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After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.
Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.
This study makes it clear that while diagnosing scurvy can be tricky, it’s crucial, especially in at-risk groups. Addressing vitamin C deficiency early may enhance patient outcomes and resolve atypical ulcerations that don’t respond to typical treatments.
It significantly reduced the formation of ulcers and harmful substances linked to oxidative stress in the ileal mucosa. This suggests that vitamin C plays a key role in reducing ulcer risk by combating oxidative damage and altering gut bacteria effectively.
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After eight weeks, those taking vitamin C showed significant improvement—ulcer healing was much better compared to the placebo group. Notably, everyone who received vitamin C healed without needing amputation, while 44% of the control group did not see any healing.
Our findings suggest vitamin C may be a beneficial treatment for chronic foot ulcers, given its accessibility and low cost.
It significantly reduced the formation of ulcers and harmful substances linked to oxidative stress in the ileal mucosa. This suggests that vitamin C plays a key role in reducing ulcer risk by combating oxidative damage and altering gut bacteria effectively.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
Through various studies, we noted that vitamin C might positively influence the healing process of ulcers. This was especially promising for individuals with diabetic foot ulcers, where effective management is crucial. While the evidence indicates potential benefits, it’s important to state that many of these studies have limitations, and we often see mixed results.
As we move forward, robust research focusing exclusively on vitamin C's effectiveness in treating ulcers is essential. Investigating different dosages and effects in diverse populations can help clarify its role and reliability as a supplementary treatment.
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Frequently Asked Questions
An ulcer is a sore that develops on the lining of the stomach, small intestine, or colon. It occurs when the digestive tract is damaged or inflamed, often due to an imbalance between stomach acid and the protective factors in the digestive system. The most common types of ulcers include peptic ulcers, which can be further categorized into gastric ulcers (located in the stomach) and duodenal ulcers (found in the first part of the small intestine). Symptoms may include burning stomach pain, bloating, and nausea, which can vary in intensity based on the severity of the condition.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
While Vitamin C is known for its immune-boosting properties and role in collagen synthesis, its direct effect on ulcers is not extensively documented. Some studies suggest that Vitamin C may promote healing due to its antioxidant properties and its ability to enhance the absorption of iron, which is crucial for healing tissues. However, there is no definitive evidence that Vitamin C can specifically cure or alleviate ulcers.
If you're dealing with ulcer-related discomfort, it's essential to consult a healthcare professional for personalized advice. They can recommend appropriate treatments, which may include medications and dietary adjustments, while also considering the potential benefits of nutrients like Vitamin C as part of a balanced approach to supporting overall healing.
Based on user reviews, individuals taking this supplement for ulcers report varying timelines for seeing results. One user noted significant improvements in overall health and comfort after using the supplement, stating they experienced less weakness and improvement in related symptoms after regular use. Specifically, they mentioned a notable decrease in stomach pain associated with their ulcer while taking the vitamin daily (Read Review). However, other users have expressed concerns, indicating that the vitamin might exacerbate symptoms in those with existing stomach issues, as one user experienced increased stomach pain and had to discontinue its use (Read Review).
Overall, users generally report some level of improvement in their symptoms, but the time it takes to see results can vary substantially from person to person. While some experienced quick benefits, others indicated adverse reactions that affected their initial experience negatively. If you're considering this supplement for ulcer management, it's essential to monitor your own reactions and consult with a healthcare provider to determine what's best for your situation.
Recent studies suggest that Vitamin C may offer some benefits for managing ulcers, especially gastric ulcers and those related to gastrointestinal health. Research involving rats has shown that Vitamin C, particularly in combination with metformin, can significantly reduce gastric mucosal damage induced by ulcer-causing agents like indomethacin [2]. Additionally, other studies indicate that Vitamin C may protect against ulcer severity in stressful conditions, such as adrenaline-induced gastric injury, by stabilizing gastric secretions and enhancing protective factors [3].
However, while these animal studies highlight promising outcomes, more comprehensive human trials are needed to substantiate the efficacy of Vitamin C as a treatment for ulcers. Although Vitamin C appears to positively influence microbial health in patients with ulcerative colitis, further investigation is essential to determine its precise role and reliability in treating various types of ulcers [1]. Thus, while the existing research shows potential benefits, it remains part of a broader landscape of treatment options and should be considered in conjunction with other therapies.
Based on user reviews, many individuals report a range of improvements in their symptoms associated with the use of this vitamin. For instance, one user highlighted that after taking the supplement, they experienced significant enhancements in their overall well-being, including less weakness, a stop to gum bleeding, and improvements in skin and hair health. They also noted a remarkable absence of colds during the year, suggesting a possible boost in immune function (Read Review). Another user mentioned a resolution of mouth ulcers, stating they no longer have these painful sores, which can be a common issue during certain seasons (Read Review).
Conversely, some users have reported negative experiences, particularly those with pre-existing gastrointestinal conditions. One individual found that the vitamin exacerbated stomach pain associated with their ulcer, leading them to cease taking the product (Read Review). Another review echoed this concern, noting gastrointestinal discomfort and recommending caution for those with similar health issues (Read Review). Thus, while many users report positive changes, including quicker healing for ailments like mouth ulcers, individual reactions can vary significantly; it's crucial to consider personal health conditions and consult a healthcare provider.
Users report a mix of experiences when combining this supplement with others for handling ulcers. Some individuals have found it beneficial, noting improvements in their health and symptom management. For example, one user with a stomach ulcer stated they have not experienced any pain from this supplement and appreciated the overall boost in their well-being, including increased energy and improved skin health (Read Review). Another user mentioned using the supplement to support their immune system during flare-ups of mouth ulcers and feeling as though their healing process accelerated (Read Review).
However, several users cautioned against using this supplement alongside other vitamins for those with pre-existing gastrointestinal issues, particularly ulcers. One individual reported that their father, who has a stomach ulcer, experienced increased stomach pain after starting the vitamin, which led to its discontinuation in their regimen (Read Review). Similarly, another user experienced gastrointestinal discomfort and advised against use for those with conditions such as gastritis or ulcers, recommending alternatives like sodium ascorbate instead (Read Review). Overall, while there are reports of benefits, users are urged to proceed with caution and consider individual health circumstances.
Based on user reviews, the right dosage of Vitamin C for treating ulcers appears to vary among individuals, with some finding it beneficial while others report discomfort. One user mentions taking a daily dose of one capsule without stomach pain despite having a 12 cm ulcer, noting improvements in overall health and a lack of colds during the year (Read Review). However, caution is advised; another user reported their father experiencing stomach pain after taking Vitamin C, leading to discontinuation of the vitamin (Read Review).
Furthermore, there are warnings regarding the formulation used. A review recommends opting for sodium ascorbate instead of ascorbic acid, especially for those with gastrointestinal issues such as ulcers, due to discomfort and heartburn associated with the latter (Read Review). Therefore, while some users experience benefits from Vitamin C for ulcers, it's critical to monitor individual responses and consider alternative formulations for sensitive stomachs.
The findings were promising: both Vitamin C and metformin demonstrated significant improvements in gastric mucosal injury, helping to alleviate the damage caused by indomethacin. We noted that the combination of Vitamin C with metformin enhanced the effectiveness of antioxidant enzymes in the stomach, such as catalase and GPx, indicating a synergistic effect.
While Vitamin C showed positive results, it's important to recognize that these effects were observed in combination with metformin, making it difficult to isolate its specific benefits. Overall, our research suggests that the combination therapy could be a beneficial option for treating gastric ulcers linked to NSAID usage.
The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.
Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.
Interestingly, we observed that those who used vitamin C supplements had more beneficial elements in their gut microbiome compared to those who did not. The study found a significant difference, indicating that vitamin C users had better microbiome readings, suggesting a positive influence on their gut health. However, while vitamin C presented statistically significant results, we noted that other factors such as antibiotic use also played a crucial role.
Importantly, the use of antibiotics negatively impacted the gut microbiome, which raises questions about the interplay between different treatments. There was also no significant impact found regarding mild COVID-19 on patients’ gut microbiomes, adding another layer to our understanding of these interactions. Ultimately, while vitamin C showed promise, the overall picture suggests that it's part of a broader landscape of factors affecting ulcerative colitis.
References
- Straume Z, Krūmiņa N, Elbere I, Rozenberga M, Erts R, et al. Impact of Vitamins, Antibiotics, Probiotics, and History of COVID-19 on the Gut Microbiome in Ulcerative Colitis Patients: A Cross-Sectional Study. Medicina (Kaunas). 2025;61. doi:10.3390/medicina61020284
- Khezri MR, Varzandeh R, Ghasemnejad-Berenji M. Concomitant Effects of Metformin and Vitamin C on Indomethacin-Induced Gastric Ulcer in Rats: Biochemical and Histopathological Approach. Drug Res (Stuttg). 2024;74:280. doi:10.1055/a-2317-7578
- Ezeani C, Beshel JA, Okon IA, Inyang EG, Owu DU. Vitamin C modulates adrenaline-augmented gastric injury via cardiac troponin/creatine kinase pathway in Wistar rats. Iran J Basic Med Sci. 2023;26:843. doi:10.22038/IJBMS.2023.68651.15019
- Mason SA, Parker L, van der Pligt P, Wadley GD. Vitamin C supplementation for diabetes management: A comprehensive narrative review. Free Radic Biol Med. 2023;194:255. doi:10.1016/j.freeradbiomed.2022.12.003
- Kurt Y, Özmen Ö. Effects of Vitamin C on the Oral-Nasal Mucosal Damage Caused by Favipiravir in Old and Young Rats. Cureus. 2022;14:e28796. doi:10.7759/cureus.28796
- Guellich A, Tella E, Mahé E. [Scurvy presenting with low-extremity necrotic and purpuric ulcers: Two cases]. Rev Med Interne. 2021;42:214. doi:10.1016/j.revmed.2020.10.382
- Gunton JE, Girgis CM, Lau T, Vicaretti M, Begg L, et al. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2021;126:1451. doi:10.1017/S0007114520003815
- Galati EM, Mondello MR, Giuffrida D, Dugo G, Miceli N, et al. Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) mill. Fruit juice: antioxidant and antiulcerogenic activity. J Agric Food Chem. 2003;51:4903.
- Bing SR, Kinouchi T, Kataoka K, Kuwahara T, Ohnishi Y. Protective effects of a culture supernatant of Lactobacillus acidophilus and antioxidants on ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug. Microbiol Immunol. 1998;42:745.
- Vishniak GN, Kharlamova KE, Gurosheva GT, Zavernaia AM, Golovnia IA. [Amben and galascorbin in the combined treatment of ulcerative-necrotic lesions of the oral mucosa]. Stomatologiia (Mosk). 1993;72:24.
