' 
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
USERS' SCORE
Good
Based on 7 Reviews
8.5
Supplement Facts
Serving Size:
Amount Per Serving
%DV
†Daily Value not established.
Top Medical Research Studies
9
Melatonin mitigates banana cold injury
Comparative transcriptomic analysis reveals the reactive oxygen species metabolism involving in melatonin-alleviated chilling injury in postharvest banana fruit.
Study shows direct melatonin effects
We explored how melatonin treatment affects chilling injury in bananas during cold storage. The study revealed that bananas treated with 500 μmol L of melatonin significantly reduced the signs of chilling injury compared to untreated control fruits during 96 hours of storage.
We observed notable changes in the activity of reactive oxygen species (ROS) metabolism. The melatonin-treated bananas showed lower rates of ROS production while also displaying higher levels of beneficial compounds like ascorbic acid and glutathione. Furthermore, the treatment helped maintain the activity of key antioxidant enzymes that typically decline under cold stress.
A thorough analysis of gene expression found 1858 differentially expressed genes, indicating how melatonin influences various biological pathways in the fruit. Interestingly, melatonin seems to boost the expression of antioxidant enzyme genes while inhibiting the expression of a gene responsible for ROS production.
Overall, these findings provide valuable insights into how melatonin can effectively mitigate cold-related injuries in bananas, helping preserve their quality during storage.
We observed notable changes in the activity of reactive oxygen species (ROS) metabolism. The melatonin-treated bananas showed lower rates of ROS production while also displaying higher levels of beneficial compounds like ascorbic acid and glutathione. Furthermore, the treatment helped maintain the activity of key antioxidant enzymes that typically decline under cold stress.
A thorough analysis of gene expression found 1858 differentially expressed genes, indicating how melatonin influences various biological pathways in the fruit. Interestingly, melatonin seems to boost the expression of antioxidant enzyme genes while inhibiting the expression of a gene responsible for ROS production.
Overall, these findings provide valuable insights into how melatonin can effectively mitigate cold-related injuries in bananas, helping preserve their quality during storage.
Read More
9
Melatonin boosts winter jujube quality
Effect of Melatonin Treatment on Storage Quality and Antioxidant System of Postharvest Winter Jujube ( Mill. cv. Dongzao).
Highly relevant to cold storage
We investigated how different concentrations of melatonin can help maintain the quality of winter jujube—a fruit that can suffer during cold storage. Specifically, we treated the jujubes with melatonin at concentrations of 100, 150, and 200 µmol/L and stored them for 90 days at a chilly 0 ± 1 °C with high humidity.
Our focus was on how melatonin impacts fruit quality and the antioxidant systems in this fruit, which is crucial since refrigeration often leads to a decline in quality. We found that melatonin treatment significantly helped in retaining the fruits' firmness and overall quality, while also slowing down the loss of weight, sweetness, and acidity.
Moreover, melatonin appeared to enhance the antioxidant defenses in the jujubes. This was indicated by increased activities of various antioxidant enzymes, and reductions in harmful compounds like malondialdehyde and hydrogen peroxide. Among the treatments, the highest concentration of 200 µmol/L yielded the most impressive results.
Overall, our findings suggest that melatonin treatment can be a valuable tool in preserving the cold-stored quality of winter jujube by boosting its antioxidant capacity, which is essential for extending the shelf life of this fruit.
Our focus was on how melatonin impacts fruit quality and the antioxidant systems in this fruit, which is crucial since refrigeration often leads to a decline in quality. We found that melatonin treatment significantly helped in retaining the fruits' firmness and overall quality, while also slowing down the loss of weight, sweetness, and acidity.
Moreover, melatonin appeared to enhance the antioxidant defenses in the jujubes. This was indicated by increased activities of various antioxidant enzymes, and reductions in harmful compounds like malondialdehyde and hydrogen peroxide. Among the treatments, the highest concentration of 200 µmol/L yielded the most impressive results.
Overall, our findings suggest that melatonin treatment can be a valuable tool in preserving the cold-stored quality of winter jujube by boosting its antioxidant capacity, which is essential for extending the shelf life of this fruit.
Read More
9
Melatonin enhances cold tolerance
A self-amplifying NO-HS loop mediates melatonin-induced CBF-responsive pathway and cold tolerance in watermelon.
Directly addresses cold tolerance
Our research aimed to uncover how melatonin influences cold stress tolerance in watermelon. We found that when watermelon plants overexpress a specific melatonin biosynthetic gene, ClCOMT1, or when we applied melatonin externally, these plants showed enhanced resistance to cold temperatures. This improved tolerance was linked to the activation of a key pathway known as the CBF-responsive pathway.
Interestingly, we observed that levels of nitric oxide (NO) and hydrogen sulfide (HS) increased alongside the activation of genes responsible for generating these molecules. The plant genes ClNR1 and ClLCD play critical roles in this process. In contrast, knocking out ClCOMT1 led to opposite results, weakening the plants' cold tolerance.
By applying sodium nitroprusside (SNP), a NO donor, and NaHS, a HS donor, we were able to further trigger the CBF pathway and bolster cold resistance in the plants. However, when we knocked out either ClNR1 or ClLCD, the production of NO or HS was inhibited, respectively, leading to a loss of the cold tolerance response triggered by melatonin.
Our findings highlight a self-amplifying loop between NO and HS, suggesting that melatonin’s ability to enhance cold tolerance in watermelon is correspondingly linked to these crucial signaling molecules. Overall, our study provides valuable insights into the role of melatonin in plant resilience against cold stress.
Interestingly, we observed that levels of nitric oxide (NO) and hydrogen sulfide (HS) increased alongside the activation of genes responsible for generating these molecules. The plant genes ClNR1 and ClLCD play critical roles in this process. In contrast, knocking out ClCOMT1 led to opposite results, weakening the plants' cold tolerance.
By applying sodium nitroprusside (SNP), a NO donor, and NaHS, a HS donor, we were able to further trigger the CBF pathway and bolster cold resistance in the plants. However, when we knocked out either ClNR1 or ClLCD, the production of NO or HS was inhibited, respectively, leading to a loss of the cold tolerance response triggered by melatonin.
Our findings highlight a self-amplifying loop between NO and HS, suggesting that melatonin’s ability to enhance cold tolerance in watermelon is correspondingly linked to these crucial signaling molecules. Overall, our study provides valuable insights into the role of melatonin in plant resilience against cold stress.
Read More
Most Useful Reviews
9.5
Strong immunity boost
These excellent vitamins, consumed since January, have clearly made a difference. I no longer feel constantly fatigued, and my energy levels have risen, benefiting both my daily activities and sports. My immunity has strengthened—I haven’t caught a cold amidst the winter months. The long-lasting dosage allows for less frequent consumption, contributing positively to my health.
Read More
8.8
Soothing relief
An excellent ointment made from clean ingredients, safe for both children and adults, including infants from two months old, effective for itching and colds. It significantly alleviates ear pain and reduces fatigue. The scent is pleasant and soothing, ensuring it does not suffocate the child. Based on past experiences with bruises, it has proven quite beneficial.
Read More
8.8
Surprising efficacy
A month ago, an unusual cold—not coronavirus or influenza—spread among my children. During this, I purchased this product as a last resort. To my astonishment, after giving it to my child following a bath, he slept through the night! The delightful taste was a hit, and although I’m cautious, it feels like a reassuring remedy for difficult nights.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
- All Researches
9
Melatonin mitigates banana cold injury
Comparative transcriptomic analysis reveals the reactive oxygen species metabolism involving in melatonin-alleviated chilling injury in postharvest banana fruit.
Study shows direct melatonin effects
We explored how melatonin treatment affects chilling injury in bananas during cold storage. The study revealed that bananas treated with 500 μmol L of melatonin significantly reduced the signs of chilling injury compared to untreated control fruits during 96 hours of storage.
We observed notable changes in the activity of reactive oxygen species (ROS) metabolism. The melatonin-treated bananas showed lower rates of ROS production while also displaying higher levels of beneficial compounds like ascorbic acid and glutathione. Furthermore, the treatment helped maintain the activity of key antioxidant enzymes that typically decline under cold stress.
A thorough analysis of gene expression found 1858 differentially expressed genes, indicating how melatonin influences various biological pathways in the fruit. Interestingly, melatonin seems to boost the expression of antioxidant enzyme genes while inhibiting the expression of a gene responsible for ROS production.
Overall, these findings provide valuable insights into how melatonin can effectively mitigate cold-related injuries in bananas, helping preserve their quality during storage.
We observed notable changes in the activity of reactive oxygen species (ROS) metabolism. The melatonin-treated bananas showed lower rates of ROS production while also displaying higher levels of beneficial compounds like ascorbic acid and glutathione. Furthermore, the treatment helped maintain the activity of key antioxidant enzymes that typically decline under cold stress.
A thorough analysis of gene expression found 1858 differentially expressed genes, indicating how melatonin influences various biological pathways in the fruit. Interestingly, melatonin seems to boost the expression of antioxidant enzyme genes while inhibiting the expression of a gene responsible for ROS production.
Overall, these findings provide valuable insights into how melatonin can effectively mitigate cold-related injuries in bananas, helping preserve their quality during storage.
Read More
9
Melatonin boosts winter jujube quality
Effect of Melatonin Treatment on Storage Quality and Antioxidant System of Postharvest Winter Jujube ( Mill. cv. Dongzao).
Highly relevant to cold storage
We investigated how different concentrations of melatonin can help maintain the quality of winter jujube—a fruit that can suffer during cold storage. Specifically, we treated the jujubes with melatonin at concentrations of 100, 150, and 200 µmol/L and stored them for 90 days at a chilly 0 ± 1 °C with high humidity.
Our focus was on how melatonin impacts fruit quality and the antioxidant systems in this fruit, which is crucial since refrigeration often leads to a decline in quality. We found that melatonin treatment significantly helped in retaining the fruits' firmness and overall quality, while also slowing down the loss of weight, sweetness, and acidity.
Moreover, melatonin appeared to enhance the antioxidant defenses in the jujubes. This was indicated by increased activities of various antioxidant enzymes, and reductions in harmful compounds like malondialdehyde and hydrogen peroxide. Among the treatments, the highest concentration of 200 µmol/L yielded the most impressive results.
Overall, our findings suggest that melatonin treatment can be a valuable tool in preserving the cold-stored quality of winter jujube by boosting its antioxidant capacity, which is essential for extending the shelf life of this fruit.
Our focus was on how melatonin impacts fruit quality and the antioxidant systems in this fruit, which is crucial since refrigeration often leads to a decline in quality. We found that melatonin treatment significantly helped in retaining the fruits' firmness and overall quality, while also slowing down the loss of weight, sweetness, and acidity.
Moreover, melatonin appeared to enhance the antioxidant defenses in the jujubes. This was indicated by increased activities of various antioxidant enzymes, and reductions in harmful compounds like malondialdehyde and hydrogen peroxide. Among the treatments, the highest concentration of 200 µmol/L yielded the most impressive results.
Overall, our findings suggest that melatonin treatment can be a valuable tool in preserving the cold-stored quality of winter jujube by boosting its antioxidant capacity, which is essential for extending the shelf life of this fruit.
Read More
9
Melatonin enhances cold tolerance
A self-amplifying NO-HS loop mediates melatonin-induced CBF-responsive pathway and cold tolerance in watermelon.
Directly addresses cold tolerance
Our research aimed to uncover how melatonin influences cold stress tolerance in watermelon. We found that when watermelon plants overexpress a specific melatonin biosynthetic gene, ClCOMT1, or when we applied melatonin externally, these plants showed enhanced resistance to cold temperatures. This improved tolerance was linked to the activation of a key pathway known as the CBF-responsive pathway.
Interestingly, we observed that levels of nitric oxide (NO) and hydrogen sulfide (HS) increased alongside the activation of genes responsible for generating these molecules. The plant genes ClNR1 and ClLCD play critical roles in this process. In contrast, knocking out ClCOMT1 led to opposite results, weakening the plants' cold tolerance.
By applying sodium nitroprusside (SNP), a NO donor, and NaHS, a HS donor, we were able to further trigger the CBF pathway and bolster cold resistance in the plants. However, when we knocked out either ClNR1 or ClLCD, the production of NO or HS was inhibited, respectively, leading to a loss of the cold tolerance response triggered by melatonin.
Our findings highlight a self-amplifying loop between NO and HS, suggesting that melatonin’s ability to enhance cold tolerance in watermelon is correspondingly linked to these crucial signaling molecules. Overall, our study provides valuable insights into the role of melatonin in plant resilience against cold stress.
Interestingly, we observed that levels of nitric oxide (NO) and hydrogen sulfide (HS) increased alongside the activation of genes responsible for generating these molecules. The plant genes ClNR1 and ClLCD play critical roles in this process. In contrast, knocking out ClCOMT1 led to opposite results, weakening the plants' cold tolerance.
By applying sodium nitroprusside (SNP), a NO donor, and NaHS, a HS donor, we were able to further trigger the CBF pathway and bolster cold resistance in the plants. However, when we knocked out either ClNR1 or ClLCD, the production of NO or HS was inhibited, respectively, leading to a loss of the cold tolerance response triggered by melatonin.
Our findings highlight a self-amplifying loop between NO and HS, suggesting that melatonin’s ability to enhance cold tolerance in watermelon is correspondingly linked to these crucial signaling molecules. Overall, our study provides valuable insights into the role of melatonin in plant resilience against cold stress.
Read More
9
Melatonin aids passion fruit cold resistance
Melatonin alleviated chilling injury of cold-stored passion fruit by modulating cell membrane structure via acting on antioxidant ability and membrane lipid metabolism.
Direct effects on chilling injury
We explored the effects of melatonin on chilling injury (CI) in passion fruit, which often suffers when stored at low temperatures. To investigate this, we treated passion fruit with melatonin before storing them at 5°C and compared the results to a control group that received only water.
During the storage period, we discovered that the melatonin-treated fruits had significantly lower levels of chilling injury. This included reduced cell membrane damage and a decrease in harmful substances that contribute to CI, such as superoxide anions and malondialdehyde.
Additionally, the melatonin treatment boosted the fruits' antioxidant defenses. We observed increased levels of important antioxidants like ascorbic acid and glutathione, as well as enhanced activity of various antioxidant enzymes. Moreover, we noted changes in the fruit's membrane lipid profile, leading to a healthier cell membrane structure, which is crucial for resisting cold stress.
By optimizing membrane integrity and improving antioxidant capacity, melatonin seems to effectively delay the chilling injury process in passion fruit, thereby potentially extending its shelf life and quality after cold storage.
During the storage period, we discovered that the melatonin-treated fruits had significantly lower levels of chilling injury. This included reduced cell membrane damage and a decrease in harmful substances that contribute to CI, such as superoxide anions and malondialdehyde.
Additionally, the melatonin treatment boosted the fruits' antioxidant defenses. We observed increased levels of important antioxidants like ascorbic acid and glutathione, as well as enhanced activity of various antioxidant enzymes. Moreover, we noted changes in the fruit's membrane lipid profile, leading to a healthier cell membrane structure, which is crucial for resisting cold stress.
By optimizing membrane integrity and improving antioxidant capacity, melatonin seems to effectively delay the chilling injury process in passion fruit, thereby potentially extending its shelf life and quality after cold storage.
Read More
9
Melatonin enhances cucumber cold tolerance
GATA3-COMT1-Melatonin as Upstream Signaling of ABA Participated in Se-Enhanced Cold Tolerance by Regulate Iron Uptake and Distribution in Cucumis sativus L.
Study highlights melatonin's role
We explored how melatonin can help cucumber seedlings withstand cold stress when combined with selenium. Our research showed that when we applied selenite, an agent containing selenium, the levels of abscisic acid—a key hormone—changed significantly under cold conditions.
Intriguingly, we observed that iron uptake and distribution also shifted during this process. This change in iron levels seems to play a crucial role in how selenium supports cold tolerance. Through analyzing the gene activity in both the leaves and roots of the seedlings, we identified important genes that likely contribute to this effect.
To further understand the relationship between melatonin and abscisic acid in enhancing cold tolerance, we used specific inhibitors to block their functions. Our findings suggest that melatonin acts as an early signal for the activity of abscisic acid in connection with selenium’s benefits. We also found that a transcription factor, CsGATA3, directly influences melatonin production, which in turn affects cold resilience.
Overall, our study offers valuable insights for cucumber farming, especially for improving cold tolerance through smart use of melatonin and selenium.
Intriguingly, we observed that iron uptake and distribution also shifted during this process. This change in iron levels seems to play a crucial role in how selenium supports cold tolerance. Through analyzing the gene activity in both the leaves and roots of the seedlings, we identified important genes that likely contribute to this effect.
To further understand the relationship between melatonin and abscisic acid in enhancing cold tolerance, we used specific inhibitors to block their functions. Our findings suggest that melatonin acts as an early signal for the activity of abscisic acid in connection with selenium’s benefits. We also found that a transcription factor, CsGATA3, directly influences melatonin production, which in turn affects cold resilience.
Overall, our study offers valuable insights for cucumber farming, especially for improving cold tolerance through smart use of melatonin and selenium.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Strong immunity boost
These excellent vitamins, consumed since January, have clearly made a difference. I no longer feel constantly fatigued, and my energy levels have risen, benefiting both my daily activities and sports. My immunity has strengthened—I haven’t caught a cold amidst the winter months. The long-lasting dosage allows for less frequent consumption, contributing positively to my health.
Read More
8.8
Soothing relief
An excellent ointment made from clean ingredients, safe for both children and adults, including infants from two months old, effective for itching and colds. It significantly alleviates ear pain and reduces fatigue. The scent is pleasant and soothing, ensuring it does not suffocate the child. Based on past experiences with bruises, it has proven quite beneficial.
Read More
8.8
Surprising efficacy
A month ago, an unusual cold—not coronavirus or influenza—spread among my children. During this, I purchased this product as a last resort. To my astonishment, after giving it to my child following a bath, he slept through the night! The delightful taste was a hit, and although I’m cautious, it feels like a reassuring remedy for difficult nights.
Read More
7.5
Helpful sleep aid
Previously, I used a liquid form, but this time opted for chewables which my children enjoy. It’s a reasonably effective melatonin supplement, particularly useful when they have a cold or return home late, allowing them to settle down to sleep quickly.
6.8
Aid for sleep struggles
We used these for jetlag while travelling from Asia to North America. They helped my son fall asleep but he would wake shortly after. While they were effective for his cold-induced sleeplessness, they weren't strong enough for jetlag, leading us to use children's Benadryl instead.
Read More
