Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 9 Reviews
8.1
Supplement Facts
Serving Size: 1 tbsp (15 ml)
Amount Per Serving
%DV
Calories
120
Total Fat
14 g
18%
Saturated Fat
2.5 g
13%
Polyunsaturated Fat
8 g
Monounsaturated Fat
2 g
Sodium
0 mg
0%
Total Carbohydrate
0 g
0%
Protein
0 g
Vitamin E
20 mg
130%
Top Medical Research Studies
9
CNP may ease knee osteoarthritis
We explored the potential of C-type natriuretic peptide (CNP) as a treatment for knee pain and osteoarthritis. This peptide was tested through intraarticular injections in a rat model of knee arthritis to assess its impact on cartilage degradation and persistent pain.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Read More
7
Collagen supplementation benefits knee pain
We conducted a randomized, double-blind, placebo-controlled study to examine whether collagen supplementation could alleviate knee pain in patients suffering from meniscopathy. Our group consisted of 32 patients, with some receiving a supplement made from types I, II, and III collagen, while others received a placebo.
Patients reported on their pain levels and quality of life through various well-recognized scales both before and after an eight-week supplementation period. The results indicated that those taking the collagen supplement experienced notable improvements in pain relief and overall quality of life. Additionally, some physical function tests showed positive results, suggesting that the collagen may indeed support better knee function and mobility.
However, it’s important to note that since response was attributed to a blend of different collagen types, isolating the exact impact of each type remains a challenge. Further research might help to clarify how these proteins specifically affect knee pain and recovery.
Patients reported on their pain levels and quality of life through various well-recognized scales both before and after an eight-week supplementation period. The results indicated that those taking the collagen supplement experienced notable improvements in pain relief and overall quality of life. Additionally, some physical function tests showed positive results, suggesting that the collagen may indeed support better knee function and mobility.
However, it’s important to note that since response was attributed to a blend of different collagen types, isolating the exact impact of each type remains a challenge. Further research might help to clarify how these proteins specifically affect knee pain and recovery.
Read More
7
Collagen supplementation aids knee pain
This study examined how a specific collagen supplement, Naturagen® 4 Joint, impacts knee pain and overall living quality for those suffering from osteoarthritis (OA). It involved 31 participants, split into two groups: one received the collagen supplement, while the other received a placebo, ensuring a fair comparison.
Over eight weeks, participants underwent various assessments to measure pain levels and physical functioning using standardized tools. We found that those taking the collagen supplement experienced noticeable improvements in pain relief and quality of life metrics, suggesting that collagen may benefit those dealing with knee pain linked to OA.
While the results are promising, indicating that collagen supplementation can enhance well-being, it’s essential to consider that the study combined multiple collagen types, making it tricky to pinpoint exactly which type contributed most to the observed benefits. Overall, this research provides valuable insights into how protein, in the form of collagen, may be a helpful ally for those managing knee discomfort.
Over eight weeks, participants underwent various assessments to measure pain levels and physical functioning using standardized tools. We found that those taking the collagen supplement experienced noticeable improvements in pain relief and quality of life metrics, suggesting that collagen may benefit those dealing with knee pain linked to OA.
While the results are promising, indicating that collagen supplementation can enhance well-being, it’s essential to consider that the study combined multiple collagen types, making it tricky to pinpoint exactly which type contributed most to the observed benefits. Overall, this research provides valuable insights into how protein, in the form of collagen, may be a helpful ally for those managing knee discomfort.
Read More
Most Useful Reviews
9
Great for joints
39 people found this helpful
I've heard so much praise for wheat germ oil and wanted to see its effects myself. It’s purported to help lighten dark areas and has been great for my joints, especially when mixed with other oils to minimise the scent. The results have been excellent.
Read More
7.5
Knee mix success
20 people found this helpful
This oil is fantastic when used with other mixtures, especially for knee and elbow treatment. The improvements I've seen are remarkable, despite the smell being somewhat off-putting.
Read More
9
Very economical
7 people found this helpful
Excellent. The price difference is notable; we have 60 ml in pharmacies for 60 riyals, making this product very economical. It has the same smell, colour, and texture. It works excellently for knees and elbows, delivering quick results. All my relatives and friends have praised it, and they really liked it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
- All Researches
9
CNP may ease knee osteoarthritis
We explored the potential of C-type natriuretic peptide (CNP) as a treatment for knee pain and osteoarthritis. This peptide was tested through intraarticular injections in a rat model of knee arthritis to assess its impact on cartilage degradation and persistent pain.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Read More
9
We examined how delivering proteins directly into the joints could impact knee pain associated with osteoarthritis (OA). The study focused on two proteins: interleukin-1 receptor antagonist (IL-1Ra), which helps reduce inflammation, and SOX9, which supports cartilage repair. Using a gene therapy approach, we injected these proteins via a viral vector into animal models that were induced with knee osteoarthritis.
Our results were promising. In one test with a rat model, we saw improvements in gait and a reduction in cartilage damage after injecting IL-1Ra alone. This suggests that IL-1Ra can significantly alleviate pain and damage in knees suffering from OA.
Additionally, when we combined IL-1Ra with SOX9, the effects were even more beneficial. This joint delivery significantly improved not only the inflammation of the synovial tissue but also protected cartilage, leading to enhanced overall joint health compared to using either protein separately.
Overall, our findings indicate that targeting knee pain with these proteins could pave the way for new therapeutic strategies in treating osteoarthritis, highlighting the potential of tailored protein treatments for better patient outcomes.
Our results were promising. In one test with a rat model, we saw improvements in gait and a reduction in cartilage damage after injecting IL-1Ra alone. This suggests that IL-1Ra can significantly alleviate pain and damage in knees suffering from OA.
Additionally, when we combined IL-1Ra with SOX9, the effects were even more beneficial. This joint delivery significantly improved not only the inflammation of the synovial tissue but also protected cartilage, leading to enhanced overall joint health compared to using either protein separately.
Overall, our findings indicate that targeting knee pain with these proteins could pave the way for new therapeutic strategies in treating osteoarthritis, highlighting the potential of tailored protein treatments for better patient outcomes.
Read More
7
Collagen supplementation benefits knee pain
We conducted a randomized, double-blind, placebo-controlled study to examine whether collagen supplementation could alleviate knee pain in patients suffering from meniscopathy. Our group consisted of 32 patients, with some receiving a supplement made from types I, II, and III collagen, while others received a placebo.
Patients reported on their pain levels and quality of life through various well-recognized scales both before and after an eight-week supplementation period. The results indicated that those taking the collagen supplement experienced notable improvements in pain relief and overall quality of life. Additionally, some physical function tests showed positive results, suggesting that the collagen may indeed support better knee function and mobility.
However, it’s important to note that since response was attributed to a blend of different collagen types, isolating the exact impact of each type remains a challenge. Further research might help to clarify how these proteins specifically affect knee pain and recovery.
Patients reported on their pain levels and quality of life through various well-recognized scales both before and after an eight-week supplementation period. The results indicated that those taking the collagen supplement experienced notable improvements in pain relief and overall quality of life. Additionally, some physical function tests showed positive results, suggesting that the collagen may indeed support better knee function and mobility.
However, it’s important to note that since response was attributed to a blend of different collagen types, isolating the exact impact of each type remains a challenge. Further research might help to clarify how these proteins specifically affect knee pain and recovery.
Read More
7
Collagen supplementation aids knee pain
This study examined how a specific collagen supplement, Naturagen® 4 Joint, impacts knee pain and overall living quality for those suffering from osteoarthritis (OA). It involved 31 participants, split into two groups: one received the collagen supplement, while the other received a placebo, ensuring a fair comparison.
Over eight weeks, participants underwent various assessments to measure pain levels and physical functioning using standardized tools. We found that those taking the collagen supplement experienced noticeable improvements in pain relief and quality of life metrics, suggesting that collagen may benefit those dealing with knee pain linked to OA.
While the results are promising, indicating that collagen supplementation can enhance well-being, it’s essential to consider that the study combined multiple collagen types, making it tricky to pinpoint exactly which type contributed most to the observed benefits. Overall, this research provides valuable insights into how protein, in the form of collagen, may be a helpful ally for those managing knee discomfort.
Over eight weeks, participants underwent various assessments to measure pain levels and physical functioning using standardized tools. We found that those taking the collagen supplement experienced noticeable improvements in pain relief and quality of life metrics, suggesting that collagen may benefit those dealing with knee pain linked to OA.
While the results are promising, indicating that collagen supplementation can enhance well-being, it’s essential to consider that the study combined multiple collagen types, making it tricky to pinpoint exactly which type contributed most to the observed benefits. Overall, this research provides valuable insights into how protein, in the form of collagen, may be a helpful ally for those managing knee discomfort.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Great for joints
39 people found this helpful
I've heard so much praise for wheat germ oil and wanted to see its effects myself. It’s purported to help lighten dark areas and has been great for my joints, especially when mixed with other oils to minimise the scent. The results have been excellent.
Read More
7.5
Knee mix success
20 people found this helpful
This oil is fantastic when used with other mixtures, especially for knee and elbow treatment. The improvements I've seen are remarkable, despite the smell being somewhat off-putting.
Read More
9
Very economical
7 people found this helpful
Excellent. The price difference is notable; we have 60 ml in pharmacies for 60 riyals, making this product very economical. It has the same smell, colour, and texture. It works excellently for knees and elbows, delivering quick results. All my relatives and friends have praised it, and they really liked it.
Read More
7.5
Knee pain relief
The quality is impressive, and I recommend it for knee pain or muscle discomfort. Its thick consistency makes it perfect for applying all over the body after a tiring day. It’s simply amazing!
Read More
7.5
Moisturises effectively
Fabulous! It's truly effective with scrubs and masks, moisturising and reducing lines while also working on the knees. However, its smell is quite unpleasant, making it unsuitable for use on the body alone.
Read More
Frequently Asked Questions
6
Daily treatment needed
Wheat germ oil. This is remarkable, as I ask for a treatment for my knees and elbows daily. I notice a difference after a month of use.
7.5
Trustworthy product
15 people found this helpful
My Rating It's very nice, girls. I trust this company and their products a lot. I have also used it for my joints and knees, and it made a noticeable difference. Give it a try and pray for me. May God bring you happiness.
2
Awaiting effects
I bought this oil for my knees and elbows, but I haven't seen any results yet. I've mixed it with my body cream. I plan to revisit after a month to assess its effectiveness. The smell is quite unpleasant, but hopefully, it will prove useful, especially since I've heard it benefits diabetics.
9
Great for joints
39 people found this helpful
I've heard so much praise for wheat germ oil and wanted to see its effects myself. It’s purported to help lighten dark areas and has been great for my joints, especially when mixed with other oils to minimise the scent. The results have been excellent.
7.5
Knee mix success
20 people found this helpful
This oil is fantastic when used with other mixtures, especially for knee and elbow treatment. The improvements I've seen are remarkable, despite the smell being somewhat off-putting.
7.5
Knee pain relief
The quality is impressive, and I recommend it for knee pain or muscle discomfort. Its thick consistency makes it perfect for applying all over the body after a tiring day. It’s simply amazing!
6
Best oil tried
6 people found this helpful
Gorgeous! It is the best oil I have tried for addressing darkening of the knees and elbows. Although its smell is somewhat annoying, it’s best used on targeted areas rather than the whole body. You can mix it with body lotion for better results, but be cautious with the quantity.
9
CNP may ease knee osteoarthritis
We explored the potential of C-type natriuretic peptide (CNP) as a treatment for knee pain and osteoarthritis. This peptide was tested through intraarticular injections in a rat model of knee arthritis to assess its impact on cartilage degradation and persistent pain.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
7
Collagen supplementation benefits knee pain
We conducted a randomized, double-blind, placebo-controlled study to examine whether collagen supplementation could alleviate knee pain in patients suffering from meniscopathy. Our group consisted of 32 patients, with some receiving a supplement made from types I, II, and III collagen, while others received a placebo.
Patients reported on their pain levels and quality of life through various well-recognized scales both before and after an eight-week supplementation period. The results indicated that those taking the collagen supplement experienced notable improvements in pain relief and overall quality of life. Additionally, some physical function tests showed positive results, suggesting that the collagen may indeed support better knee function and mobility.
However, it’s important to note that since response was attributed to a blend of different collagen types, isolating the exact impact of each type remains a challenge. Further research might help to clarify how these proteins specifically affect knee pain and recovery.
Patients reported on their pain levels and quality of life through various well-recognized scales both before and after an eight-week supplementation period. The results indicated that those taking the collagen supplement experienced notable improvements in pain relief and overall quality of life. Additionally, some physical function tests showed positive results, suggesting that the collagen may indeed support better knee function and mobility.
However, it’s important to note that since response was attributed to a blend of different collagen types, isolating the exact impact of each type remains a challenge. Further research might help to clarify how these proteins specifically affect knee pain and recovery.
7
Collagen supplementation aids knee pain
This study examined how a specific collagen supplement, Naturagen® 4 Joint, impacts knee pain and overall living quality for those suffering from osteoarthritis (OA). It involved 31 participants, split into two groups: one received the collagen supplement, while the other received a placebo, ensuring a fair comparison.
Over eight weeks, participants underwent various assessments to measure pain levels and physical functioning using standardized tools. We found that those taking the collagen supplement experienced noticeable improvements in pain relief and quality of life metrics, suggesting that collagen may benefit those dealing with knee pain linked to OA.
While the results are promising, indicating that collagen supplementation can enhance well-being, it’s essential to consider that the study combined multiple collagen types, making it tricky to pinpoint exactly which type contributed most to the observed benefits. Overall, this research provides valuable insights into how protein, in the form of collagen, may be a helpful ally for those managing knee discomfort.
Over eight weeks, participants underwent various assessments to measure pain levels and physical functioning using standardized tools. We found that those taking the collagen supplement experienced noticeable improvements in pain relief and quality of life metrics, suggesting that collagen may benefit those dealing with knee pain linked to OA.
While the results are promising, indicating that collagen supplementation can enhance well-being, it’s essential to consider that the study combined multiple collagen types, making it tricky to pinpoint exactly which type contributed most to the observed benefits. Overall, this research provides valuable insights into how protein, in the form of collagen, may be a helpful ally for those managing knee discomfort.
References
- Yamashita R, Nozawa I, Hasegawa S, Nakagawa Y, Miyatake K, et al. C-type natriuretic peptide suppresses VEGFa gene expression by attenuating IL6-STAT3 signal pathway in primary synovial fibroblasts from rat knee. Biochem Biophys Res Commun. 2025;749:151290. 10.1016/j.bbrc.2025.151290
- Zhou K, Yuan M, Sun J, Zhang F, Li X, et al. Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models. Gene Ther. 2025. 10.1038/s41434-025-00515-y
- Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study. BMC Musculoskelet Disord. 2025;26:17. 10.1186/s12891-024-08244-w
- Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study. Jt Dis Relat Surg. 2025;36:85. 10.52312/jdrs.2025.1965
