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SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.5
USERS' SCORE
Good
Based on 1 Reviews
8.5
Top Medical Research Studies
9
Vitamin A's potential in arthritis treatment
Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis.
Direct examination of vitamin A
We explored the potential of all-trans retinoic acid (ATRA), a form of vitamin A, in treating autoimmune arthritis. The research focused on how ATRA can help improve the body's immune response while reducing inflammation associated with arthritis.
Through innovative use of biodegradable microparticles, ATRA is released directly in the joints over a sustained period, enhancing the body's immune activity. This unique approach helped transform naïve T cells into protective regulatory T cells, which in turn helped to mitigate inflammatory responses.
Notably, the sustained release of ATRA not only improved joint health but also affected the entire body without leading to widespread immune suppression. In animal models of arthritis, those treated with ATRA showed less joint damage and inflammation compared to untreated counterparts, suggesting a promising avenue for managing this challenging condition.
Overall, these findings illuminate the role of vitamin A in potentially modifying the disease course for those battling autoimmune arthritis, indicating exciting new possibilities for treatment that could offer hope for improved patient outcomes.
Through innovative use of biodegradable microparticles, ATRA is released directly in the joints over a sustained period, enhancing the body's immune activity. This unique approach helped transform naïve T cells into protective regulatory T cells, which in turn helped to mitigate inflammatory responses.
Notably, the sustained release of ATRA not only improved joint health but also affected the entire body without leading to widespread immune suppression. In animal models of arthritis, those treated with ATRA showed less joint damage and inflammation compared to untreated counterparts, suggesting a promising avenue for managing this challenging condition.
Overall, these findings illuminate the role of vitamin A in potentially modifying the disease course for those battling autoimmune arthritis, indicating exciting new possibilities for treatment that could offer hope for improved patient outcomes.
Read More
9
Vitamin A aids arthritis relief
All-trans retinoic acid alleviates collagen-induced arthritis and promotes intestinal homeostasis.
Strong relevance to arthritis treatment
We established a collagen-induced arthritis (CIA) model in Wistar rats to explore the effects of all-trans retinoic acid (ATRA), a form of vitamin A, on arthritis. Over six weeks of treatment, we noted significant improvements in the arthritis index of the CIA rats. This means that the symptoms of arthritis became less severe, and key indicators of inflammation in the joints were reduced.
Our observations extended beyond just joint health. The treatment with ATRA seemed to restore balance in the immune system, specifically by reversing disruptions in a particular type of immune cell differentiation known as Th17/Treg. Importantly, we also found that ATRA led to a decrease in intestinal inflammation and improved the structural integrity of the gut lining.
Using advanced imaging techniques, we saw that ATRA helped repair the tight junctions in the intestinal walls. This included an increase in proteins that help maintain these junctions, leading to better gut health. Furthermore, ATRA influenced the gut microbiota composition, fostering beneficial bacteria like Lactobacillus while reducing those linked to inflammation.
In conclusion, our findings suggest that ATRA has the potential to alleviate symptoms of arthritis by modulating immune responses and supporting gut health. These insights introduce exciting possibilities for using vitamin A in managing arthritis.
Our observations extended beyond just joint health. The treatment with ATRA seemed to restore balance in the immune system, specifically by reversing disruptions in a particular type of immune cell differentiation known as Th17/Treg. Importantly, we also found that ATRA led to a decrease in intestinal inflammation and improved the structural integrity of the gut lining.
Using advanced imaging techniques, we saw that ATRA helped repair the tight junctions in the intestinal walls. This included an increase in proteins that help maintain these junctions, leading to better gut health. Furthermore, ATRA influenced the gut microbiota composition, fostering beneficial bacteria like Lactobacillus while reducing those linked to inflammation.
In conclusion, our findings suggest that ATRA has the potential to alleviate symptoms of arthritis by modulating immune responses and supporting gut health. These insights introduce exciting possibilities for using vitamin A in managing arthritis.
Read More
9
Vitamin A reduces arthritis risk
Causal association of diet-derived circulating antioxidants with the risk of rheumatoid arthritis: A Mendelian randomization study.
Strong relevance to study topic
We explored the connection between vitamin A, particularly through its circulating metabolites, and the risk of developing rheumatoid arthritis (RA). Using a method called Mendelian randomization, we aimed to determine whether higher levels of vitamin A in our bodies could help reduce the likelihood of RA.
Our analysis involved data from established research studies, allowing us to look at how various antioxidants, including vitamin A, influence RA. Interestingly, we discovered that increased levels of retinol metabolites—forms of vitamin A—were linked to a lower risk of overall RA and seropositive RA. This means that individuals with higher levels of these metabolites tended to have a decreased chance of developing these forms of arthritis.
However, it’s important to note that our findings did not show similar protective effects for other antioxidants like vitamin E or vitamin C. This suggests that vitamin A may be a distinct player in the prevention of RA, providing a potential avenue for dietary recommendations. Thus, incorporating more vitamin A through food sources or supplements could offer a beneficial strategy for those looking to prevent RA.
Our analysis involved data from established research studies, allowing us to look at how various antioxidants, including vitamin A, influence RA. Interestingly, we discovered that increased levels of retinol metabolites—forms of vitamin A—were linked to a lower risk of overall RA and seropositive RA. This means that individuals with higher levels of these metabolites tended to have a decreased chance of developing these forms of arthritis.
However, it’s important to note that our findings did not show similar protective effects for other antioxidants like vitamin E or vitamin C. This suggests that vitamin A may be a distinct player in the prevention of RA, providing a potential avenue for dietary recommendations. Thus, incorporating more vitamin A through food sources or supplements could offer a beneficial strategy for those looking to prevent RA.
Read More
Most Useful Reviews
8
Convenient packaging
Great for people with rheumatoid arthritis. Although it's just a pillbox, I appreciate being able to take out a day or two's worth of pills rather than the entire container. I have rheumatoid arthritis, and this box is much easier to use than any other I've tried. Time will tell how sturdy it is.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.5
9
ATRA enhances RA treatment efficacy
Exploring the supplementary potential of all-trans retinoic acid with methotrexate in rheumatoid arthritis: modulation of synovial cell apoptosis and autophagy.
Combination treatment with ATRA
We explored the role of all-trans retinoic acid (ATRA) as an auxiliary treatment alongside methotrexate (MTX) for managing rheumatoid arthritis (RA). The study focused on how ATRA could influence fibroblast-like synoviocytes (FLSs), which are crucial in the arthritis process due to their imbalance between cell death and proliferation.
To assess this, we evaluated the impact of ATRA and MTX on human RA FLSs, measuring their viability, apoptosis (programmed cell death), and autophagy (cellular cleaning process). Interestingly, methotrexate alone showed little effect on cell viability and apoptosis. However, when we added ATRA to the treatment regime, we noticed a significant decrease in cell proliferation and an increase in apoptosis and autophagy.
Mechanistically, we found that ATRA activates the ROS-JNK signaling pathway in these cells, which plays a critical role in promoting cell death and autophagy. We also conducted tests in a collagen-induced arthritis (CIA) model in rats, observing a considerable boost in anti-arthritic efficacy when ATRA and MTX were used together compared to MTX alone. Overall, ATRA's ability to enhance apoptosis and inhibit proliferation suggests its potential as a complementary therapy for RA, opening new avenues for more effective treatments.
To assess this, we evaluated the impact of ATRA and MTX on human RA FLSs, measuring their viability, apoptosis (programmed cell death), and autophagy (cellular cleaning process). Interestingly, methotrexate alone showed little effect on cell viability and apoptosis. However, when we added ATRA to the treatment regime, we noticed a significant decrease in cell proliferation and an increase in apoptosis and autophagy.
Mechanistically, we found that ATRA activates the ROS-JNK signaling pathway in these cells, which plays a critical role in promoting cell death and autophagy. We also conducted tests in a collagen-induced arthritis (CIA) model in rats, observing a considerable boost in anti-arthritic efficacy when ATRA and MTX were used together compared to MTX alone. Overall, ATRA's ability to enhance apoptosis and inhibit proliferation suggests its potential as a complementary therapy for RA, opening new avenues for more effective treatments.
Read More
9
Vitamin A aids arthritis relief
All-trans retinoic acid alleviates collagen-induced arthritis and promotes intestinal homeostasis.
Strong relevance to arthritis treatment
We established a collagen-induced arthritis (CIA) model in Wistar rats to explore the effects of all-trans retinoic acid (ATRA), a form of vitamin A, on arthritis. Over six weeks of treatment, we noted significant improvements in the arthritis index of the CIA rats. This means that the symptoms of arthritis became less severe, and key indicators of inflammation in the joints were reduced.
Our observations extended beyond just joint health. The treatment with ATRA seemed to restore balance in the immune system, specifically by reversing disruptions in a particular type of immune cell differentiation known as Th17/Treg. Importantly, we also found that ATRA led to a decrease in intestinal inflammation and improved the structural integrity of the gut lining.
Using advanced imaging techniques, we saw that ATRA helped repair the tight junctions in the intestinal walls. This included an increase in proteins that help maintain these junctions, leading to better gut health. Furthermore, ATRA influenced the gut microbiota composition, fostering beneficial bacteria like Lactobacillus while reducing those linked to inflammation.
In conclusion, our findings suggest that ATRA has the potential to alleviate symptoms of arthritis by modulating immune responses and supporting gut health. These insights introduce exciting possibilities for using vitamin A in managing arthritis.
Our observations extended beyond just joint health. The treatment with ATRA seemed to restore balance in the immune system, specifically by reversing disruptions in a particular type of immune cell differentiation known as Th17/Treg. Importantly, we also found that ATRA led to a decrease in intestinal inflammation and improved the structural integrity of the gut lining.
Using advanced imaging techniques, we saw that ATRA helped repair the tight junctions in the intestinal walls. This included an increase in proteins that help maintain these junctions, leading to better gut health. Furthermore, ATRA influenced the gut microbiota composition, fostering beneficial bacteria like Lactobacillus while reducing those linked to inflammation.
In conclusion, our findings suggest that ATRA has the potential to alleviate symptoms of arthritis by modulating immune responses and supporting gut health. These insights introduce exciting possibilities for using vitamin A in managing arthritis.
Read More
9
Vitamin A's potential in arthritis treatment
Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis.
Direct examination of vitamin A
We explored the potential of all-trans retinoic acid (ATRA), a form of vitamin A, in treating autoimmune arthritis. The research focused on how ATRA can help improve the body's immune response while reducing inflammation associated with arthritis.
Through innovative use of biodegradable microparticles, ATRA is released directly in the joints over a sustained period, enhancing the body's immune activity. This unique approach helped transform naïve T cells into protective regulatory T cells, which in turn helped to mitigate inflammatory responses.
Notably, the sustained release of ATRA not only improved joint health but also affected the entire body without leading to widespread immune suppression. In animal models of arthritis, those treated with ATRA showed less joint damage and inflammation compared to untreated counterparts, suggesting a promising avenue for managing this challenging condition.
Overall, these findings illuminate the role of vitamin A in potentially modifying the disease course for those battling autoimmune arthritis, indicating exciting new possibilities for treatment that could offer hope for improved patient outcomes.
Through innovative use of biodegradable microparticles, ATRA is released directly in the joints over a sustained period, enhancing the body's immune activity. This unique approach helped transform naïve T cells into protective regulatory T cells, which in turn helped to mitigate inflammatory responses.
Notably, the sustained release of ATRA not only improved joint health but also affected the entire body without leading to widespread immune suppression. In animal models of arthritis, those treated with ATRA showed less joint damage and inflammation compared to untreated counterparts, suggesting a promising avenue for managing this challenging condition.
Overall, these findings illuminate the role of vitamin A in potentially modifying the disease course for those battling autoimmune arthritis, indicating exciting new possibilities for treatment that could offer hope for improved patient outcomes.
Read More
9
Vitamin A's Role in Arthritis Therapy
Engineered Platelet Microparticle-Membrane Camouflaged Nanoparticles for Targeting the Golgi Apparatus of Synovial Fibroblasts to Attenuate Rheumatoid Arthritis.
Moderate relevance to study topic
We explored the effects of all-trans retinoic acid (ATRA), a form of vitamin A, on rheumatoid arthritis (RA) treatment. Our focus was on delivering ATRA using a specialized nanoparticle designed to target synovial fibroblasts, the cells responsible for joint damage in RA. This innovative approach involved creating nanoparticles coated with a membrane mimicking platelets, which helps guide ATRA directly to the Golgi apparatus in these harmful cells.
Through our study, we observed that ATRA-loaded nanoparticles disrupted the normal function of synovial fibroblasts, leading to a decrease in the production of inflammatory proteins often found in RA. This resulted in a significant reduction of pathogenic factors in joints affected by arthritis, which is crucial because these proteins can exacerbate joint damage and inflammation.
Additionally, further testing in rats with collagen-induced arthritis showed promising results. The targeted nanoparticles distributed specifically to the arthritic joints, successfully lowering levels of inflammatory cytokines and enzymes that lead to bone erosion and pain. The outcomes indicated not only potential treatment effectiveness but also minimal toxicity to vital organs, making this method a safe option for rheumatoid arthritis management.
In conclusion, our findings suggest that ATRA therapy, particularly when delivered through this innovative nanotechnology, could offer a new direction in treating rheumatoid arthritis by minimizing the harmful substances that these synovial fibroblasts produce.
Through our study, we observed that ATRA-loaded nanoparticles disrupted the normal function of synovial fibroblasts, leading to a decrease in the production of inflammatory proteins often found in RA. This resulted in a significant reduction of pathogenic factors in joints affected by arthritis, which is crucial because these proteins can exacerbate joint damage and inflammation.
Additionally, further testing in rats with collagen-induced arthritis showed promising results. The targeted nanoparticles distributed specifically to the arthritic joints, successfully lowering levels of inflammatory cytokines and enzymes that lead to bone erosion and pain. The outcomes indicated not only potential treatment effectiveness but also minimal toxicity to vital organs, making this method a safe option for rheumatoid arthritis management.
In conclusion, our findings suggest that ATRA therapy, particularly when delivered through this innovative nanotechnology, could offer a new direction in treating rheumatoid arthritis by minimizing the harmful substances that these synovial fibroblasts produce.
Read More
9
Vitamin A reduces arthritis risk
Causal association of diet-derived circulating antioxidants with the risk of rheumatoid arthritis: A Mendelian randomization study.
Strong relevance to study topic
We explored the connection between vitamin A, particularly through its circulating metabolites, and the risk of developing rheumatoid arthritis (RA). Using a method called Mendelian randomization, we aimed to determine whether higher levels of vitamin A in our bodies could help reduce the likelihood of RA.
Our analysis involved data from established research studies, allowing us to look at how various antioxidants, including vitamin A, influence RA. Interestingly, we discovered that increased levels of retinol metabolites—forms of vitamin A—were linked to a lower risk of overall RA and seropositive RA. This means that individuals with higher levels of these metabolites tended to have a decreased chance of developing these forms of arthritis.
However, it’s important to note that our findings did not show similar protective effects for other antioxidants like vitamin E or vitamin C. This suggests that vitamin A may be a distinct player in the prevention of RA, providing a potential avenue for dietary recommendations. Thus, incorporating more vitamin A through food sources or supplements could offer a beneficial strategy for those looking to prevent RA.
Our analysis involved data from established research studies, allowing us to look at how various antioxidants, including vitamin A, influence RA. Interestingly, we discovered that increased levels of retinol metabolites—forms of vitamin A—were linked to a lower risk of overall RA and seropositive RA. This means that individuals with higher levels of these metabolites tended to have a decreased chance of developing these forms of arthritis.
However, it’s important to note that our findings did not show similar protective effects for other antioxidants like vitamin E or vitamin C. This suggests that vitamin A may be a distinct player in the prevention of RA, providing a potential avenue for dietary recommendations. Thus, incorporating more vitamin A through food sources or supplements could offer a beneficial strategy for those looking to prevent RA.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.5
8
Convenient packaging
Great for people with rheumatoid arthritis. Although it's just a pillbox, I appreciate being able to take out a day or two's worth of pills rather than the entire container. I have rheumatoid arthritis, and this box is much easier to use than any other I've tried. Time will tell how sturdy it is.
Read More
