5/26/2025
Last update
5/26/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.4
Top Medical Research Studies
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
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8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Read More
8
We explored melatonin's potential to impact neurodevelopment in autism by using stem cells from children with autism. In our study, we differentiated these cells into dopaminergic neurons and tested the effects of melatonin on their growth and function. We discovered that, without melatonin, these neurons showed reduced growth and mitochondrial dysfunction.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
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Most Useful Reviews
0
Dangerous side effects
14 people found this helpful
PLEASE READ MY REVIEW! My son struggles to sleep due to autism. After being desperate for a solution, I tried this melatonin, but it has caused extreme reactions. The third time using it, he became frantic, scratching himself and crying. This was terrifying for both of us, and I feel this product should be banned. It has been a nightmare for my family.
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9
Effective sleep aid
6 people found this helpful
It really works. I use this for my sons, who are on the autism spectrum and struggle with sleep. I can confirm that it genuinely helps them to fall asleep and stay asleep throughout the night.
Read More
9
Highly effective treatment
4 people found this helpful
Perfect for kids! This product works wonderfully for my son, who has autism and often has trouble sleeping. We decided to try it and are thrilled with the outcome. I give him the appropriate dosage about 30 minutes before bed, and he enjoys taking it. Bedtime is no longer a struggle, and he's now sleeping through the night for a full 10 hours. I highly recommend it for kids facing sleep issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
- All Researches
8
We examined the link between insomnia and Autism Spectrum Disorder (ASD), particularly how melatonin can help manage sleep issues in affected children. The analysis, conducted by a team of experts, emphasized the importance of understanding sleep challenges to improve treatment outcomes for both kids and their caregivers.
Encouragingly, melatonin has been found to be both effective and safe for managing insomnia associated with ASD, particularly in prolonged-release forms. Although promising, more research is needed to further validate these findings and improve sleep management strategies.
Encouragingly, melatonin has been found to be both effective and safe for managing insomnia associated with ASD, particularly in prolonged-release forms. Although promising, more research is needed to further validate these findings and improve sleep management strategies.
Read More
8
Melatonin helps autistic zebrafish models
We explored the impact of Nomo1 deficiency on behavior in zebrafish, which mimics aspects of neuropsychiatric disorders, including autism. The study demonstrated that these zebrafish exhibited abnormal brain development and various neuropsychiatric symptoms.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
Read More
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Read More
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Read More
8
We conducted a detailed look into sleep-related rhythmic movement disorder (SR-RMD) in children, involving data from 66 patients at a UK hospital.
Our assessment included questionnaires to explore autism traits and behavioral impacts. Notably, families reported the burden of sleeplessness and concerns for their children's safety.
Intriguingly, many parents noted improvements in their children’s sleep after administering extended-release melatonin, suggesting this could be a viable treatment option in the future.
Our assessment included questionnaires to explore autism traits and behavioral impacts. Notably, families reported the burden of sleeplessness and concerns for their children's safety.
Intriguingly, many parents noted improvements in their children’s sleep after administering extended-release melatonin, suggesting this could be a viable treatment option in the future.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
0
Dangerous side effects
14 people found this helpful
PLEASE READ MY REVIEW! My son struggles to sleep due to autism. After being desperate for a solution, I tried this melatonin, but it has caused extreme reactions. The third time using it, he became frantic, scratching himself and crying. This was terrifying for both of us, and I feel this product should be banned. It has been a nightmare for my family.
Read More
9
Effective sleep aid
6 people found this helpful
It really works. I use this for my sons, who are on the autism spectrum and struggle with sleep. I can confirm that it genuinely helps them to fall asleep and stay asleep throughout the night.
Read More
9
Highly effective treatment
4 people found this helpful
Perfect for kids! This product works wonderfully for my son, who has autism and often has trouble sleeping. We decided to try it and are thrilled with the outcome. I give him the appropriate dosage about 30 minutes before bed, and he enjoys taking it. Bedtime is no longer a struggle, and he's now sleeping through the night for a full 10 hours. I highly recommend it for kids facing sleep issues.
Read More
7.5
Settling down easier
2 people found this helpful
Great for autistic kids. My 3-year-old son, with level 3 autism, has difficulty settling at bedtime. I give him his dose every night around 7pm, and by 8pm, he’s asleep, ready for pre-school the next morning. I appreciate that it's a natural remedy rather than a prescription medication.
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6
Short sleep duration
3 people found this helpful
Works but only for 2 hours. This is my first time using this for my 6-year-old with autism. Since the pandemic, we've had difficulty transitioning back to night sleep. The doctor recommended this, but the dosage only keeps her asleep for two hours. Each night, we’ve seen similar results; she wakes up after a short time, which is disappointing.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Bruni O, Biggio G, Malorgio E, Nobili L. Insomnia in children affected by autism spectrum disorder: The role of melatonin in treatment. Sleep Med. 2024;119:511. 10.1016/j.sleep.2024.05.046
- Rezzani R, Gianò M, Pinto D, Rinaldi F, van Noorden CJF, et al. Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis. Int J Mol Sci. 2024;25. 10.3390/ijms25021086
- Zhang Q, Li F, Li T, Lin J, Jian J, et al. Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO Rep. 2024;25:570. 10.1038/s44319-023-00036-y
- Wang L, Xu M, Wang Y, Wang F, Deng J, et al. Melatonin improves synapse development by PI3K/Akt signaling in a mouse model of autism spectrum disorder. Neural Regen Res. 2024;19:1618. 10.4103/1673-5374.387973
- Tse ACY, Lee PH, Sit CHP, Poon ET, Sun F, et al. Comparing the Effectiveness of Physical Exercise Intervention and Melatonin Supplement in Improving Sleep Quality in Children with ASD. J Autism Dev Disord. 2024;54:4456. 10.1007/s10803-023-06172-7
- Sadeh H, Meiri G, Zigdon D, Ilan M, Faroy M, et al. Adherence to treatment and parents' perspective about effectiveness of melatonin in children with autism spectrum disorder and sleep disturbances. Child Adolesc Psychiatry Ment Health. 2023;17:123. 10.1186/s13034-023-00669-w
- Joels H, Benny A, Sharpe A, Postigo B, Joseph B, et al. Sleep related rhythmic movement disorder: phenotypic characteristics and treatment response in a paediatric cohort. Sleep Med. 2023;112:21. 10.1016/j.sleep.2023.09.020
- Dong S, Kifune T, Kato H, Wang L, Kong J, et al. Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca regulation in autism spectrum disorder. Biochem Biophys Res Commun. 2023;681:7. 10.1016/j.bbrc.2023.09.050
- Bernardi K, Prono F, Bruni G, Panerai S, Ferri R, et al. Sleep disturbances in subjects with autism spectrum disorder: A parental perspective. Sleep Med. 2023;110:220. 10.1016/j.sleep.2023.08.020
- Horsnell J, Mangar S, Dimitriou D, Halstead EJ. Parental Experiences of Melatonin Administration to Manage Sleep Disturbances in Autistic Children and Adolescent in the UK. Healthcare (Basel). 2023;11. 10.3390/healthcare11121780
