' 
SCIENTIFIC SCORE
Questionable
Based on 27 Researches
6.7
USERS' SCORE
Good
Based on 9 Reviews
8.6
Top Medical Research Studies
9
Microneedling depth impacts scars
Evaluation of microneedling depth of penetration in management of atrophic acne scars: a split-face comparative study.
Moderate relevance to collagen treatment
In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
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9
Eicosapentaenoic acid helps acne
Exploring the potential of omega-3 fatty acids in acne patients: A prospective intervention study.
Directly addresses EPA's effects
We focused our research on the potential benefits of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, for individuals suffering from acne. Over a period of 16 weeks, we encouraged 60 patients to follow a Mediterranean diet while taking algae-derived EPA and docosahexaenoic acid (DHA) supplements. Our goal was to see if increasing their omega-3 levels could improve acne symptoms.
At the start of the study, an impressive 98.3% of the participants were found to have low levels of EPA/DHA. By the end of the study, we observed a significant increase in their omega-3 levels from an average of 4.9% to 8.3%. This boost correlated with noticeable improvements in both inflammatory and non-inflammatory acne lesions.
Interestingly, we noted that while individual perceptions of appearance varied—some reporting no improvement—overall quality of life for the participants enhanced significantly, particularly in those with papulopustular acne. Alongside dietary changes, participants reduced their intake of cow’s milk and dairy products, and we did not encounter any negative side effects from the intervention.
Ultimately, our findings suggest that boosting omega-3 fatty acids, particularly EPA, through diet and supplementation can effectively help manage acne severity in patients.
At the start of the study, an impressive 98.3% of the participants were found to have low levels of EPA/DHA. By the end of the study, we observed a significant increase in their omega-3 levels from an average of 4.9% to 8.3%. This boost correlated with noticeable improvements in both inflammatory and non-inflammatory acne lesions.
Interestingly, we noted that while individual perceptions of appearance varied—some reporting no improvement—overall quality of life for the participants enhanced significantly, particularly in those with papulopustular acne. Alongside dietary changes, participants reduced their intake of cow’s milk and dairy products, and we did not encounter any negative side effects from the intervention.
Ultimately, our findings suggest that boosting omega-3 fatty acids, particularly EPA, through diet and supplementation can effectively help manage acne severity in patients.
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8
Omega-3s beneficial for acne
Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial.
Strong relevance to eicosapentaenoic acid
We explored the potential of eicosapentaenoic acid, a key omega-3 fatty acid, in treating acne vulgaris through a structured study involving 45 participants with mild to moderate acne. Over ten weeks, participants were divided into three groups: one received 2,000 mg of eicosapentaenoic acid with docosahexaenoic acid, another got 400 mg of gamma-linolenic acid from borage oil, and a control group received no supplements.
After this supplementation period, we observed notable reductions in both inflammatory and non-inflammatory acne lesions in participants taking either the omega-3 or gamma-linolenic acid. The participants also reported improvements based on their personal assessments. Furthermore, histological examinations showed decreased inflammation and lower levels of interleukin-8, a marker related to acne inflammation.
Importantly, no severe adverse effects were reported, indicating that these fatty acids could be safely used alongside traditional acne treatments. Overall, this research suggests that eicosapentaenoic acid and gamma-linolenic acid may serve as valuable additions to acne management strategies.
After this supplementation period, we observed notable reductions in both inflammatory and non-inflammatory acne lesions in participants taking either the omega-3 or gamma-linolenic acid. The participants also reported improvements based on their personal assessments. Furthermore, histological examinations showed decreased inflammation and lower levels of interleukin-8, a marker related to acne inflammation.
Importantly, no severe adverse effects were reported, indicating that these fatty acids could be safely used alongside traditional acne treatments. Overall, this research suggests that eicosapentaenoic acid and gamma-linolenic acid may serve as valuable additions to acne management strategies.
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Most Useful Reviews
10
Cleared stubborn scars
I normally don't write reviews, but I had to for this product. I can't believe how effective it has been! With sensitive skin and eczema, I had tried numerous products to clear my acne scars without success. After a month and a half of this treatment, the majority of my scars have vanished, and it even helped with stubborn acne on my forehead. This is truly magic in a bottle!
Read More
7.5
Moisturises and fades
This oil serves as a fantastic moisturiser! Although it's a thick oil, it absorbs quickly without feeling heavy. I initially intended to use it to fade my scars and help with chapped lips, and it hasn’t disappointed! I’ve seen improvements on my face for acne scars and my legs for stretch marks within just two weeks.
Read More
9.5
Improves skin appearance
This product is incredible! I mix it with pure almond oil and use it every night. My skin has never looked better; I've seen a reduction in acne and redness. The almond oil aids in spreading it, as it doesn't glide well on its own.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 27 Researches
6.7
- All Researches
9
Lactoferrin and zinc reduce acne
A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris.
Difficult to isolate vitamin E's effect
We observed how a combination of lactoferrin, vitamin E, and zinc might affect mild to moderate acne. In a rigorously designed study, 168 participants aged 13 to 40 were randomly assigned to receive either a treatment capsule containing these ingredients or a placebo twice a day over the course of three months.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
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9
Vitamin E may reduce acne lesions
Addressing Free Radical Oxidation in Acne Vulgaris.
Study design limits isolated assessment
We explored the effects of vitamin E on acne by conducting an open-label study with 17 patients who had mild to moderate acne vulgaris. Over eight weeks, these patients followed a standard regimen involving salicylic acid and benzoyl peroxide, with the addition of topical vitamin E in sunflower seed oil.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Read More
9
Vitamin E shows positive acne effects
Modulation of sebum oxidation and interleukin-1α levels associates with clinical improvement of mild comedonal acne.
Limited isolation of vitamin E's effect
We looked into how a combination of RetinSphere® and vitamin E affects mild comedonal acne (MCA). In our study, we measured important factors like sebum oxidation and inflammatory markers before and after treatment in 18 patients with MCA and 10 healthy controls.
Our findings showed that while the amount of sebum and squalene was similar before treatment between the groups, patients with MCA had higher levels of lipid peroxidation and oxidized squalene. These elevated markers contribute to inflammation and acne formation.
After 4 weeks, there was a notable decrease in oxidized lipids and inflammation markers in the lesions, bringing them in line with unaffected areas. These changes were accompanied by visible clinical improvement in the patients by the 8-week mark.
Yet, it’s important to recognize that while vitamin E was part of the treatment mix, this study did not isolate its specific effects. Thus, while we observed positive results, we cannot definitively attribute all improvements directly to vitamin E alone.
Our findings showed that while the amount of sebum and squalene was similar before treatment between the groups, patients with MCA had higher levels of lipid peroxidation and oxidized squalene. These elevated markers contribute to inflammation and acne formation.
After 4 weeks, there was a notable decrease in oxidized lipids and inflammation markers in the lesions, bringing them in line with unaffected areas. These changes were accompanied by visible clinical improvement in the patients by the 8-week mark.
Yet, it’s important to recognize that while vitamin E was part of the treatment mix, this study did not isolate its specific effects. Thus, while we observed positive results, we cannot definitively attribute all improvements directly to vitamin E alone.
Read More
9
Microneedling depth impacts scars
Evaluation of microneedling depth of penetration in management of atrophic acne scars: a split-face comparative study.
Moderate relevance to collagen treatment
In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
Read More
9
Effective collagen treatments for scars
Efficacy of Polycaprolactone Threads in Treating Atrophic Acne Scars: A Split-face Comparative Study.
Moderate connection to collagen impact
We set out to explore the effectiveness of collagen treatment for atrophic acne scars using two different approaches: polycaprolactone (PCL) threads and microneedling combined with platelet-rich plasma (PRP). In our research, 24 patients participated in a split-face study where one side of the face was treated with PCL threads, and the other side underwent microneedling with PRP. Each participant received four sessions of microneedling on one side, while the other side was treated with just one session of threads.
After monitoring the patients for six months, we observed a significant improvement in skin texture and scar appearance. Specifically, 95.8% of patients noted progress on the side treated with threads compared to 83.3% on the microneedling side. Additionally, satisfaction ratings were notably higher among those who received the thread treatment.
Both procedures were associated with mild side effects, like transient swelling and redness, which cleared up quickly. Our findings suggest that PCL threads could be a promising collagen-boosting alternative for treating acne scars, providing effective results with minimal discomfort.
After monitoring the patients for six months, we observed a significant improvement in skin texture and scar appearance. Specifically, 95.8% of patients noted progress on the side treated with threads compared to 83.3% on the microneedling side. Additionally, satisfaction ratings were notably higher among those who received the thread treatment.
Both procedures were associated with mild side effects, like transient swelling and redness, which cleared up quickly. Our findings suggest that PCL threads could be a promising collagen-boosting alternative for treating acne scars, providing effective results with minimal discomfort.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Cleared stubborn scars
I normally don't write reviews, but I had to for this product. I can't believe how effective it has been! With sensitive skin and eczema, I had tried numerous products to clear my acne scars without success. After a month and a half of this treatment, the majority of my scars have vanished, and it even helped with stubborn acne on my forehead. This is truly magic in a bottle!
Read More
7.5
Moisturises and fades
This oil serves as a fantastic moisturiser! Although it's a thick oil, it absorbs quickly without feeling heavy. I initially intended to use it to fade my scars and help with chapped lips, and it hasn’t disappointed! I’ve seen improvements on my face for acne scars and my legs for stretch marks within just two weeks.
Read More
9.5
Improves skin appearance
This product is incredible! I mix it with pure almond oil and use it every night. My skin has never looked better; I've seen a reduction in acne and redness. The almond oil aids in spreading it, as it doesn't glide well on its own.
10
Fades acne scars
This product is pure magic! I’m completely enamoured with it. It’s significantly more effective than many scar gels for fading my acne scars and discolouration. I believe I shall continue using it indefinitely.
0
Caused breakouts
I was excited to try this after hearing it helps with acne scarring, given my struggle with acne and scars. However, after just one day, I developed several large whiteheads. I’m really disappointed because I had high hopes for this product. Now, I cannot return it, which is frustrating.
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