Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.6
Top Medical Research Studies
9
We embarked on a study to find out how dietary eicosapentaenoic acid (EPA) could help children suffering from atopic dermatitis, a common form of eczema. In a randomized triple-blind clinical trial, 48 children with this condition were divided into two groups—one received 250 mg of EPA twice daily, while the other received a placebo for four weeks.
Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.
Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.
Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.
Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.
Read More
9
Eicosapentaenoic acid improves eczema
We explored the effects of eicosapentaenoic acid (EPA) ethyl ester on symptoms of atopic dermatitis (AD), a common skin condition characterized by persistent itching and skin barrier dysfunction. In a carefully designed study using hairless mice on a special diet, we observed significant improvements in skin condition after administering EPA.
This study builds on previous findings that showed an increase in serum EPA levels from another omega-3 fatty acid, α-linolenic acid, which similarly helped restore skin health in mice with AD. When we administered EPA to the affected mice, we saw a marked alleviation in both itchy skin and barrier impairment.
A key finding was that the levels of covalently bound ceramides, essential lipids for maintaining our skin's barrier, were greatly reduced in the skin of the AD mice. With EPA treatment, these ceramides were restored, suggesting that EPA may play a crucial role in supporting skin health by improving these lipid levels.
Our findings point to the possible therapeutic application of EPA ethyl ester in treating human eczema, which could lead to effective new options for managing this often-challenging condition.
This study builds on previous findings that showed an increase in serum EPA levels from another omega-3 fatty acid, α-linolenic acid, which similarly helped restore skin health in mice with AD. When we administered EPA to the affected mice, we saw a marked alleviation in both itchy skin and barrier impairment.
A key finding was that the levels of covalently bound ceramides, essential lipids for maintaining our skin's barrier, were greatly reduced in the skin of the AD mice. With EPA treatment, these ceramides were restored, suggesting that EPA may play a crucial role in supporting skin health by improving these lipid levels.
Our findings point to the possible therapeutic application of EPA ethyl ester in treating human eczema, which could lead to effective new options for managing this often-challenging condition.
Read More
7
We focused on understanding how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid found in fish, influences the prevalence of eczema among Japanese school-aged children. The study included 135 students with eczema, 136 with asthma, and 137 healthy controls, all from the fifth and eighth grades in Shunan, Japan.
Through questionnaires, we assessed the participants' dietary intake, specifically their fish consumption, and measured total serum IgE levels, a marker linked to allergic responses. The results indicated that those who consumed fatty or dried fish had a lower prevalence of eczema compared to others, highlighting the potential protective effect of fish in our diet.
Interestingly, we saw that only the levels of EPA in the blood had a negative association with eczema, meaning higher EPA levels may reduce the incidence of this condition. Despite these encouraging findings regarding EPA and eczema, we found that fish consumption did not have a significant effect on asthma.
Overall, our findings suggest that including more fish in the diet could be beneficial for reducing eczema in children, with EPA playing a key role in this protective effect.
Through questionnaires, we assessed the participants' dietary intake, specifically their fish consumption, and measured total serum IgE levels, a marker linked to allergic responses. The results indicated that those who consumed fatty or dried fish had a lower prevalence of eczema compared to others, highlighting the potential protective effect of fish in our diet.
Interestingly, we saw that only the levels of EPA in the blood had a negative association with eczema, meaning higher EPA levels may reduce the incidence of this condition. Despite these encouraging findings regarding EPA and eczema, we found that fish consumption did not have a significant effect on asthma.
Overall, our findings suggest that including more fish in the diet could be beneficial for reducing eczema in children, with EPA playing a key role in this protective effect.
Read More
Most Useful Reviews
10
Effective for itching
7 people found this helpful
Eczema. I wanted to share my story as I am about to purchase my second bottle. This great product has really helped my daughter's eczema; she is three years old and I don't need to use any other product, just this one. If you have eczema, I recommend it 10000%. It alleviates the itching, redness, and it disappears within days.
Read More
9
Miraculous vitamin E
8 people found this helpful
Really helped my eczema! My eczema reached a stage where I began lightbox phototherapy, which worked well except for my hands and neck that worsened. It’s possible to have different forms of eczema simultaneously. My dermatologist halted treatment and prescribed a vitamin E oil ointment costing $350 after insurance. I found this 100% vitamin E oil, and it has worked wonders on these difficult areas. Though not a cure for eczema, it effectively keeps the symptoms in check, preventing the constant burning and itching. I would highly recommend this product.
Read More
7.5
Scar improvement
2 people found this helpful
Lightening the eczema patch. I have had eczema from my adolescence to my early twenties. It returned strongly in March 2020 on my right ankle. It's lightening up; I hope to have my skin back to normal by summer's end.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
- All Researches
9
We embarked on a study to find out how dietary eicosapentaenoic acid (EPA) could help children suffering from atopic dermatitis, a common form of eczema. In a randomized triple-blind clinical trial, 48 children with this condition were divided into two groups—one received 250 mg of EPA twice daily, while the other received a placebo for four weeks.
Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.
Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.
Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.
Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.
Read More
9
Eicosapentaenoic acid improves eczema
We explored the effects of eicosapentaenoic acid (EPA) ethyl ester on symptoms of atopic dermatitis (AD), a common skin condition characterized by persistent itching and skin barrier dysfunction. In a carefully designed study using hairless mice on a special diet, we observed significant improvements in skin condition after administering EPA.
This study builds on previous findings that showed an increase in serum EPA levels from another omega-3 fatty acid, α-linolenic acid, which similarly helped restore skin health in mice with AD. When we administered EPA to the affected mice, we saw a marked alleviation in both itchy skin and barrier impairment.
A key finding was that the levels of covalently bound ceramides, essential lipids for maintaining our skin's barrier, were greatly reduced in the skin of the AD mice. With EPA treatment, these ceramides were restored, suggesting that EPA may play a crucial role in supporting skin health by improving these lipid levels.
Our findings point to the possible therapeutic application of EPA ethyl ester in treating human eczema, which could lead to effective new options for managing this often-challenging condition.
This study builds on previous findings that showed an increase in serum EPA levels from another omega-3 fatty acid, α-linolenic acid, which similarly helped restore skin health in mice with AD. When we administered EPA to the affected mice, we saw a marked alleviation in both itchy skin and barrier impairment.
A key finding was that the levels of covalently bound ceramides, essential lipids for maintaining our skin's barrier, were greatly reduced in the skin of the AD mice. With EPA treatment, these ceramides were restored, suggesting that EPA may play a crucial role in supporting skin health by improving these lipid levels.
Our findings point to the possible therapeutic application of EPA ethyl ester in treating human eczema, which could lead to effective new options for managing this often-challenging condition.
Read More
7
We explored the effects of vitamin E supplementation on patients with Smith-Lemli-Opitz Syndrome (SLOS), particularly focusing on symptoms like eczema. In a three-year study, six patients who were already on dietary cholesterol treatment received vitamin E. Their vitamin E levels were initially low, but following supplementation, all patients showed a significant increase in plasma vitamin E concentrations.
Among the various symptoms assessed, including aggression, irritability, and skin issues like eczema, some patients reported improvements. Our findings indicated that three out of the six patients experienced a reduction in symptoms, including skin photosensitivity and eczema. Notably, those who responded best to therapy had lower baseline ratios of certain cholesterol-related compounds.
While the study suggests that vitamin E could provide benefits to SLOS patients—possibly contributing to improvements in skin conditions like eczema—individual responses varied. Thus, vitamin E supplementation may be worth considering in the management of SLOS, especially for those with low initial vitamin E levels and certain biochemical markers.
Among the various symptoms assessed, including aggression, irritability, and skin issues like eczema, some patients reported improvements. Our findings indicated that three out of the six patients experienced a reduction in symptoms, including skin photosensitivity and eczema. Notably, those who responded best to therapy had lower baseline ratios of certain cholesterol-related compounds.
While the study suggests that vitamin E could provide benefits to SLOS patients—possibly contributing to improvements in skin conditions like eczema—individual responses varied. Thus, vitamin E supplementation may be worth considering in the management of SLOS, especially for those with low initial vitamin E levels and certain biochemical markers.
Read More
7
We examined the potential benefits of eicosapentaenoic acid (EPA) in treating eczema by analyzing squid phospholipids derived from Todarodes pacificus. The research utilized established models, including the rat paw edema model and an atopic dermatitis-like mouse model (NC/Nga mice), allowing us to assess the effectiveness of this treatment.
The squid phospholipids primarily contained essential fatty acids like docosahexaenoic acid (DHA), EPA, and arachidonic acid, which are believed to contribute to their anti-inflammatory properties. In our testing, squid phospholipids notably reduced skin inflammation in the mouse model, leading to improvements in dermatitis symptoms. However, we observed that while these phospholipids showed promising results, the isolated impact of EPA alone could not be definitively established due to the complexities of the treatment's composition.
Our findings indicate that while squid phospholipids, which include EPA, may help in the management of eczema, other components within them also play significant roles in their overall effectiveness. Therefore, further research will be necessary to isolate and clarify how eicosapentaenoic acid specifically influences eczema outcomes.
The squid phospholipids primarily contained essential fatty acids like docosahexaenoic acid (DHA), EPA, and arachidonic acid, which are believed to contribute to their anti-inflammatory properties. In our testing, squid phospholipids notably reduced skin inflammation in the mouse model, leading to improvements in dermatitis symptoms. However, we observed that while these phospholipids showed promising results, the isolated impact of EPA alone could not be definitively established due to the complexities of the treatment's composition.
Our findings indicate that while squid phospholipids, which include EPA, may help in the management of eczema, other components within them also play significant roles in their overall effectiveness. Therefore, further research will be necessary to isolate and clarify how eicosapentaenoic acid specifically influences eczema outcomes.
Read More
7
We focused on understanding how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid found in fish, influences the prevalence of eczema among Japanese school-aged children. The study included 135 students with eczema, 136 with asthma, and 137 healthy controls, all from the fifth and eighth grades in Shunan, Japan.
Through questionnaires, we assessed the participants' dietary intake, specifically their fish consumption, and measured total serum IgE levels, a marker linked to allergic responses. The results indicated that those who consumed fatty or dried fish had a lower prevalence of eczema compared to others, highlighting the potential protective effect of fish in our diet.
Interestingly, we saw that only the levels of EPA in the blood had a negative association with eczema, meaning higher EPA levels may reduce the incidence of this condition. Despite these encouraging findings regarding EPA and eczema, we found that fish consumption did not have a significant effect on asthma.
Overall, our findings suggest that including more fish in the diet could be beneficial for reducing eczema in children, with EPA playing a key role in this protective effect.
Through questionnaires, we assessed the participants' dietary intake, specifically their fish consumption, and measured total serum IgE levels, a marker linked to allergic responses. The results indicated that those who consumed fatty or dried fish had a lower prevalence of eczema compared to others, highlighting the potential protective effect of fish in our diet.
Interestingly, we saw that only the levels of EPA in the blood had a negative association with eczema, meaning higher EPA levels may reduce the incidence of this condition. Despite these encouraging findings regarding EPA and eczema, we found that fish consumption did not have a significant effect on asthma.
Overall, our findings suggest that including more fish in the diet could be beneficial for reducing eczema in children, with EPA playing a key role in this protective effect.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Effective for itching
7 people found this helpful
Eczema. I wanted to share my story as I am about to purchase my second bottle. This great product has really helped my daughter's eczema; she is three years old and I don't need to use any other product, just this one. If you have eczema, I recommend it 10000%. It alleviates the itching, redness, and it disappears within days.
Read More
9
Miraculous vitamin E
8 people found this helpful
Really helped my eczema! My eczema reached a stage where I began lightbox phototherapy, which worked well except for my hands and neck that worsened. It’s possible to have different forms of eczema simultaneously. My dermatologist halted treatment and prescribed a vitamin E oil ointment costing $350 after insurance. I found this 100% vitamin E oil, and it has worked wonders on these difficult areas. Though not a cure for eczema, it effectively keeps the symptoms in check, preventing the constant burning and itching. I would highly recommend this product.
Read More
7.5
Scar improvement
2 people found this helpful
Lightening the eczema patch. I have had eczema from my adolescence to my early twenties. It returned strongly in March 2020 on my right ankle. It's lightening up; I hope to have my skin back to normal by summer's end.
Read More
7.5
Mild rash support
1 people found this helpful
Great for mild rash recovery. I have eczema in my ears; most medicine doesn't work. This oil allows my skin to stay moist and heal with fewer flare-ups.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Koczok K, Horváth L, Korade Z, Mezei ZA, Szabó GP, et al. Biochemical and Clinical Effects of Vitamin E Supplementation in Hungarian Smith-Lemli-Opitz Syndrome Patients. Biomolecules. 2021;11. doi:10.3390/biom11081228
- Sato A, Sato G, Yabuki A, Ogawa Y, Nemoto H, et al. Ameliorative effects of squid phospholipids from Todarodes pacificus on atopic dermatitis-like lesions in NC/Nga mice. Arch Dermatol Res. 2025;317:239. doi:10.1007/s00403-024-03773-9
- Mirrahimi B, Moazemi M, Eslami N, Jamshidi E, Mir M, et al. Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial. J Pediatr Pharmacol Ther. 2023;28:29. doi:10.5863/1551-6776-28.1.29
- Fujii M, Ohyanagi C, Kawaguchi N, Matsuda H, Miyamoto Y, et al. Eicosapentaenoic acid ethyl ester ameliorates atopic dermatitis-like symptoms in special diet-fed hairless mice, partly by restoring covalently bound ceramides in the stratum corneum. Exp Dermatol. 2018;27:837. doi:10.1111/exd.13507
- Kunitsugu I, Okuda M, Murakami N, Hashimoto M, Yamanishi R, et al. Self-reported seafood intake and atopy in Japanese school-aged children. Pediatr Int. 2012;54:233. doi:10.1111/j.1442-200X.2011.03542.x
