I take this on an empty stomach together with Thorne Research Selenomethionine and my thyroid medication, and wait at least 30 minutes before eating. Vitamin E works synergistically with selenium, increasing absorption. Selenium helps convert T4 to T3. Since adding this to my thyroid medication, my dosage of thyroid has decreased significantly. Every other brand of vitamin E I have ever tried has given me a severe headache. This brand does not. Also, it does not contain soy, which is a goitrogen and a carcinogen. I highly recommend this brand