Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.4
USERS' SCORE
Good
Based on 7 Reviews
8.3
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Magnesium (from Magnesium Aspartate)
250 mg
60%
Potassium (from Potassium Aspartate)
99 mg
2%
Taurine (Free-Form)
100 mg
†
Top Medical Research Studies
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
Read More
Most Useful Reviews
9
Mood stability
21 people found this helpful
Excellent product! I have tried various magnesium supplements; some caused diarrhea while others had no noticeable effect. However, this one is fantastic! It has alleviated my anxiety and heart palpitations, significantly improving my overall mood stability. It also helps reduce the stress associated with PMS. I've reordered, and I'm very satisfied!
Read More
9
Heart support
I order this for my mum, who has angina pectoris. It provides excellent support for her heart muscle.
Read More
8
Sleep improvement
102 people found this helpful
Excellent! My bowel function has improved noticeably, and sleep has also benefited. I take 2 capsules at night with a light meal. The capsule size is normal and easy to swallow. This product deserves an excellent rating; its quality is top notch. It will be a regular part of my orders now.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.4
- All Researches
9.5
We assessed a unique case of a woman with Sjogren's syndrome who faced severe muscle weakness due to low potassium levels, a condition known as hypokalemic paralysis. This rare complication stemmed from distal renal tubular acidosis associated with her autoimmune disorder.
After administering potassium chloride, she fully regained her muscle strength, highlighting how critical timely diagnosis and treatment are for preventing serious complications. We emphasize the need for healthcare providers to regularly check electrolyte levels in patients experiencing muscle weakness to improve health outcomes.
After administering potassium chloride, she fully regained her muscle strength, highlighting how critical timely diagnosis and treatment are for preventing serious complications. We emphasize the need for healthcare providers to regularly check electrolyte levels in patients experiencing muscle weakness to improve health outcomes.
Read More
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
9
We explored the potential of a new magnesium-aluminum layered double hydroxide combined with nano-ceria in treating rheumatoid arthritis (RA). This innovative therapy targets the unhealthy immune environment and the harmful buildup of hydrogen ions associated with RA. By neutralizing excess acidity, we observed improved immune responses, encouraging the body to heal damaged bones. This approach showed promising results in mice models, indicating it may be a viable future treatment for managing RA effectively.
Read More
9
Magnesium aids arthritis through immunity
We explored the effects of a high magnesium diet on rheumatoid arthritis using two mouse models. Our findings suggest that magnesium can significantly reduce arthritis severity and joint damage, while also promoting immune cell types that help combat inflammation.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Mood stability
21 people found this helpful
Excellent product! I have tried various magnesium supplements; some caused diarrhea while others had no noticeable effect. However, this one is fantastic! It has alleviated my anxiety and heart palpitations, significantly improving my overall mood stability. It also helps reduce the stress associated with PMS. I've reordered, and I'm very satisfied!
Read More
9
Heart support
I order this for my mum, who has angina pectoris. It provides excellent support for her heart muscle.
Read More
8
Sleep improvement
102 people found this helpful
Excellent! My bowel function has improved noticeably, and sleep has also benefited. I take 2 capsules at night with a light meal. The capsule size is normal and easy to swallow. This product deserves an excellent rating; its quality is top notch. It will be a regular part of my orders now.
Read More
7.5
Enhanced sleep quality
1 people found this helpful
Working due to the ongoing war has made me rather irritable, leaving me unable to relax or sleep well at night. I decided to try magnesium with potassium and selected this supplement based on favourable reviews. After taking it for two weeks, I noticed that I felt calmer and my sleep improved significantly.
Read More
7.5
Heart improvement
I ordered this for my aunt to enhance her heart function, and she says the effect is palpable.
Read More
Frequently Asked Questions
7.5
Enhanced sleep quality
1 people found this helpful
Working due to the ongoing war has made me rather irritable, leaving me unable to relax or sleep well at night. I decided to try magnesium with potassium and selected this supplement based on favourable reviews. After taking it for two weeks, I noticed that I felt calmer and my sleep improved significantly.
9
Mood stability
21 people found this helpful
Excellent product! I have tried various magnesium supplements; some caused diarrhea while others had no noticeable effect. However, this one is fantastic! It has alleviated my anxiety and heart palpitations, significantly improving my overall mood stability. It also helps reduce the stress associated with PMS. I've reordered, and I'm very satisfied!
8
Sleep improvement
102 people found this helpful
Excellent! My bowel function has improved noticeably, and sleep has also benefited. I take 2 capsules at night with a light meal. The capsule size is normal and easy to swallow. This product deserves an excellent rating; its quality is top notch. It will be a regular part of my orders now.
9
Heart support
I order this for my mum, who has angina pectoris. It provides excellent support for her heart muscle.
7.5
Calming properties
I ordered this for my mother as a source of potassium and magnesium. It effectively calms the nervous system, supports the heart, and notably improves sleep quality.
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
8
We explored the relationship between dietary magnesium intake and all-cause mortality in patients with rheumatoid arthritis (RA) using data from the NHANES database.
Analyzing nearly 3,000 RA patients, we found that those who consumed higher magnesium levels experienced an 11.12% lower risk of death.
This benefit was particularly notable in younger individuals under 65, females, and those with a lower body mass index.
This suggests that adequate magnesium intake could play a vital role in improving survival outcomes for RA patients.
Analyzing nearly 3,000 RA patients, we found that those who consumed higher magnesium levels experienced an 11.12% lower risk of death.
This benefit was particularly notable in younger individuals under 65, females, and those with a lower body mass index.
This suggests that adequate magnesium intake could play a vital role in improving survival outcomes for RA patients.
9
Magnesium mitigates MS-related mood issues
We investigated the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression in multiple sclerosis (MS), a disease often accompanied by these mood disorders. Our findings indicated that MgH treatment significantly improved anxiety and depression-like behaviors in mice with experimental autoimmune encephalomyelitis (EAE).
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
References
- Toaima DN, Abdel-Maksoud KS, Atef HM, Salah NY. Magnesium, fibrinolysis and clotting interplay among children and adolescents with type 1 diabetes mellitus; potential mediators of diabetic microangiopathy. Nutr Diabetes. 2025;15:13. doi:10.1038/s41387-025-00368-9
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. doi:10.3390/nu16234247
- Fu C, Huang L, Lian C, Yue J, Lin P, et al. Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder. Brain Res. 2025;1846:149234. doi:10.1016/j.brainres.2024.149234
- Yan Y, Yao C, Zhang B, Yang Z, Xie J, et al. Olanzapine vs. magnesium valproate vs. lamotrigine in anti-N-methyl-D-aspartic acid receptor encephalitis: a retrospective study. BMC Neurol. 2024;24:331. doi:10.1186/s12883-024-03811-z
- Verlato A, Laragione T, Bin S, Kim RH, Salem F, et al. Revised version with tracked changes oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus. BMC Immunol. 2024;25:58. doi:10.1186/s12865-024-00650-y
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. doi:10.1186/s41043-024-00597-1
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. doi:10.1002/advs.202307094
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. doi:10.1186/s12889-023-16906-y
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. doi:10.1016/j.ebiom.2023.104603
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
- Chen R, Fang L, Fang X, Ning J. Sjögren's syndrome complicated with hypothyroidism and osteomalacia: A case report. Medicine (Baltimore). 2024;103:e39771. doi:10.1097/MD.0000000000039771
- Fujikawa M, Okamura K. Graves' hyperthyroidism treated with potassium iodide: early response and after 2 years of follow-up. Eur Thyroid J. 2024;13. doi:10.1530/ETJ-24-0085
- Matsui R, Gojo M, Odajima K, Asakawa S, Arai S, et al. Coexistence of Sjögren's Syndrome-associated Interstitial Nephritis and Hypokalemic Nephropathy in a Patient with Distal Renal Tubular Acidosis. Intern Med. 2025;64:1067. doi:10.2169/internalmedicine.4152-24
- Fazio L, Naik VN, Therpurakal RN, Gomez Osorio FM, Rychlik N, et al. Retigabine, a potassium channel opener, restores thalamocortical neuron functionality in a murine model of autoimmune encephalomyelitis. Brain Behav Immun. 2024;122:202. doi:10.1016/j.bbi.2024.08.023
- Mehdipour Dalivand M, Abdolazimi R, Alikhani M. Hypokalemic quadriplegia in Sjogren's syndrome: A case report. Clin Case Rep. 2024;12:e9227. doi:10.1002/ccr3.9227
