Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Coenzyme Q10 (CoQ10)
100 mg
**

The product is found useful for the following medical conditions

Angina details

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.7
We focused on the effectiveness and safety of coenzyme Q10 as a treatment for patients dealing with ischemic heart disease and stable angina, specifically those at class II-III levels. Over the course of eight weeks, participants took a daily dosage of 60 mg of coenzyme Q10 alongside their standard treatment regimen.

The results were promising; we observed that patients reported significant improvements in their clinical status related to angina symptoms. Importantly, this improvement occurred without any major side effects, indicating that coenzyme Q10 could be a beneficial addition to the treatment plan for those living with this condition.

However, it is essential to note that since coenzyme Q10 was used in conjunction with standard treatments, it is challenging to pinpoint its isolated effects conclusively. Future studies could help clarify how well coenzyme Q10 works on its own, but for now, the findings suggest it may be a valuable component of therapy for angina.
10
Zero angina attacks
Most Useful Review
66 people found this helpful
This CoQ-10 product is superb! I am 51 and have dealt with angina symptoms since I was 20. A quality product puts my symptoms in remission, and I can quickly discern quality. I’ve tried various brands, but this one has ensured I have had no attacks since starting it. I even adjusted to taking it every other day, still without issues.

Chest Pain details

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 3 Reviews
8.5
We assessed the effects of coenzyme Q10 on patients suffering from ischemic heart disease, specifically those experiencing stable class II-III angina. In our study, we added coenzyme Q10 at a dosage of 60 mg per day for eight weeks to the standard treatment regimen these patients were already following.

The results showed that this addition significantly improved the clinical status of the patients. Importantly, we did not observe any clinically significant side effects associated with the use of coenzyme Q10. This suggests that it could be a beneficial adjunct therapy for individuals dealing with chest pain related to cardiac issues, enhancing their treatment experience without additional risk.
9.5
Improved quality of life
Most Useful Review
After taking CoQ10, my quality of life improved. While my cholesterol was slightly high, I also experienced chest tightness, which miraculously disappeared after using CoQ10. I felt the effects immediately and plan to improve my diet in the future.

Headache details

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 3 Reviews
8.5
We investigated the effectiveness of coenzyme Q10 in treating migraines in children, comparing it with the commonly prescribed medication, amitriptyline. Our study involved 72 children, aged 5 to 15, who met the criteria for migraine diagnosis set by the International Headache Society.

Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.

Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.
9
Effective headache relief
Most Useful Review
1 people found this helpful
Amazing. If you have issues with headaches, this is what you need!

Kidney Stones details

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.5
We explored the effectiveness of coenzyme Q10 (CoQ10) in protecting renal function in patients dealing with kidney stones who underwent extracorporeal shockwave lithotripsy (ESWL). Our study involved 100 participants randomly assigned to receive either CoQ10 or a placebo, helping us compare the outcomes of each group.

Over the course of the study, we saw promising results from those who took CoQ10. There was a significant improvement in kidney function markers, such as a notable increase in glomerular filtration. Additionally, levels of certain hormones and interleukins linked to blood vessel function and inflammation showed enhancement in the CoQ10 group, contributing to the overall health of the kidneys after the procedure.

However, it’s important to mention that we did not observe significant changes in oxidative stress parameters, which means that while CoQ10 helped with kidney function, it didn't seem to reduce oxidative stress levels as expected. Nonetheless, this research highlights the potential of CoQ10 as a protective agent for the kidneys during treatments like ESWL, suggesting a beneficial preconditioning effect before such procedures.
9
Increased energy
Most Useful Review
6 people found this helpful
Key to youth Clinical studies have shown that coenzyme Q10 is an integral part of mitochondria, which produce about 95% of the energy required by the human body. Organs such as the heart, liver, brain, and kidneys consume large amounts of energy. I take this product, one tablet in the morning, daily. My depression vanishes, energy increases, and life improves. I will continue taking it. It really works. I recommend it!

Brain Tumor details

SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
USERS' SCORE
Good
Based on 5 Reviews
8.4
The study focused on understanding how coenzyme Q10 (CoQ) could help manage glioblastoma, a particularly challenging type of brain tumor. We utilized xenograft models with U251 cells implanted in mice to observe tumor growth, inflammation, and vascular changes, alongside assessing the effects of CoQ on various related behaviors, including cell migration and invasion.

We found that CoQ treatment significantly reduced tumor volume in both xenograft and orthotopic models. Interestingly, while it did not directly hinder tumor cell proliferation, it was effective in creating a less hypoxic and vascularized environment. This indicates that CoQ can influence the tumor’s growth dynamics by targeting the underlying conditions that support tumor survival and expansion.

Additionally, CoQ treatment led to a noticeable downregulation of proteins involved in inflammation and angiogenesis, like HIF-1α and NF-kB. This change in molecular activity caused an entire reshaping of the tumor's protein landscape, ultimately impacting how the tumor interacts with its environment. Notably, we observed a restriction in tumor cell migration and invasion, attributed to changes in the cell's structural components.

Overall, our findings suggest that incorporating CoQ into current treatment protocols could provide a holistic approach to combat glioblastoma by simultaneously addressing multiple pathways that facilitate tumor growth and infiltration.
9
Significant improvement
Most Useful Review
1 people found this helpful
Highly recommended! NOW Foods' CoQ10 in 100 mg has transformed my health. Initially taken for cholesterol, it became a fantastic boost for my heart health. I feel rejuvenated, with a clear mind. My doctor was amazed by the improvement in my cardiovascular system. Additionally, my skin has become soft and smooth.

Pelvic Pain details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.3
7.5
Improved mobility
Most Useful Review
6 people found this helpful
My father is currently suffering from COPD and back pain, often unable to stand, walk, or sit; he mostly lies in bed. Due to COVID, we couldn’t take him to the hospital. Our cousin, a doctor, recommended these supplements. Thankfully, after about four to five months of consistent use, my father can now sit unaided and stand and walk a little with support.

Blood Clot details

SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Good
Based on 8 Reviews
8.2
We explored how coenzyme Q10 (CoQ10), a natural compound found in various foods, impacts blood clotting functions. Through a well-structured study, we utilized a randomized, double-blind, placebo-controlled trial with dyslipidemic patients, alongside in vitro tests on human platelets.

Our findings demonstrated that CoQ10 effectively reduces platelet aggregation, granule secretion, platelet spreading, and clot retraction. This means that CoQ10 can help prevent excessive blood clot formation, which is crucial for cardiovascular health.

We observed that CoQ10 works mainly by enhancing a signaling pathway involving cyclic AMP (cAMP) which ultimately diminishes the signaling of integrin αIIbβ3, a key player in platelet function. In addition, the treatment showed promising results in reducing thrombus growth in an animal model, suggesting significant in vivo benefits as well.

This study highlights the potential of CoQ10 supplementation as a protective measure for individuals at risk of cardiovascular diseases by regulating platelet-related processes involved in clotting.
9
Lowers blood pressure
Most Useful Review
5 people found this helpful
I noticed a difference immediately after using this product. Having mercury toxicity, I developed high blood pressure and insulin resistance over time. CoQ10 has significantly lowered both my blood pressure and blood sugar, particularly stabilising fluctuating levels. While I am allergic to carob present in the capsules, I manage by extracting the contents onto my rice waffle. It's a minor inconvenience but worth it for the benefits.

Chronic Fatigue Syndrome details

SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.2
We embarked on a study to investigate the impact of ubiquinol-10—an active form of coenzyme Q10—on patients suffering from chronic fatigue syndrome (CFS). Our research comprised two parts: an open-label study involving 20 patients and a randomized, double-blind, placebo-controlled trial with 43 participants.

In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.

Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.

Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
7.5
Improved energy levels
Most Useful Review
2 people found this helpful
I've been using CoQ10 softgels, each containing 100 mg, from a bottle of 150. CoQ10 is renowned for supporting heart health and cellular energy production. The softgels are small and easy to take daily. I started using them for their benefits, especially as I age. Since I began, I've noticed a subtle improvement in my energy levels. Although the change isn't dramatic, I feel a bit more energetic and less fatigued. The packaging is simple and effective, with a secure cap that keeps the softgels fresh. The clear and informative label offers essential details about dosage and benefits. Overall, these CoQ10 softgels are a worthy addition to support heart health and energy; they are easy to take and good value for the price.

Migraine details

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Good
Based on 8 Reviews
8.2
We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.

Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.

Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
9
Successful migraine alternative
Most Useful Review
7 people found this helpful
Migraine relief! My functional medicine doctor recommended CoQ10 as an alternative to my prescription migraine medication. I researched it and couldn't find any reason why Ubiquinol was worth the extra expense, so I began with these and was pleasantly surprised it worked! I started on a high dose and have since reduced it to a normal one with good results. There’s consistency with each order and batch. I managed to stop the prescription medication without issue, and I've been using this for almost a year now.

Heart Attack details

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 11 Reviews
8.1
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.

Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.

Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
9
Tachycardia relief
Most Useful Review
7 people found this helpful
I had frequent tachycardia attacks and didn’t think the recommended Q10 would help. However, after taking it, the attacks disappeared. Believe it or not!

Autoimmune Disorder details

SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
We explored the potential benefits of idebenone, a synthetic analog of coenzyme Q10, in treating autoimmune disorders, specifically lupus, in mouse models. By administering idebenone to mice with lupus for eight weeks, we aimed to investigate its impact on disease activity and organ damage.

Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.

Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.

This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.
7.5
Boosts energy
Most Useful Review
Excellent! I discovered IHERB products six months ago and now regularly order D3, also known as the solar vitamin. The small gelatin capsules are easy to take, and I drink two each morning. I've experienced no side effects during my use, and I've begun to feel much better overall, with increased vivacity and energy.

Cardiovascular Disease details

SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.

In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
7.5
Boosted immunity
Most Useful Review
1 people found this helpful
Since taking Coenzyme Q10, I have experienced improved immune system function and have aided my cardiovascular disease.

Sleep Apnea details

SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9.5
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
We explored the impact of various treatments, including coenzyme Q10, on obstructive sleep apnea (OSA) in a patient with adult-onset Leigh disease. This condition often presents with severe neurological symptoms, complicating the patients’ overall health and quality of life.

An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).

Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.
7.5
Memory and anxiety benefits
Most Useful Review
A wonderful complex for improving memory; my sleep has significantly enhanced and my anxiety has faded. I would recommend it wholeheartedly!

Heart Disease details

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Moderately Good
Based on 33 Reviews
7.6
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.

However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.

In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
9
Elevated energy levels
Most Useful Review
6 people found this helpful
Key to youth. Coenzyme Q10 is crucial for energy production in the body, especially for energy-demanding organs like the heart and brain. Taking one tablet daily has decreased my depressive feelings significantly and increased my energy. I will continue using it because it truly works.
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