Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.7
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.5
Supplement Facts
Serving Size: 1 Packet (10 g)
Amount Per Serving
%DV
Calories
35
Protein
9 g
0%*
Sodium
55 mg
2%
Collagen peptides (from bovine)
10 g
**
Top Medical Research Studies
9
CNP may ease knee osteoarthritis
We explored the potential of C-type natriuretic peptide (CNP) as a treatment for knee pain and osteoarthritis. This peptide was tested through intraarticular injections in a rat model of knee arthritis to assess its impact on cartilage degradation and persistent pain.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Read More
We investigated whether collagen supplements could ease pain and improve quality of life for patients with knee meniscus issues. This randomized, double-blind, placebo-controlled study involved 32 participants, half receiving collagen and half a placebo.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
Read More
8
We investigated the effects of specific collagen peptides on knee pain in athletes experiencing functional issues. Over 12 weeks, 139 participants took either 5 g of these peptides or a placebo daily.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
Read More
Most Useful Reviews
9
Reduces joint pain
3 people found this helpful
The lack of smell is great, and I use it daily. The product's quality is very high and yields amazing benefits. It moisturises incredibly and has a fantastic effect on my skin and knees. It even helps reduce weaknesses and improves my overall health while being sweet to taste.
Read More
9
Helpful for knees
This excellent product has improved my knee pain and overall well-being. Its smell is acceptable, and the delivery was prompt. I strongly recommend it as it helps fill gaps in nutrition and supports improvement and recovery. The packaging is impressive and delivery timely.
Read More
9
Improves skin health
This high-quality collagen has improved my knee condition, as well as my skin and hair health. Though the taste is manageable, it’s suitable for any age over 18 and can be taken during a diet. I highly recommend this product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.7
- All Researches
We investigated the effects of a dietary supplement containing hydrolyzed collagen, chondroitin sulfate, glucosamine, turmeric extract, and devil's claw on knee pain and function in osteoarthritis patients.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
Read More
9
This study set out to determine if oral collagen supplements could help treat knee pain linked to osteoarthritis caused by ACL injury in rats.
We found that different types of collagen, especially the protease-soluble chicken type II collagen, not only reduced pain sensitivity but also improved cartilage health.
Rats given collagen showed significant improvements compared to those who didn't receive it, leading to better joint function and less inflammation.
Overall, collagen treatment appears beneficial for managing knee pain related to osteoarthritis.
We found that different types of collagen, especially the protease-soluble chicken type II collagen, not only reduced pain sensitivity but also improved cartilage health.
Rats given collagen showed significant improvements compared to those who didn't receive it, leading to better joint function and less inflammation.
Overall, collagen treatment appears beneficial for managing knee pain related to osteoarthritis.
Read More
9
CNP may ease knee osteoarthritis
We explored the potential of C-type natriuretic peptide (CNP) as a treatment for knee pain and osteoarthritis. This peptide was tested through intraarticular injections in a rat model of knee arthritis to assess its impact on cartilage degradation and persistent pain.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Read More
9
We examined how delivering proteins directly into the joints could impact knee pain associated with osteoarthritis (OA). The study focused on two proteins: interleukin-1 receptor antagonist (IL-1Ra), which helps reduce inflammation, and SOX9, which supports cartilage repair. Using a gene therapy approach, we injected these proteins via a viral vector into animal models that were induced with knee osteoarthritis.
Our results were promising. In one test with a rat model, we saw improvements in gait and a reduction in cartilage damage after injecting IL-1Ra alone. This suggests that IL-1Ra can significantly alleviate pain and damage in knees suffering from OA.
Additionally, when we combined IL-1Ra with SOX9, the effects were even more beneficial. This joint delivery significantly improved not only the inflammation of the synovial tissue but also protected cartilage, leading to enhanced overall joint health compared to using either protein separately.
Overall, our findings indicate that targeting knee pain with these proteins could pave the way for new therapeutic strategies in treating osteoarthritis, highlighting the potential of tailored protein treatments for better patient outcomes.
Our results were promising. In one test with a rat model, we saw improvements in gait and a reduction in cartilage damage after injecting IL-1Ra alone. This suggests that IL-1Ra can significantly alleviate pain and damage in knees suffering from OA.
Additionally, when we combined IL-1Ra with SOX9, the effects were even more beneficial. This joint delivery significantly improved not only the inflammation of the synovial tissue but also protected cartilage, leading to enhanced overall joint health compared to using either protein separately.
Overall, our findings indicate that targeting knee pain with these proteins could pave the way for new therapeutic strategies in treating osteoarthritis, highlighting the potential of tailored protein treatments for better patient outcomes.
Read More
We investigated whether collagen supplements could ease pain and improve quality of life for patients with knee meniscus issues. This randomized, double-blind, placebo-controlled study involved 32 participants, half receiving collagen and half a placebo.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduces joint pain
3 people found this helpful
The lack of smell is great, and I use it daily. The product's quality is very high and yields amazing benefits. It moisturises incredibly and has a fantastic effect on my skin and knees. It even helps reduce weaknesses and improves my overall health while being sweet to taste.
Read More
9
Helpful for knees
This excellent product has improved my knee pain and overall well-being. Its smell is acceptable, and the delivery was prompt. I strongly recommend it as it helps fill gaps in nutrition and supports improvement and recovery. The packaging is impressive and delivery timely.
Read More
9
Improves skin health
This high-quality collagen has improved my knee condition, as well as my skin and hair health. Though the taste is manageable, it’s suitable for any age over 18 and can be taken during a diet. I highly recommend this product.
Read More
9
Noticeable benefits
This natural collagen has a wonderful effect on skin health and reduces collagen deficiency in my body. It effectively relieves knee pain and improves bone health. The taste is acceptable, and I notice the benefits after consistent use.
Read More
7.5
Excellent for knees
5 people found this helpful
The packaging and quality are excellent, making it easier to carry in my bag. I can add it to coffee, tea, or juice without altering the taste. It has long-term approval and is superb for knee pain, joints, and skin. Although results take time, the ingredients are excellent.
Read More
Frequently Asked Questions
7.5
Increased energy
1 people found this helpful
After using this collagen for seven days, I've experienced more energy and less muscle pain. The portable packaging is a bonus, and I’ve felt slight improvement in my gut health as well. I will provide a more extensive review after a month of use.
7.5
Less knee pain
3 people found this helpful
After a month of using this product for knee pain, I've noticed improvements. The natural ingredients and neutral taste make it easy to mix with anything. The packaging is excellent, and I've found that my ligaments feel more resilient. I will definitely continue using these convenient sachets.
7.5
Excellent for knees
5 people found this helpful
The packaging and quality are excellent, making it easier to carry in my bag. I can add it to coffee, tea, or juice without altering the taste. It has long-term approval and is superb for knee pain, joints, and skin. Although results take time, the ingredients are excellent.
9
Improves skin health
This high-quality collagen has improved my knee condition, as well as my skin and hair health. Though the taste is manageable, it’s suitable for any age over 18 and can be taken during a diet. I highly recommend this product.
9
Noticeable benefits
This natural collagen has a wonderful effect on skin health and reduces collagen deficiency in my body. It effectively relieves knee pain and improves bone health. The taste is acceptable, and I notice the benefits after consistent use.
9
Joint pain relief
I have been using this product for years and often recommend it to friends and family. It provides me with more energy and significantly reduces knee pain. I prefer the sachets for travel, while the larger tub is cost-effective for home use.
2
Mixed efficacy
I found this product average. Although many claim it improves skin and nails, this is my third attempt at using it for knee pain relief. The taste is unpleasant but can be masked.
8
This clinical study aimed to evaluate how collagen supplements might ease knee pain related to osteoarthritis.
We involved 31 participants in a controlled setting, comparing those taking collagen with a placebo group over eight weeks.
The findings indicated that collagen supplementation led to improvements in pain levels and quality of life. Some aspects of physical function also showed positive changes, highlighting collagen's potential benefits for those suffering from knee issues.
We involved 31 participants in a controlled setting, comparing those taking collagen with a placebo group over eight weeks.
The findings indicated that collagen supplementation led to improvements in pain levels and quality of life. Some aspects of physical function also showed positive changes, highlighting collagen's potential benefits for those suffering from knee issues.
We investigated the effects of a dietary supplement containing hydrolyzed collagen, chondroitin sulfate, glucosamine, turmeric extract, and devil's claw on knee pain and function in osteoarthritis patients.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
We investigated whether collagen supplements could ease pain and improve quality of life for patients with knee meniscus issues. This randomized, double-blind, placebo-controlled study involved 32 participants, half receiving collagen and half a placebo.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
7
We investigated how daily collagen peptide (CP) supplementation impacts knee pain and overall function in healthy, active middle-aged adults. In a well-structured double-blind trial, participants were given either a placebo or 10 to 20 grams of CP daily over 6 to 9 months.
The results revealed that 10 grams of CP significantly improved daily activities and pain levels, particularly in those who exercised frequently. Additionally, mental and physical health scores saw positive changes with consistent CP intake. This suggests that collagen supplements can be beneficial for managing knee pain and enhancing quality of life in active adults.
The results revealed that 10 grams of CP significantly improved daily activities and pain levels, particularly in those who exercised frequently. Additionally, mental and physical health scores saw positive changes with consistent CP intake. This suggests that collagen supplements can be beneficial for managing knee pain and enhancing quality of life in active adults.
8
We investigated the effects of specific collagen peptides on knee pain in athletes experiencing functional issues. Over 12 weeks, 139 participants took either 5 g of these peptides or a placebo daily.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
References
- Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study. BMC Musculoskelet Disord. 2025;26:17. 10.1186/s12891-024-08244-w
- Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study. Jt Dis Relat Surg. 2025;36:85. 10.52312/jdrs.2025.1965
- Puigdellívol Grifell J, Comellas Berenguer C, Steinbacher G, Kranjcec T, Álvarez Díaz P, et al. Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction. J Diet Suppl. 2024;21:374. 10.1080/19390211.2023.2284982
- Thomas DT, Prabhakar AJ, Eapen C, Patel VD, Palaniswamy V, et al. Comparison of Single and Combined Treatment with Exercise Therapy and Collagen Supplementation on Early Knee Arthritis among Athletes-A Quasi-Randomized Trial. Int J Environ Res Public Health. 2023;20. 10.3390/ijerph20237088
- van Dam L, Terink R, Mensink M, de Vos RJ, Zwerver J. The JUMPFOOD study: additional effect of hydrolyzed collagen and vitamin C to exercise treatment for patellar tendinopathy (jumper's knee) in athletes-study protocol for a double-blind randomized controlled trial. Trials. 2023;24:768. 10.1186/s13063-023-07783-2
- Yves H, Herman J, Uebelhoer M, Wauquier F, Boutin-Wittrant L, et al. Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation. BMC Musculoskelet Disord. 2023;24:748. 10.1186/s12891-023-06800-4
- Chen NF, Lin YY, Yao ZK, Tseng CC, Liu YW, et al. Oral Administration of Protease-Soluble Chicken Type II Collagen Ameliorates Anterior Cruciate Ligament Transection-Induced Osteoarthritis in Rats. Nutrients. 2023;15. 10.3390/nu15163589
- Kviatkovsky SA, Hickner RC, Cabre HE, Small SD, Ormsbee MJ. Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. J Int Soc Sports Nutr. 2023;20:2243252. 10.1080/15502783.2023.2243252
- Kwon SB, Chinta G, Kundimi S, Kim S, Cho YD, et al. A Blend of and Extracts Alleviates Monosodium Iodoacetate (MIA)-Induced Osteoarthritic Pain and Joint Inflammation in Rats. J Am Nutr Assoc. 2024;43:48. 10.1080/27697061.2023.2209880
- Chen CC, Chang SS, Chang CH, Hu CC, Nakao Y, et al. Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. Nutr J. 2023;22:17. 10.1186/s12937-023-00837-w
- Shavlovskaya OA. [Complex effects of physical exertion with dietary supplements Cartilox in pain syndrome effectiveness and safety evaluation]. Vopr Kurortol Fizioter Lech Fiz Kult. 2022;99:20. 10.17116/kurort20229904120
- Mohammed A, He S. A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort. Nutrients. 2021;13. 10.3390/nu13072454
- Lee HS, Oh KJ, Moon YW, In Y, Lee HJ, et al. Intra-articular Injection of Type I Atelocollagen to Alleviate Knee Pain: A Double-Blind, Randomized Controlled Trial. Cartilage. 2021;13:342S. 10.1177/1947603519865304
- García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, Acosta-Olivo CA, Vilchez-Cavazos F, et al. Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. Int Orthop. 2019;43:531. 10.1007/s00264-018-4211-5
- Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 2018;52:167. 10.1136/bjsports-2016-097333
- Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab. 2017;42:588. 10.1139/apnm-2016-0390
- Yamashita R, Nozawa I, Hasegawa S, Nakagawa Y, Miyatake K, et al. C-type natriuretic peptide suppresses VEGFa gene expression by attenuating IL6-STAT3 signal pathway in primary synovial fibroblasts from rat knee. Biochem Biophys Res Commun. 2025;749:151290. 10.1016/j.bbrc.2025.151290
- Zhou K, Yuan M, Sun J, Zhang F, Li X, et al. Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models. Gene Ther. 2025. 10.1038/s41434-025-00515-y
