5/18/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.4
Top Medical Research Studies
9
We encountered a case of a woman suffering from short bowel syndrome, who faced significant hair loss due to biotin deficiency while on home parenteral nutrition. After starting oral biotin supplementation of 10 mg/day for three weeks, we observed that her serum biotin levels increased, leading to noticeable new hair growth and resolution of other symptoms. Further intravenous biotin treatment maintained her on multivitamins that include biotin, preventing any future deficiency symptoms. This case highlights the importance of addressing biotin levels for hair health and overall well-being.
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9.5
We explored the effects of biotin treatment on hair loss through a case study of a girl diagnosed with biotinidase deficiency. Despite having no notable family history of the condition, her symptoms included problematic dermatitis, yellow hair, and alopecia.
After identifying low levels of biotinase and significant metabolic increases, the girl was found to have two specific mutations in her BTD gene linked to this deficiency. Following the diagnosis, we observed a clear response to biotin supplementation, with an initial dosage of 20 mg per day.
Remarkably, her dermatitis improved within a month, and her hair color returned to normal after three months of treatment. These findings suggest that biotin replacement therapy can have significant positive outcomes in cases related to biotinidase deficiency, connecting biotin to effective hair restoration.
After identifying low levels of biotinase and significant metabolic increases, the girl was found to have two specific mutations in her BTD gene linked to this deficiency. Following the diagnosis, we observed a clear response to biotin supplementation, with an initial dosage of 20 mg per day.
Remarkably, her dermatitis improved within a month, and her hair color returned to normal after three months of treatment. These findings suggest that biotin replacement therapy can have significant positive outcomes in cases related to biotinidase deficiency, connecting biotin to effective hair restoration.
Read More
9
We aimed to understand how retinoic acid (RA), a derivative of vitamin A, impacts hair loss, particularly in individuals suffering from androgenetic alopecia (AGA). By examining hair follicles from both the occipital and frontal areas of the scalp, we were able to conduct RNA sequencing to observe patterns relevant to HFSC (hair follicle stem cell) health.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
Read More
Most Useful Reviews
7.5
Recovered from hair loss
55 people found this helpful
I've been using these for three months after experiencing postpartum hair loss. Two months in, my hair stopped falling out excessively, and I feel more energetic throughout the day. It might also be filling my nutritional gaps. However, the taste could be better—it reminds me of fish oil!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.7
- All Researches
9.5
Biotin serum shows promising results
We investigated the effectiveness of the Dr. SKS Hair Booster Serum, which contains biotin and other micronutrients, for treating androgenetic alopecia in both men and women. This open-label study included 1,000 participants across multiple clinics in India who received the serum through mesotherapy or derma roller techniques for six months.
During the study, we closely monitored various indicators of hair health, including the amount of hair loss, hair growth rates, and overall hair density changes. Our findings revealed a significant reduction in hair fall and a notable improvement in hair density after treatment. Interestingly, 95% of participants reported satisfaction with the results after six months.
It’s important to note that while biotin is a key ingredient in the serum, the study did not isolate its effects from the other micronutrients, making it challenging to definitively attribute the positive outcomes solely to biotin. No major adverse effects were reported, suggesting a safe treatment profile.
Overall, the study demonstrated that the Dr. SKS Hair Booster Serum could be a viable option for those struggling with hair loss, providing promising results in the context of androgenetic alopecia.
During the study, we closely monitored various indicators of hair health, including the amount of hair loss, hair growth rates, and overall hair density changes. Our findings revealed a significant reduction in hair fall and a notable improvement in hair density after treatment. Interestingly, 95% of participants reported satisfaction with the results after six months.
It’s important to note that while biotin is a key ingredient in the serum, the study did not isolate its effects from the other micronutrients, making it challenging to definitively attribute the positive outcomes solely to biotin. No major adverse effects were reported, suggesting a safe treatment profile.
Overall, the study demonstrated that the Dr. SKS Hair Booster Serum could be a viable option for those struggling with hair loss, providing promising results in the context of androgenetic alopecia.
Read More
9.5
Alopecia areata improvement with tofacitinib
We explored the effectiveness of tofacitinib, a treatment showing promise for alopecia areata (AA), particularly in cases that have proven resistant to other therapies. In one instance, a young adult male with resistant AA had not responded to treatments like oral and topical steroids, minoxidil, and oral troxasalen.
In this study, he received tofacitinib at a dose of 5 mg twice a day along with a biotin supplement. Remarkably, hair regrowth was noted just one month into the treatment, and by the three-month mark, over 90% of his hair had regrown. It’s worth mentioning that no side effects were recorded during the treatment period.
Our findings suggest that while biotin was administered alongside tofacitinib, its specific contributions to hair regrowth outcomes cannot be distinctly isolated. Thus, further research would be necessary to clarify the role of biotin in hair loss treatments.
In this study, he received tofacitinib at a dose of 5 mg twice a day along with a biotin supplement. Remarkably, hair regrowth was noted just one month into the treatment, and by the three-month mark, over 90% of his hair had regrown. It’s worth mentioning that no side effects were recorded during the treatment period.
Our findings suggest that while biotin was administered alongside tofacitinib, its specific contributions to hair regrowth outcomes cannot be distinctly isolated. Thus, further research would be necessary to clarify the role of biotin in hair loss treatments.
Read More
9.5
We explored the effects of biotin treatment on hair loss through a case study of a girl diagnosed with biotinidase deficiency. Despite having no notable family history of the condition, her symptoms included problematic dermatitis, yellow hair, and alopecia.
After identifying low levels of biotinase and significant metabolic increases, the girl was found to have two specific mutations in her BTD gene linked to this deficiency. Following the diagnosis, we observed a clear response to biotin supplementation, with an initial dosage of 20 mg per day.
Remarkably, her dermatitis improved within a month, and her hair color returned to normal after three months of treatment. These findings suggest that biotin replacement therapy can have significant positive outcomes in cases related to biotinidase deficiency, connecting biotin to effective hair restoration.
After identifying low levels of biotinase and significant metabolic increases, the girl was found to have two specific mutations in her BTD gene linked to this deficiency. Following the diagnosis, we observed a clear response to biotin supplementation, with an initial dosage of 20 mg per day.
Remarkably, her dermatitis improved within a month, and her hair color returned to normal after three months of treatment. These findings suggest that biotin replacement therapy can have significant positive outcomes in cases related to biotinidase deficiency, connecting biotin to effective hair restoration.
Read More
9
We aimed to understand how retinoic acid (RA), a derivative of vitamin A, impacts hair loss, particularly in individuals suffering from androgenetic alopecia (AGA). By examining hair follicles from both the occipital and frontal areas of the scalp, we were able to conduct RNA sequencing to observe patterns relevant to HFSC (hair follicle stem cell) health.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
Read More
9
We designed a microneedle patch that contains zinc and curcumin, aiming to assess how these ingredients work together to promote hair growth. In our study, we utilized two different animal models to examine the effectiveness of this patch. One model represented androgenic alopecia (AGA), and the other focused on wound healing.
By delivering bioactive zinc particles directly into the skin, we explored how this method could enhance hair regrowth. Our findings showed that the zinc-curcumin combination significantly improved the viability of certain skin cells and countered the negative effects of common hair loss factors, like excess reactive oxygen species and dihydrotestosterone.
Most strikingly, the treatment not only encouraged hair regrowth in the AGA model but also facilitated wound healing. We noted an increase in hair follicles and better cell proliferation, which points to zinc's potential role in supporting both hair health and skin recovery. Overall, our research suggests a promising direction in the use of zinc for addressing hair loss and skin healing more effectively than traditional methods alone.
By delivering bioactive zinc particles directly into the skin, we explored how this method could enhance hair regrowth. Our findings showed that the zinc-curcumin combination significantly improved the viability of certain skin cells and countered the negative effects of common hair loss factors, like excess reactive oxygen species and dihydrotestosterone.
Most strikingly, the treatment not only encouraged hair regrowth in the AGA model but also facilitated wound healing. We noted an increase in hair follicles and better cell proliferation, which points to zinc's potential role in supporting both hair health and skin recovery. Overall, our research suggests a promising direction in the use of zinc for addressing hair loss and skin healing more effectively than traditional methods alone.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Recovered from hair loss
55 people found this helpful
I've been using these for three months after experiencing postpartum hair loss. Two months in, my hair stopped falling out excessively, and I feel more energetic throughout the day. It might also be filling my nutritional gaps. However, the taste could be better—it reminds me of fish oil!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Waisburd GS, Cordero AM, Núñez CR, Contreras LM, Cárdenas RH, et al. Topical effect of a specific spot-on treatment made of natural ingredients in rabbits () with skin problems: A pilot study. Vet World. 2020;13:1760. 10.14202/vetworld.2020.1760-1763
- Zhou Y, Tang G, Li X, Sun W, Liang Y, et al. Study on the chemical constituents of nut oil from Prunus mira Koehne and the mechanism of promoting hair growth. J Ethnopharmacol. 2020;258:112831. 10.1016/j.jep.2020.112831
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- Mahmoud H, Saifdeen PM, Al-Timimi D, Saeed SA. Zinc Status in Kurdish Adults With Hair Loss. Cureus. 2024;16:e67264. 10.7759/cureus.67264
- Zufishan S, Haque Z, Nazar S, Afaq E, Aamir E, et al. Role of zinc in chronic telogen effluvium in serum and hair of patients with alopecia. J Pak Med Assoc. 2024;74:S47. 10.47391/JPMA-DUHS-S10
- Lalosevic J, Gajic-Veljic M, Lalosevic Misovic J, Nikolic M. Serum Zinc Concentration in Patients with Alopecia Areata. Acta Derm Venereol. 2023;103:adv13358. 10.2340/actadv.v103.13358
- Yang Y, Wang P, Gong Y, Yu Z, Gan Y, et al. Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth. Theranostics. 2023;13:3675. 10.7150/thno.84118
- Starace M, Cedirian S, Bruni F, Alessandrini AM, Quadrelli F, et al. Clinical study on the efficacy and tolerability of an oral supplement based on arginine, l-cystine, zinc and B6 vitamin (Cystiphane®) in patients with telogen effluvium. Ital J Dermatol Venerol. 2023;158:255. 10.23736/S2784-8671.23.07576-X
- Matsuoka N, Mizutani T, Kawakami K. Symptom Profile of Patients With Post-COVID-19 Conditions and Influencing Factors for Recovery. J Clin Med Res. 2023;15:116. 10.14740/jocmr4855
- Yelich A, Jenkins H, Holt S, Miller R. Biotin for Hair Loss: Teasing Out the Evidence. J Clin Aesthet Dermatol. 2024;17:56.
- Qiu S, Pan Z, Jiang X, Lv G, Feng A, et al. The synergistic effect of phototherapy and active substances on hair growth. J Photochem Photobiol B. 2024;259:113008. 10.1016/j.jphotobiol.2024.113008
- Valentim FO, Miola AC, Miot HA, Schmitt JV. Efficacy of 5% topical minoxidil versus 5 mg oral biotin versus topical minoxidil and oral biotin on hair growth in men: randomized, crossover, clinical trial. An Bras Dermatol. 2024;99:581. 10.1016/j.abd.2023.07.008
- Khare S. Efficacy of Dr. SKS Hair Booster Serum in the Treatment of Female Pattern Alopecia in Patients With PCOS: An Open-Label, Non-randomized, Prospective Study. Cureus. 2023;15:e44941. 10.7759/cureus.44941
- Tr P, Ts R, K SK, Prasanna H. A Comparative Study of Topical Procapil With Platelet-Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet-Rich Plasma Therapy in the Treatment of Androgenetic Alopecia. Cureus. 2023;15:e38696. 10.7759/cureus.38696
- Khare S. The Efficacy and Safety of Dr. SKS Hair Booster Serum (a Cocktail of Micronutrients and Multivitamins) in Adult Males and Females With Androgenetic Alopecia: An Open-Label, Non-randomized, Prospective Study. Cureus. 2023;15:e37424. 10.7759/cureus.37424
- Sahay G. Resistant Alopecia Areata Treated with Tofacitinib. Int J Trichology. 2022;14:181. 10.4103/ijt.ijt_63_22
- Jo H, Kim SY, Kang BH, Baek C, Kwon JE, et al. Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss. Molecules. 2022;27. 10.3390/molecules27165136
- Samadi A, Ketabi Y, Firooz R, Firooz A. Efficacy of intramuscular injections of biotin and dexpanthenol in the treatment of diffuse hair loss: A randomized, double-blind controlled study comparing two brands. Dermatol Ther. 2022;35:e15695. 10.1111/dth.15695
- Starace M, Gurioli C, Carpanese MA, Bruni F, Piraccini BM, et al. Short anagen syndrome: A case series and algorithm for diagnosis. Pediatr Dermatol. 2021;38:1157. 10.1111/pde.14750
- Aksac SE, Bilgili SG, Yavuz GO, Yavuz IH, Aksac M, et al. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters. Int J Dermatol. 2021;60:980. 10.1111/ijd.15485
- Yang Y, Yang JY, Chen XJ. Biotinidase deficiency characterized by skin and hair findings. Clin Dermatol. 2020;38:477. 10.1016/j.clindermatol.2020.03.004
- Şen O, Türkçapar AG. Hair Loss After Sleeve Gastrectomy and Effect of Biotin Supplements. J Laparoendosc Adv Surg Tech A. 2021;31:296. 10.1089/lap.2020.0468
- Marotta JC, Patel G, Carvalho M, Blakeney S. Clinical Efficacy of a Topical Compounded Formulation in Male Androgenetic Alopecia: Minoxidil 10%, Finasteride 0.1%, Biotin 0.2%, and Caffeine Citrate 0.05% Hydroalcoholic Solution. Int J Pharm Compd. 2020;24:69.
- Piraccini BM, Berardesca E, Fabbrocini G, Micali G, Tosti A. Biotin: overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea. G Ital Dermatol Venereol. 2019;154:557. 10.23736/S0392-0488.19.06434-4
- Sant'Anna Addor FA, Donato LC, Melo CSA. Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. Clin Cosmet Investig Dermatol. 2018;11:431. 10.2147/CCID.S173082
- Hayashi A, Mikami Y, Miyamoto K, Kamada N, Sato T, et al. Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice. Cell Rep. 2017;20:1513. 10.1016/j.celrep.2017.07.057
- Castro-Gago M, Pérez-Gay L, Gómez-Lado C, Castiñeiras-Ramos DE, Otero-Martínez S, et al. The influence of valproic acid and carbamazepine treatment on serum biotin and zinc levels and on biotinidase activity. J Child Neurol. 2011;26:1522. 10.1177/0883073811409227
- Castro-Gago M, Gómez-Lado C, Eirís-Puñal J, Díaz-Mayo I, Castiñeiras-Ramos DE. Serum biotinidase activity in children treated with valproic acid and carbamazepine. J Child Neurol. 2010;25:32. 10.1177/0883073809336118
- Schulpis KH, Karikas GA, Tjamouranis J, Regoutas S, Tsakiris S. Low serum biotinidase activity in children with valproic acid monotherapy. Epilepsia. 2001;42:1359.
- Khalidi N, Wesley JR, Thoene JG, Whitehouse WM, Baker WL. Biotin deficiency in a patient with short bowel syndrome during home parenteral nutrition. JPEN J Parenter Enteral Nutr. 1984;8:311.
