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After analyzing the results, we found notable differences between the two groups. The high-dose group experienced a significant decrease in reactive oxygen species (ROS), suggesting that vitamin C may help reduce oxidative stress associated with chronic gastritis. In contrast, the low-dose group reported an increase in ROS levels. These findings prompt further interest in how vitamin C can protect against oxidative stress in similar conditions.
Overall, our study supports the idea that higher doses of vitamin C could have a beneficial effect on oxidative stress, particularly in those dealing with gastritis. This insight opens avenues for considering vitamin C as a potential supportive treatment for managing oxidative stress-related issues in digestive health.
The results were intriguing: while those in the high-dose group had higher levels of serum vitamin C, the levels of two important inflammatory markers—C-reactive protein (CRP) and serum amyloid A (SAA)—showed no significant difference between the low- and high-dosage groups. Both biomarkers remained fairly constant, indicating that vitamin C supplementation did not effectively reduce inflammation or infection risk among these individuals with atrophic gastritis.
Overall, our findings suggest that high doses of vitamin C may not provide the hoped-for relief from inflammation in this patient group. Thus, it appears that vitamin C supplementation alone is insufficient in managing or alleviating gastritis-related inflammation.
In our study, we treated CAG patients with vitamin C and observed significant improvements in blood parameters and the overall health of their gastric mucosa. Moreover, when we looked at gastric cells in the lab, vitamin C not only boosted cell viability but also reduced inflammation and cell death caused by a harmful compound known as MNNG. These effects included lowering the levels of inflammatory markers and apoptosis-related proteins.
Interestingly, our findings suggested that IGFBP7 plays a role in these protective effects of vitamin C. When we knocked down IGFBP7 in the lab tests, we noted changes in how vitamin C worked, suggesting a complex interaction.
Overall, our study highlights the potential of vitamin C and IGFBP7 as key players in managing chronic atrophic gastritis and enhancing gastric health, opening doors for new therapeutic approaches.
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The results were promising, showing a significant decrease in the activity of ornithine decarboxylase, an enzyme that can indicate abnormal cell growth. Remarkably, we observed that 11 out of 18 patients showed nearly total regression of their IM, which translates to a success rate of 61%.
While this study highlights the potential benefits of antioxidant supplementation, including vitamin C, it's essential to note that multiple components were present in the treatment. This complexity makes it challenging to pinpoint the specific effect of vitamin C alone on gastritis treatment.
In our study, we treated CAG patients with vitamin C and observed significant improvements in blood parameters and the overall health of their gastric mucosa. Moreover, when we looked at gastric cells in the lab, vitamin C not only boosted cell viability but also reduced inflammation and cell death caused by a harmful compound known as MNNG. These effects included lowering the levels of inflammatory markers and apoptosis-related proteins.
Interestingly, our findings suggested that IGFBP7 plays a role in these protective effects of vitamin C. When we knocked down IGFBP7 in the lab tests, we noted changes in how vitamin C worked, suggesting a complex interaction.
Overall, our study highlights the potential of vitamin C and IGFBP7 as key players in managing chronic atrophic gastritis and enhancing gastric health, opening doors for new therapeutic approaches.
Participants took levothyroxine alongside a solution that either contained or did not contain vitamin C, and we monitored their hormone levels over several months. Our findings revealed that vitamin C can actually improve levels of free T4 and T3, as well as TSH, suggesting it enhances the absorption of medication in these patients.
This is particularly significant because individuals dealing with both hypothyroidism and gastritis often struggle to maintain stable thyroid hormone levels. Our research indicates that incorporating vitamin C into their treatment regimen could serve as a beneficial strategy in managing their condition.
After assessing the severity of the lesions and measuring various biochemical markers in the gastric mucosa and serum, we found that lesions appeared 0.5 hours post treatment and continued to worsen over the next 3 hours. Notably, the administration of vitamin C right after the initial treatment appeared to significantly reduce the progression of these lesions. It also helped maintain the levels of various protective substances in the gastric lining and overall health indicators.
By the end of our study, it was clear that vitamin C has a crucial protective effect in this scenario. Our results suggest that timely vitamin C administration can prevent the worsening of gastritis caused by mast cell degranulation. This adds a promising angle to the conversation about dietary vitamins in managing gastric health.
Our findings revealed that AA2G significantly reduced oxidative stress—a harmful condition triggered by H. pylori that can damage cells. We observed that treatment with AA2G led to lower levels of harmful substances, such as reactive oxygen species, known to contribute to cell damage.
Notably, AA2G also helped restore the cells' mitochondrial function, which is often impaired during H. pylori infection. This improvement included an increase in ATP levels and enhanced mitochondrial membrane potential, both essential for cell energy production and health.
Ultimately, we found that AA2G effectively reduces the apoptosis (or programmed cell death) that results from H. pylori infection, suggesting that it provides a protective effect on gastric epithelial cells. Our research supports the potential use of AA2G as a beneficial intervention for combatting the adverse effects of H. pylori infection on gastritis.
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Frequently Asked Questions
Gastritis is an inflammation of the stomach lining, which can lead to a range of symptoms including abdominal pain, nausea, vomiting, and indigestion. This condition can be acute, arising suddenly and lasting for a short period, or chronic, developing gradually and persisting over time. Various factors can contribute to gastritis, such as excessive alcohol consumption, prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs), bacterial infections (most notably Helicobacter pylori), and autoimmune disorders.
Treatment for gastritis often focuses on addressing the underlying cause and might include medications to reduce stomach acid, antibiotics for infections, and lifestyle modifications like avoiding irritating foods and beverages. While many people recover from gastritis with adequate care, it's important to consult a healthcare professional for a proper diagnosis and treatment plan. If left untreated, gastritis can lead to more serious complications, such as stomach ulcers or even an increased risk for gastric cancer.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
While Vitamin C is known for its immune-boosting properties and its role in collagen synthesis, its effectiveness specifically for treating gastritis is not well established. Gastritis, which is an inflammation of the stomach lining, can be caused by various factors including bacterial infection, excessive alcohol consumption, or prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs). Some studies suggest that an adequate intake of Vitamin C might contribute to overall gastrointestinal health, but it is not a primary treatment for gastritis itself.
If you're experiencing symptoms of gastritis, such as stomach pain, nausea, or indigestion, it’s essential to consult a healthcare professional for a proper diagnosis and treatment plan. They may recommend dietary changes, medications, or other therapies tailored to your specific condition. While maintaining a nutritious diet that includes Vitamin C-rich foods like oranges, broccoli, and peppers can support overall health, relying solely on Vitamin C for gastritis management is not advisable.
Based on user reviews, the time it takes to see results from taking vitamin C for gastritis can vary significantly among individuals. Some users report experiencing noticeable relief from stomach discomfort associated with gastritis within a month of consistent use. One user noted that after taking vitamin C daily for a month, their initial stomach discomfort had vanished and they felt more energized (Read Review). Another user mentioned they felt no side effects and found the vitamin well-tolerated, suggesting a smooth acclimation to the supplement (Read Review).
However, there are cautionary tales as well; some users experienced gastrointestinal discomfort when taking this supplement, even when they had gastritis (Read Review). While it’s clear that many users tolerate the vitamin—and even find it beneficial—there is also the recommendation from those who experienced irritation to consider alternatives like sodium ascorbate for individuals with specific gastric issues (Read Review). Ultimately, results can vary, so monitoring your own reaction to the supplement is crucial for determining its effectiveness for gastritis.
Recent studies suggest that vitamin C may play a beneficial role in managing gastritis, particularly regarding its association with Helicobacter pylori and oxidative stress. For instance, research indicates that vitamin C can reduce oxidative stress caused by H. pylori, potentially providing a protective effect on gastric epithelial cells, which is crucial in treating gastritis. Trials that administered vitamin C demonstrated lower levels of reactive oxygen species, highlighting its potential to mitigate damage to stomach cells [3]. Furthermore, adding vitamin C to treatment regimens for gastritis patients has been shown to enhance the effectiveness of standard therapies [7].
However, the evidence is not entirely consistent. Some studies found that while higher doses of vitamin C improved certain gastric health indicators, they did not significantly reduce inflammation [5]. Moreover, other research suggests that vitamin C's role may be more complex, requiring combination treatments to achieve optimal effects on gastritis [10]. Therefore, while vitamin C shows promise as a supportive measure in gastritis management, it's clear that more research is needed to fully understand its effects and best uses in clinical settings.
Based on user reviews, many individuals report significant improvements in their symptoms related to gastritis when taking vitamin C. One user noted that after a month of daily use, their stomach discomfort vanished, leading to a surge in overall energy and the cessation of cramps and heartburn (Read Review). Another praised the formula for being well-tolerated, stating they experienced no adverse symptoms even with chronic gastritis (Read Review). Similar sentiments echo throughout various experiences, where users appreciated the absence of irritation, suggesting that certain formulations, like those enhanced with bioflavonoids, could be less troublesome (Read Review).
However, it's important to highlight that individual results can vary significantly. Several users shared cautionary experiences, reporting that vitamin C aggravated their stomach issues, particularly for those with existing gastrointestinal conditions (Read Review). Those who faced difficulties often recommended alternatives like sodium ascorbate instead of conventional ascorbic acid (Read Review). Thus, while many users have enjoyed improved symptoms, monitoring personal reactions is essential to find the best approach for managing gastritis.
Based on user reviews, there is a mix of experiences when it comes to combining this vitamin C supplement with others for managing gastritis. Some users reported that taking vitamin C enhanced with bioflavonoids was beneficial and well-tolerated, leading to improvements in symptoms like stomach discomfort and digestive issues. For instance, one user shared that after a month of use, their gastritis symptoms such as cramps and heartburn completely disappeared, allowing them to feel more energized (Read Review). Another user noted that their chronic gastritis symptoms remained stable without causing any side effects, especially when taken after meals (Read Review).
However, there are significant cautionary tales as well. A few users reported experiencing gastrointestinal discomfort and increased stomach pain when taking this specific vitamin C supplement. One noted that individuals with gastritis should be particularly careful, as they found the vitamin aggravated their condition (Read Review). Similarly, another user strongly recommended opting for sodium ascorbate instead of ascorbic acid for those with stomach issues, emphasizing that the latter could lead to adverse reactions (Read Review). It appears that while combining this supplement with others such as zinc and vitamin D might enhance recovery from ailments like colds, caution is warranted specifically for those with gastritis.
Users report varying experiences with Vitamin C for treating gastritis, highlighting that the right dosage and formulation can be crucial. Some users found relief from gastritis symptoms with lower doses, such as taking one capsule daily after meals, which helped alleviate discomfort without side effects like heartburn or cramps (Read Review). Others noted that taking it twice daily, specifically in a sodium ascorbate form, provided good results for stomach issues (Read Review).
However, caution is advised, as some users experienced aggravation of their gastritis symptoms with certain formulations, especially those containing ascorbic acid (Read Review). Notably, other users suggested that the inclusion of bioflavonoids could enhance tolerance and efficacy for those with chronic gastritis (Read Review). Overall, it seems that a lower dosage, post-meal intake, and possibly opting for sodium ascorbate rather than ascorbic acid can be beneficial for those managing gastritis.
Our findings revealed that AA2G significantly reduced oxidative stress—a harmful condition triggered by H. pylori that can damage cells. We observed that treatment with AA2G led to lower levels of harmful substances, such as reactive oxygen species, known to contribute to cell damage.
Notably, AA2G also helped restore the cells' mitochondrial function, which is often impaired during H. pylori infection. This improvement included an increase in ATP levels and enhanced mitochondrial membrane potential, both essential for cell energy production and health.
Ultimately, we found that AA2G effectively reduces the apoptosis (or programmed cell death) that results from H. pylori infection, suggesting that it provides a protective effect on gastric epithelial cells. Our research supports the potential use of AA2G as a beneficial intervention for combatting the adverse effects of H. pylori infection on gastritis.
After this treatment period, we collected tissue samples from different areas of the stomach to examine any changes in inflammation and vitamin levels. The results showed that vitamin C levels increased significantly in the stomach mucosa, alongside vitamin E levels.
More importantly, both the intensity of H. pylori and neutrophil activity, which indicates inflammation, decreased after supplementation. This suggests that taking these vitamins could help create a less favorable environment for the bacteria, potentially improving treatment outcomes for gastritis.
Overall, while our findings highlight the importance of vitamins C and E in reducing stomach inflammation, they also suggest that these vitamins may help improve the effectiveness of conventional treatments against H. pylori.
The results were intriguing: while those in the high-dose group had higher levels of serum vitamin C, the levels of two important inflammatory markers—C-reactive protein (CRP) and serum amyloid A (SAA)—showed no significant difference between the low- and high-dosage groups. Both biomarkers remained fairly constant, indicating that vitamin C supplementation did not effectively reduce inflammation or infection risk among these individuals with atrophic gastritis.
Overall, our findings suggest that high doses of vitamin C may not provide the hoped-for relief from inflammation in this patient group. Thus, it appears that vitamin C supplementation alone is insufficient in managing or alleviating gastritis-related inflammation.
The results were promising, showing a significant decrease in the activity of ornithine decarboxylase, an enzyme that can indicate abnormal cell growth. Remarkably, we observed that 11 out of 18 patients showed nearly total regression of their IM, which translates to a success rate of 61%.
While this study highlights the potential benefits of antioxidant supplementation, including vitamin C, it's essential to note that multiple components were present in the treatment. This complexity makes it challenging to pinpoint the specific effect of vitamin C alone on gastritis treatment.
References
- Cheng X, Gu H, Chong Y, Li F, Bei S, et al. Vitamin C Mediates IGFBP7 to Alleviate Chronic Atrophic Gastritis via the HIF-1α/VEGF Pathway. J Cell Mol Med. 2025;29:e70392. doi:10.1111/jcmm.70392
- Mei H, Tu H. Vitamin C and Infection: Current Knowledge and Future Prospects. Front Physiol. 2018;9:1103. doi:10.3389/fphys.2018.01103
- Chen X, Liu R, Liu X, Xu C, Wang X. L-ascorbic Acid-2-Glucoside inhibits Helicobacter pylori-induced apoptosis through mitochondrial pathway in Gastric Epithelial cells. Biomed Pharmacother. 2018;97:75. doi:10.1016/j.biopha.2017.10.030
- Jubiz W, Ramirez M. Effect of vitamin C on the absorption of levothyroxine in patients with hypothyroidism and gastritis. J Clin Endocrinol Metab. 2014;99:E1031. doi:10.1210/jc.2013-4360
- Ma E, Sasazuki S, Sasaki S, Tsubono Y, Okubo S, et al. Vitamin C supplementation in relation to inflammation in individuals with atrophic gastritis: a randomised controlled trial in Japan. Br J Nutr. 2013;109:1089. doi:10.1017/S0007114512002954
- Aditi A, Graham DY. Vitamin C, gastritis, and gastric disease: a historical review and update. Dig Dis Sci. 2012;57:2504. doi:10.1007/s10620-012-2203-7
- Sezikli M, Çetinkaya ZA, Güzelbulut F, Çimen B, Özcan Ö, et al. Effects of alpha tocopherol and ascorbic acid on Helicobacter pylori colonization and the severity of gastric inflammation. Helicobacter. 2012;17:127. doi:10.1111/j.1523-5378.2011.00925.x
- Kohler JE, Blass AL, Liu J, Tai K, Soybel DI. Antioxidant pre-treatment prevents omeprazole-induced toxicity in an in vitro model of infectious gastritis. Free Radic Biol Med. 2010;49:786. doi:10.1016/j.freeradbiomed.2010.05.034
- Sasazuki S, Hayashi T, Nakachi K, Sasaki S, Tsubono Y, et al. Protective effect of vitamin C on oxidative stress: a randomized controlled trial. Int J Vitam Nutr Res. 2008;78:121. doi:10.1024/0300-9831.78.3.121
- Draudin-Krylenko VA, Petukhov AB, Kuvshinov IuP, Levchuk AA, Bukin IuV. [Effect of antioxidant use in dietary therapy in patients with chronic athrofic hastritis]. Vopr Pitan. 2006;75:53.
- Rembiasz K, Budzynski A, Karcz D, Konturek PC, Konturek SJ, et al. Multifocal atrophic gastritis: pathogenesis and therapeutic implications. Eur J Gastroenterol Hepatol. 2005;17:857.
- Kamiya Y, Ohta Y, Imai Y, Arisawa T, Nakano H. A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats. World J Gastroenterol. 2005;11:1324.
