Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
The product is found useful for the following medical conditions
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.7
8
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
9
No allergies experienced
Most Useful Review
3 people found this helpful
I consistently take this vitamin D, and I find the cost and quality to be optimal! There hasn’t been any intolerance, unlike other, cheaper supplements that caused allergies. My doctor recommended 2000 units, and I take this supplement every other day.
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.7
8
We investigated the effects of vitamin D, specifically its active form calcitriol, on glioblastoma, the most common type of primary brain cancer in adults. With very limited treatment options and a grim prognosis, glioblastoma poses a serious challenge due to its ability to develop resistance to therapies and acquire stem-like properties that fuel its growth.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
10
Migraine relief
Most Useful Review
40 people found this helpful
I've suffered from migraines for over two decades, since my youth, to the extent that doctors suspected a brain tumour, leading to an MRI and spinal tap. A suggestion to try vitamin D initially met with scepticism from me, but after considerable persuasion, I gave it a shot. Remarkably, I have not experienced a migraine in TWO MONTHS. This is absolutely unprecedented for me. I am continually anticipating its return, yet it has not happened. It's an absolute life changer! I take 1,000 IU in the morning and 1,000 IU at night, though consulting your doctor for your specific needs is advisable. I'm incredibly thankful for this product!
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 10 Reviews
8.6
9
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
9
Improved bone density
Most Useful Review
96 people found this helpful
D3 supports bone health and aids sleep. For four months, I've taken two D3 soft gels daily, totalling 10,000 I.U. My doctor initially prescribed only 2,000 I.U. to address low levels, but I found the results to be remarkable. I had chronic pain in my left knee for years, yet my bone density seems to be repairing, and inflammation has vanished. With added chiropractic adjustments about a month apart, I find I am healing without medication or surgery. I believe many doctors underestimate the required D3 dosage for treating bone loss.
Arthritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 7 Reviews
8.5
8
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
9
High-quality relief
Most Useful Review
27 people found this helpful
During this challenging year due to COVID-19, I started taking vitamin D on my rheumatologist's advice. It works well against my rheumatoid arthritis and prevents colds and viruses. Having used other brands, I find Jarrow's quality outstanding. The delivery to Kazakhstan is also good, and everything is well packaged.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.5
8
We explored the potential connection between vitamin D levels and headaches through a thorough investigation using two-sample Mendelian randomization analysis. Our goal was to determine if there’s a causal relationship between high vitamin D levels and the risk of experiencing headaches.
Our findings revealed that higher levels of vitamin D are linked to a lower risk of headaches. Specifically, we found that vitamin D may have a preventive effect, reducing the likelihood of headaches occurring. However, we also observed that there is no evidence to suggest that headaches cause changes in vitamin D levels.
This means while supplementing vitamin D may help keep headaches at bay, headaches themselves do not appear to affect vitamin D levels. This information contributes valuable insights into how maintaining sufficient vitamin D could play a role in headache management.
Our findings revealed that higher levels of vitamin D are linked to a lower risk of headaches. Specifically, we found that vitamin D may have a preventive effect, reducing the likelihood of headaches occurring. However, we also observed that there is no evidence to suggest that headaches cause changes in vitamin D levels.
This means while supplementing vitamin D may help keep headaches at bay, headaches themselves do not appear to affect vitamin D levels. This information contributes valuable insights into how maintaining sufficient vitamin D could play a role in headache management.
9
No more headaches
Most Useful Review
Good composition, fast delivery, and high-quality packaging. The capsules are a tad large but easy to swallow and taste citrusy. I've taken one daily for ten days, along with other supplements. I’ve noticed significant benefits; headaches have ceased, fatigue has reduced, and my mood has improved greatly. I highly recommend it for those interested in sports, fitness, or dieting, as omega-3 energises and replenishes the body effectively.
Influenza details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
We explored the link between vitamin D supplementation and its effectiveness in preventing influenza. In our analysis, we reviewed ten randomized controlled trials, which included a total of 4,859 participants. This rigorous investigation was thorough, pulling data from trusted sources such as PubMed, Cochrane Library, and Embase.
Our findings showed that vitamin D supplementation was associated with a significant reduction in the risk of influenza infections. Specifically, we noted a 22% decrease in risk, with our calculations presenting a risk ratio of 0.78. Notably, there was little variability in outcomes among the included studies, suggesting that the results were quite consistent.
Additionally, our research indicated no signs of publication bias, adding credibility to our findings. This suggests that incorporating vitamin D supplementation into preventive strategies for influenza could be beneficial. Overall, vitamin D stands out as a promising option for reducing the risk of influenza infections, reinforcing the idea that it plays a crucial role in bolstering our immune defenses.
Our findings showed that vitamin D supplementation was associated with a significant reduction in the risk of influenza infections. Specifically, we noted a 22% decrease in risk, with our calculations presenting a risk ratio of 0.78. Notably, there was little variability in outcomes among the included studies, suggesting that the results were quite consistent.
Additionally, our research indicated no signs of publication bias, adding credibility to our findings. This suggests that incorporating vitamin D supplementation into preventive strategies for influenza could be beneficial. Overall, vitamin D stands out as a promising option for reducing the risk of influenza infections, reinforcing the idea that it plays a crucial role in bolstering our immune defenses.
9
Maintains immunity
Most Useful Review
The dosage serves a prophylactic purpose; we take it during periods of ARVI and influenza to support our immunity.
Leg Cramps details
SCIENTIFIC SCORE
Very Likely Ineffective
Based on 2 Researches
2
USERS' SCORE
Good
Based on 3 Reviews
8.5
4
We assessed the impact of vitamin D on leg cramps experienced during pregnancy, referring to data from various studies. One of the key findings was that vitamin D treatment showed little to no difference when it came to reducing the frequency of leg cramps.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
9
Pain relief
Most Useful Review
3 people found this helpful
My love! I adore vitamin D and take 5000ME regularly. It guarantees a state of cheer. At 60, I work mainly on my feet, and since I started taking vitamin D, the pain and heaviness in my legs have disappeared. I'm feeling great!
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
7
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
9
Psoriasis improvement
Most Useful Review
I realised I was vitamin D deficient for some time. I've also been suffering from psoriasis and psoriatic arthritis for years. I started taking vitamin D during an insomnia episode, requiring one pill daily for a week. The psoriasis on my scalp has nearly disappeared, and I haven’t needed the topical steroids I relied on for five days. I also haven’t needed ibuprofen for my arthritis. If you’re vitamin D deficient and suffer from psoriasis, I recommend trying this.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.4
8
High-dose vitamin D reduces anxiety
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
9
Reduced anxiety
Most Useful Review
I trust the Jarrow brand and was satisfied with their vitamin D, which I take with my family at breakfast. Coupled with K2, we have fallen ill less often, and my feelings of anxiety have diminished. This product has truly benefited our health, and I highly recommend it.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
5.8
USERS' SCORE
Good
Based on 5 Reviews
8.4
0
We conducted a study to see if high-dose vitamin D3 could improve vascular health and reduce fatigue in individuals suffering from chronic fatigue syndrome (CFS). This was a well-structured trial involving 50 participants, all of whom met specific diagnostic criteria for CFS. Participants were divided into two groups: one received 100,000 units of vitamin D3 every two months, while the other received a placebo over a period of six months.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
7.5
Fatigue improvement
Most Useful Review
3 people found this helpful
I received my order and started taking Vitamin D as I have a deficiency, despite living in the south. After two weeks, I noticed improvements; my fatigue has diminished and my sleep has improved significantly. I would recommend it to my friends and others.
Psoriasis details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.3
USERS' SCORE
Good
Based on 6 Reviews
8.4
8
Vitamin D3 ethosomal gel for psoriasis
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
8
Improved immunity
Most Useful Review
212 people found this helpful
In general, the role of vitamin D in the body is significant. Vitamin D is essential for everyone, especially since sunlight alone does not prevent deficiency. It is swiftly excreted and involved in various metabolic processes. Vitamin D helps strengthen the immune system, aiding in the fight against Covid-19 and reducing the likelihood of autoimmune diseases. I believe it has contributed to my psoriasis improvement.
Breast Cancer details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
We examined the relationship between vitamin D intake and breast cancer, delving into how this vitamin may play a role in prevention and management. The findings suggest that vitamin D may have a protective effect, potentially lowering the risk of developing breast cancer.
While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.
Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.
Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.
While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.
Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.
Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.
7.5
Immune function support
Most Useful Review
I prefer Jarrow Vitamin D3 for its effects on immune function, significantly enhancing my wellbeing. It's also suggested that maintaining vitamin D sufficiency may reduce the long-term risk of developing breast cancer and certain infections, including COVID-19.
Common Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 10 Reviews
8.3
8
We explored the connection between vitamin D levels and the frequency of upper respiratory tract infections (URTI) in physically active individuals throughout different seasons. In our research, we observed over 1,600 military recruits during their basic training, noting that only 21% were vitamin D sufficient during winter. Alarmingly, those who had sufficient vitamin D levels were found to be 40% less likely to experience URTIs compared to their deficient counterparts, suggesting that maintaining adequate vitamin D may be crucial for better respiratory health during demanding training periods.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
9
Enhances strength
Most Useful Review
10 people found this helpful
I take various vitamin D3 supplements to ensure diverse benefits. It truly supports me through the cold, dark season, enhancing my health and motivation during such times.
Menopause details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.9
USERS' SCORE
Good
Based on 4 Reviews
8.3
8
Vitamin D supports bone health
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
9
Bone health support
Most Useful Review
This vitamin D3 is best absorbed in this form. It lowers the risk of cardiovascular diseases, osteoporosis, and assists with nutrient absorption during menopause. A deficiency hampers the body's ability to combat viruses and infections. It's crucial to take the right dose based on analysis.
Multiple Sclerosis details
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
5.9
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
We explored how vitamin D (VitD) levels relate to the activity of multiple sclerosis (MS) in patients about to start treatment. By measuring serum levels of a specific form of VitD in 230 untreated individuals with relapsing-remitting MS, we aimed to see if higher VitD could reduce disease activity over the subsequent two years.
Our findings revealed that lower VitD levels were linked to a greater likelihood of disease activity, specifically noting that patients with VitD levels below 20 ng/mL faced more than double the risk of experiencing such activity. Interestingly, we found that genetic factors also played a role; those with a genetic predisposition to higher VitD levels were more likely to have a delayed onset of MS and a better chance of maintaining a status known as No-Evidence of Disease Activity-3 (NEDA-3).
Through further analysis using Mendelian randomization, we confirmed that there is a causal relationship between VitD levels and disease activity in MS. This research highlights the potential benefits of monitoring and possibly supplementing VitD for patients, prompting a greater interest in lifestyle changes that could help manage the disease.
Our findings revealed that lower VitD levels were linked to a greater likelihood of disease activity, specifically noting that patients with VitD levels below 20 ng/mL faced more than double the risk of experiencing such activity. Interestingly, we found that genetic factors also played a role; those with a genetic predisposition to higher VitD levels were more likely to have a delayed onset of MS and a better chance of maintaining a status known as No-Evidence of Disease Activity-3 (NEDA-3).
Through further analysis using Mendelian randomization, we confirmed that there is a causal relationship between VitD levels and disease activity in MS. This research highlights the potential benefits of monitoring and possibly supplementing VitD for patients, prompting a greater interest in lifestyle changes that could help manage the disease.
7.5
Vitamin D findings
Most Useful Review
4 people found this helpful
I researched the link between D3 and multiple sclerosis and found a preliminary study contrasting high versus low daily doses. Those on 1000 IU of D3 experienced remarkably better outcomes, with nearly absent symptoms after a year. Although this study involved only 20 participants, it suggests that for those of us with MS, lesser doses may be more beneficial. I've now switched from 2000 IU to 1000 IU daily.
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 7 Reviews
8.3
8
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
9
Enhances bodily functions
Most Useful Review
4 people found this helpful
Very important supplement at a reasonable price. People increasingly understand the importance of vitamin D, and my doctor states it enhances many bodily functions. I believe these supplements are becoming essential for those with osteoporosis.
Back Pain details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.7
USERS' SCORE
Good
Based on 6 Reviews
8.2
9.5
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
9
Relieved back pain
Most Useful Review
2 people found this helpful
One of the best capsules I have purchased; it greatly alleviated my back pain. The olive oil included helps with the absorption of Vitamin D, making it excellent quality. The pills are small and easy to swallow.
Cold details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.8
USERS' SCORE
Good
Based on 24 Reviews
8.2
8
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
9
Immune support
Most Useful Review
2 people found this helpful
Essential during the virus and cold season. A respected company with a good vitamin D3 form and adequate dosage to combat deficiencies and support the immune system. My wife and I take it, and we buy it for our parents, monitoring levels through analysis. The capsules are small and easy to swallow, even for the elderly. Highly recommended!
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7
USERS' SCORE
Good
Based on 6 Reviews
8.2
9
Vitamin D supports depression management
We conducted a double-blind, randomized, placebo-controlled trial to explore how cholecalciferol, a form of vitamin D, influences depressive symptoms in individuals suffering from type 2 diabetes mellitus (T2DM). This clinical study lasted for 12 weeks and involved participants who were either given a daily dose of 4000 IU of cholecalciferol or a placebo.
Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.
Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.
Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes.
Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.
Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.
Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes.
9
Energy boost
Most Useful Review
1 people found this helpful
This supplement invigorates and significantly improves my mood! I experience heightened energy, a stable mood, and no autumn depression. It's more effective than D3 tablets for me!
Flu details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
USERS' SCORE
Good
Based on 8 Reviews
8.2
8
We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
10
No flu shots
Most Useful Review
2 people found this helpful
I take 10,000 IU daily during winter. My doctor monitors my vitamin D levels, and they are good! I would be seriously deficient without supplementation. In summer, I reduce to 5,000 IU. I never have the flu shot – nor the flu. This supplement is essential for me, and Jarrow is excellent. Just ensure you get your levels checked!
Heart Disease details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.9
USERS' SCORE
Good
Based on 3 Reviews
8
7
Vitamin D's role in heart health
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
7.5
Strengthens against heart disease
Most Useful Review
3 people found this helpful
Vitamin D3 is essential for improving levels in the body, strengthening bones, and reducing chronic disease risks, including heart disease. It also enhances the immune system and promotes dental health. I’ve experienced positive effects from it.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
5
We conducted an observational study to examine the levels of vitamin D in female patients with benign and malignant breast diseases. The research aimed to determine if there is a significant difference in vitamin D levels between those with non-cancerous conditions and those diagnosed with breast cancer.
During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.
Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.
At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.
Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.
At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
9
Cancer cell inhibition
Most Useful Review
Vitamin D supports cell growth, restores immunity, and inhibits the growth of cancer cells, making it essential for overall health.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
7.5
Significant improvement
Most Useful Review
94 people found this helpful
The quality is superb, as recommended by my doctor for health. I’m very pleased with its effects and look forward to ordering more.
Eczema details
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.9
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.5
8
We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
4
Supports bone health
Most Useful Review
Vitamin D3 helps improve the absorption of calcium and phosphorus, essential for maintaining strong bones. It effectively supports immunity and is packaged well. The dosage is convenient, with one tablet taken every other day, although daily intake is possible. It has a soft shell, making it suitable for those who struggle to swallow.
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.2
8
Vitamin D benefits for insomnia
We set out to explore the relationship between vitamin D and insomnia by examining how low-fat milk and yogurt fortified with 1,500 IU of nano-encapsulated vitamin D could improve sleep issues and overall quality of life.
In our analysis, we included adults with abdominal obesity and a history of insomnia, identifying twenty-nine participants through insomnia severity questionnaires. They were split into four groups: one receiving fortified low-fat milk, another with unfortified milk, a third group consuming fortified yogurt, and a fourth with unfortified yogurt. Over a ten-week period, we tracked changes in insomnia symptoms and quality of life.
Our findings revealed that those drinking the vitamin D fortified milk experienced significant improvements in insomnia scores compared to those consuming regular milk. Additionally, quality of life assessments showed positive changes for both fortified and unfortified milk groups. However, the yogurt groups did not demonstrate significant benefits, indicating that while fortified dairy has potential, yogurt may not be as effective in this context.
In conclusion, incorporating fortified low-fat milk into our diets could help ease insomnia symptoms and enhance life satisfaction, although yogurt did not show the same promise.
In our analysis, we included adults with abdominal obesity and a history of insomnia, identifying twenty-nine participants through insomnia severity questionnaires. They were split into four groups: one receiving fortified low-fat milk, another with unfortified milk, a third group consuming fortified yogurt, and a fourth with unfortified yogurt. Over a ten-week period, we tracked changes in insomnia symptoms and quality of life.
Our findings revealed that those drinking the vitamin D fortified milk experienced significant improvements in insomnia scores compared to those consuming regular milk. Additionally, quality of life assessments showed positive changes for both fortified and unfortified milk groups. However, the yogurt groups did not demonstrate significant benefits, indicating that while fortified dairy has potential, yogurt may not be as effective in this context.
In conclusion, incorporating fortified low-fat milk into our diets could help ease insomnia symptoms and enhance life satisfaction, although yogurt did not show the same promise.
9
No insomnia issue
Most Useful Review
Works brilliantly! Vitamin D is high quality, with an optimal dosage of 5000. I take it in the evening after dinner; I've found it’s better absorbed at night. There’s no effect on my sleep, no insomnia at all!
