Last update
4/6/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Magnesium (from Magnesium Aspartate)
250 mg
60%
Potassium (from Potassium Aspartate)
99 mg
2%
Taurine (Free-Form)
100 mg
†
Top Medical Research Studies
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
8
Riluzole effectively reduces bone pain
We explored whether riluzole could help ease bone pain caused by prostate cancer. Using a mouse model that mimicked human bone cancer pain, we treated some mice with riluzole while others were not.
Our findings indicated that riluzole significantly reduced pain sensitivity without hindering cancer progression or bone health. This treatment seems effective in offering relief from unpleasant pain sensations associated with bone metastases.
Our findings indicated that riluzole significantly reduced pain sensitivity without hindering cancer progression or bone health. This treatment seems effective in offering relief from unpleasant pain sensations associated with bone metastases.
Read More
8
We explored a unique case where a 39-year-old man presented with severe bone pain due to Sjögren's syndrome-related renal issues. He also exhibited symptoms like polydipsia and hypophosphatemic osteomalacia. After one month of potassium, phosphate, vitamin D, and sodium bicarbonate supplements, we observed significant relief in his bone pain, alongside normalized potassium and phosphorus levels. This indicates that potassium intake can play a crucial role in alleviating bone pain linked to kidney dysfunction in autoimmune conditions, such as Sjögren's syndrome.
Read More
Most Useful Reviews
7.5
Enhanced bone health
1 people found this helpful
My mother took this just before bed, and not only did she stop snoring (which was a relief for me), but her mood was noticeably better the following morning! I quickly recommended she continue with this supplement. Combined with magnesium, it seems to be absorbed more easily than a potassium-only supplement. Over the following months, we witnessed improvements in her bone health, including better posture, more stable movements, and straighter bones.
Read More
7.5
Lower back relief
This magnesium product boasts clean ingredients and an appropriate portion size. I genuinely felt it helped relieve my lower back pain. However, I noticed it made me sleepy if taken during the day.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
- All Researches
8
Riluzole effectively reduces bone pain
We explored whether riluzole could help ease bone pain caused by prostate cancer. Using a mouse model that mimicked human bone cancer pain, we treated some mice with riluzole while others were not.
Our findings indicated that riluzole significantly reduced pain sensitivity without hindering cancer progression or bone health. This treatment seems effective in offering relief from unpleasant pain sensations associated with bone metastases.
Our findings indicated that riluzole significantly reduced pain sensitivity without hindering cancer progression or bone health. This treatment seems effective in offering relief from unpleasant pain sensations associated with bone metastases.
Read More
8
We explored a unique case where a 39-year-old man presented with severe bone pain due to Sjögren's syndrome-related renal issues. He also exhibited symptoms like polydipsia and hypophosphatemic osteomalacia. After one month of potassium, phosphate, vitamin D, and sodium bicarbonate supplements, we observed significant relief in his bone pain, alongside normalized potassium and phosphorus levels. This indicates that potassium intake can play a crucial role in alleviating bone pain linked to kidney dysfunction in autoimmune conditions, such as Sjögren's syndrome.
Read More
8
We examined the effects of low-dose adefovir therapy on bone pain in patients showing signs of nephrogenic hypophosphatemic osteomalacia. Over two years, five patients developed reduced phosphate levels and renal issues, leading to bone pain. After stopping the treatment and providing phosphate and potassium supplements, we noticed significant decreases in bone pain and improved mobility in some patients. This indicates that potassium treatment, alongside phosphate supplementation, can positively affect bone pain related to kidney issues stemming from adefovir.
Read More
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Enhanced bone health
1 people found this helpful
My mother took this just before bed, and not only did she stop snoring (which was a relief for me), but her mood was noticeably better the following morning! I quickly recommended she continue with this supplement. Combined with magnesium, it seems to be absorbed more easily than a potassium-only supplement. Over the following months, we witnessed improvements in her bone health, including better posture, more stable movements, and straighter bones.
Read More
7.5
Lower back relief
This magnesium product boasts clean ingredients and an appropriate portion size. I genuinely felt it helped relieve my lower back pain. However, I noticed it made me sleepy if taken during the day.
Read More
Frequently Asked Questions
7.5
Enhanced bone health
1 people found this helpful
My mother took this just before bed, and not only did she stop snoring (which was a relief for me), but her mood was noticeably better the following morning! I quickly recommended she continue with this supplement. Combined with magnesium, it seems to be absorbed more easily than a potassium-only supplement. Over the following months, we witnessed improvements in her bone health, including better posture, more stable movements, and straighter bones.
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
8
We explored a unique case where a 39-year-old man presented with severe bone pain due to Sjögren's syndrome-related renal issues. He also exhibited symptoms like polydipsia and hypophosphatemic osteomalacia. After one month of potassium, phosphate, vitamin D, and sodium bicarbonate supplements, we observed significant relief in his bone pain, alongside normalized potassium and phosphorus levels. This indicates that potassium intake can play a crucial role in alleviating bone pain linked to kidney dysfunction in autoimmune conditions, such as Sjögren's syndrome.
8
We examined the effects of low-dose adefovir therapy on bone pain in patients showing signs of nephrogenic hypophosphatemic osteomalacia. Over two years, five patients developed reduced phosphate levels and renal issues, leading to bone pain. After stopping the treatment and providing phosphate and potassium supplements, we noticed significant decreases in bone pain and improved mobility in some patients. This indicates that potassium treatment, alongside phosphate supplementation, can positively affect bone pain related to kidney issues stemming from adefovir.
References
- Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. 10.3389/fbioe.2023.1153969
- Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593. PubMed
- Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129. PubMed
- Chen R, Fang L, Fang X, Ning J. Sjögren's syndrome complicated with hypothyroidism and osteomalacia: A case report. Medicine (Baltimore). 2024;103:e39771. 10.1097/MD.0000000000039771
- Delanne-Cuménal M, Lamoine S, Meleine M, Aissouni Y, Prival L, et al. The TREK-1 potassium channel is involved in both the analgesic and anti-proliferative effects of riluzole in bone cancer pain. Biomed Pharmacother. 2024;176:116887. 10.1016/j.biopha.2024.116887
- Filler G, Schott C, Salerno FR, Ens A, McIntyre CW, et al. Growth hormone therapy in HHRH. Bone Rep. 2022;16:101591. 10.1016/j.bonr.2022.101591
- Geng Y, Zhao Y, Zhang Z. Tubulointerstitial nephritis-induced hypophosphatemic osteomalacia in Sjögren's syndrome: a case report and review of the literature. Clin Rheumatol. 2018;37:257. 10.1007/s10067-017-3762-y
- Xu Y, Shen P, Pan X, Chen N. Nephrogenic hypophosphatemic osteomalacia during adefovir monotherapy for chronic hepatitis B monoinfection. Clin Kidney J. 2013;6:379. 10.1093/ckj/sft069
- Earle KE, Seneviratne T, Shaker J, Shoback D. Fanconi's syndrome in HIV+ adults: report of three cases and literature review. J Bone Miner Res. 2004;19:714. PubMed
