5/18/2025
Last update
5/18/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 8 Reviews
8.7
Supplement Facts
Serving Size: 1 tbsp (15 ml)
Amount Per Serving
%DV
Calories
120
Total Fat
14 g
18%
Saturated Fat
2.5 g
13%
Polyunsaturated Fat
8 g
Monounsaturated Fat
2 g
Sodium
0 mg
0%
Total Carbohydrate
0 g
0%
Protein
0 g
Vitamin E
20 mg
130%
Top Medical Research Studies
8
We explored the potential of recombinant phospholipase A5, also known as Ves v 5, to improve the diagnosis of yellow jacket venom allergies. Our study involved seven individuals, including those who had allergic reactions and those who did not. By isolating serum samples from these participants, we assessed their reactions to both bee venom and the recombinant allergens.
The production of Ves v 5 was successfully carried out in Escherichia coli, leading to the creation of soluble proteins that we then purified. We performed various tests to evaluate these proteins' functionality. This included assessing their biochemical characteristics and how well they interacted with the immune system.
Our findings highlighted the significant role of Ves v 5 in allergic reactions to hymenoptera venoms. The results suggest that recombinant proteins can be a promising alternative for diagnosing these allergies, moving away from traditional methods that rely on whole venom extracts. Ultimately, allergen-specific therapies could provide more effective and tailored treatment options for those prone to these allergies.
The production of Ves v 5 was successfully carried out in Escherichia coli, leading to the creation of soluble proteins that we then purified. We performed various tests to evaluate these proteins' functionality. This included assessing their biochemical characteristics and how well they interacted with the immune system.
Our findings highlighted the significant role of Ves v 5 in allergic reactions to hymenoptera venoms. The results suggest that recombinant proteins can be a promising alternative for diagnosing these allergies, moving away from traditional methods that rely on whole venom extracts. Ultimately, allergen-specific therapies could provide more effective and tailored treatment options for those prone to these allergies.
8
We designed a study to explore how propofol, a widely used anesthetic, influences allergic rhinitis (AR) in mice. Using a model where mice were sensitized and challenged with ovalbumin (OVA), we observed how propofol interacts with immune cells that play a crucial role in inflammation. Our findings revealed that propofol effectively reduced the levels of certain immune cells and cytokines associated with type II inflammation.
Specifically, we noted a decrease in markers for immune cell types like eosinophils and T-helper cells, indicating a reduction in the overall inflammatory response. Interestingly, propofol treatment led to a significant drop in type II cytokines, like IL-5 and IL-13, which are typically elevated in AR.
We also saw that when CD4+ T cells and innate lymphoid cells (ILC2s) interacted, the presence of more type II cells (TH2) increased. However, introducing propofol in these co-cultures reduced the percentage of TH2 cells, suggesting it has an inhibitive effect on allergic inflammation. These results suggest that propofol might offer a new perspective in managing allergic conditions by regulating both innate and adaptive immune responses.
Specifically, we noted a decrease in markers for immune cell types like eosinophils and T-helper cells, indicating a reduction in the overall inflammatory response. Interestingly, propofol treatment led to a significant drop in type II cytokines, like IL-5 and IL-13, which are typically elevated in AR.
We also saw that when CD4+ T cells and innate lymphoid cells (ILC2s) interacted, the presence of more type II cells (TH2) increased. However, introducing propofol in these co-cultures reduced the percentage of TH2 cells, suggesting it has an inhibitive effect on allergic inflammation. These results suggest that propofol might offer a new perspective in managing allergic conditions by regulating both innate and adaptive immune responses.
7
We explored how nasal epithelial cells (NECs) communicate with regulatory T cells (Tregs) in the context of allergic rhinitis, particularly through the protein CCL1. In our study, we used a co-culture system involving human NECs and Tregs from both allergy sufferers and healthy controls. This design allowed us to analyze the changes in chemokine expressions and surface markers after exposure to allergens.
Our results showed that Tregs expressed higher levels of certain markers after interacting with NECs than in isolation. We observed that the allergic response to the allergen Derp1 triggered increased levels of cytokines like TSLP, but surprisingly, CCL1 levels were lower in those with allergies compared to the controls.
When we examined the correlations between NEC-derived cytokines and Treg markers, we found that CCL1 and CCR8 had a positive correlation, suggesting that this pathway might play a significant role in how NECs and Tregs interact in the immune response associated with allergies. Our findings indicate that understanding this communication could be crucial for developing new treatments for allergic rhinitis, emphasizing CCL1's potential as a key player in allergy management.
Our results showed that Tregs expressed higher levels of certain markers after interacting with NECs than in isolation. We observed that the allergic response to the allergen Derp1 triggered increased levels of cytokines like TSLP, but surprisingly, CCL1 levels were lower in those with allergies compared to the controls.
When we examined the correlations between NEC-derived cytokines and Treg markers, we found that CCL1 and CCR8 had a positive correlation, suggesting that this pathway might play a significant role in how NECs and Tregs interact in the immune response associated with allergies. Our findings indicate that understanding this communication could be crucial for developing new treatments for allergic rhinitis, emphasizing CCL1's potential as a key player in allergy management.
Most Useful Reviews
10
Beautiful packaging
Today I received my order. I will share my experiences regarding its use, smell, quality, size, lifespan, and benefits. The packaging is lovely and well-sealed. There's nothing in its formula that triggers my allergies. I hope to see a positive difference!
10
Hydrates well
The smell is delightful and easy to use. The quality is excellent with a large package size. The benefits include softening and nourishing both hair and skin, providing beautiful hydration. Over time, it lightens the skin and reduces pigmentation. It has not caused any allergies for me.
9
Excellent comfort
The quality is excellent, the comfort is great, the size is good, the installation is superb, and it does not cause allergies. The age suitability is good, and the benefits are commendable.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
9
We investigated the effects of a traditional Chinese medicine formula, known as PTQX, on alleviating symptoms of atopic dermatitis, an itchy and persistent skin condition often triggered by allergens like house dust mites. In our study, we used NC/Nga mice, dividing them into groups: a control group, an allergy model group, and a PTQX-treated group, all exposed to HDM ointment.
Our findings revealed that the PTQX formula significantly eased inflammatory responses. It reduced the serum immunoglobulin E (IgE) levels by more than twofold and lowered the secretion of various inflammatory cytokines, suggesting a remarkable anti-inflammatory effect. We also observed a reduction in the proportion of Th2 cells in the lymph nodes, which are typically elevated during allergic reactions.
The mechanism of action seems to involve pathways related to NF-κB and Toll-like receptors. Specifically, proteomics analysis highlighted the downregulation of certain proteins, particularly TRADD, which leads to diminished activity of the NF-κB signaling pathway. Overall, these results suggest that PTQX may alleviate allergy symptoms by targeting a specific protein complex and suppressing inflammation effectively.
Our findings revealed that the PTQX formula significantly eased inflammatory responses. It reduced the serum immunoglobulin E (IgE) levels by more than twofold and lowered the secretion of various inflammatory cytokines, suggesting a remarkable anti-inflammatory effect. We also observed a reduction in the proportion of Th2 cells in the lymph nodes, which are typically elevated during allergic reactions.
The mechanism of action seems to involve pathways related to NF-κB and Toll-like receptors. Specifically, proteomics analysis highlighted the downregulation of certain proteins, particularly TRADD, which leads to diminished activity of the NF-κB signaling pathway. Overall, these results suggest that PTQX may alleviate allergy symptoms by targeting a specific protein complex and suppressing inflammation effectively.
8
We designed a study to explore how propofol, a widely used anesthetic, influences allergic rhinitis (AR) in mice. Using a model where mice were sensitized and challenged with ovalbumin (OVA), we observed how propofol interacts with immune cells that play a crucial role in inflammation. Our findings revealed that propofol effectively reduced the levels of certain immune cells and cytokines associated with type II inflammation.
Specifically, we noted a decrease in markers for immune cell types like eosinophils and T-helper cells, indicating a reduction in the overall inflammatory response. Interestingly, propofol treatment led to a significant drop in type II cytokines, like IL-5 and IL-13, which are typically elevated in AR.
We also saw that when CD4+ T cells and innate lymphoid cells (ILC2s) interacted, the presence of more type II cells (TH2) increased. However, introducing propofol in these co-cultures reduced the percentage of TH2 cells, suggesting it has an inhibitive effect on allergic inflammation. These results suggest that propofol might offer a new perspective in managing allergic conditions by regulating both innate and adaptive immune responses.
Specifically, we noted a decrease in markers for immune cell types like eosinophils and T-helper cells, indicating a reduction in the overall inflammatory response. Interestingly, propofol treatment led to a significant drop in type II cytokines, like IL-5 and IL-13, which are typically elevated in AR.
We also saw that when CD4+ T cells and innate lymphoid cells (ILC2s) interacted, the presence of more type II cells (TH2) increased. However, introducing propofol in these co-cultures reduced the percentage of TH2 cells, suggesting it has an inhibitive effect on allergic inflammation. These results suggest that propofol might offer a new perspective in managing allergic conditions by regulating both innate and adaptive immune responses.
8
We explored the potential of recombinant phospholipase A5, also known as Ves v 5, to improve the diagnosis of yellow jacket venom allergies. Our study involved seven individuals, including those who had allergic reactions and those who did not. By isolating serum samples from these participants, we assessed their reactions to both bee venom and the recombinant allergens.
The production of Ves v 5 was successfully carried out in Escherichia coli, leading to the creation of soluble proteins that we then purified. We performed various tests to evaluate these proteins' functionality. This included assessing their biochemical characteristics and how well they interacted with the immune system.
Our findings highlighted the significant role of Ves v 5 in allergic reactions to hymenoptera venoms. The results suggest that recombinant proteins can be a promising alternative for diagnosing these allergies, moving away from traditional methods that rely on whole venom extracts. Ultimately, allergen-specific therapies could provide more effective and tailored treatment options for those prone to these allergies.
The production of Ves v 5 was successfully carried out in Escherichia coli, leading to the creation of soluble proteins that we then purified. We performed various tests to evaluate these proteins' functionality. This included assessing their biochemical characteristics and how well they interacted with the immune system.
Our findings highlighted the significant role of Ves v 5 in allergic reactions to hymenoptera venoms. The results suggest that recombinant proteins can be a promising alternative for diagnosing these allergies, moving away from traditional methods that rely on whole venom extracts. Ultimately, allergen-specific therapies could provide more effective and tailored treatment options for those prone to these allergies.
8
We explored the potential of a specially designed nanoemulsion containing vitamin E to address the symptoms of atopic dermatitis (AD), a chronic skin condition that significantly impacts quality of life. In this study, the formulation, named PV-NE, aimed to balance the immune system and reduce inflammation characterized by the overproduction of reactive oxygen species (ROS), which are linked to worsening allergic reactions.
Through our research, we noted that while PV-NE demonstrated effectiveness in restoring immune balance and alleviating symptoms like itching and skin irritation, it did not isolate the effects of vitamin E specifically on allergies. Instead, the focus was on how the combination worked as a whole. This means that while vitamin E plays a role in the treatment via the nanoemulsion, we can't conclusively say it effectively treats allergies when considered on its own.
Ultimately, our findings establish a foundation for further exploration of vitamin E's contributions within broader therapeutic systems, indicating its biocompatibility and importance in future treatments for AD and potentially other allergies.
Through our research, we noted that while PV-NE demonstrated effectiveness in restoring immune balance and alleviating symptoms like itching and skin irritation, it did not isolate the effects of vitamin E specifically on allergies. Instead, the focus was on how the combination worked as a whole. This means that while vitamin E plays a role in the treatment via the nanoemulsion, we can't conclusively say it effectively treats allergies when considered on its own.
Ultimately, our findings establish a foundation for further exploration of vitamin E's contributions within broader therapeutic systems, indicating its biocompatibility and importance in future treatments for AD and potentially other allergies.
7
We explored how nasal epithelial cells (NECs) communicate with regulatory T cells (Tregs) in the context of allergic rhinitis, particularly through the protein CCL1. In our study, we used a co-culture system involving human NECs and Tregs from both allergy sufferers and healthy controls. This design allowed us to analyze the changes in chemokine expressions and surface markers after exposure to allergens.
Our results showed that Tregs expressed higher levels of certain markers after interacting with NECs than in isolation. We observed that the allergic response to the allergen Derp1 triggered increased levels of cytokines like TSLP, but surprisingly, CCL1 levels were lower in those with allergies compared to the controls.
When we examined the correlations between NEC-derived cytokines and Treg markers, we found that CCL1 and CCR8 had a positive correlation, suggesting that this pathway might play a significant role in how NECs and Tregs interact in the immune response associated with allergies. Our findings indicate that understanding this communication could be crucial for developing new treatments for allergic rhinitis, emphasizing CCL1's potential as a key player in allergy management.
Our results showed that Tregs expressed higher levels of certain markers after interacting with NECs than in isolation. We observed that the allergic response to the allergen Derp1 triggered increased levels of cytokines like TSLP, but surprisingly, CCL1 levels were lower in those with allergies compared to the controls.
When we examined the correlations between NEC-derived cytokines and Treg markers, we found that CCL1 and CCR8 had a positive correlation, suggesting that this pathway might play a significant role in how NECs and Tregs interact in the immune response associated with allergies. Our findings indicate that understanding this communication could be crucial for developing new treatments for allergic rhinitis, emphasizing CCL1's potential as a key player in allergy management.
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Beautiful packaging
Today I received my order. I will share my experiences regarding its use, smell, quality, size, lifespan, and benefits. The packaging is lovely and well-sealed. There's nothing in its formula that triggers my allergies. I hope to see a positive difference!
10
Hydrates well
The smell is delightful and easy to use. The quality is excellent with a large package size. The benefits include softening and nourishing both hair and skin, providing beautiful hydration. Over time, it lightens the skin and reduces pigmentation. It has not caused any allergies for me.
9
Excellent comfort
The quality is excellent, the comfort is great, the size is good, the installation is superb, and it does not cause allergies. The age suitability is good, and the benefits are commendable.
9
Gentle formula
It has a beautiful scent, is easy to use, and the product quality is exceptional. The quantity is reasonable and suitable for adults, lasting six months. The benefits are impressive, especially for my hair; the formula is gentle and suitable for children, works in all seasons, and does not cause allergies, made from natural ingredients.
9
Suitable for all
It's excellent for those with sensitive skin and allergies, appropriate for both children and adults. The quality is outstanding and as expected from iHerb. The packaging is securely sealed upon delivery.
Frequently Asked Questions
10
Hydrates well
The smell is delightful and easy to use. The quality is excellent with a large package size. The benefits include softening and nourishing both hair and skin, providing beautiful hydration. Over time, it lightens the skin and reduces pigmentation. It has not caused any allergies for me.
9
Suitable for all
It's excellent for those with sensitive skin and allergies, appropriate for both children and adults. The quality is outstanding and as expected from iHerb. The packaging is securely sealed upon delivery.
9
Moisturises effectively
2 people found this helpful
The smell is pleasant, and it serves as a skin lotion. The quality is high, and the size excellent. The package is tightly sealed. The ingredients are oil that does not cause allergies, providing benefits in cleansing and moisturising both skin and hair. It contains omegas, fights inflammation, and is good for heart health. The flavour has a nice texture. I will certainly repeat this experience.
9
No problems found
It’s good; the smell is acceptable, and the quality is excellent. I did not encounter any allergies or issues.
10
Beautiful packaging
Today I received my order. I will share my experiences regarding its use, smell, quality, size, lifespan, and benefits. The packaging is lovely and well-sealed. There's nothing in its formula that triggers my allergies. I hope to see a positive difference!
9
We investigated the effects of a traditional Chinese medicine formula, known as PTQX, on alleviating symptoms of atopic dermatitis, an itchy and persistent skin condition often triggered by allergens like house dust mites. In our study, we used NC/Nga mice, dividing them into groups: a control group, an allergy model group, and a PTQX-treated group, all exposed to HDM ointment.
Our findings revealed that the PTQX formula significantly eased inflammatory responses. It reduced the serum immunoglobulin E (IgE) levels by more than twofold and lowered the secretion of various inflammatory cytokines, suggesting a remarkable anti-inflammatory effect. We also observed a reduction in the proportion of Th2 cells in the lymph nodes, which are typically elevated during allergic reactions.
The mechanism of action seems to involve pathways related to NF-κB and Toll-like receptors. Specifically, proteomics analysis highlighted the downregulation of certain proteins, particularly TRADD, which leads to diminished activity of the NF-κB signaling pathway. Overall, these results suggest that PTQX may alleviate allergy symptoms by targeting a specific protein complex and suppressing inflammation effectively.
Our findings revealed that the PTQX formula significantly eased inflammatory responses. It reduced the serum immunoglobulin E (IgE) levels by more than twofold and lowered the secretion of various inflammatory cytokines, suggesting a remarkable anti-inflammatory effect. We also observed a reduction in the proportion of Th2 cells in the lymph nodes, which are typically elevated during allergic reactions.
The mechanism of action seems to involve pathways related to NF-κB and Toll-like receptors. Specifically, proteomics analysis highlighted the downregulation of certain proteins, particularly TRADD, which leads to diminished activity of the NF-κB signaling pathway. Overall, these results suggest that PTQX may alleviate allergy symptoms by targeting a specific protein complex and suppressing inflammation effectively.
8
We designed a study to explore how propofol, a widely used anesthetic, influences allergic rhinitis (AR) in mice. Using a model where mice were sensitized and challenged with ovalbumin (OVA), we observed how propofol interacts with immune cells that play a crucial role in inflammation. Our findings revealed that propofol effectively reduced the levels of certain immune cells and cytokines associated with type II inflammation.
Specifically, we noted a decrease in markers for immune cell types like eosinophils and T-helper cells, indicating a reduction in the overall inflammatory response. Interestingly, propofol treatment led to a significant drop in type II cytokines, like IL-5 and IL-13, which are typically elevated in AR.
We also saw that when CD4+ T cells and innate lymphoid cells (ILC2s) interacted, the presence of more type II cells (TH2) increased. However, introducing propofol in these co-cultures reduced the percentage of TH2 cells, suggesting it has an inhibitive effect on allergic inflammation. These results suggest that propofol might offer a new perspective in managing allergic conditions by regulating both innate and adaptive immune responses.
Specifically, we noted a decrease in markers for immune cell types like eosinophils and T-helper cells, indicating a reduction in the overall inflammatory response. Interestingly, propofol treatment led to a significant drop in type II cytokines, like IL-5 and IL-13, which are typically elevated in AR.
We also saw that when CD4+ T cells and innate lymphoid cells (ILC2s) interacted, the presence of more type II cells (TH2) increased. However, introducing propofol in these co-cultures reduced the percentage of TH2 cells, suggesting it has an inhibitive effect on allergic inflammation. These results suggest that propofol might offer a new perspective in managing allergic conditions by regulating both innate and adaptive immune responses.
7
We explored how nasal epithelial cells (NECs) communicate with regulatory T cells (Tregs) in the context of allergic rhinitis, particularly through the protein CCL1. In our study, we used a co-culture system involving human NECs and Tregs from both allergy sufferers and healthy controls. This design allowed us to analyze the changes in chemokine expressions and surface markers after exposure to allergens.
Our results showed that Tregs expressed higher levels of certain markers after interacting with NECs than in isolation. We observed that the allergic response to the allergen Derp1 triggered increased levels of cytokines like TSLP, but surprisingly, CCL1 levels were lower in those with allergies compared to the controls.
When we examined the correlations between NEC-derived cytokines and Treg markers, we found that CCL1 and CCR8 had a positive correlation, suggesting that this pathway might play a significant role in how NECs and Tregs interact in the immune response associated with allergies. Our findings indicate that understanding this communication could be crucial for developing new treatments for allergic rhinitis, emphasizing CCL1's potential as a key player in allergy management.
Our results showed that Tregs expressed higher levels of certain markers after interacting with NECs than in isolation. We observed that the allergic response to the allergen Derp1 triggered increased levels of cytokines like TSLP, but surprisingly, CCL1 levels were lower in those with allergies compared to the controls.
When we examined the correlations between NEC-derived cytokines and Treg markers, we found that CCL1 and CCR8 had a positive correlation, suggesting that this pathway might play a significant role in how NECs and Tregs interact in the immune response associated with allergies. Our findings indicate that understanding this communication could be crucial for developing new treatments for allergic rhinitis, emphasizing CCL1's potential as a key player in allergy management.
8
We explored the potential of a specially designed nanoemulsion containing vitamin E to address the symptoms of atopic dermatitis (AD), a chronic skin condition that significantly impacts quality of life. In this study, the formulation, named PV-NE, aimed to balance the immune system and reduce inflammation characterized by the overproduction of reactive oxygen species (ROS), which are linked to worsening allergic reactions.
Through our research, we noted that while PV-NE demonstrated effectiveness in restoring immune balance and alleviating symptoms like itching and skin irritation, it did not isolate the effects of vitamin E specifically on allergies. Instead, the focus was on how the combination worked as a whole. This means that while vitamin E plays a role in the treatment via the nanoemulsion, we can't conclusively say it effectively treats allergies when considered on its own.
Ultimately, our findings establish a foundation for further exploration of vitamin E's contributions within broader therapeutic systems, indicating its biocompatibility and importance in future treatments for AD and potentially other allergies.
Through our research, we noted that while PV-NE demonstrated effectiveness in restoring immune balance and alleviating symptoms like itching and skin irritation, it did not isolate the effects of vitamin E specifically on allergies. Instead, the focus was on how the combination worked as a whole. This means that while vitamin E plays a role in the treatment via the nanoemulsion, we can't conclusively say it effectively treats allergies when considered on its own.
Ultimately, our findings establish a foundation for further exploration of vitamin E's contributions within broader therapeutic systems, indicating its biocompatibility and importance in future treatments for AD and potentially other allergies.
References
- Cheng Z, Ma X, Luo F, Mo X, Liu J, et al. PeiTuQingXin formula alleviated atopic dermatitis symptoms via inhibiting TRADD/TRAF2/RIP1 complex mediated NF-κB signaling pathway activation. Arch Dermatol Res. 2025;317:535. 10.1007/s00403-025-03998-2
- Chen X, Liu W, Guo X, Zeng Y, Song X, et al. Inhibitory Effect of Propofol on Type II Inflammation in Mice with Allergic Rhinitis. Iran J Allergy Asthma Immunol. 2025;24:71. 10.18502/ijaai.v24i1.18022
- Sha J, Yang M, Lei Y, Sun L, Meng C, et al. Interaction between nasal epithelial cells and Tregs in allergic rhinitis responses to allergen via CCL1/CCR8. Front Immunol. 2025;16:1526081. 10.3389/fimmu.2025.1526081
- Mahmoudzadeh S, Rezapour H, Chamani S, Safarpour H, Fereidouni M. Pattern of sensitization to yellow jacket venom and expression of recombinant antigen 5 (Ves v 5) from yellow jacket venom. BMC Immunol. 2025;26:14. 10.1186/s12865-025-00689-5
- Lu Y, Shan X, Huang J, Zhou H, Zhu Y, et al. Reductive Adjuvant Nanosystem for Alleviated Atopic Dermatitis Syndromes. ACS Nano. 2025;19:4195. 10.1021/acsnano.4c08767
