Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%**
Saturated Fat
< 0.5 g
2%**
Polyunsaturated Fat
0.5 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Omega-3 Fatty Acids:
Eicosapentaenoic Acid (EPA)
180 mg
†
Docosahexaenoic Acid (DHA)
120 mg
†
Top Medical Research Studies
7
We examined the effects of omega-3 supplementation on rheumatoid arthritis through a meta-analysis of 18 randomized controlled trials involving over 1,000 patients.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall.
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We conducted a systematic review of randomized placebo-controlled trials to investigate whether omega-3 fatty acids can benefit those with rheumatoid arthritis (RA). Our analysis of 23 studies found that while there were some signs of reduced pain and fewer tender and swollen joints, the effects were minimal and not clinically significant.
Additionally, we noted a small reduction in the intake of NSAIDs and c-reactive protein levels, but overall, the evidence quality was low. Thus, omega-3 supplementation appears to have limited effectiveness in managing RA symptoms.
Additionally, we noted a small reduction in the intake of NSAIDs and c-reactive protein levels, but overall, the evidence quality was low. Thus, omega-3 supplementation appears to have limited effectiveness in managing RA symptoms.
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8
We examined the effects of omega-3 fatty acids on autoimmune diseases through a comprehensive review and a Mendelian randomization analysis. Our findings suggest that omega-3 fatty acids can help reduce disease activity and lower inflammation in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
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Most Useful Reviews
9
Effective for inflammation
14 people found this helpful
This product is effective for reducing inflammation and has worked well for my rheumatoid arthritis for years. I've discovered that taking larger doses in the morning and evening delivers the best results.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
- All Researches
8
We examined the effects of omega-3 fatty acids on autoimmune diseases through a comprehensive review and a Mendelian randomization analysis. Our findings suggest that omega-3 fatty acids can help reduce disease activity and lower inflammation in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
Read More
8
Promising therapy for rheumatoid arthritis
We explored the impact of a lipid mediator derived from docosahexaenoic acid (DHA) on rheumatoid arthritis. In our study, the mediator showed promise in reducing inflammation in mice with collagen antibody-induced arthritis.
This treatment significantly decreased joint swelling and improved overall arthritis symptoms. Additionally, it lowered levels of harmful cytokines in the serum and boosted protective cytokines.
Our findings suggest that this lipid mediator could be a beneficial addition to rheumatoid arthritis therapy, potentially alleviating symptoms and repairing joint damage.
This treatment significantly decreased joint swelling and improved overall arthritis symptoms. Additionally, it lowered levels of harmful cytokines in the serum and boosted protective cytokines.
Our findings suggest that this lipid mediator could be a beneficial addition to rheumatoid arthritis therapy, potentially alleviating symptoms and repairing joint damage.
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8
This study focused on how omega-3 and omega-6 fatty acids might influence disease activity in patients with early rheumatoid arthritis (RA). We examined the serum profiles of 669 patients and identified distinct fatty acid patterns.
Our findings revealed that a higher presence of omega-3 fatty acids was linked to lower disease activity after six months. Similarly, an omega-6 profile also showed reduced disease activity. These results suggest that incorporating these fatty acids could beneficially impact RA management.
Our findings revealed that a higher presence of omega-3 fatty acids was linked to lower disease activity after six months. Similarly, an omega-6 profile also showed reduced disease activity. These results suggest that incorporating these fatty acids could beneficially impact RA management.
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8
We examined the potential benefits of omega-3 fatty acids on rheumatoid arthritis (RA) through a systematic review of 71 studies. Our findings suggest that a diet rich in these fatty acids may help reduce pain and disease activity in RA patients.
Consuming fish, a primary source of omega-3s, could also lower the incidence of RA. Given their anti-inflammatory properties, we believe that integrating omega-3s into treatment plans, alongside standard medications, could significantly enhance the quality of life for those living with RA.
Consuming fish, a primary source of omega-3s, could also lower the incidence of RA. Given their anti-inflammatory properties, we believe that integrating omega-3s into treatment plans, alongside standard medications, could significantly enhance the quality of life for those living with RA.
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8
We explored the impact of omega-3 fatty acids on pain relief in rheumatoid arthritis (RA) patients treated with Janus kinase inhibitors (JAKi).
By analyzing lipid levels, we found that those on JAKi showed a significant increase in omega-3 fatty acids and docosahexaenoic acid (DHA).
Notably, 66.7% of these patients reported manageable pain after 24 weeks, and the reduction in pain correlated with the rise in DHA levels. This suggests that omega-3 fatty acids may play a key role in enhancing the pain-relief benefits of JAKi treatment.
By analyzing lipid levels, we found that those on JAKi showed a significant increase in omega-3 fatty acids and docosahexaenoic acid (DHA).
Notably, 66.7% of these patients reported manageable pain after 24 weeks, and the reduction in pain correlated with the rise in DHA levels. This suggests that omega-3 fatty acids may play a key role in enhancing the pain-relief benefits of JAKi treatment.
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User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for inflammation
14 people found this helpful
This product is effective for reducing inflammation and has worked well for my rheumatoid arthritis for years. I've discovered that taking larger doses in the morning and evening delivers the best results.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Wang Y, Hu S, Zhang W, Zhang B, Yang Z. Dietary factors and rheumatoid arthritis: new perspectives from a Mendelian randomisation analysis. Br J Nutr. 2025;133:107. doi:10.1017/S0007114524002721
- Hong K, Hun M, Wu F, Mao J, Wang Y, et al. Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian randomization analysis. Autoimmun Rev. 2024;23:103651. doi:10.1016/j.autrev.2024.103651
- Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. doi:10.1007/s10067-024-07040-0
- Kang T, Xi Y, Qian T, Lu S, Du M, et al. Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: NHANES 1999-2020 study. Clin Exp Rheumatol. 2024;42:1720. doi:10.55563/clinexprheumatol/91tmfb
- Laevski AM, Doucet MR, Doucet MS, LeBlanc AA, Pineau PE, et al. Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr. 2024;63:2221. doi:10.1007/s00394-024-03397-9
- Su Y, Han Y, Choi HS, Lee GY, Cho HW, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis. Biomed Pharmacother. 2024;171:116153. doi:10.1016/j.biopha.2024.116153
- Léger T, Brun A, Lanchais K, Rigaudière JP, Briat A, et al. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sci. 2023;327:121826. doi:10.1016/j.lfs.2023.121826
- Marchand NE, Choi MY, Oakes EG, Cook NR, Stevens E, et al. Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2023;190:102542. doi:10.1016/j.plefa.2023.102542
- Gkiouras K, Grammatikopoulou MG, Myrogiannis I, Papamitsou T, Rigopoulou EI, et al. Efficacy of n-3 fatty acid supplementation on rheumatoid arthritis' disease activity indicators: a systematic review and meta-analysis of randomized placebo-controlled trials. Crit Rev Food Sci Nutr. 2024;64:16. doi:10.1080/10408398.2022.2104210
- Sigaux J, Bellicha A, Buscail C, Julia C, Flipo RM, et al. Serum Fatty Acid Profiles Are Associated with Disease Activity in Early Rheumatoid Arthritis: Results from the ESPOIR Cohort. Nutrients. 2022;14. doi:10.3390/nu14142947
- Sigaux J, Mathieu S, Nguyen Y, Sanchez P, Letarouilly JG, et al. Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis. Arthritis Res Ther. 2022;24:100. doi:10.1186/s13075-022-02781-2
- Tański W, Świątoniowska-Lonc N, Tabin M, Jankowska-Polańska B. The Relationship between Fatty Acids and the Development, Course and Treatment of Rheumatoid Arthritis. Nutrients. 2022;14. doi:10.3390/nu14051030
- Amjad S, Ahmad N, Afreen A, Ashraf S, Ahmed Z. Efficacy of Flaxseed and Fish Oils on Adults with Rheumatoid Arthritis. J Pak Med Assoc. 2022;72:22. doi:10.47391/JPMA.02-290
- Hahn J, Cook NR, Alexander EK, Friedman S, Walter J, et al. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. BMJ. 2022;376:e066452. doi:10.1136/bmj-2021-066452
- Chang CK, Chen PK, Chen CC, Chang SH, Chen CH, et al. Increased Levels of Omega-3 Fatty Acids and DHA Are Linked to Pain Reduction in Rheumatoid Arthritis Patients Treated with Janus Kinase Inhibitors. Nutrients. 2021;13. doi:10.3390/nu13093050
- Kucharská J, Poništ S, Vančová O, Gvozdjáková A, Uličná O, et al. Treatment with coenzyme Q10, omega-3-polyunsaturated fatty acids and their combination improved bioenergetics and levels of coenzyme Q9 and Q10 in skeletal muscle mitochondria in experimental model of arthritis. Physiol Res. 2021;70:723.
