Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Moderately Good
Based on 33 Reviews
7.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Coenzyme Q10 (CoQ10)
100 mg
**
Top Medical Research Studies
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
9
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More
Most Useful Reviews
9
Elevated energy levels
6 people found this helpful
Key to youth. Coenzyme Q10 is crucial for energy production in the body, especially for energy-demanding organs like the heart and brain. Taking one tablet daily has decreased my depressive feelings significantly and increased my energy. I will continue using it because it truly works.
Read More
9
Youthful vitality
4 people found this helpful
No more ageing! Coenzyme Q10, also known as ubiquinone, is vital for maintaining energy and slowing down the ageing process. It is a powerful antioxidant that protects cells from damage and improves cardiovascular health. I take 1-2 capsules daily to maintain its levels in my body, and I recommend it for improved well-being and vitality.
Read More
10
Antioxidant benefits
2 people found this helpful
Ubiquinone is essential! Discovered in 1957, it is known as a revolutionary means for preventing cardiovascular diseases. By the age of 35, the body’s coenzyme Q10 levels decrease, leading to health issues. Ubiquinone fights free radicals and slows down the ageing process while enhancing energy metabolism. I regularly consume it to combat ageing and maintain health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9
We aimed to investigate the effects of Coenzyme Q10 (CoQ10) on heart health in the context of CDKL5 deficiency disorder (CDD). CDD is a complex condition caused by mutations in the CDKL5 gene, leading to severe developmental challenges and systemic issues, including oxidative stress.
Our study demonstrated that CoQ10 supplementation can significantly reduce harmful levels of reactive oxygen species (ROS) and help restore a balanced state of glutathione in the body. This is important because oxidative stress is believed to contribute to various health problems, including those affecting the heart.
Additionally, we found that CoQ10 not only improved markers of cellular health and proliferation in a human neuron model but also provided protective effects against lipid peroxidation and DNA damage in the hearts of a mouse model of CDD.
Overall, our findings suggest that CoQ10 may play a crucial role in alleviating oxidative stress and protecting heart health in individuals with CDD, offering a potential therapeutic avenue worth exploring further.
Our study demonstrated that CoQ10 supplementation can significantly reduce harmful levels of reactive oxygen species (ROS) and help restore a balanced state of glutathione in the body. This is important because oxidative stress is believed to contribute to various health problems, including those affecting the heart.
Additionally, we found that CoQ10 not only improved markers of cellular health and proliferation in a human neuron model but also provided protective effects against lipid peroxidation and DNA damage in the hearts of a mouse model of CDD.
Overall, our findings suggest that CoQ10 may play a crucial role in alleviating oxidative stress and protecting heart health in individuals with CDD, offering a potential therapeutic avenue worth exploring further.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
9
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
9
CoQ10 mitigates chemotherapy-related heart damage
We aimed to explore the effects of Coenzyme Q10 (CoQ10) on heart health in the context of Doxorubicin treatment, a common chemotherapy known for its side effects, including heart damage. Our study involved 27 white albino rats, which we divided into three groups: one receiving CoQ10, another receiving Doxorubicin, and a final group receiving both treatments.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 33 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Elevated energy levels
6 people found this helpful
Key to youth. Coenzyme Q10 is crucial for energy production in the body, especially for energy-demanding organs like the heart and brain. Taking one tablet daily has decreased my depressive feelings significantly and increased my energy. I will continue using it because it truly works.
Read More
9
Youthful vitality
4 people found this helpful
No more ageing! Coenzyme Q10, also known as ubiquinone, is vital for maintaining energy and slowing down the ageing process. It is a powerful antioxidant that protects cells from damage and improves cardiovascular health. I take 1-2 capsules daily to maintain its levels in my body, and I recommend it for improved well-being and vitality.
Read More
10
Antioxidant benefits
2 people found this helpful
Ubiquinone is essential! Discovered in 1957, it is known as a revolutionary means for preventing cardiovascular diseases. By the age of 35, the body’s coenzyme Q10 levels decrease, leading to health issues. Ubiquinone fights free radicals and slows down the ageing process while enhancing energy metabolism. I regularly consume it to combat ageing and maintain health.
Read More
9
Addressing deficiency
1 people found this helpful
Until 40, Q10 levels in a healthy individual are high, but this decreases significantly with age, affecting heart function. The shortage of Q10 can result in tiredness and lethargy. It's almost impossible to increase its intake through food alone, necessitating supplements. I appreciate the simple dosage and felt an immediate positive effect. I recommend it for more energy and vitality.
Read More
9
Impressive heart recovery
1 people found this helpful
Great value for money, but I would prefer different ingredients aside from ubiquinone. My son underwent heart surgery years ago, and doctors are amazed at how well his heart has fared. He has been taking CoQ10 and K2 for a decade.
Read More
Frequently Asked Questions
8
Supports cardiovascular health
I am very pleased with this coenzyme Q10. Each capsule contains 100 mg, which aids in maintaining energy levels and heart health. After a few weeks, I noticed an improvement in my overall endurance and reduced fatigue. The capsules are easy to swallow and have no unpleasant aftertaste. I recommend this to anyone seeking an effective way to support their cardiovascular health and energy levels.
7.5
Significant health improvements
93 people found this helpful
Excellent preparation. It truly helps and is worth the money. I’m over 50 and regret not learning about coenzyme Q10 sooner, as its levels decrease with age. I began taking it for its anti-ageing properties about a year ago. Initially, I saw no change, but after 5-6 months, I noticed significant improvements: my headaches nearly disappeared, sleep improved, and I felt more energetic. Most importantly, my heart no longer feels burdened, likely due to the energy-stimulating effects of coenzyme. It’s essential to take it daily for maximum benefit.
9
Boosted energy levels
1 people found this helpful
Since I began taking NOW Foods CoQ10 100 mg, I’ve experienced a noticeable increase in energy and vitality. This supplement has become essential to my health routine, particularly given my active lifestyle. The softgels are easy to swallow and taste-free. Importantly, I have experienced no negative side effects, only positive outcomes. I highly recommend this product as a natural boost for heart health and cellular energy.
9
Remarkable heart improvement
1 people found this helpful
I gave this to a friend who had significant heart damage after chemotherapy, and her ejection fraction improved dramatically. I take it for overall health, and my husband used it when taking statins, which deplete CoQ10.
7.5
Notable recovery
6 people found this helpful
I am 45, and after suffering from COVID last year, my heart began to ache, and I experienced insomnia and hair loss. My doctor advised me to take coenzyme with omega-3. After a month, my condition improved remarkably. I didn’t expect such effects from supplements but felt better, especially regarding my heart health and skin condition.
9
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
9
CoQ10 mitigates chemotherapy-related heart damage
We aimed to explore the effects of Coenzyme Q10 (CoQ10) on heart health in the context of Doxorubicin treatment, a common chemotherapy known for its side effects, including heart damage. Our study involved 27 white albino rats, which we divided into three groups: one receiving CoQ10, another receiving Doxorubicin, and a final group receiving both treatments.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
We explored how Coenzyme Q10 (CoQ10) combined with ultrasound-targeted microbubble destruction (UTMD) could help treat diabetic cardiomyopathy (DCM) in rats. In our study, we took a close look at the heart health of diabetic rats after using these innovative treatments. Specifically, we used a group of 60 male rats, inducing diabetes in most of them and setting up control groups for comparison.
After treating the rats for 12 weeks, we observed that the group receiving CoQ10 encapsulated in nanoliposomes combined with UTMD showed promising signs of improvement. Notably, their heart structure appeared intact, and they had improved heart function metrics like left ventricular dimensions. We found significant reductions in harmful indicators of heart stress and damage among the treatment group compared to those not receiving the combined therapy.
It's important to mention that while CoQ10 seemed beneficial in this context, the study did not isolate the effects of CoQ10 alone. This means we cannot definitively conclude its exclusive role without considering the combined effect with UTMD. Overall, our findings indicate that CoQ10, especially with the support of advanced delivery techniques, can contribute to better heart health in diabetes-affected conditions.
After treating the rats for 12 weeks, we observed that the group receiving CoQ10 encapsulated in nanoliposomes combined with UTMD showed promising signs of improvement. Notably, their heart structure appeared intact, and they had improved heart function metrics like left ventricular dimensions. We found significant reductions in harmful indicators of heart stress and damage among the treatment group compared to those not receiving the combined therapy.
It's important to mention that while CoQ10 seemed beneficial in this context, the study did not isolate the effects of CoQ10 alone. This means we cannot definitively conclude its exclusive role without considering the combined effect with UTMD. Overall, our findings indicate that CoQ10, especially with the support of advanced delivery techniques, can contribute to better heart health in diabetes-affected conditions.
7
We explored the effects of coenzyme Q10 (CoQ10) on heart disease, particularly in relation to diabetic cardiomyopathy, a common complication for those with diabetes. The study discussed various treatment options for heart issues stemming from diabetes, highlighting how CoQ10 might play a role.
While CoQ10 has shown promise in some areas of heart health, the study indicates it does not deliver clear benefits when isolated from other treatments. This suggests that while it may be part of a broader treatment strategy, relying solely on CoQ10 for heart disease management may not be effective.
In addition to CoQ10, we noted the importance of lifestyle changes such as maintaining a healthy diet and engaging in regular physical activity. These factors are crucial in combatting the progression of diabetic cardiomyopathy and improving overall heart health.
While CoQ10 has shown promise in some areas of heart health, the study indicates it does not deliver clear benefits when isolated from other treatments. This suggests that while it may be part of a broader treatment strategy, relying solely on CoQ10 for heart disease management may not be effective.
In addition to CoQ10, we noted the importance of lifestyle changes such as maintaining a healthy diet and engaging in regular physical activity. These factors are crucial in combatting the progression of diabetic cardiomyopathy and improving overall heart health.
4
Ubiquinone shows mixed heart surgery effects
In our exploration of how coenzyme Q10, also known as ubiquinone, affects outcomes for patients undergoing cardiac surgery, we analyzed its potential benefits in preventing acute kidney injury (AKI). This condition is a significant concern, impacting nearly half of the patients after heart surgery due to factors like ischemia-reperfusion injury and oxidative stress.
For this study, we compared a group of patients who received high doses of ubiquinone—8 mg per kg per day, divided into three doses—with a control group given a placebo. While the intervention did not lead to a significant reduction in the incidence of cardiac surgery-related acute kidney injury, we noted some interesting secondary outcomes. Patients who took ubiquinone experienced less postoperative bleeding and lower levels of a specific heart protein (hs-TnI) indicating less heart damage.
Although ubiquinone didn’t demonstrate a clear advantage in preventing kidney injury, its effect on reducing postoperative bleeding and heart stress markers suggests there may still be beneficial aspects worth further exploration. This study provides a foundation for considering how coenzyme Q10 might play a role in enhancing recovery after heart surgery, even if its effects on kidney injury were not significant.
For this study, we compared a group of patients who received high doses of ubiquinone—8 mg per kg per day, divided into three doses—with a control group given a placebo. While the intervention did not lead to a significant reduction in the incidence of cardiac surgery-related acute kidney injury, we noted some interesting secondary outcomes. Patients who took ubiquinone experienced less postoperative bleeding and lower levels of a specific heart protein (hs-TnI) indicating less heart damage.
Although ubiquinone didn’t demonstrate a clear advantage in preventing kidney injury, its effect on reducing postoperative bleeding and heart stress markers suggests there may still be beneficial aspects worth further exploration. This study provides a foundation for considering how coenzyme Q10 might play a role in enhancing recovery after heart surgery, even if its effects on kidney injury were not significant.
References
- Loi M, Valenti F, Medici G, Mottolese N, Candini G, et al. Beneficial Antioxidant Effects of Coenzyme Q10 in In Vitro and In Vivo Models of CDKL5 Deficiency Disorder. Int J Mol Sci. 2025;26. doi:10.3390/ijms26052204
- Vučemilović H, Kovač R, Stanišić L, Sanader Vučemilović A, Mrčela D, et al. Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac Surgery-Associated Acute Kidney Injury? A Randomized Controlled Trial. Antioxidants (Basel). 2025;14. doi:10.3390/antiox14020243
- Alghibiwi HK, Alhusiani AM, Sarawi WS, Fadda L, Alomar HA, et al. Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4/NF-κB signaling and necroptosis in rats. Cell Mol Biol (Noisy-le-grand). 2025;71:118. doi:10.14715/cmb/2025.70.1.13
- Zhang M, Sun MY, He WY, Yu SF, Ma WC. [Experimental study on the treatment of diabetic cardiomyopathy in rats by using ultrasound-targeted microbubble destruction combined with coenzyme Q10 loaded long-circulating nanoliposomes]. Zhonghua Yi Xue Za Zhi. 2024;104:3765. doi:10.3760/cma.j.cn112137-20240605-01273
- Xu J, Xiang L, Yin X, Song H, Chen C, et al. Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2024;24:592. doi:10.1186/s12872-024-04232-z
- Guo Z, Tian Y, Liu N, Chen Y, Chen X, et al. Mitochondrial Stress as a Central Player in the Pathogenesis of Hypoxia-Related Myocardial Dysfunction: New Insights. Int J Med Sci. 2024;21:2502. doi:10.7150/ijms.99359
- Qazi SU, Bin Naeem MA, Umar M, Zahid MJ, Kan Changez MI, et al. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024;20:221. doi:10.1080/14796678.2024.2352308
- Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. doi:10.47391/JPMA.S6-ACSA-16
- Ali S, Sulaiman E, Dhiaa S. HISTOLOGICAL EFFECTS OF CO ENZYME Q10 ON DOXORUBICIN-INDUCED DEFICITS OF CARDIOPULMONARY AXIS IN WHITE ALBINO RATS. Georgian Med News. 2024.
- Alehagen U, Aaseth J, Schomburg L, Larsson A, Opstad T, et al. Selenoprotein P increases upon selenium and coenzyme Q supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality. Free Radic Biol Med. 2024;222:403. doi:10.1016/j.freeradbiomed.2024.06.027
- Zeng M, Chen Z, Zhang Y, Pang Y. Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis. J Infect Dev Ctries. 2024;18:658. doi:10.3855/jidc.18776
- Du H, Zhao Y, Wen J, Dai B, Hu G, et al. LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1. Circulation. 2024;150:1030. doi:10.1161/CIRCULATIONAHA.123.067861
- Graczyk P, Dach A, Dyrka K, Pawlik A. Pathophysiology and Advances in the Therapy of Cardiomyopathy in Patients with Diabetes Mellitus. Int J Mol Sci. 2024;25. doi:10.3390/ijms25095027
- Alehagen U, Alexander J, Aaseth JO, Larsson A, Opstad TB. Supplementation with selenium and coenzyme Q in an elderly Swedish population low in selenium - positive effects on thyroid hormones, cardiovascular mortality, and quality of life. BMC Med. 2024;22:191. doi:10.1186/s12916-024-03411-1
- Antar SA, Abdo W, Helal AI, Abduh MS, Hakami ZH, et al. Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice. Life Sci. 2024;348:122688. doi:10.1016/j.lfs.2024.122688
- Seo JS. Chronological change of left ventricular global longitudinal strain in patients with maternally inherited diabetes and deafness: A case series. Medicine (Baltimore). 2024;103:e37447. doi:10.1097/MD.0000000000037447
