' 
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.7
Supplement Facts
Serving Size:
Amount Per Serving
%DV
†Daily Value not established.
Top Medical Research Studies
8
Melatonin improves MS-related symptoms
12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial.
Relevant findings for MS treatment
We explored the impact of melatonin on patients with multiple sclerosis (MS), aiming to improve heart function and sleep. In a randomized controlled trial, participants received either melatonin or a placebo for 12 weeks.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
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8
Melatonin improves MS-related symptoms
12-week melatonin supplementation improved dynamic postural stability and walking performance in persons living with multiple sclerosis: A randomized controlled trial.
Moderate therapeutic relevance noted
We explored the effects of a 12-week melatonin treatment in individuals with multiple sclerosis (MS), focusing on postural stability, walking performance, and overall quality of life. Our study involved 27 participants divided into two groups: one received melatonin while the other got a placebo.
After the intervention, we observed notable improvements in dynamic balance and walking performance among those taking melatonin. Additionally, participants reported better sleep quality, reduced fatigue, and less neuropathic pain.
Overall, melatonin appears to be a supportive treatment option for addressing some symptoms associated with MS.
After the intervention, we observed notable improvements in dynamic balance and walking performance among those taking melatonin. Additionally, participants reported better sleep quality, reduced fatigue, and less neuropathic pain.
Overall, melatonin appears to be a supportive treatment option for addressing some symptoms associated with MS.
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7
Melatonin improves balance and strength
Effects of a nighttime melatonin ingestion on dynamic postural balance and muscle strength the following morning in people living with multiple sclerosis: A preliminary study.
Relevance score: moderate impact.
We investigated the effects of melatonin on postural balance and muscle strength in individuals with multiple sclerosis. Fourteen participants took either melatonin or a placebo before bedtime. The next morning, we measured their balance, leg strength, pain levels, sleep quality, and fatigue perception.
We found that acute melatonin intake was safe and showed promising results in improving dynamic postural stability and lower-extremity muscle strength. This suggests that melatonin may help alleviate some challenges faced by those with this condition.
We found that acute melatonin intake was safe and showed promising results in improving dynamic postural stability and lower-extremity muscle strength. This suggests that melatonin may help alleviate some challenges faced by those with this condition.
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Most Useful Reviews
1
No improvement
My son has struggled with sleep since he was four. I bought this with hope, but after two initial nights of good sleep, we reverted to poor patterns. I'm unsure if it's just him or if these tablets were ineffective. I won't be ordering again.
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1
Limited effectiveness
I tried this medicine to normalise my son's sleep, but it only gave him four hours of rest. He would wake up after that, leaving us frustrated.
Read More
7.5
Game changer
After years of bedtime hassles, my son's occupational therapist recommended melatonin. We tried everything, but this was a game changer. He can only manage a quarter of a chewable tablet to avoid emotional reactions the next day, but it has significantly improved his sleep.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9.5
Effective early diagnosis biomarkers identified
Metabolomics study reveals blood biomarkers for early diagnosis of chronic kidney disease and IgA nephropathy: A retrospective cross-sectional study.
High relevance due to novel findings
We explored how plasma metabolites can help us diagnose chronic kidney disease (CKD) and IgA nephropathy (IgAN) early on. By analyzing blood samples using advanced techniques, we found that melatonin itself can identify early CKD with over 95% accuracy.
Additionally, combining melatonin with tryptophan achieved a remarkable 100% accuracy for CKD diagnoses. Indole-3-lactic acid also showed great potential in distinguishing IgAN in CKD patients, reaching over 85% accuracy for early IgAN diagnosis.
Additionally, combining melatonin with tryptophan achieved a remarkable 100% accuracy for CKD diagnoses. Indole-3-lactic acid also showed great potential in distinguishing IgAN in CKD patients, reaching over 85% accuracy for early IgAN diagnosis.
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9
Melatonin improves MS-related functions
Effects of Melatonin Supplementation on Muscle Strength, Manual Dexterity, and Postural Balance in Patients Living with Multiple sclerosis - A Randomized Controlled Trial.
High relevance for MS management
We investigated how melatonin supplementation impacts motor skills and cognitive function in patients with multiple sclerosis. In a controlled trial, 27 participants were divided into a melatonin group and a placebo group for a 12-week period.
The results were promising: the melatonin group showed improvements in knee muscle strength, manual dexterity, and balance, alongside better mood and cognitive performance. This suggests that melatonin may be beneficial for enhancing quality of life in those managing multiple sclerosis symptoms.
The results were promising: the melatonin group showed improvements in knee muscle strength, manual dexterity, and balance, alongside better mood and cognitive performance. This suggests that melatonin may be beneficial for enhancing quality of life in those managing multiple sclerosis symptoms.
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9
Melatonin reduces inflammation and atrophy
Melatonin Regulates Rheumatoid Synovial Fibroblasts-Related Inflammation: Implications for Pathological Skeletal Muscle Treatment.
High relevance for autoimmune research
We explored how melatonin affects rheumatoid arthritis-related muscle atrophy. By analyzing its anti-inflammatory properties, we found that melatonin can significantly decrease inflammation in rheumatoid synovial fibroblasts and enhance muscle cell growth.
Our research included the use of a collagen-induced arthritis mouse model, showing improvements in swelling and muscle strength after melatonin treatment. This study highlights melatonin’s potential in combating muscle atrophy and fostering muscle growth in autoimmune conditions like rheumatoid arthritis.
Our research included the use of a collagen-induced arthritis mouse model, showing improvements in swelling and muscle strength after melatonin treatment. This study highlights melatonin’s potential in combating muscle atrophy and fostering muscle growth in autoimmune conditions like rheumatoid arthritis.
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9
Melatonin shows promise in MS treatment
Melatonin synergistically potentiates the effect of methylprednisolone on reducing neuroinflammation in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis.
High relevance in autoimmune research.
We investigated how melatonin may influence autoimmune disorders, specifically in a mouse model of multiple sclerosis. By combining melatonin with methylprednisolone, a common glucocorticoid treatment, we noticed a protective effect in reducing neuroinflammation. This combination therapy not only decreased harmful immune cells in the central nervous system but also shifted the immune response towards a more regulated state.
Notably, melatonin seems to improve the effects of methylprednisolone, suggesting it could be a promising complement in treating relapses of multiple sclerosis.
Notably, melatonin seems to improve the effects of methylprednisolone, suggesting it could be a promising complement in treating relapses of multiple sclerosis.
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9
Melatonin improves rheumatoid arthritis treatment
Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route.
Highly relevant study findings
In our exploration of melatonin's potential in rheumatoid arthritis (RA) treatment, we utilized hyalurosomes within a collagen gel to enhance its therapeutic effects. The study involved both laboratory and animal testing, showing that melatonin encapsulated in these carriers significantly improved joint healing and cartilage repair in rats.
While traditional RA treatments often have limited effectiveness and side effects, our findings suggest that this innovative approach may offer a safer alternative. Importantly, no adverse interactions were found, indicating a promising future for melatonin in RA management.
While traditional RA treatments often have limited effectiveness and side effects, our findings suggest that this innovative approach may offer a safer alternative. Importantly, no adverse interactions were found, indicating a promising future for melatonin in RA management.
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User Reviews
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.7
- All Reviews
- Positive Reviews
- Negative Reviews
1
No improvement
My son has struggled with sleep since he was four. I bought this with hope, but after two initial nights of good sleep, we reverted to poor patterns. I'm unsure if it's just him or if these tablets were ineffective. I won't be ordering again.
1
Limited effectiveness
I tried this medicine to normalise my son's sleep, but it only gave him four hours of rest. He would wake up after that, leaving us frustrated.
7.5
Game changer
After years of bedtime hassles, my son's occupational therapist recommended melatonin. We tried everything, but this was a game changer. He can only manage a quarter of a chewable tablet to avoid emotional reactions the next day, but it has significantly improved his sleep.
1
No effect
My daughter, aged three, has been extremely hyper in the evenings, making sleep difficult. Despite positive reviews, these pills had no effect. Instead, she would wake up after 40 minutes, crying.
6.8
Sleep improvement
My son struggled with sleep for three years. After trying various methods, I gave him this remedy. A quarter tablet helped him to sleep within 15-30 minutes. After a 14-day course, he now has a proper sleep routine. However, I later noticed stomach cramps as a side effect. Overall, it worked for what I needed.
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