Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Read More
7
Zinc treatment in hypozincemia study
Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan.
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Read More
4
Zinc affects post-op nausea minimally
Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty.
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Read More
Most Useful Reviews
9
No nausea experienced
54 people found this helpful
This zinc is exceptional and far better than the expensive duds sold in pharmacies. I experienced no nausea or stomach pain with this product, unlike others. I recommend taking it during meals, and I've noticed positive effects on my skin and hair. Just avoid taking it with calcium for best results.
Read More
9
No nausea at all
21 people found this helpful
For me, zinc picolinate is one of the best forms. It has produced results, especially during colds. It's important to take it after meals to avoid nausea. I recommend not exceeding 1-3 weeks of usage without checking for deficiencies. The packaging is ample enough for seasonal use.
Read More
9
No nausea experienced
10 people found this helpful
Unlike other brands, this zinc does not cause any stomach aches or nausea for me, even when taken before or after meals. I appreciate having a drinkable form for my mega vitamin therapy.
Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Read More
7
Zinc treatment in hypozincemia study
Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan.
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Read More
4
Zinc affects post-op nausea minimally
Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty.
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Read More
4
Zinc's tolerability in diarrhoea treatment
New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh.
We aimed to understand how zinc tablets, often recommended for treating diarrhoea in young children, affect nausea and overall treatment adherence. In this open-label study, we involved children aged 3 to 59 months who visited the outpatient department at Dhaka Hospital.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 48 Reviews
6.8
All Reviews
Positive Reviews
Negative Reviews
9
No nausea experienced
54 people found this helpful
This zinc is exceptional and far better than the expensive duds sold in pharmacies. I experienced no nausea or stomach pain with this product, unlike others. I recommend taking it during meals, and I've noticed positive effects on my skin and hair. Just avoid taking it with calcium for best results.
Read More
9
No nausea at all
21 people found this helpful
For me, zinc picolinate is one of the best forms. It has produced results, especially during colds. It's important to take it after meals to avoid nausea. I recommend not exceeding 1-3 weeks of usage without checking for deficiencies. The packaging is ample enough for seasonal use.
Read More
9
No nausea experienced
10 people found this helpful
Unlike other brands, this zinc does not cause any stomach aches or nausea for me, even when taken before or after meals. I appreciate having a drinkable form for my mega vitamin therapy.
Read More
9
Eliminates nausea
5 people found this helpful
This is my second order of the picolinate form my nutritionist recommended, and it's been great. I previously felt nausea with other zinc forms, but this one is fine anytime. I've noticed improvements in my hair and nails, and it clears my skin.
Read More
9
No nausea reported
3 people found this helpful
I love that this zinc doesn't cause nausea, which is a common side effect. I always choose this product because it is effective for immunity and strengthening hair.
Nausea is a sensation that often precedes vomiting and is characterized by an uneasy feeling in the stomach. It can be caused by a variety of factors, including motion sickness, certain medications, food poisoning, or underlying health conditions. The experience of nausea can range from mildly uncomfortable to intensely distressing and is often accompanied by other symptoms such as sweating, increased salivation, or a feeling of lightheadedness.
Many people experience nausea at some point in their lives, making it a common issue. Fortunately, there are several remedies and treatments available that can help alleviate this unpleasant sensation. Over-the-counter medications, home remedies like ginger tea, and lifestyle changes, such as eating smaller meals or avoiding certain triggers, can be effective in reducing nausea. However, if nausea is persistent or accompanied by severe symptoms like severe abdominal pain or fever, it’s essential to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc may play a role in alleviating certain types of nausea, especially when it is associated with specific conditions, such as pregnancy or certain gastrointestinal issues. Some studies have indicated that zinc supplements might help in reducing nausea symptoms due to their potential to support overall gut health and maintain immune function. However, the evidence is not conclusive, and results can vary from person to person.
It's important to note that while zinc supplementation might benefit some individuals, it is not universally effective for all types of nausea. If you're considering using zinc to address nausea, consult with a healthcare professional to ensure it's appropriate for your situation and to discuss the ideal dosage. Additionally, it's crucial to address the underlying cause of nausea rather than just treating the symptom itself.
Based on user reviews, the time it takes to see results from zinc supplements for nausea can vary. Many users note that taking zinc after meals significantly helps mitigate nausea, with improvements often noticeable within a few days to a week of consistent use Read Review. However, others caution that some forms of zinc can cause nausea if not taken properly, which may delay a user's ability to notice positive effects Read Review.
For those who experience nausea when taking zinc, switching to a better-absorbed form like zinc picolinate seems to be beneficial. Many users report that this specific type, when taken appropriately, causes no discomfort and has yielded results in skin health and overall immune function (reviews id='8e6d3f10-760f-45d3-8544-c95ab8bb78af' and 'fe8315a9-359a-4d79-9483-2321fda9c188'). Overall, while initial side effects such as nausea may occur with certain formulations, once these are managed, users typically begin feeling the benefits of zinc supplementation in a matter of days.
Scientific research indicates that zinc supplements may indeed be helpful in managing nausea, though the results can be mixed. For instance, one study focusing on zinc-infused packs after surgery showed that patients using zinc solution-impregnated gauze reported significantly less severe nausea two hours post-operation compared to those receiving standard saline packs [3]. This highlights a potential benefit of zinc in reducing nausea in specific contexts, such as post-operative care.
However, other studies present a more nuanced picture. In examining zinc acetate dihydrate over a longer duration, nausea was reported in a small percentage of the subjects, but the exact efficacy of zinc for nausea alone remains unclear due to the overlapping symptoms being studied [2]. Additionally, another investigation into zinc tablets for children found that while most children tolerated the tablets well, a notable number did experience nausea and vomiting [4]. Therefore, while there is some supportive evidence suggesting zinc could aid in alleviating nausea, particularly post-operatively, more focused research is necessary to firmly establish its effectiveness for this specific issue.
Based on user reviews, many individuals have reported significant improvements in their symptoms after switching to zinc picolinate, particularly in terms of skin health and immune function. Users have highlighted positive changes such as clearer skin, improved hair and nail condition, and a reduction in the frequency of colds and upper respiratory infections (review id='73574325-beef-4191-b904-f07550fed7f0' and 'fe8315a9-359a-4d79-9483-2321fda9c188'). Notably, those who experienced nausea with other zinc forms found that zinc picolinate did not cause any stomach discomfort, making it a preferred option for many (review id='42e19a91-0963-4541-913b-027148d2a3bc' and 'd7e06a73-4b90-482d-8a4a-937454624fae').
However, it's important to note that individual results can vary widely. Some users did report experiencing nausea, particularly with other zinc formulations, highlighting the need to take zinc after meals to minimize side effects (review id='b105a9f9-4c5f-4e96-9f31-cafb4e89027a' and 'f32d922b-38e4-41da-8ca0-d6cdd082dcb5'). Overall, while many users have found relief and improvement in their health symptoms, others have faced challenges that underline the necessity of personalized approaches when it comes to supplementation.
Users generally report positive experiences when combining zinc picolinate with other supplements, particularly magnesium, noting improved effects without nausea. One user mentioned taking zinc alongside magnesium nightly and starting to feel positive effects, highlighting that this combination worked well for them without causing stomach discomfort Read Review. However, it is important to approach combinations with caution; some users experienced nausea when zinc was taken with multivitamins that included zinc, prompting them to stop use altogether Read Review.
Many reviews emphasize the importance of taking zinc with meals to minimize nausea, with users recommending to avoid taking it with calcium or iron supplements as this might exacerbate gastrointestinal discomfort (review id='4bb49238-4000-11e8-b45d-23eac092f901' and '42e19a91-0963-4541-913b-027148d2a3bc'). Ultimately, while combining zinc with other supplements can be beneficial for some, individual experiences vary, underscoring the need for users to monitor their responses carefully and adjust their supplementation routine accordingly.
Users report that taking zinc, particularly in the form of zinc picolinate, can help avoid nausea when consumed at the right times. Several reviewers stress the importance of taking zinc after meals to minimize stomach discomfort, with users like those in reviews Read Review and Read Review specifically noting that timing is crucial. While some users have found forms of zinc that do not cause nausea at all, others experienced adverse effects when taking it on an empty stomach or with incompatible minerals like calcium or iron, as highlighted in reviews Read Review and Read Review.
In terms of dosage, there seems to be a consensus on avoiding excessive amounts to prevent nausea, with several users suggesting a moderate intake. For example, one user cautioned against exceeding 50mg, as this could lead to nausea or headaches, which is addressed in review Read Review. Most users recommend sticking to doses of around 25mg to 30mg, acknowledging the relationship between dosage and potential side effects, such as nausea and interactions with copper levels Read Review.
7.5
Nausea possible
1 people found this helpful
Take zinc with meals to avoid nausea on an empty stomach and not with calcium or iron. Zinc is crucial for immunity, hair growth, and overall health. I chose zinc picolinate for its good bioavailability. The dosage of 25 mg is suitable for adults.
0
Caused nausea
3 people found this helpful
My cosmetologist recommended zinc picolinate for skin health. Unfortunately, it caused nausea, which was disappointing as I had hoped for better results.
9
No nausea effect
3 people found this helpful
This zinc product is easy to take, with no aftertaste or nausea. I take one nightly alongside magnesium and have started to feel the positive effects. However, I worry that the 50mg dose exceeds the daily maximum of 30mg, which could affect copper levels.
0
Nausea occurs
1 people found this helpful
Taking this with a multivitamin containing zinc results in nausea, even when consumed alone. I stopped because of these symptoms.
9
No nausea at all
21 people found this helpful
For me, zinc picolinate is one of the best forms. It has produced results, especially during colds. It's important to take it after meals to avoid nausea. I recommend not exceeding 1-3 weeks of usage without checking for deficiencies. The packaging is ample enough for seasonal use.
9
Difficult to swallow
1 people found this helpful
I had been using domestic zinc supplements but chose this brand, believing in its effectiveness. Although the capsule is large and hard to swallow, I take it after meals to prevent nausea. The large capacity means I will repeat my order.
9
Managing nausea
1 people found this helpful
Zinc is effective for boosting immunity. However, taking too much may result in nausea or headaches; if 50mg feels excessive, consider taking less. My delivery arrived on the 17th and 21st of November with an expiry of 26th March.
4
Zinc affects post-op nausea minimally
Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty.
We explored the effectiveness of zinc-impregnated pharyngeal packs in reducing post-operative nausea and sore throat among patients undergoing septorhinoplasty. In this study, we divided 220 patients into four groups, each receiving different types of pharyngeal packs: normal saline-impregnated vibril, normal saline-impregnated gauze, zinc solution-impregnated vibril, and zinc solution-impregnated gauze.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
7
Zinc treatment in hypozincemia study
Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan.
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
4
Zinc's tolerability in diarrhoea treatment
New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh.
We aimed to understand how zinc tablets, often recommended for treating diarrhoea in young children, affect nausea and overall treatment adherence. In this open-label study, we involved children aged 3 to 59 months who visited the outpatient department at Dhaka Hospital.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
References
Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. 10.1016/j.jtemb.2024.127558
Ezoe S, Ishihara T, Hosogai T, Kokubo T. Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan. Pharmazie. 2024;79:29. 10.1691/ph.2024.3630
Parvizi A, Haddadi S, Akbari M, Akbarpour M, Taghipour Rudsari F, et al. Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty. Anesth Pain Med. 2022;12:e127262. 10.5812/aapm-127262
Nuzhat S, Ahmed T, Alam J, Billal SM, Khan AI, et al. New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh. J Paediatr Child Health. 2022;58:1215. 10.1111/jpc.15953