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SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Magnesium (from Magnesium Aspartate)
250 mg
60%
Potassium (from Potassium Aspartate)
99 mg
2%
Taurine (Free-Form)
100 mg
†
Top Medical Research Studies
9
Taurine aids diabetic neuropathy
Taurine ameliorates axonal damage in sciatic nerve of diabetic rats and high glucose exposed DRG neuron by PI3K/Akt/mTOR-dependent pathway.
Direct impact on neuropathy
We explored how taurine can help in treating diabetic peripheral neuropathy, a common complication arising from diabetes characterized mainly by issues in nerve function. Our research demonstrated that taurine notably reduced blood sugar levels, alleviated insulin resistance, and improved abnormal nerve conduction in diabetic rats, showing its potential as a treatment option.
We observed that taurine not only corrected the damaged structure of axons in the sciatic nerve of these rats but also stimulated the growth of axons in Dorsal root ganglion (DRG) neurons that were exposed to high glucose levels. Moreover, taurine elevated the phosphorylation of key proteins in the PI3K/Akt/mTOR signaling pathway, which plays an important role in cell growth and survival.
However, when we applied specific inhibitors for Akt and mTOR, they blocked taurine's positive effects on axonal damage. This indicates that taurine’s protective benefits against axonal deterioration in diabetic rats depend on activating this particular signaling pathway. Our findings suggest that taurine might be a promising candidate for addressing nerve damage associated with diabetes.
We observed that taurine not only corrected the damaged structure of axons in the sciatic nerve of these rats but also stimulated the growth of axons in Dorsal root ganglion (DRG) neurons that were exposed to high glucose levels. Moreover, taurine elevated the phosphorylation of key proteins in the PI3K/Akt/mTOR signaling pathway, which plays an important role in cell growth and survival.
However, when we applied specific inhibitors for Akt and mTOR, they blocked taurine's positive effects on axonal damage. This indicates that taurine’s protective benefits against axonal deterioration in diabetic rats depend on activating this particular signaling pathway. Our findings suggest that taurine might be a promising candidate for addressing nerve damage associated with diabetes.
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8
Taurine alters miRNA profiles
The microRNAs Expression Profile in Sciatic Nerves of Diabetic Neuropathy Rats After Taurine Treatment by Sequencing.
Strong relevance to taurine research
We aimed to understand how taurine treatment impacts diabetic neuropathy by examining changes in microRNA (miRNA) expression in the sciatic nerves of rats. The study included three groups: a control group, a diabetic group, and a taurine-treated group. Our findings revealed significant differences in miRNA expressions between these groups, with 80 miRNAs differing in the diabetic group compared to the control.
Diabetic rats showed a mix of up-regulation and down-regulation in miRNAs, while the taurine treatment group exhibited a shift of 215 differential miRNAs compared to the diabetic group. Interestingly, only 1 miRNA was found to be up-regulated in the taurine-treated group, while a majority of 214 were down-regulated. We identified twelve specific miRNAs and analyzed their potential target genes, revealing connections to essential processes like neuron generation and nerve development.
Ultimately, our study provides valuable insights into the protective effects of taurine against diabetic peripheral neuropathy by shedding light on miRNA profiles. This research paves the way for further exploration into taurine's mechanisms of action in nerve health.
Diabetic rats showed a mix of up-regulation and down-regulation in miRNAs, while the taurine treatment group exhibited a shift of 215 differential miRNAs compared to the diabetic group. Interestingly, only 1 miRNA was found to be up-regulated in the taurine-treated group, while a majority of 214 were down-regulated. We identified twelve specific miRNAs and analyzed their potential target genes, revealing connections to essential processes like neuron generation and nerve development.
Ultimately, our study provides valuable insights into the protective effects of taurine against diabetic peripheral neuropathy by shedding light on miRNA profiles. This research paves the way for further exploration into taurine's mechanisms of action in nerve health.
Read More
9
Magnesium's potential in neuropathy treatment
Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.
Strong correlation to neuropathy
A recent study explored the connection between magnesium levels and diabetic sensorimotor polyneuropathy. We measured serum magnesium and plasma methylglyoxal levels in recently diagnosed type 2 diabetes patients—some with neuropathy and others without.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
Read More
Most Useful Reviews
8.8
Minimal neuropathy
This product is helping to keep my neuropathy minimal and, I believe, aids a bit with my blood pressure as well.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
9
Magnesium's potential in neuropathy treatment
Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.
Strong correlation to neuropathy
A recent study explored the connection between magnesium levels and diabetic sensorimotor polyneuropathy. We measured serum magnesium and plasma methylglyoxal levels in recently diagnosed type 2 diabetes patients—some with neuropathy and others without.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
Read More
9
Magnesium enhances methadone efficacy
Magnesium Salt, a Simple Strategy to Improve Methadone Analgesia in Chronic Pain: An Isobolographic Preclinical Study in Neuropathic Mice.
Moderate relevance due to combination use
We explored how magnesium could enhance the pain relief effects of methadone in a study involving mice with neuropathy. The research focused on whether combining magnesium sulfate with methadone could provide better analgesic benefits compared to methadone alone.
To assess this, we used the formalin test which measures pain responses in a controlled environment. By injecting formalin into the neuropathic limb of these mice, we were able to observe their pain behavior over a set observation period.
The results showed that both magnesium and methadone effectively reduced pain responses on their own. However, the combination of magnesium sulfate and methadone produced a superadditive interaction, meaning they worked better together than expected. This finding suggests that incorporating magnesium could potentially allow for lower doses of methadone, reducing the risk of side effects while improving pain management in neuropathic conditions.
To assess this, we used the formalin test which measures pain responses in a controlled environment. By injecting formalin into the neuropathic limb of these mice, we were able to observe their pain behavior over a set observation period.
The results showed that both magnesium and methadone effectively reduced pain responses on their own. However, the combination of magnesium sulfate and methadone produced a superadditive interaction, meaning they worked better together than expected. This finding suggests that incorporating magnesium could potentially allow for lower doses of methadone, reducing the risk of side effects while improving pain management in neuropathic conditions.
Read More
9
Taurine aids diabetic neuropathy recovery
Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway.
Direct effects of taurine confirmed
We explored the effects of taurine on spinal cord axon injury associated with diabetic neuropathy, a common complication of diabetes that primarily leads to axonal degeneration. In our study, we used a rat model induced by streptozotocin to assess the potential neuroprotective properties of taurine.
Our findings revealed that taurine significantly improved the condition of spinal cord axons, demonstrating both structural and functional benefits. Not only did it help repair axonal damage, but it also encouraged the growth of neurites in neurons exposed to high glucose levels, which is crucial in a diabetic context.
Further analysis showed that taurine increased the levels of nerve growth factor (NGF) and GAP-43, a protein associated with neurite growth. It also enhanced the phosphorylation of key signaling proteins such as TrkA, Akt, and mTOR, indicating that taurine activates important pathways that promote nerve health. We noted that the positive effects of taurine were diminished when we introduced inhibitors targeting NGF, Akt, or mTOR, suggesting its neuroprotective action relies on these pathways.
In conclusion, taurine appears to play a valuable role in promoting the repair of spinal cord axons following injury caused by diabetes, highlighting its potential as a therapeutic option for managing diabetic neuropathy.
Our findings revealed that taurine significantly improved the condition of spinal cord axons, demonstrating both structural and functional benefits. Not only did it help repair axonal damage, but it also encouraged the growth of neurites in neurons exposed to high glucose levels, which is crucial in a diabetic context.
Further analysis showed that taurine increased the levels of nerve growth factor (NGF) and GAP-43, a protein associated with neurite growth. It also enhanced the phosphorylation of key signaling proteins such as TrkA, Akt, and mTOR, indicating that taurine activates important pathways that promote nerve health. We noted that the positive effects of taurine were diminished when we introduced inhibitors targeting NGF, Akt, or mTOR, suggesting its neuroprotective action relies on these pathways.
In conclusion, taurine appears to play a valuable role in promoting the repair of spinal cord axons following injury caused by diabetes, highlighting its potential as a therapeutic option for managing diabetic neuropathy.
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9
Taurine aids nerve regeneration
Bridging potential of Taurine-loading PCL conduits transplanted with hEnSCs on resected sciatic nerves.
Study's mixed effectiveness noted
We explored the potential benefits of taurine in repairing damaged nerves through our study that tested its effects with specially designed conduits. We used a material called polycaprolactone (PCL) and added taurine to it, alongside human endothelial stem cells (hEnSCs), in a series of experiments with forty-two Wistar rats. These rats were divided into different groups: some received no treatment, while others were exposed to a nerve graft, a simple PCL conduit, taurine-infused PCL conduits, PCL conduits with stem cells, and finally, the taurine conduits with stem cells.
Our analysis revealed that rats with the taurine-loaded conduits enhanced recovery of both motor and sensory nerves compared to the other groups. We noted improved muscle response and reduced latency of nerve signals. Histological evaluations indicated impressive nerve regeneration and significant bridging in the taurine and stem cell combination group, signifying a robust healing effect.
Overall, we found that taurine-loaded PCL conduits combined with human endothelial stem cells may provide an effective approach for promoting nerve regeneration in the sciatic nerve. This study highlights the promising role of taurine in enhancing recovery, although we must acknowledge that our findings also depend on the interaction between the conduit material and the stem cells used.
Our analysis revealed that rats with the taurine-loaded conduits enhanced recovery of both motor and sensory nerves compared to the other groups. We noted improved muscle response and reduced latency of nerve signals. Histological evaluations indicated impressive nerve regeneration and significant bridging in the taurine and stem cell combination group, signifying a robust healing effect.
Overall, we found that taurine-loaded PCL conduits combined with human endothelial stem cells may provide an effective approach for promoting nerve regeneration in the sciatic nerve. This study highlights the promising role of taurine in enhancing recovery, although we must acknowledge that our findings also depend on the interaction between the conduit material and the stem cells used.
Read More
9
Taurine mitigates diabetic neuropathy
Taurine Ameliorates Oxidative Stress in Spinal Cords of Diabetic Rats via Keap1-Nrf2 Signaling.
Highly relevant to taurine’s effects
We aimed to understand how taurine, a well-known antioxidant, impacts neuropathy linked to diabetes. In a carefully designed experiment, we injected diabetic rats with a compound called STZ to induce diabetes and then treated them with taurine through their drinking water.
Throughout the study, we recorded the changes in body weight and blood glucose levels. We also looked at key proteins like Gap-43 and MBP that are important for nerve function. Measurements of oxidative stress indicators—such as superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels—provided insight into the cell damage associated with diabetes.
What we found was truly interesting. In diabetic rats, we observed weight loss, increased blood glucose, and decreased levels of Gap-43 and MBP. However, these negative changes were significantly improved with taurine treatment. Specifically, taurine helped to increase SOD activity and reduce MDA levels, suggesting a decrease in oxidative stress.
We also evaluated the gene expression of proteins involved in the Keap1-Nrf2 signaling pathway, which plays a critical role in cellular defense. Our results indicated that taurine led to lower levels of Keap1 while boosting the production of Nrf2 and HO-1, further supporting its role in reducing oxidative stress in diabetic neuropathy.
Overall, taurine appears to be effective in mitigating the harmful effects of oxidative stress and improving nerve function in diabetic rats, making it a potential therapeutic option for neuropathy.
Throughout the study, we recorded the changes in body weight and blood glucose levels. We also looked at key proteins like Gap-43 and MBP that are important for nerve function. Measurements of oxidative stress indicators—such as superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels—provided insight into the cell damage associated with diabetes.
What we found was truly interesting. In diabetic rats, we observed weight loss, increased blood glucose, and decreased levels of Gap-43 and MBP. However, these negative changes were significantly improved with taurine treatment. Specifically, taurine helped to increase SOD activity and reduce MDA levels, suggesting a decrease in oxidative stress.
We also evaluated the gene expression of proteins involved in the Keap1-Nrf2 signaling pathway, which plays a critical role in cellular defense. Our results indicated that taurine led to lower levels of Keap1 while boosting the production of Nrf2 and HO-1, further supporting its role in reducing oxidative stress in diabetic neuropathy.
Overall, taurine appears to be effective in mitigating the harmful effects of oxidative stress and improving nerve function in diabetic rats, making it a potential therapeutic option for neuropathy.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Minimal neuropathy
This product is helping to keep my neuropathy minimal and, I believe, aids a bit with my blood pressure as well.
