5/12/2025
Last update
5/12/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Packet (10 g)
Amount Per Serving
%DV
Calories
35
Protein
9 g
0%*
Sodium
55 mg
2%
Collagen peptides (from bovine)
10 g
**
Top Medical Research Studies
9
Collagen may alleviate knee OA symptoms
We explored the effects of collagen-based supplements on knee osteoarthritis (OA) by analyzing data from 11 randomized controlled trials, involving 870 participants.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
8
Collagen supplement benefits knee osteoarthritis
We conducted a robust multicenter, double-blind trial involving 212 patients with knee osteoarthritis to assess the effectiveness and safety of the Artneo complex, which contains undenatured type II collagen.
Participants were divided into two groups: one received the collagen supplement for 180 days, while the other was given a placebo. Our findings indicated a significant improvement in pain, quality of life, and reduction of NSAID use among those taking the collagen compared to the placebo group.
Overall, the study supports the use of Artneo collagen as a beneficial treatment for knee osteoarthritis.
Participants were divided into two groups: one received the collagen supplement for 180 days, while the other was given a placebo. Our findings indicated a significant improvement in pain, quality of life, and reduction of NSAID use among those taking the collagen compared to the placebo group.
Overall, the study supports the use of Artneo collagen as a beneficial treatment for knee osteoarthritis.
8
We conducted a thorough investigation into how collagen peptides can help alleviate knee joint osteoarthritis. Our double-blind, randomized clinical trial involved 100 participants and compared a new high-functional Type J bovine collagen against conventional collagen supplements over 90 days.
Participants reported improvements in pain levels, overall quality of life, and joint function. Notably, two doses of the new collagen were found to be just as effective as the standard treatment.
This exciting finding suggests that specific collagen supplements can provide meaningful benefits for those affected by osteoarthritis.
Participants reported improvements in pain levels, overall quality of life, and joint function. Notably, two doses of the new collagen were found to be just as effective as the standard treatment.
This exciting finding suggests that specific collagen supplements can provide meaningful benefits for those affected by osteoarthritis.
Most Useful Reviews
10
Significant pain reduction
3 people found this helpful
I have experienced severe joint pain in my left hip, lower back, and neck for years, suspected to be due to arthritis. I take Arthrotec daily, which offers only temporary relief. After trying the Vitals Protein based on reviews, I can hardly believe the difference! No more hip or back pain, I sleep much better, have more energy, and improved digestion. While my weight hasn't changed, I do mix one scoop into my hot coffee every morning, and there’s no aftertaste. This product has worked so well that I’ve added it to my Amazon subscription list.
9
Effective pain relief
1 people found this helpful
Fantastic! I use this alongside CBD, and it provides the best relief I’ve experienced for my arthritis pain.
7.5
Notable improvement
57 people found this helpful
I was uncertain if this would be helpful, as I have cancer and arthritis. However, I noticed a difference after just two months of taking this supplement. It's completely flavourless, allowing me to mix it into any drink without altering the taste. Now, I add it to my coffee every morning and have even bought it as gifts for family and friends who suffer from joint pain or brittle nails/hair. I highly recommend it!
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
- All Researches
9
We looked into how BD400 could potentially help with collagen-induced arthritis (CIA) in rats. Using a model to mimic the disease, we observed that BD400 significantly reduced arthritis scores and paw swelling.
It also decreased harmful inflammatory markers and improved gut health by enhancing intestinal barrier function. Essentially, BD400 seems to help alter gut bacteria and metabolism, which may slow down the progression of rheumatoid arthritis.
It also decreased harmful inflammatory markers and improved gut health by enhancing intestinal barrier function. Essentially, BD400 seems to help alter gut bacteria and metabolism, which may slow down the progression of rheumatoid arthritis.
9
Collagen may alleviate knee OA symptoms
We explored the effects of collagen-based supplements on knee osteoarthritis (OA) by analyzing data from 11 randomized controlled trials, involving 870 participants.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
We evaluated how a nutritional supplement containing hydrolyzed collagen and other ingredients affects osteoarthritis (OA) pain. In a multicenter study involving 186 participants, we found that after 6 months, participants reported a significant decrease in pain and improved physical function. Specifically, scores on self-perceived pain and functional indices showed notable improvement, indicating that the supplement may effectively help manage OA symptoms. Importantly, the treatment was well-tolerated with no severe adverse events reported.
9
Collagen peptides may prevent osteoarthritis
We examined how collagen peptides derived from Atlantic salmon impact osteoarthritis development. Using both controlled laboratory conditions and an animal model, we observed that these peptides improve cartilage health by reducing inflammation and promoting collagen production.
The results indicated enhanced tolerance to pain in rats and decreases in inflammatory markers. Despite these positive findings, more research is needed to fully understand the mechanisms behind these benefits.
Overall, collagen peptides could be a promising dietary option for managing osteoarthritis.
The results indicated enhanced tolerance to pain in rats and decreases in inflammatory markers. Despite these positive findings, more research is needed to fully understand the mechanisms behind these benefits.
Overall, collagen peptides could be a promising dietary option for managing osteoarthritis.
9
We explored the role of stromal cell-derived factor 1 (SDF-1) in alleviating osteoarthritis (OA), the most prevalent joint disease affecting millions. Our research delved into how SDF-1 could mitigate the progression of OA symptoms, focusing specifically on its impact on mitochondrial dysfunction within cartilage cells.
Using both OA chondrocytes and a collagen-induced osteoarthritis (CIOA) mouse model, we treated these cells and animals with SDF-1. We then assessed various markers related to mitochondrial function and cartilage health. Interestingly, we discovered that levels of important proteins like SOD2 and PGC-1α were lower in OA affected cells and tissues. Treatment with SDF-1 notably corrected these deficits, suggesting a promising pathway for restoring mitochondrial health and, consequently, improving OA symptoms.
Notably, when we inhibited Sirt3—an enzyme linked to mitochondrial function—prior to SDF-1 treatment, the benefits were diminished. This suggests that the Sirt3/PGC-1α signaling pathway is critical for the therapeutic effect of SDF-1 in OA. Thus, our findings indicate that SDF-1 stands out as a potential new treatment for OA, offering hope beyond traditional symptom management strategies.
Using both OA chondrocytes and a collagen-induced osteoarthritis (CIOA) mouse model, we treated these cells and animals with SDF-1. We then assessed various markers related to mitochondrial function and cartilage health. Interestingly, we discovered that levels of important proteins like SOD2 and PGC-1α were lower in OA affected cells and tissues. Treatment with SDF-1 notably corrected these deficits, suggesting a promising pathway for restoring mitochondrial health and, consequently, improving OA symptoms.
Notably, when we inhibited Sirt3—an enzyme linked to mitochondrial function—prior to SDF-1 treatment, the benefits were diminished. This suggests that the Sirt3/PGC-1α signaling pathway is critical for the therapeutic effect of SDF-1 in OA. Thus, our findings indicate that SDF-1 stands out as a potential new treatment for OA, offering hope beyond traditional symptom management strategies.
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Significant pain reduction
3 people found this helpful
I have experienced severe joint pain in my left hip, lower back, and neck for years, suspected to be due to arthritis. I take Arthrotec daily, which offers only temporary relief. After trying the Vitals Protein based on reviews, I can hardly believe the difference! No more hip or back pain, I sleep much better, have more energy, and improved digestion. While my weight hasn't changed, I do mix one scoop into my hot coffee every morning, and there’s no aftertaste. This product has worked so well that I’ve added it to my Amazon subscription list.
9
Effective pain relief
1 people found this helpful
Fantastic! I use this alongside CBD, and it provides the best relief I’ve experienced for my arthritis pain.
7.5
Notable improvement
57 people found this helpful
I was uncertain if this would be helpful, as I have cancer and arthritis. However, I noticed a difference after just two months of taking this supplement. It's completely flavourless, allowing me to mix it into any drink without altering the taste. Now, I add it to my coffee every morning and have even bought it as gifts for family and friends who suffer from joint pain or brittle nails/hair. I highly recommend it!
Frequently Asked Questions
7
We conducted a double-blind, randomized, placebo-controlled study to explore how a collagen supplement affects osteoarthritis (OA) symptoms.
Involving 31 participants aged 35-65, we divided them into two groups: one received the collagen supplement while the other received a placebo.
After eight weeks, our results indicated that the collagen supplement did improve pain levels and quality of life, alongside some enhancements in physical function. Overall, collagen supplements may offer promising relief for those managing OA.
Involving 31 participants aged 35-65, we divided them into two groups: one received the collagen supplement while the other received a placebo.
After eight weeks, our results indicated that the collagen supplement did improve pain levels and quality of life, alongside some enhancements in physical function. Overall, collagen supplements may offer promising relief for those managing OA.
9
Collagen may alleviate knee OA symptoms
We explored the effects of collagen-based supplements on knee osteoarthritis (OA) by analyzing data from 11 randomized controlled trials, involving 870 participants.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
9
We looked into how BD400 could potentially help with collagen-induced arthritis (CIA) in rats. Using a model to mimic the disease, we observed that BD400 significantly reduced arthritis scores and paw swelling.
It also decreased harmful inflammatory markers and improved gut health by enhancing intestinal barrier function. Essentially, BD400 seems to help alter gut bacteria and metabolism, which may slow down the progression of rheumatoid arthritis.
It also decreased harmful inflammatory markers and improved gut health by enhancing intestinal barrier function. Essentially, BD400 seems to help alter gut bacteria and metabolism, which may slow down the progression of rheumatoid arthritis.
8
Collagen supplement benefits knee osteoarthritis
We conducted a robust multicenter, double-blind trial involving 212 patients with knee osteoarthritis to assess the effectiveness and safety of the Artneo complex, which contains undenatured type II collagen.
Participants were divided into two groups: one received the collagen supplement for 180 days, while the other was given a placebo. Our findings indicated a significant improvement in pain, quality of life, and reduction of NSAID use among those taking the collagen compared to the placebo group.
Overall, the study supports the use of Artneo collagen as a beneficial treatment for knee osteoarthritis.
Participants were divided into two groups: one received the collagen supplement for 180 days, while the other was given a placebo. Our findings indicated a significant improvement in pain, quality of life, and reduction of NSAID use among those taking the collagen compared to the placebo group.
Overall, the study supports the use of Artneo collagen as a beneficial treatment for knee osteoarthritis.
References
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. 10.3389/fimmu.2025.1518181
- Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study. Jt Dis Relat Surg. 2025;36:85. 10.52312/jdrs.2025.1965
- Stabile M, Fracassi L, Lacitignola L, Garcia-Pedraza E, Girelli CR, et al. Effects of a feed supplement, containing undenatured type II collagen (UC II®) and Boswellia Serrata, in the management of mild/moderate mobility disorders in dogs: A randomized, double-blind, placebo controlled, cross-over study. PLoS One. 2024;19:e0305697. 10.1371/journal.pone.0305697
- Dobenecker B, Böswald LF, Reese S, Steigmeier-Raith S, Trillig L, et al. The oral intake of specific Bioactive Collagen Peptides (BCP) improves gait and quality of life in canine osteoarthritis patients-A translational large animal model for a nutritional therapy option. PLoS One. 2024;19:e0308378. 10.1371/journal.pone.0308378
- Simental-Mendía M, Ortega-Mata D, Acosta-Olivo CA, Simental-Mendía LE, Peña-Martínez VM, et al. Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials. Clin Exp Rheumatol. 2025;43:126. 10.55563/clinexprheumatol/kflfr5
- Zhao Q, Li Z, Liu Z, Zhao X, Fan Y, et al. Preparation, typical structural characteristics and relieving effects on osteoarthritis of squid cartilage type II collagen peptides. Food Res Int. 2024;191:114697. 10.1016/j.foodres.2024.114697
- Yu M, Park C, Son YB, Jo SE, Jeon SH, et al. Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection. Nutrients. 2024;16. 10.3390/nu16121885
- Alekseeva LI, Kashevarova NG, Taskina EA, Strebkova EA, Korotkova TA, et al. [Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial]. Ter Arkh. 2024;96:500. 10.26442/00403660.2024.05.202788
- Devasia S, Joseph JT, P S S, Koizumi S, Clarke L, et al. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability. Cartilage. 2024;15:363. 10.1177/19476035231221211
- Puigdellívol Grifell J, Comellas Berenguer C, Steinbacher G, Kranjcec T, Álvarez Díaz P, et al. Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction. J Diet Suppl. 2024;21:374. 10.1080/19390211.2023.2284982
- Thomas DT, Prabhakar AJ, Eapen C, Patel VD, Palaniswamy V, et al. Comparison of Single and Combined Treatment with Exercise Therapy and Collagen Supplementation on Early Knee Arthritis among Athletes-A Quasi-Randomized Trial. Int J Environ Res Public Health. 2023;20. 10.3390/ijerph20237088
- Chen NF, Lin YY, Yao ZK, Tseng CC, Liu YW, et al. Oral Administration of Protease-Soluble Chicken Type II Collagen Ameliorates Anterior Cruciate Ligament Transection-Induced Osteoarthritis in Rats. Nutrients. 2023;15. 10.3390/nu15163589
- Kviatkovsky SA, Hickner RC, Cabre HE, Small SD, Ormsbee MJ. Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. J Int Soc Sports Nutr. 2023;20:2243252. 10.1080/15502783.2023.2243252
- Kwon SB, Chinta G, Kundimi S, Kim S, Cho YD, et al. A Blend of and Extracts Alleviates Monosodium Iodoacetate (MIA)-Induced Osteoarthritic Pain and Joint Inflammation in Rats. J Am Nutr Assoc. 2024;43:48. 10.1080/27697061.2023.2209880
- Chen CC, Chang SS, Chang CH, Hu CC, Nakao Y, et al. Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. Nutr J. 2023;22:17. 10.1186/s12937-023-00837-w
- Luo X, Liu W, Zhao M, Liu T, Xiong F, et al. A novel Atlantic salmon (Salmo salar) bone collagen peptide delays osteoarthritis development by inhibiting cartilage matrix degradation and anti-inflammatory. Food Res Int. 2022;162:112148. 10.1016/j.foodres.2022.112148
- Onishi A, Tanaka M, Fujii T, Murata K, Murakami K, et al. Comparative effectiveness of subcutaneous sarilumab 200 mg biweekly, subcutaneous Tocilizumab 162 mg biweekly, and intravenous Tocilizumab 8 mg/kg every 4 weeks in patients with rheumatoid arthritis: a prospective cohort study. Arthritis Res Ther. 2025;27:52. 10.1186/s13075-025-03514-x
- Zhao Y, Lin D, Zhu X, Yan J, Liang Y, et al. SDF-1 alleviates osteoarthritis by resolving mitochondrial dysfunction through the activation of the Sirt3/PGC-1α signalling pathway. Arthritis Res Ther. 2025;27:51. 10.1186/s13075-025-03509-8
- Zhu XX, Xu AJ, Cai WW, Han ZJ, Zhang SJ, et al. NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of HS into the synovium. J Nanobiotechnology. 2025;23:192. 10.1186/s12951-025-03286-1
- Chen S, Xue W, Wu Z, Lu D, Zheng L, et al. Quercetin, a Compound of the Total Flavonoids of Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-α. J Inflamm Res. 2025;18:2879. 10.2147/JIR.S497166
- Stöckl S, Taheri S, Maier V, Asid A, Toelge M, et al. Effects of intra-articular applied rat BMSCs expressing alpha-calcitonin gene-related peptide or substance P on osteoarthritis pathogenesis in a murine surgical osteoarthritis model. Stem Cell Res Ther. 2025;16:117. 10.1186/s13287-025-04155-2
- Weinblatt ME, Taylor PC, McInnes IB, Atsumi T, Strand V, et al. Long-term safety and efficacy of anti-GM-CSF otilimab in patients with rheumatoid arthritis: long-term extension of three phase 3 randomised trials (contRAst X). BMJ Open. 2025;15:e088869. 10.1136/bmjopen-2024-088869
- Kim MJ, Yoo HM, Lee YJ, Jang HH, Shim SC, et al. Clonorchis sinensis excretory/secretory proteins ameliorate inflammation in rheumatoid arthritis and ankylosing spondylitis. Parasit Vectors. 2025;18:85. 10.1186/s13071-025-06677-3
- Liu L, Ambe K, Onishi M, Yoshii Y, Makino T, et al. Comparison of the Efficacy and Safety of Disease-Modifying Antirheumatic Drugs Combination Therapies: A Systematic Review and Network Meta-Analysis. Clin Transl Sci. 2025;18:e70156. 10.1111/cts.70156
- Chen M, Wang Z, Chen H, Li J, Guo X, et al. Biomimetic Nanoparticles Inhibit the HIF-1α/iNOS/NLRP3 Pathway to Alleviate Rheumatoid Arthritis. Nano Lett. 2025. 10.1021/acs.nanolett.4c05782
