Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
USERS' SCORE
Good
Based on 16 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E (as d-alpha Tocopheryl Acetate)
268 mg
1787%
Top Medical Research Studies
9
Potential atheroprotective effects of T3
We aimed to explore how pure tocotrienol (T3), a form of vitamin E, might help in fighting atherosclerosis, a condition often linked to high cholesterol. In our study, 30 rabbits were fed high-cholesterol diets and then divided into groups receiving different doses of T3 or a control without T3.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
Read More
8
Tocopheryl quinone benefits high cholesterol
We examined how tocopheryl quinone, a form of vitamin E, impacts high cholesterol in rats fed a high-fat diet linked to liver disease. Our findings showed that while these rats had increased cholesterol levels, tocopheryl quinone treatment was able to reverse these effects.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
Read More
8
We explored how alpha-tocopherol, a form of vitamin E, affects the development of nonalcoholic steatohepatitis (NASH) in rabbits fed a high-cholesterol diet. Our study revealed that without alpha-tocopherol, rabbits experienced significant inflammation and liver damage linked to NASH. However, supplementing with alpha-tocopherol effectively reduced these harmful inflammatory responses and damage, showing promise in protecting against NASH development. Interestingly, while alpha-tocopherol helped lower the inflammatory signals and apoptosis in liver cells, it did not alter cholesterol levels or fat accumulation in the liver.
Read More
Most Useful Reviews
9
Strong antioxidant benefits
4 people found this helpful
I find Vitamin E to be a vital antioxidant that protects against heart attacks and cleanses the blood, improving circulation without toxicity, unlike some anticoagulant drugs. I take it with omega acids for better absorption, especially helpful for my high cholesterol condition.
Read More
9
Effective cardiovascular support
4 people found this helpful
Each capsule contains 400 IU of Vitamin E, which is beneficial as an antioxidant and supports heart health, improving blood circulation and preventing the oxidation of good cholesterol. I take it alongside omega acids for optimal benefit.
Read More
9
Improved menstrual cycle
3 people found this helpful
I was suffering from menorrhagia and a delayed cycle, but after starting high doses of vitamins C and E, along with D3 and K2, my period normalised. I believe these vitamins also helped with headaches, further enhancing my overall health; however, I'll consider reducing my intake if it remains stable.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
- All Researches
9
Potential atheroprotective effects of T3
We aimed to explore how pure tocotrienol (T3), a form of vitamin E, might help in fighting atherosclerosis, a condition often linked to high cholesterol. In our study, 30 rabbits were fed high-cholesterol diets and then divided into groups receiving different doses of T3 or a control without T3.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
Read More
8
We investigated how a high cholesterol diet impacts male fertility by activating stress in testicular cells, leading to cell death. Using rabbits as our model, we found that this diet noticeably increased apoptosis in the testicular tubules. However, when we supplemented the rabbits' diets with α-tocopherol, a form of vitamin E, we observed a remarkable reduction in this cholesterol-induced cell death. This suggests that vitamin E might serve as a protective agent against damage caused by high cholesterol, helping to preserve testicular health.
Read More
8
Tocopheryl quinone benefits high cholesterol
We examined how tocopheryl quinone, a form of vitamin E, impacts high cholesterol in rats fed a high-fat diet linked to liver disease. Our findings showed that while these rats had increased cholesterol levels, tocopheryl quinone treatment was able to reverse these effects.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
Read More
8
We explored how alpha-tocopherol, a form of vitamin E, affects the development of nonalcoholic steatohepatitis (NASH) in rabbits fed a high-cholesterol diet. Our study revealed that without alpha-tocopherol, rabbits experienced significant inflammation and liver damage linked to NASH. However, supplementing with alpha-tocopherol effectively reduced these harmful inflammatory responses and damage, showing promise in protecting against NASH development. Interestingly, while alpha-tocopherol helped lower the inflammatory signals and apoptosis in liver cells, it did not alter cholesterol levels or fat accumulation in the liver.
Read More
8
Vitamin E aids in cholesterol reduction
We explored the impact of combined treatment with hepatoprotectors and an antioxidant preparation of vitamins A and E on patients experiencing non-alcoholic steatohepatitis (NASH) after the Chornobyl disaster.
Our study involved 72 patients, examining biochemical blood analyses and liver structures.
The results were promising, showing improvements in antioxidant levels and a decrease in cholesterol levels, suggesting that vitamin E treatment could effectively restore metabolic balance and support liver health.
Our study involved 72 patients, examining biochemical blood analyses and liver structures.
The results were promising, showing improvements in antioxidant levels and a decrease in cholesterol levels, suggesting that vitamin E treatment could effectively restore metabolic balance and support liver health.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Strong antioxidant benefits
4 people found this helpful
I find Vitamin E to be a vital antioxidant that protects against heart attacks and cleanses the blood, improving circulation without toxicity, unlike some anticoagulant drugs. I take it with omega acids for better absorption, especially helpful for my high cholesterol condition.
Read More
9
Effective cardiovascular support
4 people found this helpful
Each capsule contains 400 IU of Vitamin E, which is beneficial as an antioxidant and supports heart health, improving blood circulation and preventing the oxidation of good cholesterol. I take it alongside omega acids for optimal benefit.
Read More
9
Improved menstrual cycle
3 people found this helpful
I was suffering from menorrhagia and a delayed cycle, but after starting high doses of vitamins C and E, along with D3 and K2, my period normalised. I believe these vitamins also helped with headaches, further enhancing my overall health; however, I'll consider reducing my intake if it remains stable.
Read More
9
Normal cholesterol levels
1 people found this helpful
Excellent! This is very effective for acne. If I forget to take it, my skin rapidly becomes irritated. Also, trying to supplement with fish or nuts requires a lot, making supplements more cost-effective. Natural vitamin E seems to work better than synthetic, and thanks to this, my high cholesterol levels have returned to normal.
Read More
7.5
Supports cholesterol control
44 people found this helpful
I recommend this nutritional supplement as it contains Vitamin E, a natural antioxidant beneficial for the liver's detoxification processes. It aids in reducing harmful cholesterol levels and promotes healthy skin and hair while delaying the onset of wrinkles.
Read More
Frequently Asked Questions
9
Improved menstruation quality
24 people found this helpful
Over three years, I noticed my menstruation improved after taking 3000 IU of Vitamin E. The colour became healthier, and I reduced my triglycerides from 131 to 73 without dietary changes. I wonder if the lecithin I'm also taking helps in treating my high cholesterol.
9
Heart attack prevention
7 people found this helpful
Vitamin E, in a dosage of 400 IU daily, protects against heart attacks and cleanses the blood of harmful fats, thus improving circulation. I take it with omega acids as it helps with the absorption and is non-toxic compared to medications for high cholesterol.
2
Ineffective for me
I had high hopes based on positive reviews, but it did not work for me.
9
Improved menstrual cycle
3 people found this helpful
I was suffering from menorrhagia and a delayed cycle, but after starting high doses of vitamins C and E, along with D3 and K2, my period normalised. I believe these vitamins also helped with headaches, further enhancing my overall health; however, I'll consider reducing my intake if it remains stable.
9
Strong antioxidant benefits
4 people found this helpful
I find Vitamin E to be a vital antioxidant that protects against heart attacks and cleanses the blood, improving circulation without toxicity, unlike some anticoagulant drugs. I take it with omega acids for better absorption, especially helpful for my high cholesterol condition.
9
Effective cardiovascular support
4 people found this helpful
Each capsule contains 400 IU of Vitamin E, which is beneficial as an antioxidant and supports heart health, improving blood circulation and preventing the oxidation of good cholesterol. I take it alongside omega acids for optimal benefit.
8
Tocopheryl quinone benefits high cholesterol
We examined how tocopheryl quinone, a form of vitamin E, impacts high cholesterol in rats fed a high-fat diet linked to liver disease. Our findings showed that while these rats had increased cholesterol levels, tocopheryl quinone treatment was able to reverse these effects.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
7
Vitamin E's limited cholesterol impact
We explored how vitamin E might influence high cholesterol's impact on atherosclerosis, a condition where plaques build up in arteries. The study focused on how vitamin E affects endoplasmic reticulum (ER) stress, which is linked to this plaque formation.
While vitamin E showed potential in reducing ER stress caused by a high-cholesterol diet, it didn’t significantly improve cholesterol levels or reduce atherosclerosis. Overall, the results highlight vitamin E's complex interactions but indicate no major breakthroughs in cholesterol management.
While vitamin E showed potential in reducing ER stress caused by a high-cholesterol diet, it didn’t significantly improve cholesterol levels or reduce atherosclerosis. Overall, the results highlight vitamin E's complex interactions but indicate no major breakthroughs in cholesterol management.
8
Tocopheryl phosphates reduce cholesterol impact
We examined how tocopheryl phosphates (TPM), a form of vitamin E, impacts high cholesterol and atherosclerosis in mice lacking apolipoprotein E. Over 24 weeks, mice on a high-fat, high-cholesterol diet received either TPM or standard vitamin E (TA).
Interestingly, we found that TPM led to significant decreases in atherosclerotic lesions and inflammatory markers. In contrast, the standard vitamin E supplement did not show similar benefits, highlighting the potential of TPM in managing cholesterol-related complications. Overall, the study suggests that vitamin E may help combat inflammation and oxidative stress linked to heart disease.
Interestingly, we found that TPM led to significant decreases in atherosclerotic lesions and inflammatory markers. In contrast, the standard vitamin E supplement did not show similar benefits, highlighting the potential of TPM in managing cholesterol-related complications. Overall, the study suggests that vitamin E may help combat inflammation and oxidative stress linked to heart disease.
7
We investigated how a high cholesterol diet influences heart health, particularly focusing on the relationship between dietary oxysterols, fatty acids, and protein changes.
Our findings highlighted that high cholesterol leads to increased unsaturated fatty acids and specific receptor expressions that could harm heart function.
Interestingly, we found that Vitamin E supplementation may help counteract some of these negative effects by reducing certain protein levels, suggesting that it could play a protective role against cholesterol-induced changes.
Our findings highlighted that high cholesterol leads to increased unsaturated fatty acids and specific receptor expressions that could harm heart function.
Interestingly, we found that Vitamin E supplementation may help counteract some of these negative effects by reducing certain protein levels, suggesting that it could play a protective role against cholesterol-induced changes.
References
- Sozen E, Demirel-Yalciner T, Koroglu MK, Elmas MA, Ercan F, et al. High cholesterol diet activates ER stress mediated apoptosis in testes tissue: Role of α-tocopherol. IUBMB Life. 2022;74:85. doi:10.1002/iub.2535
- Sun T, Zhang B, Ru QJ, Chen XM, Lv BD. Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) restoring the balance of intestinal flora in rats. Pharm Biol. 2021;59:723. doi:10.1080/13880209.2021.1916542
- Demirel-Yalciner T, Sozen E, Ozaltin E, Sahin A, Ozer NK. alpha-Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis. Biofactors. 2021;47:403. doi:10.1002/biof.1700
- Bozaykut P, Ekren R, Sezerman OU, Gladyshev VN, Ozer NK. High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E. Biofactors. 2020;46:653. doi:10.1002/biof.1635
- Sarkisova EA, Chumak AA, Ovsyannikova LM, Alekhina LM, Nosach OV, et al. THE EFFECT OF APPLICATION OF ANTIOXIDANT THERAPY IN THE TREATMENT OF NON-ALKOHOLIC STEATOHEPATATIS IN CHORNOBYL NPP ACCIDENT SUFFERERS IN THE REMOTE PERIOD AFTER IRRADIATION. Probl Radiac Med Radiobiol. 2018;23:452. doi:10.33145/2304-8336-2018-23-452-461
- Sozen E, Yazgan B, Sahin A, Ince U, Ozer NK. High Cholesterol Diet-Induced Changes in Oxysterol and Scavenger Receptor Levels in Heart Tissue. Oxid Med Cell Longev. 2018;2018:8520746. doi:10.1155/2018/8520746
- Farràs M, Fernández-Castillejo S, Rubió L, Arranz S, Catalán Ú, et al. Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial. J Nutr Biochem. 2018;51:99. doi:10.1016/j.jnutbio.2017.09.010
- Libinaki R, Vinh A, Tesanovic-Klajic S, Widdop R, Gaspari T. The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice. Clin Exp Pharmacol Physiol. 2017;44 Suppl 1:107. doi:10.1111/1440-1681.12821
- Rahman TA, Hassim NF, Zulkafli N, Muid S, Kornain NK, et al. Atheroprotective effects of pure tocotrienol supplementation in the treatment of rabbits with experimentally induced early and established atherosclerosis. Food Nutr Res. 2016;60:31525. doi:10.3402/fnr.v60.31525
- Bumrungpert A, Pavadhgul P, Kalpravidh RW. Camellia Oil-Enriched Diet Attenuates Oxidative Stress and Inflammatory Markers in Hypercholesterolemic Subjects. J Med Food. 2016;19:895. doi:10.1089/jmf.2016.3659
- Apostolidou C, Adamopoulos K, Lymperaki E, Iliadis S, Papapreponis P, et al. Cardiovascular risk and benefits from antioxidant dietary intervention with red wine in asymptomatic hypercholesterolemics. Clin Nutr ESPEN. 2015;10:e224. doi:10.1016/j.clnesp.2015.08.001
- Katsarou AI, Kaliora AC, Chiou A, Kalogeropoulos N, Papalois A, et al. Amelioration of oxidative and inflammatory status in hearts of cholesterol-fed rats supplemented with oils or oil-products with extra virgin olive oil components. Eur J Nutr. 2016;55:1283. doi:10.1007/s00394-015-0947-5
- Schuchardt JP, Heine S, Hahn A. A combination of palm oil tocotrienols and citrus peel polymethoxylated flavones does not influence elevated LDL cholesterol and high-sensitivity C-reactive protein levels. Eur J Clin Nutr. 2015;69:1209. doi:10.1038/ejcn.2015.44
- Busso D, Mascareño L, Salas F, Berkowitz L, Santander N, et al. Early onset intrauterine growth restriction in a mouse model of gestational hypercholesterolemia and atherosclerosis. Biomed Res Int. 2014;2014:280497. doi:10.1155/2014/280497
- Bento AP, Cominetti C, Simões Filho A, Naves MM. Baru almond improves lipid profile in mildly hypercholesterolemic subjects: a randomized, controlled, crossover study. Nutr Metab Cardiovasc Dis. 2014;24:1330. doi:10.1016/j.numecd.2014.07.002
- Hobbs T, Caso R, McMahon D, Nymark M. A novel, multi-ingredient supplement to manage elevated blood lipids in patients with no evidence of cardiovascular disease: a pilot study. Altern Ther Health Med. 2014;20:18.
