' 
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
The product is found useful for the following medical conditions
Anemia
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Researches
9
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
9
Vitamin D may reduce anemia risk
Serum Vitamin D Levels and Risk of Iron Deficiency Anemia in Adults: A Cross-Sectional Study and Mendelian Randomization Analysis.
Most Relevant Research
Our investigation centered on whether vitamin D levels play a significant role in iron deficiency anemia (IDA). We examined data from the National Health and Nutrition Examination Survey, which included over 3,700 participants, to explore the relationship between vitamin D and IDA.
Our findings indicated that higher levels of serum vitamin D are linked to a lower risk of developing IDA. Specifically, those in the highest quartile of vitamin D levels had a significantly reduced risk compared to those in the lowest quartile. Interestingly, this protective effect appeared to be more pronounced in women.
We also found a non-linear relationship, suggesting that the effects of vitamin D on anemia become more complex at different levels. This was further supported by a Mendelian randomization analysis, which provided genetic evidence for a causal connection between vitamin D and IDA.
Overall, our results suggest that adequate vitamin D levels could be important for preventing anemia, especially among women. However, further research is certainly needed to confirm these findings and to investigate the potential for vitamin D treatment in managing IDA directly.
Our findings indicated that higher levels of serum vitamin D are linked to a lower risk of developing IDA. Specifically, those in the highest quartile of vitamin D levels had a significantly reduced risk compared to those in the lowest quartile. Interestingly, this protective effect appeared to be more pronounced in women.
We also found a non-linear relationship, suggesting that the effects of vitamin D on anemia become more complex at different levels. This was further supported by a Mendelian randomization analysis, which provided genetic evidence for a causal connection between vitamin D and IDA.
Overall, our results suggest that adequate vitamin D levels could be important for preventing anemia, especially among women. However, further research is certainly needed to confirm these findings and to investigate the potential for vitamin D treatment in managing IDA directly.
9.5
Improved health
Most Useful Review
Jarrow Formulas vitamin D3 has been a lifesaver for me. After my third child, I felt extremely unwell, experiencing cramps and paleness due to anemia. My doctor advised D3, and after three weeks, I noticed significant improvements—no more leg pain, a healthier complexion, and better energy levels. I take it with breakfast and dinner, and it absorbs well alongside fatty foods. The tablets are of excellent quality, and while the taste is unremarkable, the results speak for themselves.
Anxiety
SCIENTIFIC SCORE
Most Likely Effective
Based on 8 Researches
7.5
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
8
High-dose vitamin D reduces anxiety
Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.
Most Relevant Research
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
9.5
Reduced anxiety
Most Useful Review
I trust the Jarrow brand and was satisfied with their vitamin D, which I take with my family at breakfast. Coupled with K2, we have fallen ill less often, and my feelings of anxiety have diminished. This product has truly benefited our health, and I highly recommend it.
Bloating
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
9.5
No bloating
Most Useful Review
This is a fantastic product that my family loves. I truly appreciate this shop as it meets all my needs – I never expected to find everything in one place. My digestion has improved significantly, with no bloating or constipation since I started drinking this. The packaging is excellent, and the product's quality and taste are superb. I'll definitely buy again from this comprehensive shop with fast shipping.
Constipation
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
9.5
No constipation noted
Most Useful Review
I truly love this shop; it's a one-stop shop that has everything I need. I never thought I would find a place with all my requirements available. iHerb is superb, and I will certainly buy from this complete shop again! The shipment was incredibly fast, and my digestion improved greatly. There was no bloating or constipation after I started drinking this. I also appreciate the superb packaging and the quality of the product. The taste is delightful as well.
Frozen Shoulder
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
9.5
Pain relief achieved
Most Useful Review
Using Vitamin D initially made me feel lethargic and fatigued for no apparent reason. Thankfully, all the pain in my joints and shoulders, particularly with my frozen shoulder, has vanished.
Allergies
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.6
USERS' SCORE
Excellent
Based on 9 Reviews
9.3
8
Vitamin D deficiency linked to allergies
Does vitamin D deficiency predispose to allergic proctocolitis?
Most Relevant Research
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
9.5
No allergies experienced
Most Useful Review
I consistently take this vitamin D, and I find the cost and quality to be optimal! There hasn’t been any intolerance, unlike other, cheaper supplements that caused allergies. My doctor recommended 2000 units, and I take this supplement every other day.
Headache
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 4 Reviews
9.3
9.5
No more headaches
Most Useful Review
Good composition, fast delivery, and high-quality packaging. The capsules are a tad large but easy to swallow and taste citrusy. I've taken one daily for ten days, along with other supplements. I’ve noticed significant benefits; headaches have ceased, fatigue has reduced, and my mood has improved greatly. I highly recommend it for those interested in sports, fitness, or dieting, as omega-3 energises and replenishes the body effectively.
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 3 Reviews
9.3
9.5
Pain relief
Most Useful Review
My love! I adore vitamin D and take 5000ME regularly. It guarantees a state of cheer. At 60, I work mainly on my feet, and since I started taking vitamin D, the pain and heaviness in my legs have disappeared. I'm feeling great!
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 5 Reviews
9.2
8.8
Fatigue improvement
Most Useful Review
I received my order and started taking Vitamin D as I have a deficiency, despite living in the south. After two weeks, I noticed improvements; my fatigue has diminished and my sleep has improved significantly. I would recommend it to my friends and others.
Influenza
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
9.5
Maintains immunity
Most Useful Review
The dosage serves a prophylactic purpose; we take it during periods of ARVI and influenza to support our immunity.
Sleep Apnea
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
9.5
Psoriasis improvement
Most Useful Review
I realised I was vitamin D deficient for some time. I've also been suffering from psoriasis and psoriatic arthritis for years. I started taking vitamin D during an insomnia episode, requiring one pill daily for a week. The psoriasis on my scalp has nearly disappeared, and I haven’t needed the topical steroids I relied on for five days. I also haven’t needed ibuprofen for my arthritis. If you’re vitamin D deficient and suffer from psoriasis, I recommend trying this.
Back Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
6.7
USERS' SCORE
Excellent
Based on 5 Reviews
9.1
9.5
Vitamin D aids back pain recovery
An Unusual Mimic of Axial Spondyloarthritis: A Case Report.
Most Relevant Research
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
9.5
Relieved back pain
Most Useful Review
One of the best capsules I have purchased; it greatly alleviated my back pain. The olive oil included helps with the absorption of Vitamin D, making it excellent quality. The pills are small and easy to swallow.
Kidney Stones
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 1 Reviews
9
9
Improved well-being
Most Useful Review
This brand suited me better than others. I replaced the originally used 5000 ME with 2500 ME to prevent vitamin D deficiency, living in a very northern latitude. I noticed an improvement in my well-being with the Jarrow brand, especially initially. My sensitive kidneys have not hurt either. I did not experience the same benefits from other brands, and my kidneys had previously ached, possibly due to kidney stones.
Menopause
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 4 Reviews
9
9.5
Bone health support
Most Useful Review
This vitamin D3 is best absorbed in this form. It lowers the risk of cardiovascular diseases, osteoporosis, and assists with nutrient absorption during menopause. A deficiency hampers the body's ability to combat viruses and infections. It's crucial to take the right dose based on analysis.
Psoriasis
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.3
USERS' SCORE
Excellent
Based on 5 Reviews
9
8
Vitamin D3 ethosomal gel for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Most Relevant Research
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
9
Improved immunity
Most Useful Review
In general, the role of vitamin D in the body is significant. Vitamin D is essential for everyone, especially since sunlight alone does not prevent deficiency. It is swiftly excreted and involved in various metabolic processes. Vitamin D helps strengthen the immune system, aiding in the fight against Covid-19 and reducing the likelihood of autoimmune diseases. I believe it has contributed to my psoriasis improvement.
Depression
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 6 Reviews
8.9
9.5
Energy boost
Most Useful Review
This supplement invigorates and significantly improves my mood! I experience heightened energy, a stable mood, and no autumn depression. It's more effective than D3 tablets for me!
Osteoporosis
SCIENTIFIC SCORE
Most Likely Effective
Based on 10 Researches
7.4
USERS' SCORE
Very Good
Based on 6 Reviews
8.9
8
Vitamin D's impact on osteoporosis
The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis.
Most Relevant Research
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
9.5
Childhood development
Most Useful Review
Vitamin D3 strengthens teeth and bones, supporting normal skeletal growth in children. It also enhances muscle strength and heart health, helping prevent illnesses like osteoporosis and rickets.
Breast Cancer
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 2 Reviews
8.8
8.8
Immune function support
Most Useful Review
I prefer Jarrow Vitamin D3 for its effects on immune function, significantly enhancing my wellbeing. It's also suggested that maintaining vitamin D sufficiency may reduce the long-term risk of developing breast cancer and certain infections, including COVID-19.
Hives
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
8.8
No hives experienced
Most Useful Review
I take various brands of vitamin D, and I like this one. It does not cause hives for me, and the dosage is ideal for my area.
Liver Disease
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
8.8
Reduced illness severity
Most Useful Review
Since beginning vitamin D supplementation, my levels improved significantly from 18 to 59. Although I'm unsure if this is rapid, I’ve noticed a reduction in aches and colds, which I often experienced with low levels. Recent discussions highlight the link between vitamin D levels and the severity of liver disease related to COVID-19; higher levels may correlate with milder disease. Stay healthy.
Multiple Sclerosis
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
5.9
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
8
Vitamin D linked to MS activity
Vitamin D affects the risk of disease activity in multiple sclerosis.
Most Relevant Research
We explored how vitamin D (VitD) levels relate to the activity of multiple sclerosis (MS) in patients about to start treatment. By measuring serum levels of a specific form of VitD in 230 untreated individuals with relapsing-remitting MS, we aimed to see if higher VitD could reduce disease activity over the subsequent two years.
Our findings revealed that lower VitD levels were linked to a greater likelihood of disease activity, specifically noting that patients with VitD levels below 20 ng/mL faced more than double the risk of experiencing such activity. Interestingly, we found that genetic factors also played a role; those with a genetic predisposition to higher VitD levels were more likely to have a delayed onset of MS and a better chance of maintaining a status known as No-Evidence of Disease Activity-3 (NEDA-3).
Through further analysis using Mendelian randomization, we confirmed that there is a causal relationship between VitD levels and disease activity in MS. This research highlights the potential benefits of monitoring and possibly supplementing VitD for patients, prompting a greater interest in lifestyle changes that could help manage the disease.
Our findings revealed that lower VitD levels were linked to a greater likelihood of disease activity, specifically noting that patients with VitD levels below 20 ng/mL faced more than double the risk of experiencing such activity. Interestingly, we found that genetic factors also played a role; those with a genetic predisposition to higher VitD levels were more likely to have a delayed onset of MS and a better chance of maintaining a status known as No-Evidence of Disease Activity-3 (NEDA-3).
Through further analysis using Mendelian randomization, we confirmed that there is a causal relationship between VitD levels and disease activity in MS. This research highlights the potential benefits of monitoring and possibly supplementing VitD for patients, prompting a greater interest in lifestyle changes that could help manage the disease.
8.8
Effective for management
Most Useful Review
I suffer from multiple sclerosis and live in Ireland, where extra Vitamin D3 is essential due to limited sun exposure. I have been using this product for a long time and am very pleased with its quality. The pills are tiny and easy to swallow, with the right strength. My recent D3 levels are within range, confirming its effectiveness. I highly recommend this product and this company.
Nausea
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
8.8
No nausea experienced
Most Useful Review
Good quality. Vit D3 derived from extra virgin olive oil. I experienced no nausea. I have vitamin D deficiency and am taking 5000 IU as per my doctor's recommendation. The packaging is secure and it has helped enhance my immunity.
Vertigo
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
8.8
Aids vertigo issues
Most Useful Review
Good D3, great quality and brand. It helps with my D3 deficiency, particularly when I experience vertigo.
Arthritis
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.6
USERS' SCORE
Very Good
Based on 5 Reviews
8.6
8
Vitamin D aids rheumatoid arthritis
The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review.
Most Relevant Research
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
8.3
High-quality relief
Most Useful Review
During this challenging year due to COVID-19, I started taking vitamin D on my rheumatologist's advice. It works well against my rheumatoid arthritis and prevents colds and viruses. Having used other brands, I find Jarrow's quality outstanding. The delivery to Kazakhstan is also good, and everything is well packaged.
Autoimmune Disorder
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 10 Reviews
8.5
8.8
Significant improvement
Most Useful Review
The quality is superb, as recommended by my doctor for health. I’m very pleased with its effects and look forward to ordering more.
Bone Pain
SCIENTIFIC SCORE
Most Likely Effective
Based on 3 Researches
8.7
USERS' SCORE
Very Good
Based on 9 Reviews
8.5
9
Vitamin D3 correction improves pain
Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.
Most Relevant Research
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
9.5
Cumulative effect
Most Useful Review
The effect is cumulative and long-lasting. I noticed a significant improvement in my hair and skin, as well as relief from bone pain. This classy supplement doesn't cause side effects. I take it in the morning or early afternoon because it can overstimulate the nervous system, leading to insomnia. The quality is excellent.
Cancer
SCIENTIFIC SCORE
Most Likely Effective
Based on 3 Researches
7.3
USERS' SCORE
Very Good
Based on 8 Reviews
8.5
5
Vitamin D's role in breast disease
Levels of Serum 25-Hydroxy Vitamin D in Benign and Malignant Breast Disease Patients: An Observational Study.
Most Relevant Research
We conducted an observational study to examine the levels of vitamin D in female patients with benign and malignant breast diseases. The research aimed to determine if there is a significant difference in vitamin D levels between those with non-cancerous conditions and those diagnosed with breast cancer.
During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.
Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.
At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.
Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.
At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
9.5
Cancer cell inhibition
Most Useful Review
Vitamin D supports cell growth, restores immunity, and inhibits the growth of cancer cells, making it essential for overall health.
Brain Tumor
SCIENTIFIC SCORE
Most Likely Effective
Based on 4 Researches
8
USERS' SCORE
Very Good
Based on 2 Reviews
8.4
8
Vitamin D treatment shows promise
Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells.
Most Relevant Research
We investigated the effects of vitamin D, specifically its active form calcitriol, on glioblastoma, the most common type of primary brain cancer in adults. With very limited treatment options and a grim prognosis, glioblastoma poses a serious challenge due to its ability to develop resistance to therapies and acquire stem-like properties that fuel its growth.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
8.8
Essential medication
Most Useful Review
I take this small capsule three times a week to maintain my levels. I undergo a blood test annually, and my doctor determines the appropriate dosage. I have a rare condition, Fahr's disease, which calcifies my brain, necessitating precise dosage to support my treatment for the brain tumour.
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 10 Reviews
8.2
8.3
Enhances strength
Most Useful Review
I take various vitamin D3 supplements to ensure diverse benefits. It truly supports me through the cold, dark season, enhancing my health and motivation during such times.
Heart Disease
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 3 Reviews
8.2
8.8
Strengthens against heart disease
Most Useful Review
Vitamin D3 is essential for improving levels in the body, strengthening bones, and reducing chronic disease risks, including heart disease. It also enhances the immune system and promotes dental health. I’ve experienced positive effects from it.
