compared to the standard triple therapy. Our participant group consisted of 92 patients who showed symptoms of dyspepsia and tested positive on a urea breath test for the infection.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
Read More
9.5
Zinc supports recovery in CCS
Case of Cronkhite Canada syndrome shows improvement with enteral supplements.
Our examination focuses on the intriguing case of a 33-year-old man diagnosed with Cronkhite-Canada syndrome (CCS), a rare condition affecting the gastrointestinal tract and skin. During his hospital stay, he presented with severe gastrointestinal symptoms alongside notable skin changes.
To address his condition, the treatment regime included high protein supplements, proton pump inhibitors, and zinc-vitamin supplements. Over the course of five months, we observed a complete improvement in his symptoms. While this particular case emphasizes the role of zinc within a comprehensive treatment plan, it’s important to note that zinc was part of a multi-component strategy that makes it difficult to isolate its individual effects on gastritis directly.
Nonetheless, this case illustrates how early diagnosis and a well-structured treatment approach—integrating nutritional support—can lead to significant recovery in rare syndromes like CCS.
Read More
8
Zinc protects against gastritis damage
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.
We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Read More
8
Polaprezinc shows promise in gastritis
Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
We conducted a systematic review to assess how Polaprezinc, a zinc-l-carnosine complex, might influence the treatment of gastritis. Focusing on its effectiveness when combined with standard triple therapy, which includes antibiotics, we analyzed data from three randomized controlled trials involving 396 participants.
Our findings suggest that adding Polaprezinc to the triple therapy improved the eradication rates of the bacteria responsible for gastritis. Specifically, we observed a significant increase in successful treatment outcomes, indicating a potential advantage of Polaprezinc as a complementary approach.
However, it's important to note that while the combination therapy showed better results, both treatment groups reported similar instances of adverse events. This means that Polaprezinc appears to offer a beneficial effect on treatment outcomes without increasing side effects.
Despite these positive results, we recognize that the evidence is still limited. More extensive trials are needed to confirm these findings and establish Polaprezinc's role in gastritis management firmly. Overall, this treatment could be a promising addition but needs further exploration before becoming a standard approach.
Read More
8
Zinc's role in gastritis improvement
Study of Serum Ferritin, Zinc, and Copper Levels in Children With Helicobacter pylori Gastritis and the Effect of the Treatment.
We conducted a study to understand how zinc influences children suffering from gastritis due to Helicobacter pylori infection. Our investigation included 70 young patients exhibiting symptoms of upper gastrointestinal distress. By dividing the group into H. pylori-positive and H. pylori-negative children, we could directly observe the differences in serum levels of hemoglobin, ferritin, zinc, and copper.
Notably, we found that children with H. pylori had lower levels of serum ferritin and zinc compared to those without the infection. However, the copper levels remained unaffected. Interestingly, after treating the infected children, we observed significant improvements in their hemoglobin, ferritin, and zinc levels. This suggests that while zinc deficiency is often present in these patients, simply providing zinc treatment alone cannot solely isolate its specific impact on gastritis.
Furthermore, we noted that more severe gastritis correlated with lower hemoglobin and zinc levels, and higher transferrin receptor levels. Although zinc appears to play a crucial role in the overall health of these children, our findings indicate that its treatment effect should be viewed alongside other potential factors influencing gastritis recovery.
Zinc is essential for restoring the gastrointestinal tract and serves as a co-enzyme. I purchased a convenient course, taking one capsule after dinner. With 120 capsules, it lasts us about a month and a half at an affordable price. Picolinate is the best form for gastritis and ulcers. Pay attention to dosages; this one offers 50mg.
Read More
9
Gentle on stomach
I frequently buy dietary supplements from Now Foods. This zinc form does not irritate my stomach, which is a relief as I have gastritis.
Read More
7.5
Health through zinc
1 people found this helpful
Zinc picolinate is used for gastritis, especially during stressful times, as chronic diseases worsen. It is suitable for those with reduced stomach acidity. I wish health to everyone in Ukraine during these difficult times.
Read More
Frequently Asked Questions
Gastritis is an inflammation of the stomach lining, which can lead to a range of symptoms including abdominal pain, nausea, vomiting, and indigestion. This condition can be acute, arising suddenly and lasting for a short period, or chronic, developing gradually and persisting over time. Various factors can contribute to gastritis, such as excessive alcohol consumption, prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs), bacterial infections (most notably Helicobacter pylori), and autoimmune disorders.
Treatment for gastritis often focuses on addressing the underlying cause and might include medications to reduce stomach acid, antibiotics for infections, and lifestyle modifications like avoiding irritating foods and beverages. While many people recover from gastritis with adequate care, it's important to consult a healthcare professional for a proper diagnosis and treatment plan. If left untreated, gastritis can lead to more serious complications, such as stomach ulcers or even an increased risk for gastric cancer.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc is often recognized for its various health benefits, including its role in supporting the immune system and promoting wound healing. In the context of gastritis, which is an inflammation of the stomach lining, zinc may have a supportive role due to its potential anti-inflammatory properties and its involvement in cell regeneration. Some studies indicate that zinc supplements can help in healing gastric mucosal injuries and may alleviate symptoms associated with gastritis. However, the evidence is not definitive and varies based on the individual’s health status and the cause of their gastritis.
That said, it's essential to approach supplementation cautiously. While zinc can be beneficial, taking too much can lead to adverse effects, including nausea, diarrhea, and interference with the absorption of other essential minerals. If you suspect you have gastritis or are considering zinc supplements as part of your treatment plan, it’s always best to consult with a healthcare provider first. They can provide personalized advice and ensure that any supplements or changes in diet won't adversely affect your condition or interact with other medications you might be taking.
Based on user reviews, the timeframe for seeing results from taking zinc picolinate for gastritis varies among individuals. Some users have reported experiencing relief and positive effects relatively quickly, often within a few weeks of consistent use. For instance, one user mentioned that the supplement does not irritate their stomach, which is a significant benefit for those managing gastritis symptoms Read Review.
Additionally, another user highlighted that zinc picolinate is particularly effective for gastritis and ulcers, especially during times of stress, suggesting that those with reduced stomach acidity may notice improvements sooner Read Review. Overall, while individual responses can vary, many users seem to notice improvements in their gastritis symptoms within a few weeks of using this supplement regularly.
Recent research suggests that zinc and its derivatives may offer potential benefits for individuals suffering from gastritis. For instance, a study highlights that zinc supplementation effectively reduces inflammation and oxidative stress in chronic gastritis by modulating harmful signaling pathways in the gastric mucosa [1]. Additionally, zinc-l-carnosine has demonstrated a significant role in treating gastritis, particularly when used alongside standard therapies. A systematic review indicates that when combined with conventional triple therapy, Polaprezinc can markedly improve treatment outcomes, achieving higher eradication rates of H. pylori, which is a common cause of gastritis [2][6].
Moreover, further studies have found that zinc supplementation can assist in managing the inflammation associated with autoimmune atrophic gastritis and enhance overall treatment effectiveness when used in conjunction with other therapies [4]. Zinc's role in enhancing the body’s ability to tackle H. pylori is also evident in clinical trials where its combination with traditional treatments resulted in better symptom improvement and eradication rates [7]. While these findings point to zinc as a promising adjunctive treatment for gastritis, more extensive research is needed to solidify its role and effectiveness within standard treatment protocols.
Based on user reviews, many have reported notable improvements in their gastritis symptoms after using zinc picolinate. For instance, one user emphasized the supplement's essential role in restoring the gastrointestinal tract, especially noting its effectiveness against gastritis and ulcers Read Review. Another user specifically pointed out that this form of zinc does not irritate their stomach, which they found particularly reassuring while managing their gastritis Read Review.
Furthermore, the supplement appears to be especially beneficial for those experiencing gastritis during times of stress. One review highlights zinc picolinate's effectiveness in these situations, suggesting that it may aid individuals with reduced stomach acidity in finding relief from discomfort Read Review. While individual results can vary, many users seem to experience a reduction in gastrointestinal distress after regular use of zinc picolinate.
Users report varying experiences with zinc supplementation for treating gastritis, particularly noting the importance of dosage and form. One user mentioned taking a daily dose of 50mg of zinc picolinate, which they found to be the best option for addressing gastritis and ulcers, emphasizing its restorative properties for the gastrointestinal tract Read Review. Many users agree that the 50mg dosage is effective, but caution that individual responses may vary, and quality of the supplement matters as well.
9
Gentle on stomach
I frequently buy dietary supplements from Now Foods. This zinc form does not irritate my stomach, which is a relief as I have gastritis.
7.5
Health through zinc
1 people found this helpful
Zinc picolinate is used for gastritis, especially during stressful times, as chronic diseases worsen. It is suitable for those with reduced stomach acidity. I wish health to everyone in Ukraine during these difficult times.
9
Affordable gastritis option
Zinc is essential for restoring the gastrointestinal tract and serves as a co-enzyme. I purchased a convenient course, taking one capsule after dinner. With 120 capsules, it lasts us about a month and a half at an affordable price. Picolinate is the best form for gastritis and ulcers. Pay attention to dosages; this one offers 50mg.
8
Zinc protects against gastritis damage
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.
We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
8
Polaprezinc shows promise in gastritis
Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
We conducted a systematic review to assess how Polaprezinc, a zinc-l-carnosine complex, might influence the treatment of gastritis. Focusing on its effectiveness when combined with standard triple therapy, which includes antibiotics, we analyzed data from three randomized controlled trials involving 396 participants.
Our findings suggest that adding Polaprezinc to the triple therapy improved the eradication rates of the bacteria responsible for gastritis. Specifically, we observed a significant increase in successful treatment outcomes, indicating a potential advantage of Polaprezinc as a complementary approach.
However, it's important to note that while the combination therapy showed better results, both treatment groups reported similar instances of adverse events. This means that Polaprezinc appears to offer a beneficial effect on treatment outcomes without increasing side effects.
Despite these positive results, we recognize that the evidence is still limited. More extensive trials are needed to confirm these findings and establish Polaprezinc's role in gastritis management firmly. Overall, this treatment could be a promising addition but needs further exploration before becoming a standard approach.
8
Zinc enhances H. pylori treatment
Polaprezinc combined with clarithromycin-based triple therapy for Helicobacter pylori-associated gastritis: A prospective, multicenter, randomized clinical trial.
We conducted a study to understand how zinc, specifically through polaprezinc, works alongside traditional treatments for gastritis caused by Helicobacter pylori. In this multicenter trial, participants were divided into different groups to test the effectiveness of polaprezinc when combined with standard triple therapy—omeprazole, amoxicillin, and clarithromycin—versus the triple therapy on its own.
Our findings revealed that patients receiving polaprezinc along with triple therapy had a significantly higher success rate in eradicating H. pylori compared to those who only received the triple therapy. Specifically, those in the group with standard dose polaprezinc achieved an eradication rate of about 77%, dramatically better than the 58.6% seen in the control group.
Additionally, all groups reported improvements in symptoms after treatment. However, it's important to note that the higher dosage of polaprezinc was linked to a slightly increased rate of adverse events. Despite this, there were no serious side effects noted across any group.
Overall, we observed that incorporating standard dose polaprezinc improves H. pylori eradication rates without significantly raising toxicity, suggesting that zinc can be a valuable addition to the treatment regimen for gastritis affected by this bacteria.
7
Zinc-l-carnosine reduces inflammation
Mucosal Overexpression of Thymic Stromal Lymphopoietin and Proinflammatory Cytokines in Patients With Autoimmune Atrophic Gastritis.
We explored the immune changes in patients with autoimmune atrophic gastritis (AAG) and looked at how zinc-l-carnosine impacts inflammation associated with the condition. The study gathered gastric biopsies from over 60 individuals, including patients with AAG and healthy controls, to assess various immune cells and cytokines involved in gastric inflammation.
Our findings showed that patients with AAG had higher levels of certain immune cells, like plasma cells, and an increase in harmful cytokines compared to healthy individuals. Interestingly, when zinc-l-carnosine was tested, it significantly reduced levels of several proinflammatory cytokines, such as interferon-γ and TNF-α. This suggests that zinc-l-carnosine may help soothe inflammation in the gastric mucosa.
However, we should note that the effects of zinc-l-carnosine were studied in combination with another treatment, short TSLP, making it difficult to determine its specific impact alone. While zinc-l-carnosine shows promise in reducing inflammation, further studies are needed to clarify its role in treating gastritis effectively.
8
Zinc shows effectiveness against H. pylori
Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori.
We explored the effectiveness of zinc chloride (ZnCl) in treating Helicobacter pylori (H. pylori) infections, particularly concerning various gastritis conditions. Our study involved testing 116 clinical isolates of H. pylori to see how they responded to ZnCl, bismuth subsalicylate (BSS), and clarithromycin (CLR).
Using a method called agar gel dilution, we found that 95% of the H. pylori strains tested were susceptible to ZnCl at a concentration of 40 μg/ml. This is a promising figure, especially when compared to 98% susceptibility for BSS and 79% for CLR. Interestingly, H. pylori isolates from patients with nonulcer dyspepsia and peptic ulcers showed similar levels of susceptibility to ZnCl.
It's important to note that while ZnCl demonstrated a significant antimicrobial effect against H. pylori, making it a potential candidate for treatment, the study also indicated that its effectiveness was comparable to CLR, but slightly less than BSS. This suggests that while ZnCl may be beneficial in treating H. pylori infections, it should not be viewed as a standalone solution, particularly in gastritis management.
Ultimately, our findings indicate that zinc chloride holds promise in tackling H. pylori, potentially contributing to improved treatment strategies for those suffering from gastritis and related disorders.
References
Sun X, Xu S, Liu T, Wu J, Yang J, et al. Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model. Food Funct. 2024;15:7136. 10.1039/d4fo01142b
Mahmoud A, Abuelazm M, Ahmed AAS, Abdalshafy H, Abdelazeem B, et al. Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2022;14. 10.3390/nu14194126
Elsaadany E, Amin S, Abdel-Hafez M, El Amrousy D, Kasem S, et al. Study of Serum Ferritin, Zinc, and Copper Levels in Children With Helicobacter pylori Gastritis and the Effect of the Treatment. J Pediatr Gastroenterol Nutr. 2022;75:e88. 10.1097/MPG.0000000000003585
Lenti MV, Facciotti F, Miceli E, Vanoli A, Fornasa G, et al. Mucosal Overexpression of Thymic Stromal Lymphopoietin and Proinflammatory Cytokines in Patients With Autoimmune Atrophic Gastritis. Clin Transl Gastroenterol. 2022;13:e00510. 10.14309/ctg.0000000000000510
Ibrahim N, El Said H, Choukair A. Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study. World J Clin Cases. 2022;10:227. 10.12998/wjcc.v10.i1.227
Tan B, Luo HQ, Xu H, Lv NH, Shi RH, et al. Polaprezinc combined with clarithromycin-based triple therapy for Helicobacter pylori-associated gastritis: A prospective, multicenter, randomized clinical trial. PLoS One. 2017;12:e0175625. 10.1371/journal.pone.0175625
Yakoob J, Abbas Z, Usman MW, Awan S, Naz S, et al. Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori. Microb Drug Resist. 2014;20:305. 10.1089/mdr.2013.0086
Lipin SP, Paul B, Nazimudeen E, Jacob BS. Case of Cronkhite Canada syndrome shows improvement with enteral supplements. J Assoc Physicians India. 2012;60:61.