We investigated how exposure to ultrafine particles (UFPs) in cold and humid environments impacts respiratory health. Using a controlled study with male Balb/c mice, we found that exposure to carbon black nanoparticles worsened lung function and increased inflammation and oxidative stress.
Notably, the combination of UFPs and cold-humid conditions intensified these adverse effects. However, when we administered Vitamin E, it helped reduce these harmful impacts. This suggests that Vitamin E could be a potential protector against indoor air pollutants, offering insights for healthier living spaces.
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Most Useful Reviews
7.5
Reduced cold feeling
7 people found this helpful
Excellent! I often felt sluggish and cold when not drinking. During my period, I endured a melancholic state. Since starting E, I feel less cold, and the pain from awful menstrual cramps has improved remarkably.
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9
Warm hands
3 people found this helpful
I started taking this supplement due to concerns about cold hands and feet, yet they are now warm all the time. My complexion has improved, and the dark circles under my eyes seem to have faded. I used to lose sleep over my cold extremities! I truly want to continue this supplement!
We investigated how exposure to ultrafine particles (UFPs) in cold and humid environments impacts respiratory health. Using a controlled study with male Balb/c mice, we found that exposure to carbon black nanoparticles worsened lung function and increased inflammation and oxidative stress.
Notably, the combination of UFPs and cold-humid conditions intensified these adverse effects. However, when we administered Vitamin E, it helped reduce these harmful impacts. This suggests that Vitamin E could be a potential protector against indoor air pollutants, offering insights for healthier living spaces.
Read More
User Reviews
USERS' SCORE
Good
Based on 42 Reviews
8
All Reviews
Positive Reviews
Negative Reviews
7.5
Reduced cold feeling
7 people found this helpful
Excellent! I often felt sluggish and cold when not drinking. During my period, I endured a melancholic state. Since starting E, I feel less cold, and the pain from awful menstrual cramps has improved remarkably.
Read More
9
Warm hands
3 people found this helpful
I started taking this supplement due to concerns about cold hands and feet, yet they are now warm all the time. My complexion has improved, and the dark circles under my eyes seem to have faded. I used to lose sleep over my cold extremities! I truly want to continue this supplement!
Read More
9
Cold limbs improved
1 people found this helpful
Is good. The cold of my limbs is gone.
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9
Circulation enhanced
1 people found this helpful
Since I began taking Vitamin E, I have been less anxious about my hands and feet getting cold. My circulation has improved, and my cold symptoms have notably lessened, especially during winter.
Read More
9
Blood flow aid
1 people found this helpful
Following the Fujikawa theory, I increased my dosage from one to three. Within an hour, I felt blood circulating in my fingers and toes. With continued use, my cold extremities disappeared, and I no longer experience cold hands and feet in winter. I also noticed a reduction in tinnitus when I take it.
Cold is a term that refers to a state of low temperature, often associated with a perceptibly chilly environment or the sensation of being cool to the touch. Scientifically, cold is relative to the presence and movement of heat, which is a measure of energy within matter. In everyday terms, we experience cold through weather changes, such as during winter months, and it can also be described in the context of specific temperature ranges – for example, temperatures below 32 degrees Fahrenheit (0 degrees Celsius) generally signify freezing conditions, which can impact outdoor activities, personal comfort, and various ecological systems.
Moreover, the sensation of cold is not solely dependent on temperature; factors like humidity and wind chill can enhance the feeling of coldness. When discussing cold in terms of human health, prolonged exposure to cold conditions can lead to hypothermia or frostbite if body heat is not effectively maintained. Hence, it's crucial to dress appropriately and take necessary precautions during colder months to prevent adverse effects. Understanding the concept of cold can help individuals better prepare for seasonal changes and ensure their comfort and safety.
Vitamin E is a fat-soluble nutrient that plays a crucial role in various bodily functions, primarily acting as an antioxidant. This means it helps to neutralize free radicals, which are unstable molecules that can cause oxidative stress, leading to cellular damage. Vitamin E is not just one compound, but a group of several related compounds, with tocopherols and tocotrienols being the most studied forms. These compounds are found in various foods, including nuts, seeds, and green leafy vegetables, making it relatively easy to obtain sufficient amounts through a balanced diet.
Research suggests that Vitamin E may contribute to immune function, skin health, and the overall maintenance of cardiovascular health. While most people can get enough Vitamin E from their diet, supplements may be necessary for those with specific deficiencies or conditions that impair absorption. However, it’s important to consult a healthcare provider before starting any supplement regimen, as excessive intake of Vitamin E can lead to adverse effects. Overall, maintaining adequate Vitamin E levels is essential for promoting long-term health and preventing potential deficiencies.
Based on user reviews, the time it typically takes to see results from taking this supplement for cold symptoms can vary. Some users report experiencing benefits within just a few hours, like the individual who stated they felt blood circulation in their fingers and toes within an hour after increasing their dosage Read Review. Others have noted improvements over a longer period; for instance, one user shared that significant changes in their cold sensitivity were observed after approximately two months of continuous use Read Review.
Additionally, many users feel that the effects become more pronounced with regular use. A review highlights that taking the supplement daily has led to a noticeable reduction in cold symptoms Read Review. Generally, while some experience immediate relief, most seem to find consistent use is key to minimizing cold sensitivity and improving overall warmth over several weeks to months.
While direct evidence linking specific supplements to cold relief is limited, one study suggests that Vitamin E may offer benefits in cold and humid conditions. In a controlled study involving mice, exposure to ultrafine particles in these environments led to worsened lung function and increased inflammation. However, the administration of Vitamin E was found to help mitigate these harmful effects [1]. This indicates that Vitamin E could play a role in protecting respiratory health in cold and humid conditions, although its efficacy specifically for treating common colds in humans remains unclear.
Therefore, while Vitamin E shows promise in maintaining respiratory function and potentially combating some adverse effects associated with cold environments, more specific research is needed to conclusively establish its effectiveness as a supplement for relieving cold symptoms in humans. As always, it's advisable to consult with a healthcare professional before starting any new supplementation regimen.
Based on user reviews, many individuals have reported significant improvements in their symptoms related to cold sensitivity after taking the supplement. For example, users like the individual who experienced a marked decrease in menstrual cramps alongside feeling warmer overall Read Review and another who noted that their hands and feet no longer feel cold, especially during sleep Read Review. Another reviewer mentioned feeling less anxious about cold extremities, attributing consistent use to improved circulation and a reduction in cold symptoms over time Read Review.
In addition to cold sensitivity, several users also experienced secondary benefits. For instance, one user reported enhancements in sleep quality and a decrease in dry skin and cold-related skin issues Read Review. Others noted improvements in their overall complexion and the alleviation of specific conditions, such as period pain and dry skin, possibly indicating a holistic benefit from the supplement Read Review. Overall, while individual results can vary, these anecdotal experiences suggest that consistent use of the supplement may lead to notable improvements in managing cold sensitivity, skin conditions, and overall well-being.
Based on user reviews, there is a clear trend of individuals successfully combining this supplement with other vitamins, including Vitamin C and B complex, to enhance their overall effectiveness in managing cold symptoms. For instance, one user reported that after using the supplement alongside Vitamin C and B complex for eight months, they noticed improvements in circulation and a significant reduction in cold sensations Read Review. Another user mentioned taking the supplement with vitamin C and iron, expressing satisfaction with their improved circulation and lack of colds Read Review.
Additionally, multiple reviewers noted enhanced effects when combining it with other supplements. One individual took it with vitamin C and zinc, reporting significant benefits in cold sensitivity Read Review, while another emphasized the synergy of supplements in improving overall immunity against colds Read Review. These anecdotal experiences suggest that users may derive greater benefits from the supplement when integrated into a broader regimen of vitamins for cold management.
Based on user reviews, it seems that the right dose of Vitamin E for alleviating symptoms related to cold varies among individuals, with many users reporting beneficial effects at higher doses. One user noted that increasing from one to three capsules led to immediate improvements in blood circulation to their extremities, effectively warming their fingers and toes, while another found that taking three capsules a day significantly reduced their cold sensitivity and improved their overall condition Read ReviewRead Review. Several reviews suggest that a common therapeutic dose seems to hover around two to three capsules, with some users noting remarkable results at this level Read ReviewRead Review.
Users have observed that Vitamin E can help with cold extremities and symptoms of sensitivity to cold, leading to a warmer and more comfortable state, especially during winter. For example, one user mentioned that taking three small tablets each morning aided in mitigating their cold symptoms entirely Read Review. While the exact dosage that works may differ per individual, the experiences shared imply that higher doses may yield beneficial outcomes in managing cold-related discomforts, particularly when integrated with other vitamins and minerals Read Review.
9
Blood flow aid
1 people found this helpful
Following the Fujikawa theory, I increased my dosage from one to three. Within an hour, I felt blood circulating in my fingers and toes. With continued use, my cold extremities disappeared, and I no longer experience cold hands and feet in winter. I also noticed a reduction in tinnitus when I take it.
9
Warm body improvement
I have used it with VC and VB complex for 8 months. After 2 months, my hand numbness disappeared, my body feels warmer, and the cold sensation has gone. Unexpectedly, my bowel movements have also improved.
9
Stopped catching colds
It was good. By taking it every day, I no longer catch colds.
7.5
Reduced cold feeling
7 people found this helpful
Excellent! I often felt sluggish and cold when not drinking. During my period, I endured a melancholic state. Since starting E, I feel less cold, and the pain from awful menstrual cramps has improved remarkably.
9
Warms extremities
My hands and feet are perpetually cold due to severe cold sensitivity! Since I started this supplement, my extremities have warmed up, especially during sleep! I plan to continue.
9
Circulation enhanced
1 people found this helpful
Since I began taking Vitamin E, I have been less anxious about my hands and feet getting cold. My circulation has improved, and my cold symptoms have notably lessened, especially during winter.
9
Cold sensitivity improved
Since I started taking this regularly, my sensitivity to cold has improved. I could sleep without an electric blanket for the first time this season, and my skin is less dry. I take it with other supplements. I recommend it.
9
Skin improved
My husband’s doctor prescribed this for his dry, peeling skin in winter. After a week, the dryness lessened, and now, with the arrival of cold weather, he no longer has this issue. His skin looks beautiful.
7.5
Improved circulation
1 people found this helpful
After reading Dr. Tokumi Fujikawa's book, I began taking it with vitamin C and iron. Concerned about my blood flow due to age, I have been taking it for years. Thankfully, I haven’t caught a single cold, my circulation is good, and my skin looks great. I plan to keep using vitamin E.
9
Improves cold sensitivity
Natural vitamin E has significantly improved my sensitivity to cold. I will continue taking it along with vitamin C and zinc after breakfast.
9
Therapeutic effects
The quality is excellent and the dosage is very convenient. I take 3 capsules for therapeutic effects. This vitamin penetrates well and produces remarkable results: my skin looks youthful, and it helps me feel warm despite my ongoing cold sensations.
6
Warmed up
6 people found this helpful
The quality is superb, with convenient size and dosage. For therapeutic effect, I use three capsules, roughly 800 mg. The impact is remarkable! Oil doesn’t absorb due to pancreatitis, yet this vitamin is absorbed and produces fantastic results. I am always very cold, but taking two capsules twice daily helps warm me, and I appreciate the quality.
7.5
Sensitivity improved
1 people found this helpful
I take 2-3 tablets after breakfast. Although I'm uncertain if it’s due to other supplements, my sensitivity to cold has significantly improved. I've also noticed my period pain has diminished.
9
No colds
I take three small, easy-to-swallow tablets each morning, and I no longer catch a cold. I wish to continue taking them.
8
Vitamin E mitigates respiratory damage
A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments.
We investigated how exposure to ultrafine particles (UFPs) in cold and humid environments impacts respiratory health. Using a controlled study with male Balb/c mice, we found that exposure to carbon black nanoparticles worsened lung function and increased inflammation and oxidative stress.
Notably, the combination of UFPs and cold-humid conditions intensified these adverse effects. However, when we administered Vitamin E, it helped reduce these harmful impacts. This suggests that Vitamin E could be a potential protector against indoor air pollutants, offering insights for healthier living spaces.
References
Shu Z, Qing S, Yang X, Ma P, Wu Y, et al. A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments. Ecotoxicol Environ Saf. 2025;289:117638. 10.1016/j.ecoenv.2024.117638